Christopher T. Lemke

1.3k citations

27 papers · 647 indexed · h-index 15

Co-authors: Nathalie Goudreau P. Lynne Howell Steve Titolo Stephen W. Mason Anne‐Marie Faucher Stephen H. Kawai Soma S. R. Banik Elizabeth Wardrop
Topics: HIV/AIDS drug development and treatment (14 papers)Hepatitis C virus research (9 papers)HIV Research and Treatment (8 papers)
Cited by: Virology Infectious Diseases Hepatology
Journals: Journal of Biological Chemistry Cancer Research Journal of Virology
Partner nations: Canada United States Egypt

In The Last Decade

Christopher T. Lemke

26 papers receiving 639 citations

Peers

Countries citing papers authored by Christopher T. Lemke

Since Specialization

Citations

This map shows the geographic impact of Christopher T. Lemke's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christopher T. Lemke with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christopher T. Lemke more than expected).

Fields of papers citing papers by Christopher T. Lemke

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christopher T. Lemke. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christopher T. Lemke. The network helps show where Christopher T. Lemke may publish in the future.

Co-authorship network of co-authors of Christopher T. Lemke

This figure shows the co-authorship network connecting the top 25 collaborators of Christopher T. Lemke. A scholar is included among the top collaborators of Christopher T. Lemke based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christopher T. Lemke. Christopher T. Lemke is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Sotorasib Is a Pan- RAS G12C Inhibitor Capable of Driving Clinical Response in NRAS G12C Cancers 2024 ·Cancer Discovery ·Douglas A. Rubinson,Noritaka Tanaka,Ferran Fece de la Cruz,Kevin S. Kapner,Michael H. Rosenthal,(unknown),(unknown),(unknown),(unknown),Lauren K. Brais,Christopher T. Lemke,Andrew J. Aguirre,Ryan B. Corcoran	23
2	Abstract 506: ANJ810 is a highly selective novel MCL1 inhibitor with optimized in vivo clearance showing robust efficacy in preclinical solid and hematological tumor models 2023 ·Cancer Research ·(unknown),(unknown),Michael H. Serrano‐Wu,Georgios Kosmidis,Stefan Kaulfuß,Franziska Siegel,(unknown),James M. McFarland,Christopher T. Lemke,Nicolas D. Werbeck,(unknown),(unknown),Stephan Menz,Matthias Ocker,(unknown),Virendar K. Kaushik,Karl Ziegelbauer,Todd R. Golub	1
3	Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069 2022 ·Journal of Medicinal Chemistry ·Douglas L. Orsi,Elisabeth Pook,(unknown),Anders Friberg,Philip Lienau,Christopher T. Lemke,Timo Stellfeld,Ulf Brüggemeier,Vera Pütter,(unknown),(unknown),(unknown),Andrew D. Cherniack,Lindsay Westlake,Samantha Bender,Mustafa Kocak,Craig A. Strathdee,Matthew Meyerson,Knut Eis,Jonathan T. Goldstein	9
4	Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using ¹⁹F Ligand‐and ¹⁵N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series 2013 ·ChemMedChem ·Nathalie Goudreau,René Coulombe,Anne‐Marie Faucher,Chantal Grand‐Maître,(unknown),Christopher T. Lemke,Éric Malenfant,Yves Bousquet,Lee D. Fader,Bruno Simoneau,Jean‐François Mercier,Steve Titolo,Stephen W. Mason	14
5	Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: Discovery of potent succinamide inhibitors 2013 ·Bioorganic & Medicinal Chemistry Letters ·Murray D. Bailey,Josée Bordeleau,Michel Garneau,Mélissa Leblanc,Christopher T. Lemke,Jeff A. O’Meara,Peter W. White,Montse Llinàs‐Brunet	0
6	Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-Arylproline analogs 2013 ·Bioorganic & Medicinal Chemistry Letters ·François Bilodeau,Murray D. Bailey,(unknown),Josée Bordeleau,Pat Forgione,Michel Garneau,Élise Ghiro,Vida Gorys,Ted Halmos,(unknown),Mélissa Leblanc,Christopher T. Lemke,Julie Naud,Jeff A. O’Meara,Peter W. White,Montse Llinàs‐Brunet	4
7	Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: Addressing configurational instability through scaffold modification 2013 ·Bioorganic & Medicinal Chemistry Letters ·Lee D. Fader,Serge Landry,Sébastien Morin,Stephen H. Kawai,Yves Bousquet,Oliver Hucke,Nathalie Goudreau,Christopher T. Lemke,Pierre Bonneau,Steve Titolo,Stephen W. Mason,Bruno Simoneau	15
