Clint Mitchell

3.0k citations

43 papers · 2.5k indexed · h-index 30

Impact in

Oncology top 5%
- Drug Transport and Resistance Mechanisms
Molecular Biology top 5%
- Sphingolipid Metabolism and Signaling
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
- Histone Deacetylase Inhibitors Research

Papers in ⓘ

Oncology 19
- Cancer-related Molecular Pathways 9
- Drug Transport and Resistance Mechanisms 4
Molecular Biology 34
- Cell death mechanisms and regulation 14
- Sphingolipid Metabolism and Signaling 7
- Protein Kinase Regulation and GTPase Signaling 5

Co-authors: Paul Dent (37 shared papers)Steven Grant (25 shared papers)Adly Yacoub (27 shared papers)Margaret A. Park (14 shared papers)Paul B. Fisher (16 shared papers)Mohamed Rahmani (10 shared papers)Sarah Spiegel (6 shared papers)Aditi Pandya Martin (7 shared papers)
Journals: Molecular Pharmacology (8 papers)Cancer Biology & Therapy (8 papers)Molecular Cancer Therapeutics (7 papers)Cancer Research (4 papers)Hepatology (3 papers)
Partner nations: United States Russia Canada

In The Last Decade

Clint Mitchell

43 papers receiving 2.4k citations

Peers

Countries citing papers authored by Clint Mitchell

Since Specialization

Citations

This map shows the geographic impact of Clint Mitchell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Clint Mitchell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Clint Mitchell more than expected).

Fields of papers citing papers by Clint Mitchell

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Clint Mitchell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Clint Mitchell. The network helps show where Clint Mitchell may publish in the future.

