René Coulombe

2.3k citations

33 papers · 1.5k indexed · h-index 19

Co-authors: Mirosław Cygler John S. Mort Paweł Grochulski J. Sivaraman Robert Ménard Alice Vrielink Pierre Bonneau Pierre L. Beaulieu
Topics: HIV/AIDS drug development and treatment (12 papers)Hepatitis C virus research (10 papers)HIV Research and Treatment (6 papers)
Cited by: Virology Infectious Diseases Cancer Research
Journals: Journal of the American Chemical Society Journal of Biological Chemistry The EMBO Journal
Partner nations: Canada United States Germany

In The Last Decade

René Coulombe

32 papers receiving 1.5k citations

Peers

Countries citing papers authored by René Coulombe

Since Specialization

Citations

This map shows the geographic impact of René Coulombe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by René Coulombe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites René Coulombe more than expected).

Fields of papers citing papers by René Coulombe

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by René Coulombe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by René Coulombe. The network helps show where René Coulombe may publish in the future.

Co-authorship network of co-authors of René Coulombe

This figure shows the co-authorship network connecting the top 25 collaborators of René Coulombe. A scholar is included among the top collaborators of René Coulombe based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with René Coulombe. René Coulombe is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV 2014 ·ACS Medicinal Chemistry Letters ·Lee D. Fader,Rebekah Carson,Sébastien Morin,François Bilodeau,Catherine Chabot,Ted Halmos,Murray D. Bailey,Stephen H. Kawai,René Coulombe,Steven R. LaPlante,(unknown),Araz Jakalian,Michel Garneau,Jianmin Duan,Stephen W. Mason,Bruno Simoneau,Craig Fenwick,Youla S. Tsantrizos,Christiane Yoakim	14
2	Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using ¹⁹F Ligand‐and ¹⁵N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series 2013 ·ChemMedChem ·Nathalie Goudreau,René Coulombe,Anne‐Marie Faucher,Chantal Grand‐Maître,(unknown),Christopher T. Lemke,Éric Malenfant,Yves Bousquet,Lee D. Fader,Bruno Simoneau,Jean‐François Mercier,Steve Titolo,Stephen W. Mason	14
3	Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay 2013 ·Bioorganic & Medicinal Chemistry Letters ·Timothy A. Stammers,René Coulombe,Martin Duplessis,Gulrez Fazal,Alexandre Gagnon,Michel Garneau,Sylvie Goulet,Araz Jakalian,Steven R. LaPlante,Jean Rancourt,Bounkham Thavonekham,Dominik Wernic,George Kukolj,Pierre L. Beaulieu	15
4	N- versus O-alkylation: Utilizing NMR methods to establish reliable primary structure determinations for drug discovery 2013 ·Bioorganic & Medicinal Chemistry Letters ·Steven R. LaPlante,François Bilodeau,Norman Aubry,James Gillard,Jeff A. O’Meara,René Coulombe	16
5	Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors 2013 ·Bioorganic & Medicinal Chemistry Letters ·Timothy A. Stammers,René Coulombe,Jean Rancourt,Bounkham Thavonekham,Gulrez Fazal,Sylvie Goulet,Araz Jakalian,(unknown),Youla S. Tsantrizos,Marc‐André Poupart,Michael Bös,Ginette McKercher,Louise Thauvette,George Kukolj,Pierre L. Beaulieu	19
6	Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype 2013 ·Bioorganic & Medicinal Chemistry Letters ·Pierre L. Beaulieu,René Coulombe,Jianmin Duan,Gulrez Fazal,Cédrickx Godbout,Oliver Hucke,Araz Jakalian,(unknown),Olivier Lepage,Montse Llinàs‐Brunet,Julie Naud,Martin Poirier,Nathalie Rioux,Bounkham Thavonekham,George Kukolj,Timothy A. Stammers	21
7	Conformation-Based Restrictions and Scaffold Replacements in the Design of Hepatitis C Virus Polymerase Inhibitors: Discovery of Deleobuvir (BI 207127) 2013 ·Journal of Medicinal Chemistry ·Steven R. LaPlante,Michael Bös,Christian Brochu,Catherine Chabot,René Coulombe,James Gillard,Araz Jakalian,Martin Poirier,Jean Rancourt,Timothy A. Stammers,Bounkham Thavonekham,Pierre L. Beaulieu,George Kukolj,Youla S. Tsantrizos	27