8	A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallizationviacompound-mediated dimerization 2013 ·Acta Crystallographica Section D Biological Crystallography ·Christopher T. Lemke,Steve Titolo,Nathalie Goudreau,Anne‐Marie Faucher,Stephen W. Mason,Pierre Bonneau	27
9	Discovery of novel P2 substituted 4-biaryl proline inhibitors of hepatitis C virus NS3 serine protease 2013 ·Bioorganic & Medicinal Chemistry Letters ·Murray D. Bailey,(unknown),Christopher T. Lemke	1
10	Ligand Bioactive Conformation Plays a Critical Role in the Design of Drugs That Target the Hepatitis C Virus NS3 Protease 2013 ·Journal of Medicinal Chemistry ·Steven R. LaPlante,Herbert Nar,Christopher T. Lemke,Araz Jakalian,Norman Aubry,Stephen H. Kawai	36
11	Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance 2012 ·Journal of Biological Chemistry ·Jeff A. O’Meara,Christopher T. Lemke,Cédrickx Godbout,George Kukolj,Lisette Lagacé,Benoît Moreau,Diane Thibeault,Peter W. White,Montse Llinàs‐Brunet	11
12	Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold 2012 ·Bioorganic & Medicinal Chemistry Letters ·Martin Tremblay,Pierre Bonneau,Yves Bousquet,Patrick DeRoy,Jianmin Duan,Martin Duplessis,Alexandre Gagnon,Michel Garneau,Nathalie Goudreau,Ingrid Guse,Oliver Hucke,Stephen H. Kawai,Christopher T. Lemke,Stephen W. Mason,Bruno Simoneau,(unknown),Steve Titolo,Christiane Yoakim	28
13	Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335 2011 ·Journal of Biological Chemistry ·Christopher T. Lemke,Nathalie Goudreau,Songping Zhao,Oliver Hucke,Diane Thibeault,Montse Llinàs‐Brunet,Peter W. White	38
14	Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila 2010 ·Journal of Biological Chemistry ·(unknown),Christopher T. Lemke,Ji‐Young Hwang,Bing Xiong,Albert M. Berghuis	36
15	Potent triazolyl-proline-based inhibitors of HCV NS3 protease 2008 ·Bioorganic & Medicinal Chemistry Letters ·Julie Naud,Christopher T. Lemke,Nathalie Goudreau,(unknown),(unknown),Montse Llinàs‐Brunet,Pat Forgione	24
16	Substructure Determination in Multiwavelength Anomalous Diffraction, Single Anomalous Diffraction, and Single Isomorphous Replacement With Anomalous Scattering Data Using <i>Shake-and-Bake</i> 2006 ·Humana Press eBooks ·G. David Smith,Christopher T. Lemke,P. Lynne Howell	2
17	Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase fromLegionella pneumophila 2005 ·Acta Crystallographica Section F Structural Biology and Crystallization Communications ·Christopher T. Lemke,Ji‐Young Hwang,Bing Xiong,Nicholas P. Cianciotto,Albert M. Berghuis	3
18	S-SAD, Se-SAD and S/Se-SIRAS using Cu Kα radiation: why wait for synchrotron time? 2002 ·Acta Crystallographica Section D Biological Crystallography ·Christopher T. Lemke,G. David Smith,P. Lynne Howell	12
19	Substrate Induced Conformational Changes in Argininosuccinate Synthetase 2002 ·Journal of Biological Chemistry ·Christopher T. Lemke,P. Lynne Howell	19
20	The 1.6 Å Crystal Structure of E. coli Argininosuccinate Synthetase Suggests a Conformational Change during Catalysis 2001 ·Structure ·Christopher T. Lemke,P. Lynne Howell	29

About Christopher T. Lemke

Christopher T. Lemke is a scholar working on Virology, Hepatology and Infectious Diseases, having authored 27 papers that have together received 647 indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (14 papers), Hepatitis C virus research (9 papers) and HIV Research and Treatment (8 papers). The work is most often cited by research in Virology (276 citations), Infectious Diseases (287 citations) and Hepatology (90 citations). Christopher T. Lemke has collaborated with scholars based in Canada, United States and Egypt. Frequent co-authors include Nathalie Goudreau, P. Lynne Howell, Steve Titolo, Stephen W. Mason, Anne‐Marie Faucher, Stephen H. Kawai, Soma S. R. Banik, Elizabeth Wardrop, Wesley I. Sundquist and Oliver Hucke. Their work appears in journals such as Journal of Biological Chemistry, Cancer Research and Journal of Virology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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