Keiji Hirota

12.6k total citations · 11 hit papers
55 papers, 9.8k citations indexed

About

Keiji Hirota is a scholar working on Immunology, Molecular Biology and Pharmaceutical Science. According to data from OpenAlex, Keiji Hirota has authored 55 papers receiving a total of 9.8k indexed citations (citations by other indexed papers that have themselves been cited), including 47 papers in Immunology, 7 papers in Molecular Biology and 4 papers in Pharmaceutical Science. Recurrent topics in Keiji Hirota's work include T-cell and B-cell Immunology (33 papers), Immune Cell Function and Interaction (23 papers) and Immunotherapy and Immune Responses (16 papers). Keiji Hirota is often cited by papers focused on T-cell and B-cell Immunology (33 papers), Immune Cell Function and Interaction (23 papers) and Immunotherapy and Immune Responses (16 papers). Keiji Hirota collaborates with scholars based in Japan, United States and Germany. Keiji Hirota's co-authors include Brigitta Stockinger, Marc Veldhoen, Shimon Sakaguchi, Takashi Nomura, João H. Duarte, Tomoyuki Yamaguchi, J. Daniel, Noriko Sakaguchi, Jan Buer and Astrid M. Westendorf and has published in prestigious journals such as Nature, Science and Nature Communications.

In The Last Decade

Keiji Hirota

52 papers receiving 9.6k citations

Hit Papers

The aryl hydrocarbon receptor links TH17-cell-mediated au... 2005 2026 2012 2019 2008 2011 2007 2009 2016 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    2008 1.3k citations Marc Veldhoen, Keiji Hirota et al. Nature profile →
  2. Fate mapping of IL-17-producing T cells in inflammatory responses
    2011 895 citations Keiji Hirota, João H. Duarte et al. Nature Immunology profile →
  3. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    2007 749 citations Keiji Hirota, Hiroyuki Yoshitomi et al. The Journal of Experimental Medicine profile →
  4. Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals
    2009 679 citations Bruno Martin, Keiji Hirota et al. Immunity profile →
  5. Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine
    2016 482 citations Daisuke Motooka, Keiji Hirota et al. Arthritis & Rheumatology profile →
  6. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells
    2005 409 citations Sayuri Yamazaki, Kyoko Nakamura et al. The Journal of Experimental Medicine profile →
  7. The pathogenicity of Th17 cells in autoimmune diseases
    2019 405 citations Keiko Yasuda, Yusuke Takeuchi et al. profile →
  8. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    2007 399 citations Keiji Hirota, Motomu Hashimoto et al. The Journal of Experimental Medicine profile →
  9. A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
    2005 359 citations Hiroyuki Yoshitomi, Noriko Sakaguchi et al. The Journal of Experimental Medicine profile →
  10. Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment
    2016 262 citations Yohko Kitagawa, Naganari Ohkura et al. Nature Immunology profile →
  11. Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis
    2018 135 citations Keiji Hirota, Motomu Hashimoto et al. Immunity profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Keiji Hirota Japan 34 6.8k 1.9k 1.4k 862 660 55 9.8k
Yeonseok Chung South Korea 43 9.2k 1.3× 2.0k 1.1× 2.4k 1.8× 570 0.7× 818 1.2× 127 12.0k
Alejandro V. Villarino United States 39 6.4k 0.9× 2.2k 1.2× 2.7k 1.9× 1.0k 1.2× 657 1.0× 64 10.2k
Estelle Bettelli United States 23 8.7k 1.3× 1.9k 1.0× 2.0k 1.4× 882 1.0× 768 1.2× 25 12.1k
Amit Awasthi India 33 6.1k 0.9× 1.2k 0.6× 1.3k 0.9× 499 0.6× 535 0.8× 99 8.4k
Marc Veldhoen United Kingdom 39 9.2k 1.3× 2.2k 1.2× 1.5k 1.1× 546 0.6× 971 1.5× 78 12.8k
Liang Zhou United States 29 9.1k 1.3× 2.5k 1.3× 1.7k 1.2× 552 0.6× 1.0k 1.6× 56 12.4k
Laure Dumoutier Belgium 40 5.5k 0.8× 1.2k 0.7× 1.9k 1.3× 377 0.4× 600 0.9× 82 7.7k
Seon Hee Chang United States 35 8.4k 1.2× 1.9k 1.0× 1.9k 1.4× 706 0.8× 802 1.2× 50 11.4k
Yan Zheng China 28 4.7k 0.7× 2.0k 1.1× 1.2k 0.9× 315 0.4× 658 1.0× 152 7.9k
Takeshi Takahashi Japan 41 8.5k 1.2× 1.7k 0.9× 2.6k 1.9× 496 0.6× 1.1k 1.7× 146 11.8k

Countries citing papers authored by Keiji Hirota

Since Specialization
Citations

This map shows the geographic impact of Keiji Hirota's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keiji Hirota with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keiji Hirota more than expected).

