René Coulombe

2.3k total citations
33 papers, 1.5k citations indexed

About

René Coulombe is a scholar working on Molecular Biology, Infectious Diseases and Hepatology. According to data from OpenAlex, René Coulombe has authored 33 papers receiving a total of 1.5k indexed citations (citations by other indexed papers that have themselves been cited), including 16 papers in Molecular Biology, 13 papers in Infectious Diseases and 10 papers in Hepatology. Recurrent topics in René Coulombe's work include HIV/AIDS drug development and treatment (12 papers), Hepatitis C virus research (10 papers) and HIV Research and Treatment (6 papers). René Coulombe is often cited by papers focused on HIV/AIDS drug development and treatment (12 papers), Hepatitis C virus research (10 papers) and HIV Research and Treatment (6 papers). René Coulombe collaborates with scholars based in Canada, United States and Germany. René Coulombe's co-authors include Mirosław Cygler, John S. Mort, Paweł Grochulski, J. Sivaraman, Robert Ménard, Alice Vrielink, Pierre Bonneau, Pierre L. Beaulieu, Araz Jakalian and Sandro Ghisla and has published in prestigious journals such as Journal of the American Chemical Society, Journal of Biological Chemistry and The EMBO Journal.

In The Last Decade

René Coulombe

32 papers receiving 1.5k citations

Peers

René Coulombe
Pierre Bonneau Canada
Jinming Zhou China
Sherin S. Abdel‐Meguid United States
Shridhar Bhat United States
Alexander E. Aleshin United States
Sanjeev Munshi United States
Nickolay Y. Chirgadze United States
Zhenyu Li China
Ted Fox United States
Stephen A. Margosiak United States
Pierre Bonneau Canada
René Coulombe
Citations per year, relative to René Coulombe René Coulombe (= 1×) peers Pierre Bonneau

Countries citing papers authored by René Coulombe

Since Specialization
Citations

This map shows the geographic impact of René Coulombe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by René Coulombe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites René Coulombe more than expected).

Fields of papers citing papers by René Coulombe

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by René Coulombe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by René Coulombe. The network helps show where René Coulombe may publish in the future.

Co-authorship network of co-authors of René Coulombe

This figure shows the co-authorship network connecting the top 25 collaborators of René Coulombe. A scholar is included among the top collaborators of René Coulombe based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with René Coulombe. René Coulombe is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Fader, Lee D., Rebekah Carson, Sébastien Morin, et al.. (2014). Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. ACS Medicinal Chemistry Letters. 5(6). 711–716. 14 indexed citations
2.
Goudreau, Nathalie, René Coulombe, Anne‐Marie Faucher, et al.. (2013). Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using 19F Ligand‐and 15N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series. ChemMedChem. 8(3). 405–414. 14 indexed citations
3.
Stammers, Timothy A., René Coulombe, Martin Duplessis, et al.. (2013). Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay. Bioorganic & Medicinal Chemistry Letters. 23(24). 6879–6885. 15 indexed citations
4.
LaPlante, Steven R., François Bilodeau, Norman Aubry, et al.. (2013). N- versus O-alkylation: Utilizing NMR methods to establish reliable primary structure determinations for drug discovery. Bioorganic & Medicinal Chemistry Letters. 23(16). 4663–4668. 16 indexed citations
5.
Stammers, Timothy A., René Coulombe, Jean Rancourt, et al.. (2013). Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23(9). 2585–2589. 19 indexed citations
6.
Beaulieu, Pierre L., René Coulombe, Jianmin Duan, et al.. (2013). Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: Discovery of a quinazolinone chemotype. Bioorganic & Medicinal Chemistry Letters. 23(14). 4132–4140. 21 indexed citations
7.
LaPlante, Steven R., Michael Bös, Christian Brochu, et al.. (2013). Conformation-Based Restrictions and Scaffold Replacements in the Design of Hepatitis C Virus Polymerase Inhibitors: Discovery of Deleobuvir (BI 207127). Journal of Medicinal Chemistry. 57(5). 1845–1854. 27 indexed citations
8.
Beaulieu, Pierre L., James Gillard, Christian Brochu, et al.. (2010). N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies. Bioorganic & Medicinal Chemistry Letters. 20(3). 857–861. 12 indexed citations
9.
Gagnon, Alexandre, Serge Landry, René Coulombe, et al.. (2008). Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases. Bioorganic & Medicinal Chemistry Letters. 19(4). 1199–1205. 48 indexed citations
10.
O’Meara, Jeff A., Araz Jakalian, Steven R. LaPlante, et al.. (2007). Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17(12). 3362–3366. 43 indexed citations
11.
Gagnon, Alexandre, Ma’an Amad, Pierre Bonneau, et al.. (2007). Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases. Bioorganic & Medicinal Chemistry Letters. 17(16). 4437–4441. 47 indexed citations
12.
Wang, Yong, René Coulombe, Dale R. Cameron, et al.. (2004). Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor. Journal of Biological Chemistry. 279(8). 6976–6985. 71 indexed citations
13.
Coulombe, René, et al.. (2001). Oxygen Access to the Active Site of Cholesterol Oxidase through a Narrow Channel Is Gated by an Arg-Glu Pair. Journal of Biological Chemistry. 276(32). 30435–30441. 99 indexed citations
14.
Cygler, Mirosław, J. Sivaraman, Paweł Grochulski, et al.. (1996). Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion. Structure. 4(4). 405–416. 139 indexed citations
15.
Coulombe, René, Yunge Li, Sachiko Takebe, et al.. (1996). Crystallization and preliminary x-ray diffraction studies of human procathepsin L. Proteins Structure Function and Bioinformatics. 25(3). 398–400. 11 indexed citations
16.
Sygusch, J., et al.. (1996). Protein crystallization in low gravity by step gradient diffusion method. Journal of Crystal Growth. 162(3-4). 167–172. 11 indexed citations
17.
Féthière, James, Yuko Tsuda, René Coulombe, Yasuo Konishi, & Mirosław Cygler. (1996). Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human α‐thrombin. Protein Science. 5(6). 1174–1183. 13 indexed citations
18.
Coulombe, René, et al.. (1996). Novel active site in Escherichia coli fructose 1,6-bisphosphate aldolase. Nature Structural & Molecular Biology. 3(10). 856–862. 73 indexed citations
19.
Coulombe, René, Paweł Grochulski, J. Sivaraman, et al.. (1996). Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.. The EMBO Journal. 15(20). 5492–5503. 325 indexed citations
20.
Coulombe, René, Yunge Li, Sachiko Takebe, et al.. (1996). Crystallization and preliminary x‐ray diffraction studies of human procathepsin L. Proteins Structure Function and Bioinformatics. 25(3). 398–400. 7 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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