Co-authors

The 25 scholars most cited alongside Clint Mitchell, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Clint Mitchell Line = papers co-authored together Clint Mitchell links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 43 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance Cancer Research ·Nathan T. Ihle, Robert Lemos, Peter Wipf, Adly Yacoub, Clint Mitchell, Doris R. Siwak, Gordon B. Mills, Paul Dent, D. Lynn Kirkpatrick, Garth Powis	2008	225
2	Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts Cancer Research ·Dmitri Kapitonov, Jeremy C. Allegood, Clint Mitchell, Nitai C. Hait, Jorge A. Almenara, Jeffrey K. Adams, Robert E. Zipkin, Paul Dent, Tomasz Kordula, Sheldon Milstien, Sarah Spiegel	2009	154
3	Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation Cancer Biology & Therapy ·Margaret A. Park, Guo Zhang, Aditi Pandya Martin, Hossein A. Hamed, Clint Mitchell, Philip B. Hylemon, Martin R. Graf, Mohamed Rahmani, Kevin M. Ryan, Xiang Liu, Sarah Spiegel, James N. Norris, Paul B. Fisher, Steven Grant, Paul Dent	2008	146
4	Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction Proceedings of the National Academy of Sciences ·Anindita Das, David Durrant, Clint Mitchell, Eric K. Mayton, Nicholas N Hoke, Fadi N. Salloum, Margaret A. Park, Ian Qureshi, Ray Lee, Paul Dent, Rakesh C. Kukreja	2010	137
5	Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes Hepatology ·Youwen Fang, Song Iy Han, Clint Mitchell, Seema Gupta, Elaine Studer, Steven Grant, Phillip B. Hylemon, Paul Dent	2004	109
6	Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation Clinical Cancer Research ·Guo Zhang, Margaret A. Park, Clint Mitchell, Hossein A. Hamed, Mohamed Rahmani, Aditi Pandya Martin, David T. Curiel, Adly Yacoub, Martin R. Graf, Ray Lee, John D. Roberts, Paul B. Fisher, Steven Grant, Paul Dent	2008	101
7	Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes† Hepatology ·Paul Dent, Youwen Fang, Seema Gupta, Elaine Studer, Clint Mitchell, Sarah Spiegel, Philip B. Hylemon	2005	100
8	PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda -7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells Cancer Research ·Adly Yacoub, Hossein A. Hamed, Jeremy C. Allegood, Clint Mitchell, Sarah Spiegel, Maciej S. Lesniak, Besim Öğretmen, Rupesh Dash, Devanand Sarkar, William C. Broaddus, Steven Grant, David T. Curiel, Paul B. Fisher, Paul Dent	2010	89
9	Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+- De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway Cancer Research ·Margaret A. Park, Clint Mitchell, Guo Zhang, Adly Yacoub, Jeremy C. Allegood, Dieter Häussinger, Roland Reinehr, Andrew C. Larner, Sarah Spiegel, Paul B. Fisher, Christina Voelkel‐Johnson, Besim Öğretmen, Steven Grant, Paul Dent	2010	86
10	Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy Cancer Biology & Therapy ·Aditi Pandya Martin, Clint Mitchell, Mohamed Rahmani, Kenneth P. Nephew, Steven Grant, Paul Dent	2009	81
11	Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms Molecular Pharmacology ·Teneille Walker, Clint Mitchell, Margaret A. Park, Adly Yacoub, Martin Graf, Mohamed Rahmani, Peter J. Houghton, Christina Voelkel‐Johnson, Steven Grant, Paul Dent	2009	81
12	mda-7(IL-24) Inhibits Growth and Enhances Radiosensitivity of Glioma Cells In Vitro via JNK Signaling Cancer Biology & Therapy ·Adly Yacoub, Clint Mitchell, Irina V. Lebedeva, Devanand Sarkar, Zao-zhong Su, Robert McKinstry, Rahul V. Gopalkrishnan, Steven Grant, Paul B. Fisher, Paul Dent	2003	80
13	BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing Molecular Pharmacology ·Aditi Pandya Martin, Margaret A. Park, Clint Mitchell, Teneille Walker, Mohamed Rahmani, Andrew Thorburn, Dieter Häussinger, Roland Reinehr, Steven Grant, Paul Dent	2009	72
14	MDA-7 regulates cell growth and radiosensitivity in vitro of primary (Non-Established) human glioma cells Cancer Biology & Therapy ·Adly Yacoub, Clint Mitchell, Young Ki Hong, Rahul V. Gopalkrishnan, Zhao-zhong Su, Pankaj Gupta, Moira Sauane, Irina V. Lebedeva, David T. Curiel, Parameshwar J. Mahasreshti, Myrna R. Rosenfeld, William C. Broaddus, Claire D. James, Steven Grant, Paul B. Fisher, Paul Dent	2004	70
15	OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells Molecular Pharmacology ·Adly Yacoub, Margaret A. Park, David E. Hanna, Young Ki Hong, Clint Mitchell, Aditi P. Pandya, Hisashi Harada, Garth Powis, Ching-Shih Chen, Constantinos Koumenis, Steven Grant, Paul Dent	2006	66
16	Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo Cancer Biology & Therapy ·Clint Mitchell, Adly Yacoub, Hamed Hossein, Aditi Pandya Martin, M. Danielle Bareford, Patrick Eulitt, Yang Chen, Kenneth P. Nephew, Paul Dent	2010	63
17	Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival Molecular Cancer Therapeutics ·Rubén W. Carón, Adly Yacoub, Min Li, Xiaoyu Zhu, Clint Mitchell, Young Ki Hong, William Hawkins, Takehiko Sasazuki, Senji Shirasawa, Alan P. Kozikowski, Philip A. Dennis, Michael P. Hagan, Steven Grant, Paul Dent	2005	62
18	Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation Molecular Pharmacology ·Aditi Pandya Martin, Anna V. Miller, Luni Emad, Mohamed Rahmani, Teneille Walker, Clint Mitchell, Michael P. Hagan, Margaret A. Park, Adly Yacoub, Paul B. Fisher, Steven Grant, Paul Dent	2008	52
19	MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity. PubMed ·Adly Yacoub, Clint Mitchell, Jessica Brannon, Elizabeth Rosenberg, Liang Qiao, Robert McKinstry, W. Marston Linehan, Zao-shong Su, Devanand Sarkar, Irina V. Lebedeva, Kristoffer Valerie, Rahul V. Gopalkrishnan, Steven Grant, Paul B. Fisher, Paul Dent	2003	49
20	Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK Blood ·Yun Dai, Mohamed Rahmani, Xin‐Yan Pei, Payal Khanna, Song Iy Han, Clint Mitchell, Paul Dent, Steven Grant	2004	49

About Clint Mitchell

Clint Mitchell is a scholar working on Oncology, Molecular Biology, Physiology, Cell Biology and Hepatology, having authored 43 papers that have together received 2.5k indexed citations. Recurring topics across this work include Cell death mechanisms and regulation (14 papers), Cancer-related Molecular Pathways (9 papers), Sphingolipid Metabolism and Signaling (7 papers), Autophagy in Disease and Therapy (6 papers), Protein Kinase Regulation and GTPase Signaling (5 papers), Endoplasmic Reticulum Stress and Disease (4 papers), Drug Transport and Resistance Mechanisms (4 papers) and Cancer Research and Treatments (3 papers). The work is most often cited by research in Oncology (846 citations), Molecular Biology (1.6k citations), Cell Biology (347 citations), Physiology (91 citations) and Epidemiology (528 citations). Clint Mitchell has collaborated with scholars based in United States, Russia and Canada. Frequent co-authors include Paul Dent, Steven Grant, Adly Yacoub, Margaret A. Park, Paul B. Fisher, Mohamed Rahmani, Sarah Spiegel, Aditi Pandya Martin, Elaine Studer and Youwen Fang. Their work appears in journals such as Molecular Pharmacology, Cancer Biology & Therapy, Molecular Cancer Therapeutics, Cancer Research and Hepatology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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