Fields of papers citing papers by Keiji Hirota

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keiji Hirota. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keiji Hirota. The network helps show where Keiji Hirota may publish in the future.

Co-authorship network of co-authors of Keiji Hirota

This figure shows the co-authorship network connecting the top 25 collaborators of Keiji Hirota. A scholar is included among the top collaborators of Keiji Hirota based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Keiji Hirota. Keiji Hirota is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Shimba, Akihiro, Guangwei Cui, Shinya Abe, et al.. (2025). Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells. Cell Reports. 44(8). 116093–116093.
2.
3.
Hirota, Keiji, Yasutaka Okabe, Junji Uehori, et al.. (2024). Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity. Science Advances. 10(9). eadk0820–eadk0820. 7 indexed citations
4.
Takeuchi, Yusuke, et al.. (2024). Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells . Cellular and Molecular Immunology. 21(11). 1183–1200. 11 indexed citations
5.
Sasaki, Takashi, Mariko Hara‐Chikuma, Keiji Hirota, et al.. (2023). Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition. iScience. 27(1). 108646–108646.
6.
Hirota, Keiji, et al.. (2022). Attenuation of regulatory T cell function by type I IFN signaling in an MDA5 gain-of-function mutant mouse model. Biochemical and Biophysical Research Communications. 629. 171–175. 3 indexed citations
7.
Shirakashi, Mirei, Mikako Maruya, Keiji Hirota, et al.. (2021). Effect of Impaired T Cell Receptor Signaling on the Gut Microbiota in a Mouse Model of Systemic Autoimmunity. Arthritis & Rheumatology. 74(4). 641–653. 30 indexed citations
8.
Takeuchi, Yusuke, Keiji Hirota, & Shimon Sakaguchi. (2019). Synovial Tissue Inflammation Mediated by Autoimmune T Cells. Frontiers in Immunology. 10. 1989–1989. 33 indexed citations
9.
Masuda, Kyoko, Keiko Yasuda, Yusuke Takeuchi, et al.. (2019). Identification of a genomic enhancer that enforces proper apoptosis induction in thymic negative selection. Nature Communications. 10(1). 2603–2603. 12 indexed citations
10.
Doty, Amy C., Keiji Hirota, Karl Olsen, et al.. (2016). Validation of a cage implant system for assessing in vivo performance of long-acting release microspheres. Biomaterials. 109. 88–96. 25 indexed citations
11.
Kitagawa, Yohko, Naganari Ohkura, Yujiro Kidani, et al.. (2016). Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment. Nature Immunology. 18(2). 173–183. 262 indexed citations breakdown →
12.
Meglio, Paola Di, João H. Duarte, Helena Ahlfors, et al.. (2014). Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions. Immunity. 40(6). 989–1001. 273 indexed citations
13.
Duarte, João H., Paola Di Meglio, Keiji Hirota, Helena Ahlfors, & Brigitta Stockinger. (2013). Differential Influences of the Aryl Hydrocarbon Receptor on Th17 Mediated Responses in vitro and in vivo. PLoS ONE. 8(11). e79819–e79819. 103 indexed citations
14.
Yamazaki, Sayuri, Kyoko Nakamura, Tomohisa Nishioka, et al.. (2012). Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. The Journal of Experimental Medicine. 209(2). 423–423. 201 indexed citations
15.
Hashimoto, Motomu, Keiji Hirota, Hiroyuki Yoshitomi, et al.. (2010). Complement drives Th17 cell differentiation and triggers autoimmune arthritis. The Journal of Experimental Medicine. 207(6). 1135–1143. 165 indexed citations
16.
Martin, Bruno, Keiji Hirota, J. Daniel, Brigitta Stockinger, & Marc Veldhoen. (2009). Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals. Immunity. 31(2). 321–330. 679 indexed citations breakdown →
17.
Veldhoen, Marc, Keiji Hirota, Astrid M. Westendorf, et al.. (2008). The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature. 453(7191). 106–109. 1298 indexed citations breakdown →
18.
Veldhoen, Marc, Keiji Hirota, Jillian R. Christensen, Anne O’Garra, & Brigitta Stockinger. (2008). Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. The Journal of Experimental Medicine. 206(1). 43–49. 424 indexed citations
19.
Hirota, Keiji, Hiroyuki Yoshitomi, Motomu Hashimoto, et al.. (2007). Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. The Journal of Experimental Medicine. 204(12). 2803–2812. 749 indexed citations breakdown →
20.
Yamazaki, Sayuri, Kyoko Nakamura, Tomohisa Nishioka, et al.. (2005). Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells. The Journal of Experimental Medicine. 202(7). 885–891. 409 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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