Akiko Kokubu

3.7k total citations · 1 hit paper
29 papers, 3.0k citations indexed

About

Akiko Kokubu is a scholar working on Molecular Biology, Oncology and Surgery. According to data from OpenAlex, Akiko Kokubu has authored 29 papers receiving a total of 3.0k indexed citations (citations by other indexed papers that have themselves been cited), including 24 papers in Molecular Biology, 13 papers in Oncology and 7 papers in Surgery. Recurrent topics in Akiko Kokubu's work include PI3K/AKT/mTOR signaling in cancer (5 papers), Cholangiocarcinoma and Gallbladder Cancer Studies (5 papers) and Genomics, phytochemicals, and oxidative stress (4 papers). Akiko Kokubu is often cited by papers focused on PI3K/AKT/mTOR signaling in cancer (5 papers), Cholangiocarcinoma and Gallbladder Cancer Studies (5 papers) and Genomics, phytochemicals, and oxidative stress (4 papers). Akiko Kokubu collaborates with scholars based in Japan, United Kingdom and United States. Akiko Kokubu's co-authors include Tatsuhiro Shibata, Setsuo Hirohashi, Masayuki Yamamoto, Tsutomu Ohta, Hidenori Ojima, Koji Tsuta, Michiie Sakamoto, Hisao Asamura, Kit I. Tong and Masahiro Gotoh and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Gastroenterology.

In The Last Decade

Akiko Kokubu

29 papers receiving 2.9k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

2008 602 citations Tatsuhiro Shibata, Tsutomu Ohta et al. Proceedings of the National Academy of Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Akiko Kokubu Japan	25	2.2k	649	594	404	375	29	3.0k
Jun‐ichi Akahira Japan	37	1.4k 0.6×	841 1.3×	756 1.3×	570 1.4×	400 1.1×	108	3.6k
Elaine Kilgour United Kingdom	30	2.3k 1.1×	949 1.5×	677 1.1×	840 2.1×	426 1.1×	80	3.5k
Richard Kendall United States	24	1.8k 0.8×	837 1.3×	476 0.8×	268 0.7×	173 0.5×	43	3.0k
Owen W.J. Prall Australia	26	1.9k 0.9×	637 1.0×	300 0.5×	285 0.7×	397 1.1×	45	2.9k
Takako Asano Japan	27	1.3k 0.6×	378 0.6×	469 0.8×	412 1.0×	219 0.6×	84	2.1k
Prashant Bavi Saudi Arabia	34	1.4k 0.7×	929 1.4×	699 1.2×	343 0.8×	188 0.5×	76	2.8k
Toshiyuki Sakamaki United States	19	2.1k 1.0×	1.0k 1.6×	712 1.2×	315 0.8×	124 0.3×	25	2.9k
Daniela Califano Italy	29	1.6k 0.7×	964 1.5×	577 1.0×	211 0.5×	170 0.5×	62	2.6k
Nelson S. Yee United States	30	1.2k 0.6×	780 1.2×	354 0.6×	308 0.8×	481 1.3×	83	3.0k
Suzanne E. Wardell United States	28	1.6k 0.8×	930 1.4×	1.0k 1.8×	670 1.7×	525 1.4×	50	3.4k

Countries citing papers authored by Akiko Kokubu

Since Specialization

Citations

This map shows the geographic impact of Akiko Kokubu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Akiko Kokubu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Akiko Kokubu more than expected).

Fields of papers citing papers by Akiko Kokubu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Akiko Kokubu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Akiko Kokubu. The network helps show where Akiko Kokubu may publish in the future.

Co-authorship network of co-authors of Akiko Kokubu

This figure shows the co-authorship network connecting the top 25 collaborators of Akiko Kokubu. A scholar is included among the top collaborators of Akiko Kokubu based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Akiko Kokubu. Akiko Kokubu is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Ojima, Hidenori, Takuya Shirakihara, Akiko Kokubu, et al.. (2013). Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma. Cancer Science. 104(5). 543–551. 69 indexed citations

Shibata, Tatsuhiro, Akiko Kokubu, Shigeru Saito, et al.. (2011). NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer. Neoplasia. 13(9). 864–IN26. 182 indexed citations

Miyamoto, M, Hidenori Ojima, Motoki Iwasaki, et al.. (2011). Prognostic significance of overexpression of c-Met oncoprotein in cholangiocarcinoma. British Journal of Cancer. 105(1). 131–138. 108 indexed citations

