Setsuo Hirohashi

34.9k citations

441 papers · 28.4k indexed · 5 hit papers · h-index 90

Impact in

Hepatology top 0.2%
- Hepatocellular Carcinoma Treatment and Prognosis
Oncology top 0.1%
- Cancer-related Molecular Pathways

Papers in

Hepatology 46
- Hepatocellular Carcinoma Treatment and Prognosis 43
Oncology 152

Co-authors: Michiie Sakamoto Yae Kanai Tesshi Yamada Hitoshi Tsuda Tomoo Kosuge Tatsuhiro Shibata Yukío Shimosato Yoshinori Ino
Journals: Cancer (32 papers)Cancer Science (22 papers)International Journal of Cancer (17 papers)Clinical Cancer Research (14 papers)Cancer Research (14 papers)
Partner nations: Japan United Kingdom United States

In The Last Decade

Setsuo Hirohashi

435 papers receiving 27.6k citations

Hit Papers

5 papers align trajectories log scale

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy 2008 · 602 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2008 Proceedings of the National Academy of Sciences
2008 Cancer Research
2006 Clinical Cancer Research
2000 The Lancet
1998 American Journal Of Pathology

Peers

Countries citing papers authored by Setsuo Hirohashi

Since Specialization

Citations

This map shows the geographic impact of Setsuo Hirohashi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Setsuo Hirohashi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Setsuo Hirohashi more than expected).