8	N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies 2010 ·Bioorganic & Medicinal Chemistry Letters ·Pierre L. Beaulieu,(unknown),James Gillard,Christian Brochu,René Coulombe,Nathalie Dansereau,Jianmin Duan,Michel Garneau,Araz Jakalian,Peter Kühn,Lisette Lagacé,Steven R. LaPlante,Ginette McKercher,(unknown),Martin Poirier,Marc‐André Poupart,Timothy A. Stammers,Louise Thauvette,Bounkham Thavonekham,George Kukolj	12
9	Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases 2008 ·Bioorganic & Medicinal Chemistry Letters ·Alexandre Gagnon,Serge Landry,René Coulombe,Araz Jakalian,Ingrid Guse,Bounkham Thavonekham,Pierre Bonneau,Christiane Yoakim,Bruno Simoneau	48
10	Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors 2007 ·Bioorganic & Medicinal Chemistry Letters ·Jeff A. O’Meara,Araz Jakalian,Steven R. LaPlante,Pierre Bonneau,René Coulombe,Anne‐Marie Faucher,Ingrid Guse,Serge Landry,Jennifer Racine,Bruno Simoneau,Bounkham Thavonekham,Christiane Yoakim	43
11	Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases 2007 ·Bioorganic & Medicinal Chemistry Letters ·Alexandre Gagnon,Ma’an Amad,Pierre Bonneau,René Coulombe,Patrick DeRoy,Louise Doyon,Jianmin Duan,Michel Garneau,Ingrid Guse,Araz Jakalian,(unknown),Serge Landry,Éric Malenfant,Bruno Simoneau,Christiane Yoakim	47
12	Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor 2004 ·Journal of Biological Chemistry ·Yong Wang,René Coulombe,Dale R. Cameron,Louise Thauvette,Marie-Josée Massariol,Lynn M. Amon,Dominique Fink,Steve Titolo,(unknown),Christiane Yoakim,Jacques Archambault,Peter W. White	71
13	Oxygen Access to the Active Site of Cholesterol Oxidase through a Narrow Channel Is Gated by an Arg-Glu Pair 2001 ·Journal of Biological Chemistry ·René Coulombe,(unknown),Sandro Ghisla,Alice Vrielink	99
14	Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion 1996 ·Structure ·Mirosław Cygler,J. Sivaraman,Paweł Grochulski,René Coulombe,Andrew C. Storer,John S. Mort	139
15	Crystallization and preliminary x-ray diffraction studies of human procathepsin L 1996 ·Proteins Structure Function and Bioinformatics ·René Coulombe,Yunge Li,Sachiko Takebe,Robert Ménard,Patrizia Mason,John S. Mort,Mirosław Cygler	11
16	Protein crystallization in low gravity by step gradient diffusion method 1996 ·Journal of Crystal Growth ·J. Sygusch,René Coulombe,(unknown),(unknown),Paul Todd	11
17	Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human α‐thrombin 1996 ·Protein Science ·James Féthière,Yuko Tsuda,René Coulombe,Yasuo Konishi,Mirosław Cygler	13
18	Novel active site in Escherichia coli fructose 1,6-bisphosphate aldolase 1996 ·Nature Structural & Molecular Biology ·(unknown),(unknown),René Coulombe,J. Sygusch	73
19	Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. 1996 ·The EMBO Journal ·René Coulombe,Paweł Grochulski,J. Sivaraman,Robert Ménard,John S. Mort,Mirosław Cygler	325
20	Crystallization and preliminary x‐ray diffraction studies of human procathepsin L 1996 ·Proteins Structure Function and Bioinformatics ·René Coulombe,Yunge Li,Sachiko Takebe,Robert Ménard,Patrizia Mason,John S. Mort,Mirosław Cygler	7

About René Coulombe

René Coulombe is a scholar working on Virology, Hepatology and Infectious Diseases, having authored 33 papers that have together received 1.5k indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (12 papers), Hepatitis C virus research (10 papers) and HIV Research and Treatment (6 papers). The work is most often cited by research in Virology (185 citations), Infectious Diseases (295 citations) and Cancer Research (218 citations). René Coulombe has collaborated with scholars based in Canada, United States and Germany. Frequent co-authors include Mirosław Cygler, John S. Mort, Paweł Grochulski, J. Sivaraman, Robert Ménard, Alice Vrielink, Pierre Bonneau, Pierre L. Beaulieu, Araz Jakalian and Sandro Ghisla. Their work appears in journals such as Journal of the American Chemical Society, Journal of Biological Chemistry and The EMBO Journal.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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