Shibata, Tatsuhiro, Shigeru Saito, Akiko Kokubu, et al.. (2010). Global Downstream Pathway Analysis Reveals a Dependence of Oncogenic NF-E2–Related Factor 2 Mutation on the mTOR Growth Signaling Pathway. Cancer Research. 70(22). 9095–9105. 106 indexed citations

Kubo, Takashi, Akiko Kokubu, Fumie Hosoda, et al.. (2009). Resequencing Analysis of the Human Tyrosine Kinase Gene Family in Pancreatic Cancer. Pancreas. 38(7). e200–e206. 17 indexed citations

Kubo, Takashi, Hiroko Shimizu, Akiko Kokubu, et al.. (2009). Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer. Carcinogenesis. 30(11). 1857–1864. 33 indexed citations

Yoshikawa, Daitaro, Hidenori Ojima, Akiko Kokubu, et al.. (2009). Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma. British Journal of Cancer. 100(8). 1257–1266. 86 indexed citations

Shibata, Tatsuhiro, Akiko Kokubu, Koji Tsuta, & Setsuo Hirohashi. (2009). Oncogenic mutation of PIK3CA in small cell lung carcinoma: A potential therapeutic target pathway for chemotherapy-resistant lung cancer. Cancer Letters. 283(2). 203–211. 55 indexed citations

Shibata, Tatsuhiro, Tsutomu Ohta, Kit I. Tong, et al.. (2008). Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proceedings of the National Academy of Sciences. 105(36). 13568–13573. 602 indexed citations breakdown →

10.

Shibata, Tatsuhiro, Akiko Kokubu, Masahiro Gotoh, et al.. (2008). Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer. Gastroenterology. 135(4). 1358–1368.e4. 397 indexed citations

11.

Shibata, Tatsuhiro, Satoko Hanada, Akiko Kokubu, et al.. (2007). Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma. Cancer Science. 98(7). 985–991. 27 indexed citations

12.

Loukopoulos, Panayiotis, Tatsuhiro Shibata, Hiroto Katoh, et al.. (2007). Genome‐wide array‐based comparative genomic hybridization analysis of pancreatic adenocarcinoma: Identification of genetic indicators that predict patient outcome. Cancer Science. 98(3). 392–400. 120 indexed citations

13.

Katoh, Hiroto, Hidenori Ojima, Akiko Kokubu, et al.. (2007). Genetically Distinct and Clinically Relevant Classification of Hepatocellular Carcinoma: Putative Therapeutic Targets. Gastroenterology. 133(5). 1475–1486. 62 indexed citations

14.

Katoh, Hiroto, Tatsuhiro Shibata, Akiko Kokubu, et al.. (2006). Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: A case report. Genes Chromosomes and Cancer. 45(11). 1050–1057. 14 indexed citations

15.

Katoh, Hiroto, Tatsuhiro Shibata, Akiko Kokubu, et al.. (2006). Epigenetic Instability and Chromosomal Instability in Hepatocellular Carcinoma. American Journal Of Pathology. 168(4). 1375–1384. 44 indexed citations

16.

Katoh, Hiroto, Tatsuhiro Shibata, Akiko Kokubu, et al.. (2005). Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: Identification of genetic indicators to predict patient outcome. Journal of Hepatology. 43(5). 863–874. 57 indexed citations

17.

Shibata, Tatsuhiro, Akiko Kokubu, Fumie Hosoda, et al.. (2005). Genetic Classification of Lung Adenocarcinoma Based on Array-Based Comparative Genomic Hybridization Analysis: Its Association with Clinicopathologic Features. Clinical Cancer Research. 11(17). 6177–6185. 85 indexed citations

18.

Shibata, Tatsuhiro, Makoto Chuma, Akiko Kokubu, Michiie Sakamoto, & Setsuo Hirohashi. (2003). Ebp50, A β–Catenin-Associating Protein, Enhances Wnt Signaling and Is Over–Expressed in Hepatocellular Carcinoma. Hepatology. 38(1). 178–186. 129 indexed citations

19.

Noguchi, Kohji, et al.. (2001). ASK1-Signaling Promotes c-Myc Protein Stability during Apoptosis. Biochemical and Biophysical Research Communications. 281(5). 1313–1320. 28 indexed citations

20.

Noguchi, Kohji, et al.. (1999). Regulation of c-Myc through Phosphorylation at Ser-62 and Ser-71 by c-Jun N-Terminal Kinase. Journal of Biological Chemistry. 274(46). 32580–32587. 151 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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