Fields of papers citing papers by Setsuo Hirohashi

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Setsuo Hirohashi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Setsuo Hirohashi. The network helps show where Setsuo Hirohashi may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Setsuo Hirohashi, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Setsuo Hirohashi Line = papers co-authored together Setsuo Hirohashi links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Reduced Plasma Level of CXC Chemokine Ligand 7 in Patients with Pancreatic Cancer Cancer Epidemiology Biomarkers & Prevention ·Junichi Matsubara, Kazufumi Honda, Masaya Ono, Yoshinori Tanaka, Michimoto Kobayashi, Giman Jung, Alfred E. Ehm, Tomohiro Sakuma, Shoji Nakamori, Naohiro Sata, Hideo Nagai, Tatsuya Ioka, Takuji Okusaka, Tomoo Kosuge, Akihiko Tsuchida, Masashi Shimahara, Yohichi Yasunami, Tsutomu Chiba, Setsuo Hirohashi, Tesshi Yamada	2011	43
2	Combined Functional Genome Survey of Therapeutic Targets for Hepatocellular Carcinoma Clinical Cancer Research ·Reiko Satow, Miki Shitashige, Yae Kanai, Fumitaka Takeshita, Hidenori Ojima, Takafumi Jigami, Kazufumi Honda, Tomoo Kosuge, Takahiro Ochiya, Setsuo Hirohashi, Tesshi Yamada	2010	138
3	Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma Molecular Cancer Therapeutics ·Eisuke Kobayashi, Mari Masuda, Robert Nakayama, Hitoshi Ichikawa, Reiko Satow, Miki Shitashige, Kazufumi Honda, Umio Yamaguchi, Ayako Shoji, Naobumi Tochigi, Hideo Morioka, Yoshiaki Toyama, Setsuo Hirohashi, Akira Kawai, Tesshi Yamada	2010	97
4	Global Downstream Pathway Analysis Reveals a Dependence of Oncogenic NF-E2–Related Factor 2 Mutation on the mTOR Growth Signaling Pathway Cancer Research ·Tatsuhiro Shibata, Shigeru Saito, Akiko Kokubu, Takafumi Suzuki, Masayuki Yamamoto, Setsuo Hirohashi	2010	106
5	Nucleophosmin as a Candidate Prognostic Biomarker of Ewing's Sarcoma Revealed by Proteomics Clinical Cancer Research ·Kazutaka Kikuta, Naobumi Tochigi, Tadakazu Shimoda, Hiroki Yabe, Hideo Morioka, Yoshiaki Toyama, Ako Hosono, Yasuo Beppu, Akira Kawai, Setsuo Hirohashi, Tadashi Kondo	2009	43
6	Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer Cancer Research ·童亮 TONG Liang, Hitoshi Tsuda, Ken‐ichi Kozaki, Yae Kanai, Takahiro Kasamatsu, Kazuo Sengoku, Setsuo Hirohashi, Johji Inazawa, Issei Imoto	2008	48
7	Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth Cancer Research ·Tsutomu Ohta, Kumiko Iijima, Mamiko Miyamoto, Izumi Nakahara, Hiroshi Tanaka, Makiko Ohtsuji, Takafumi Suzuki, Akira Kobayashi, Jun Yokota, Tokuki Sakiyama, Tatsuhiro Shibata, Masayuki Yamamoto, Setsuo Hirohashi Hit paper breakdown →	2008	526
8	Expression and Gene Amplification of Actinin-4 in Invasive Ductal Carcinoma of the Pancreas Clinical Cancer Research ·Satoru Kikuchi, Kazufumi Honda, Hitoshi Tsuda, Nobuyoshi Hiraoka, Issei Imoto, Tomoo Kosuge, 健太宇田川, Kaoru Onozato, Miki Shitashige, Umio Yamaguchi, Masaya Ono, Akihiko Tsuchida, Tatsuya Aoki, Johji Inazawa, Setsuo Hirohashi, Tesshi Yamada	2008	96
9	Distinct Gene Expression–Defined Classes of Gastrointestinal Stromal Tumor Journal of Clinical Oncology ·Umio Yamaguchi, Robert Nakayama, Kazufumi Honda, Hitoshi Ichikawa, Tadashi Hasegawa, Miki Shitashige, Masaya Ono, Ayako Shoji, Tomohiro Sakuma, Carlos Manuel Amaya Rojas, Yasuhiro Shimada, Mitsuru Sasako, Tadakazu Shimoda, Akira Kawai, Setsuo Hirohashi, Tesshi Yamada	2008	97
10	Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy Proceedings of the National Academy of Sciences ·Tatsuhiro Shibata, Tsutomu Ohta, Kit I. Tong, Akiko Kokubu, 成田俊介, Koji Tsuta, Hisao Asamura, Masayuki Yamamoto, Setsuo Hirohashi Hit paper breakdown →	2008	602
11	Proteomic Signature Corresponding to the Response to Gefitinib (Iressa, ZD1839), an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Lung Adenocarcinoma Clinical Cancer Research ·Tetsuya Okano, Tadashi Kondo, Kiyonaga Fujii, Toshihide Nishimura, Toshimi Takano, Yuichiro Ohe, Koji Tsuta, Yoshihiro Matsuno, Akihiko Gemma, It, Shoji Kudoh, Setsuo Hirohashi	2007	49
12	Ku70 and Poly(ADP-Ribose) Polymerase-1 Competitively Regulate β-Catenin and T-Cell Factor-4–Mediated Gene Transactivation: Possible Linkage of DNA Damage Recognition and Wnt Signaling Cancer Research ·Masashi Idogawa, Mitsuko Masutani, Miki Shitashige, Kazufumi Honda, Takashi Tokino, Yasuhisa Shinomura, Kohzoh Imai, Setsuo Hirohashi, Tesshi Yamada	2007	62
13	Promoter Hypermethylation Contributes to Frequent Inactivation of a Putative Conditional Tumor Suppressor Gene Connective Tissue Growth Factor in Ovarian Cancer Cancer Research ·童亮 TONG Liang, Hitoshi Tsuda, Yae Kanai, Takahiro Kasamatsu, Kazuo Sengoku, Setsuo Hirohashi, Johji Inazawa, Issei Imoto	2007	68
14	Chemokine (C-C Motif) Ligand 2 Mediates the Prometastatic Effect of Dysadherin in Human Breast Cancer Cells Cancer Research ·Jeong‐Seok Nam, Mi‐Jin Kang, M. Reza Roshandel, Takeshi Shimamura, Ethan A. Kohn, Aleksandra M. Michalowska, V. Craig Jordan, Setsuo Hirohashi, Lalage M. Wakefield	2006	89
15	Possible Prediction of Chemoradiosensitivity of Esophageal Cancer by Serum Protein Profiling Clinical Cancer Research ·Yasuharu Hayashida, Kazufumi Honda, Yoshiaki Osaka, Tomohiko Hara, 健太宇田川, Akihiko Tsuchida, Tatsuya Aoki, Setsuo Hirohashi, Tesshi Yamada	2005	42
16	Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers Human Molecular Genetics ·Hiroyuki Izumi, Jun Inoue, Sana Yokoi, Hiroshi Hosoda, Tatsuhiro Shibata, M Sunamori, Setsuo Hirohashi, Johji Inazawa, Issei Imoto	2005	52
17	Integrin α6β4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer Gastroenterology ·Yoshiyuki Ishii, Atsushi Ochiai, Tesshi Yamada, Shingo Akimoto, Kazuyoshi Yanagihara, Masaki Kitajima, Setsuo Hirohashi	2000	36
18	Clinicopathologic significance of laminin‐5 γ2 chain expression in squamous cell carcinoma of the tongue Cancer ·Yukiko Ono, Yukihiro Nakanishi, Yoshinori Ino, Toshiro Niki, Minlong Zhu, Kimio Yoshimura, Masahisa Saikawa, Tamio Nakajima, Setsuo Hirohashi	1999	2
19	Clinicopathologic significance of laminin-5 ?2 chain expression in squamous cell carcinoma of the tongue Cancer ·Yukiko Ono, Yukihiro Nakanishi, Yoshinori Ino, Toshiro Niki, Tesshi Yamada, Kimio Yoshimura, Masahisa Saikawa, Tamio Nakajima, Setsuo Hirohashi	1999	103
20	Molecular Mechanisms of Cancer Metastasis ACTA HISTOCHEMICA ET CYTOCHEMICA ·Setsuo Hirohashi	1999	8

About Setsuo Hirohashi

Setsuo Hirohashi is a scholar working on Hepatology, Oncology, Immunology and Allergy, Cancer Research and Molecular Biology, having authored 441 papers that have together received 28.4k indexed citations. Recurring topics across this work include Wnt/β-catenin signaling in development and cancer (67 papers), Cancer-related gene regulation (67 papers), Hepatocellular Carcinoma Treatment and Prognosis (43 papers), Cancer Genomics and Diagnostics (37 papers), RNA modifications and cancer (36 papers), Epigenetics and DNA Methylation (35 papers), Cholangiocarcinoma and Gallbladder Cancer Studies (34 papers) and Genetic factors in colorectal cancer (34 papers). The work is most often cited by research in Hepatology (2.9k citations), Oncology (8.7k citations), Cancer Research (4.6k citations), Molecular Biology (15.3k citations) and Immunology and Allergy (1.3k citations). Setsuo Hirohashi has collaborated with scholars based in Japan, United Kingdom and United States. Frequent co-authors include Michiie Sakamoto, Yae Kanai, Tesshi Yamada, Hitoshi Tsuda, Tomoo Kosuge, Tatsuhiro Shibata, Yukío Shimosato, Yoshinori Ino, Yukihiro Nakanishi and Tadashi Kondo. Their work appears in journals such as Cancer, Cancer Science, International Journal of Cancer, Clinical Cancer Research and Cancer Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact