Lee D. Fader

2.3k citations

19 papers · 1.5k indexed · 2 hit papers · h-index 12

Co-authors: Oliver Hucke Steven R. LaPlante Paul Edwards Araz Jakalian Ray Kemper Keith R. Fandrick Daniel R. Fandrick Stephen Miller
Topics: HIV Research and Treatment (5 papers)DNA and Nucleic Acid Chemistry (5 papers)HIV/AIDS drug development and treatment (5 papers)
Cited by: Spectroscopy Organic Chemistry Virology
Journals: Journal of Virology Journal of Medicinal Chemistry The Journal of Organic Chemistry
Partner nations: Canada United States Switzerland

In The Last Decade

Lee D. Fader

17 papers receiving 1.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Assessing Atropisomer Axial Chirality in Drug Discovery and Development

2011 671 citations Steven R. LaPlante, Lee D. Fader et al. Journal of Medicinal Chemistry profile →
Revealing Atropisomer Axial Chirality in Drug Discovery

2011 419 citations Steven R. LaPlante, Paul Edwards et al. ChemMedChem profile →

Peers

Countries citing papers authored by Lee D. Fader

Since Specialization

Citations

This map shows the geographic impact of Lee D. Fader's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lee D. Fader with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lee D. Fader more than expected).

Fields of papers citing papers by Lee D. Fader

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lee D. Fader. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lee D. Fader. The network helps show where Lee D. Fader may publish in the future.

Co-authorship network of co-authors of Lee D. Fader

This figure shows the co-authorship network connecting the top 25 collaborators of Lee D. Fader. A scholar is included among the top collaborators of Lee D. Fader based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lee D. Fader. Lee D. Fader is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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19 of 19 papers shown

#	Work	Indexed citations
1	Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization 2024 ·ACS Medicinal Chemistry Letters ·Patrick Cyr,Lee D. Fader,Jason D. Burch,Kelly A. Pike,(unknown),(unknown),Stéphane Ciblat,Nicolas Sgarioto,Alexander Skeldon,(unknown),Pierre Gros,(unknown),Daniel J. McKay,(unknown),(unknown),Ramsay E. Beveridge	0
2	Discovery of NXT-10796, an orally active, intestinally restricted EP4 agonist prodrug for the treatment of inflammatory bowel disease 2023 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Amandine Chefson,(unknown),(unknown),(unknown),Stéphane Dorich,Jennifer H. Cox,Alexandre Caron,Jason D. Burch,M. David Percival,Alex G. Therien,Lee D. Fader	0
3	Novel pyridone EP4 agonists featuring allylic alcohol ω-chains 2020 ·Bioorganic & Medicinal Chemistry Letters ·Stéphane Dorich,Jennifer H. Cox,Jason D. Burch,(unknown),Bin Chen,Serge Léger,Miguel St‐Onge,Lee D. Fader	6
4	Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV 2014 ·ACS Medicinal Chemistry Letters ·Lee D. Fader,Rebekah Carson,Sébastien Morin,François Bilodeau,Catherine Chabot,Ted Halmos,Murray D. Bailey,Stephen H. Kawai,René Coulombe,Steven R. LaPlante,(unknown),Araz Jakalian,Michel Garneau,Jianmin Duan,Stephen W. Mason,Bruno Simoneau,Craig Fenwick,Youla S. Tsantrizos,Christiane Yoakim	14
5	Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using ¹⁹F Ligand‐and ¹⁵N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series 2013 ·ChemMedChem ·Nathalie Goudreau,René Coulombe,Anne‐Marie Faucher,Chantal Grand‐Maître,(unknown),Christopher T. Lemke,Éric Malenfant,Yves Bousquet,Lee D. Fader,Bruno Simoneau,Jean‐François Mercier,Steve Titolo,Stephen W. Mason	14
6	Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: Addressing configurational instability through scaffold modification 2013 ·Bioorganic & Medicinal Chemistry Letters ·Lee D. Fader,Serge Landry,Sébastien Morin,Stephen H. Kawai,Yves Bousquet,Oliver Hucke,Nathalie Goudreau,Christopher T. Lemke,Pierre Bonneau,Steve Titolo,Stephen W. Mason,Bruno Simoneau	15
7	Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: Structure–activity relationships (SAR) of the C3-phenyl moiety 2013 ·Bioorganic & Medicinal Chemistry Letters ·Lee D. Fader,Serge Landry,Sylvie Goulet,Sébastien Morin,Stephen H. Kawai,Yves Bousquet,(unknown),Oliver Hucke,Nathalie Goudreau,Christopher T. Lemke,Jean Rancourt,Pierre Bonneau,Steve Titolo,Ma’an Amad,Michel Garneau,Jianmin Duan,Stephen W. Mason,Bruno Simoneau	16
8	Total Synthesis of Bafilomycin A₁ 2012 ·Chemistry - A European Journal ·Florian Kleinbeck,(unknown),Lee D. Fader,Erick M. Carreira	27
9	Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein 2012 ·Journal of Virology ·Christopher T. Lemke,Steve Titolo,Uta von Schwedler,Nathalie Goudreau,(unknown),Elizabeth Wardrop,Anne‐Marie Faucher,René Coulombe,Soma S. R. Banik,Lee D. Fader,Alexandre Gagnon,Stephen H. Kawai,Jean Rancourt,Martin Tremblay,Christiane Yoakim,Bruno Simoneau,Jacques Archambault,Wesley I. Sundquist,Stephen W. Mason	102
10	Assessing Atropisomer Axial Chirality in Drug Discovery and Developmentbreakdown → 2011 ·Journal of Medicinal Chemistry ·Steven R. LaPlante,Lee D. Fader,Keith R. Fandrick,Daniel R. Fandrick,Oliver Hucke,Ray Kemper,Stephen Miller,Paul Edwards	671
11	Revealing Atropisomer Axial Chirality in Drug Discoverybreakdown → 2011 ·ChemMedChem ·Steven R. LaPlante,Paul Edwards,Lee D. Fader,Araz Jakalian,Oliver Hucke	419
12	Arylcyclopropanes: Properties, Synthesis and Use in Medicinal Chemistry 2010 ·Organic Preparations and Procedures International ·Alexandre Gagnon,Martin Duplessis,Lee D. Fader	106
13	ChemInform Abstract: Product Class 3: Propargylic Alcohols 2009 ·ChemInform ·Pat Forgione,Lee D. Fader	1
14	Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties 2004 ·Tetrahedron ·Lee D. Fader,Eddie L. Myers,Youla S. Tsantrizos	7
15	Stereochemically Rich Pentaketides from Bis(isoxazolines): A General Strategy for Efficient Polyketide Synthesis 2004 ·Organic Letters ·Lee D. Fader,Erick M. Carreira	39
16	Hybridization Properties of Aromatic Peptide Nucleic Acids: A Novel Class of Oligonucleotide Analogues 2001 ·Organic Letters ·Lee D. Fader,Youla S. Tsantrizos	6
17	Backbone Modifications of Aromatic Peptide Nucleic Acid (APNA) Monomers and Their Hybridization Properties with DNA and RNA 2001 ·The Journal of Organic Chemistry ·Lee D. Fader,Michael J. Boyd,Youla S. Tsantrizos	15
18	ChemInform Abstract: Stereoselective Synthesis of a Thymine Derivative of (S)‐2‐Hydroxy‐4‐(2‐aminophenyl)butanoic Acid. A Novel Building Block for the Synthesis of Aromatic Peptidic Nucleic Acid Oligomers. 1998 ·ChemInform ·Youla S. Tsantrizos,(unknown),(unknown),Lee D. Fader,Marieangela C. Wilson	1
19	Stereoselective Synthesis of a Thymine Derivative of (S)-2-Hydroxy-4-(2-aminophenyl)butanoic Acid. A Novel Building Block for the Synthesis of Aromatic Peptidic Nucleic Acid Oligomers¹ 1997 ·The Journal of Organic Chemistry ·Youla S. Tsantrizos,(unknown),Michael J. Boyd,Lee D. Fader,(unknown)	29

About Lee D. Fader

Lee D. Fader is a scholar working on Virology, Organic Chemistry and Infectious Diseases, having authored 19 papers that have together received 1.5k indexed citations. Recurring topics across this work include HIV Research and Treatment (5 papers), DNA and Nucleic Acid Chemistry (5 papers) and HIV/AIDS drug development and treatment (5 papers). The work is most often cited by research in Spectroscopy (700 citations), Organic Chemistry (1.2k citations) and Virology (116 citations). Lee D. Fader has collaborated with scholars based in Canada, United States and Switzerland. Frequent co-authors include Oliver Hucke, Steven R. LaPlante, Paul Edwards, Araz Jakalian, Ray Kemper, Keith R. Fandrick, Daniel R. Fandrick, Stephen Miller, Alexandre Gagnon and Martin Duplessis. Their work appears in journals such as Journal of Virology, Journal of Medicinal Chemistry and The Journal of Organic Chemistry.

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