Setsuo Hirohashi

34.9k total citations · 5 hit papers
441 papers, 28.4k citations indexed

About

Setsuo Hirohashi is a scholar working on Molecular Biology, Oncology and Surgery. According to data from OpenAlex, Setsuo Hirohashi has authored 441 papers receiving a total of 28.4k indexed citations (citations by other indexed papers that have themselves been cited), including 232 papers in Molecular Biology, 152 papers in Oncology and 73 papers in Surgery. Recurrent topics in Setsuo Hirohashi's work include Wnt/β-catenin signaling in development and cancer (67 papers), Cancer-related gene regulation (67 papers) and Hepatocellular Carcinoma Treatment and Prognosis (43 papers). Setsuo Hirohashi is often cited by papers focused on Wnt/β-catenin signaling in development and cancer (67 papers), Cancer-related gene regulation (67 papers) and Hepatocellular Carcinoma Treatment and Prognosis (43 papers). Setsuo Hirohashi collaborates with scholars based in Japan, United Kingdom and United States. Setsuo Hirohashi's co-authors include Michiie Sakamoto, Yae Kanai, Tesshi Yamada, Hitoshi Tsuda, Tomoo Kosuge, Tatsuhiro Shibata, Yukío Shimosato, Yoshinori Ino, Yukihiro Nakanishi and Tadashi Kondo and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and The Lancet.

In The Last Decade

Setsuo Hirohashi

435 papers receiving 27.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human Cancers

1998 710 citations Setsuo Hirohashi profile →
Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial

2000 688 citations Tomoo Kosuge, Setsuo Hirohashi et al. profile →
Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions

2006 642 citations Nobuyoshi Hiraoka, Kaoru Onozato et al. Clinical Cancer Research profile →
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

2008 602 citations Tatsuhiro Shibata, Tsutomu Ohta et al. Proceedings of the National Academy of Sciences profile →
Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

2008 526 citations Tsutomu Ohta, Kumiko Iijima et al. Cancer Research profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Setsuo Hirohashi Japan	90	15.3k	8.7k	4.6k	4.3k	3.9k	441	28.4k
Ravi Salgia United States	90	12.5k 0.8×	10.6k 1.2×	3.7k 0.8×	8.4k 2.0×	1.8k 0.5×	626	27.5k
Paolo M. Comoglio Italy	104	19.9k 1.3×	8.5k 1.0×	4.6k 1.0×	3.4k 0.8×	5.1k 1.3×	403	35.5k
Irene Oi‐Lin Ng Hong Kong	97	15.4k 1.0×	7.9k 0.9×	9.4k 2.0×	2.8k 0.7×	5.5k 1.4×	483	31.4k
Jessica Zucman‐Rossi France	82	13.9k 0.9×	7.2k 0.8×	7.8k 1.7×	7.7k 1.8×	4.6k 1.2×	322	31.8k
Owen J. Sansom United Kingdom	80	14.4k 0.9×	8.8k 1.0×	4.9k 1.1×	1.6k 0.4×	2.6k 0.7×	311	23.8k
Ming‐Sound Tsao Canada	98	16.5k 1.1×	15.3k 1.8×	8.3k 1.8×	13.8k 3.2×	3.0k 0.8×	653	37.2k
Kevin C. Gatter United Kingdom	88	12.7k 0.8×	8.2k 0.9×	8.4k 1.8×	3.5k 0.8×	1.9k 0.5×	311	26.8k
Ivan Bièche France	76	11.1k 0.7×	5.9k 0.7×	5.7k 1.2×	2.6k 0.6×	1.5k 0.4×	497	20.2k
Nabeel Bardeesy United States	84	19.1k 1.2×	12.0k 1.4×	7.4k 1.6×	2.3k 0.5×	5.1k 1.3×	182	30.8k
M. Ángela Nieto Spain	66	23.8k 1.6×	13.8k 1.6×	8.0k 1.7×	3.6k 0.8×	2.3k 0.6×	156	35.5k

Countries citing papers authored by Setsuo Hirohashi

Since Specialization

Citations

This map shows the geographic impact of Setsuo Hirohashi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Setsuo Hirohashi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Setsuo Hirohashi more than expected).

Fields of papers citing papers by Setsuo Hirohashi

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Setsuo Hirohashi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Setsuo Hirohashi. The network helps show where Setsuo Hirohashi may publish in the future.

Co-authorship network of co-authors of Setsuo Hirohashi

This figure shows the co-authorship network connecting the top 25 collaborators of Setsuo Hirohashi. A scholar is included among the top collaborators of Setsuo Hirohashi based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Setsuo Hirohashi. Setsuo Hirohashi is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Matsubara, Junichi, Kazufumi Honda, Masaya Ono, et al.. (2011). Reduced Plasma Level of CXC Chemokine Ligand 7 in Patients with Pancreatic Cancer. Cancer Epidemiology Biomarkers & Prevention. 20(1). 160–171. 43 indexed citations

Satow, Reiko, Miki Shitashige, Yae Kanai, et al.. (2010). Combined Functional Genome Survey of Therapeutic Targets for Hepatocellular Carcinoma. Clinical Cancer Research. 16(9). 2518–2528. 138 indexed citations

Kobayashi, Eisuke, Mari Masuda, Robert Nakayama, et al.. (2010). Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma. Molecular Cancer Therapeutics. 9(3). 535–544. 97 indexed citations

Shibata, Tatsuhiro, Shigeru Saito, Akiko Kokubu, et al.. (2010). Global Downstream Pathway Analysis Reveals a Dependence of Oncogenic NF-E2–Related Factor 2 Mutation on the mTOR Growth Signaling Pathway. Cancer Research. 70(22). 9095–9105. 106 indexed citations

Kikuta, Kazutaka, Naobumi Tochigi, Tadakazu Shimoda, et al.. (2009). Nucleophosmin as a Candidate Prognostic Biomarker of Ewing's Sarcoma Revealed by Proteomics. Clinical Cancer Research. 15(8). 2885–2894. 43 indexed citations

Tsuda, Hitoshi, Ken‐ichi Kozaki, Yae Kanai, et al.. (2008). Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer. Cancer Research. 68(13). 5067–5075. 48 indexed citations

Ohta, Tsutomu, Kumiko Iijima, Mamiko Miyamoto, et al.. (2008). Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth. Cancer Research. 68(5). 1303–1309. 526 indexed citations breakdown →

Kikuchi, Satoru, Kazufumi Honda, Hitoshi Tsuda, et al.. (2008). Expression and Gene Amplification of Actinin-4 in Invasive Ductal Carcinoma of the Pancreas. Clinical Cancer Research. 14(17). 5348–5356. 96 indexed citations

Yamaguchi, Umio, Robert Nakayama, Kazufumi Honda, et al.. (2008). Distinct Gene Expression–Defined Classes of Gastrointestinal Stromal Tumor. Journal of Clinical Oncology. 26(25). 4100–4108. 97 indexed citations

10.

Shibata, Tatsuhiro, Tsutomu Ohta, Kit I. Tong, et al.. (2008). Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proceedings of the National Academy of Sciences. 105(36). 13568–13573. 602 indexed citations breakdown →

11.

Okano, Tetsuya, Tadashi Kondo, Kiyonaga Fujii, et al.. (2007). Proteomic Signature Corresponding to the Response to Gefitinib (Iressa, ZD1839), an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Lung Adenocarcinoma. Clinical Cancer Research. 13(3). 799–805. 49 indexed citations

12.

Idogawa, Masashi, Mitsuko Masutani, Miki Shitashige, et al.. (2007). Ku70 and Poly(ADP-Ribose) Polymerase-1 Competitively Regulate β-Catenin and T-Cell Factor-4–Mediated Gene Transactivation: Possible Linkage of DNA Damage Recognition and Wnt Signaling. Cancer Research. 67(3). 911–918. 62 indexed citations

13.

Tsuda, Hitoshi, Yae Kanai, Takahiro Kasamatsu, et al.. (2007). Promoter Hypermethylation Contributes to Frequent Inactivation of a Putative Conditional Tumor Suppressor Gene Connective Tissue Growth Factor in Ovarian Cancer. Cancer Research. 67(15). 7095–7105. 68 indexed citations

14.

Nam, Jeong‐Seok, Mi‐Jin Kang, Takeshi Shimamura, et al.. (2006). Chemokine (C-C Motif) Ligand 2 Mediates the Prometastatic Effect of Dysadherin in Human Breast Cancer Cells. Cancer Research. 66(14). 7176–7184. 89 indexed citations

15.

Hayashida, Yasuharu, Kazufumi Honda, Yoshiaki Osaka, et al.. (2005). Possible Prediction of Chemoradiosensitivity of Esophageal Cancer by Serum Protein Profiling. Clinical Cancer Research. 11(22). 8042–8047. 42 indexed citations

16.

Izumi, Hiroyuki, Jun Inoue, Sana Yokoi, et al.. (2005). Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. Human Molecular Genetics. 14(8). 997–1007. 52 indexed citations

17.

Ishii, Yoshiyuki, Atsushi Ochiai, Tesshi Yamada, et al.. (2000). Integrin α6β4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer. Gastroenterology. 118(3). 497–506. 36 indexed citations

18.

Ono, Yukiko, Yukihiro Nakanishi, Yoshinori Ino, et al.. (1999). Clinicopathologic significance of laminin‐5 γ2 chain expression in squamous cell carcinoma of the tongue. Cancer. 85(11). 2315–2321. 2 indexed citations

19.

Ono, Yukiko, Yukihiro Nakanishi, Yoshinori Ino, et al.. (1999). Clinicopathologic significance of laminin-5 ?2 chain expression in squamous cell carcinoma of the tongue. Cancer. 85(11). 2315–2321. 103 indexed citations

20.

Hirohashi, Setsuo. (1999). Molecular Mechanisms of Cancer Metastasis. ACTA HISTOCHEMICA ET CYTOCHEMICA. 32(6). 487. 8 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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