Sheldon Milstien

31.7k total citations · 8 hit papers
237 papers, 26.6k citations indexed

About

Sheldon Milstien is a scholar working on Molecular Biology, Cell Biology and Physiology. According to data from OpenAlex, Sheldon Milstien has authored 237 papers receiving a total of 26.6k indexed citations (citations by other indexed papers that have themselves been cited), including 174 papers in Molecular Biology, 70 papers in Cell Biology and 49 papers in Physiology. Recurrent topics in Sheldon Milstien's work include Sphingolipid Metabolism and Signaling (133 papers), Lipid Membrane Structure and Behavior (47 papers) and Metabolism and Genetic Disorders (41 papers). Sheldon Milstien is often cited by papers focused on Sphingolipid Metabolism and Signaling (133 papers), Lipid Membrane Structure and Behavior (47 papers) and Metabolism and Genetic Disorders (41 papers). Sheldon Milstien collaborates with scholars based in United States, Japan and Czechia. Sheldon Milstien's co-authors include Sarah Spiegel, Michael Maceyka, Nitai C. Hait, Seymour Kaufman, Kazuaki Takabe, Kuzhuvelil B. Harikumar, Shawn G. Payne, Steven W. Paugh, Jeremy C. Allegood and Zvonimir S. Katušić and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Sheldon Milstien

236 papers receiving 26.0k citations

Hit Papers

Sphingosine-1-phosphate: an enigmatic signalling lipid 2000 2026 2008 2017 2003 2011 2009 2011 2010 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Sphingosine-1-phosphate: an enigmatic signalling lipid
    2003 1.8k citations Sarah Spiegel, Sheldon Milstien Nature Reviews Molecular Cell Biology profile →
  2. Sphingosine-1-phosphate signaling and its role in disease
    2011 830 citations Michael Maceyka, Kuzhuvelil B. Harikumar et al. profile →
  3. Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
    2009 802 citations Nitai C. Hait, Jeremy C. Allegood et al. Science profile →
  4. The outs and the ins of sphingosine-1-phosphate in immunity
    2011 652 citations Sarah Spiegel, Sheldon Milstien Nature reviews. Immunology profile →
  5. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
    2010 615 citations Kuzhuvelil B. Harikumar, Nitai C. Hait et al. profile →
  6. “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets
    2008 580 citations Kazuaki Takabe, Steven W. Paugh et al. profile →
  7. Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform
    2000 558 citations Sheldon Milstien, Takafumi Kohama et al. Journal of Biological Chemistry profile →
  8. SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism
    2005 530 citations Michael Maceyka, Heidi Sankala et al. Journal of Biological Chemistry profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Sheldon Milstien United States 88 20.5k 7.3k 4.8k 3.7k 1.8k 237 26.6k
Daria Mochly‐Rosen United States 88 17.3k 0.8× 2.7k 0.4× 3.9k 0.8× 1.6k 0.4× 2.0k 1.1× 319 26.1k
John H. Exton United States 90 18.0k 0.9× 5.7k 0.8× 5.8k 1.2× 1.4k 0.4× 1.6k 0.9× 275 27.1k
Jerold Chun United States 99 23.9k 1.2× 6.7k 0.9× 4.2k 0.9× 3.9k 1.0× 1.1k 0.6× 334 31.6k
Junken Aoki Japan 80 16.0k 0.8× 4.6k 0.6× 3.1k 0.6× 2.7k 0.7× 1.3k 0.7× 396 21.5k
Lina M. Obeid United States 94 26.4k 1.3× 7.4k 1.0× 5.3k 1.1× 3.3k 0.9× 2.4k 1.4× 291 30.5k
Peter J. Parker United Kingdom 95 25.3k 1.2× 7.6k 1.0× 3.0k 0.6× 3.5k 0.9× 1.3k 0.7× 406 33.7k
Robin F. Irvine United Kingdom 76 21.2k 1.0× 7.5k 1.0× 3.7k 0.8× 1.9k 0.5× 820 0.5× 223 31.0k
Luca Scorrano Italy 81 25.1k 1.2× 4.2k 0.6× 4.9k 1.0× 1.9k 0.5× 5.4k 3.1× 186 31.7k
Masahiko Negishi United States 96 15.7k 0.8× 4.9k 0.7× 2.8k 0.6× 1.8k 0.5× 1.9k 1.1× 514 33.2k
Jean‐Claude Martinou Switzerland 79 22.0k 1.1× 2.3k 0.3× 2.2k 0.4× 2.6k 0.7× 3.1k 1.8× 194 27.9k

Countries citing papers authored by Sheldon Milstien

Since Specialization
Citations

This map shows the geographic impact of Sheldon Milstien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sheldon Milstien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sheldon Milstien more than expected).

Fields of papers citing papers by Sheldon Milstien

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sheldon Milstien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sheldon Milstien. The network helps show where Sheldon Milstien may publish in the future.

Co-authorship network of co-authors of Sheldon Milstien

This figure shows the co-authorship network connecting the top 25 collaborators of Sheldon Milstien. A scholar is included among the top collaborators of Sheldon Milstien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Sheldon Milstien. Sheldon Milstien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Weigel, Cynthia, Melissa A. Maczis, Elisa N.D. Palladino, et al.. (2022). Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer. Cancer Research. 83(4). 553–567. 16 indexed citations
2.
Oyeniran, Clément, Jamie Sturgill, Jason Newton, et al.. (2020). Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma. Journal of Allergy and Clinical Immunology. 147(5). 1936–1948.e9. 60 indexed citations
3.
Yamada, Akimitsu, Masayuki Nagahashi, Tomoyoshi Aoyagi, et al.. (2018). ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer. Molecular Cancer Research. 16(6). 1059–1070. 61 indexed citations
4.
Nagahashi, Masayuki, Akimitsu Yamada, Eriko Katsuta, et al.. (2018). Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis. Cancer Research. 78(7). 1713–1725. 165 indexed citations
5.
Nagahashi, Masayuki, Subramaniam Ramachandran, Eugene Y. Kim, et al.. (2012). Sphingosine-1-Phosphate Produced by Sphingosine Kinase 1 Promotes Breast Cancer Progression by Stimulating Angiogenesis and Lymphangiogenesis. Cancer Research. 72(3). 726–735. 265 indexed citations
6.
Spiegel, Sarah & Sheldon Milstien. (2011). The outs and the ins of sphingosine-1-phosphate in immunity. Nature reviews. Immunology. 11(6). 403–415. 652 indexed citations breakdown →
7.
Oskeritzian, Carole A., Megan M. Price, Nitai C. Hait, et al.. (2010). Essential roles of sphingosine-1–phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema. The Journal of Experimental Medicine. 207(3). 465–474. 101 indexed citations
8.
Kapitonov, Dmitri, Jeremy C. Allegood, Clint Mitchell, et al.. (2009). Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts. Cancer Research. 69(17). 6915–6923. 154 indexed citations
9.
Hait, Nitai C., Jeremy C. Allegood, Michael Maceyka, et al.. (2009). Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate. Science. 325(5945). 1254–1257. 802 indexed citations breakdown →
10.
Sankala, Heidi, Nitai C. Hait, Steven W. Paugh, et al.. (2007). Involvement of Sphingosine Kinase 2 in p53-Independent Induction of p21 by the Chemotherapeutic Drug Doxorubicin. Cancer Research. 67(21). 10466–10474. 132 indexed citations
11.
Oskeritzian, Carole A., Sheldon Milstien, & Sarah Spiegel. (2007). Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. Pharmacology & Therapeutics. 115(3). 390–399. 81 indexed citations
12.
Milstien, Sheldon & Sarah Spiegel. (2006). Targeting sphingosine-1-phosphate: A novel avenue for cancer therapeutics. Cancer Cell. 9(3). 148–150. 100 indexed citations
13.
Milstien, Sheldon, et al.. (2006). マスト細胞からのスフィンゴシン‐1‐りん酸の運び出しに果たすABCC1の役割. Proc Natl Acad Sci USA. 103(44). 16394–16399. 89 indexed citations
14.
Hait, Nitai C., Sukumar Sarkar, Hervé Le Stunff, et al.. (2005). Role of Sphingosine Kinase 2 in Cell Migration toward Epidermal Growth Factor. Journal of Biological Chemistry. 280(33). 29462–29469. 127 indexed citations
15.
Spiegel, Sarah & Sheldon Milstien. (2003). Sphingosine-1-phosphate: an enigmatic signalling lipid. Nature Reviews Molecular Cell Biology. 4(5). 397–407. 1761 indexed citations breakdown →
16.
Olivera, Ana, Takafumi Kohama, Zhenxing Tu, Sheldon Milstien, & Sarah Spiegel. (1998). Purification and Characterization of Rat Kidney Sphingosine Kinase. Journal of Biological Chemistry. 273(20). 12576–12583. 196 indexed citations
17.
Kinoshita, Hiroyuki, Masato Tsutsui, Sheldon Milstien, & Zvonimir S. Katušić. (1997). Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone. Progress in Neurobiology. 52(4). 295–302. 38 indexed citations
18.
Krämer, A., Stefan Z. Wiktor, Dietmar Fuchs, et al.. (1989). Neopterin: a predictive marker of acquired immune deficiency syndrome in human immunodeficiency virus infection.. PubMed. 2(3). 291–6. 39 indexed citations
19.
Irons, Mira, Harvey L. Levy, Margaret E. O’Flynn, et al.. (1987). Folinic acid therapy in treatment of dihydropteridine reductase deficiency. The Journal of Pediatrics. 110(1). 61–67. 28 indexed citations
20.
Hoganson, George, Stanley Berlow, Seymour Kaufman, et al.. (1984). Biopterin Synthesis Defects: Problems in Diagnosis. PEDIATRICS. 74(6). 1004–1011. 17 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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