Kyle V. Butler

2.4k total citations · 1 hit paper
26 papers, 1.8k citations indexed

About

Kyle V. Butler is a scholar working on Molecular Biology, Oncology and Organic Chemistry. According to data from OpenAlex, Kyle V. Butler has authored 26 papers receiving a total of 1.8k indexed citations (citations by other indexed papers that have themselves been cited), including 23 papers in Molecular Biology, 4 papers in Oncology and 3 papers in Organic Chemistry. Recurrent topics in Kyle V. Butler's work include Protein Degradation and Inhibitors (8 papers), Histone Deacetylase Inhibitors Research (8 papers) and Epigenetics and DNA Methylation (6 papers). Kyle V. Butler is often cited by papers focused on Protein Degradation and Inhibitors (8 papers), Histone Deacetylase Inhibitors Research (8 papers) and Epigenetics and DNA Methylation (6 papers). Kyle V. Butler collaborates with scholars based in United States, Canada and Italy. Kyle V. Butler's co-authors include Alan P. Kozikowski, Jay H. Kalin, Brett Langley, Giulio Vistoli, Camille Brochier, Jian Jin, Wayne W. Hancock, Tatiana Akimova, Bryan L. Roth and Peter J. Brown and has published in prestigious journals such as Journal of the American Chemical Society, Nucleic Acids Research and Nature Biotechnology.

In The Last Decade

Kyle V. Butler

25 papers receiving 1.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

2010 620 citations Kyle V. Butler, Jay H. Kalin et al. Journal of the American Chemical Society profile →

Peers

Kyle V. Butler

ONCOL

CMN

IMMUN

Choel Kim United States

Tara Mirzadegan United States

Jonathan S. Rosenblum United States

Greet Vanhoof Belgium

Anchal Chandra United States

Kevin P. Madauss United States

Rink‐Jan Lohman Australia

Carla M. Suto United States

Anna Kaplan United States

Xiangshu Xiao United States

Choel Kim United States

Kyle V. Butler

2.0k ×1.3

200 ×0.4

ONCOL

177 ×0.7

172 ×1.0

CMN

94 ×0.8

IMMUN

Citations per year, relative to Kyle V. Butler Kyle V. Butler (= 1×) peers Choel Kim

Countries citing papers authored by Kyle V. Butler

Since Specialization

Citations

This map shows the geographic impact of Kyle V. Butler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kyle V. Butler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kyle V. Butler more than expected).

Fields of papers citing papers by Kyle V. Butler

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kyle V. Butler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kyle V. Butler. The network helps show where Kyle V. Butler may publish in the future.

Co-authorship network of co-authors of Kyle V. Butler

This figure shows the co-authorship network connecting the top 25 collaborators of Kyle V. Butler. A scholar is included among the top collaborators of Kyle V. Butler based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kyle V. Butler. Kyle V. Butler is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Wali, Aminah, Kyle V. Butler, Yan Xiong, et al.. (2023). MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing. Frontiers in Oncology. 13. 1099550–1099550. 3 indexed citations

MacDonald, Ian A., Kyle V. Butler, Laura E. Herring, et al.. (2019). Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations. SLAS DISCOVERY. 24(8). 802–816. 3 indexed citations

Chiarella, Anna M., Kyle V. Butler, Berkley E. Gryder, et al.. (2019). Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nature Biotechnology. 38(1). 50–55. 57 indexed citations

Chiarella, Anna M., et al.. (2018). Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers. Journal of Visualized Experiments. 4 indexed citations

Schuman‐Olivier, Zev, Jacob T. Borodovsky, Jackson Steinkamp, et al.. (2018). MySafeRx: a mobile technology platform integrating motivational coaching, adherence monitoring, and electronic pill dispensing for enhancing buprenorphine/naloxone adherence during opioid use disorder treatment: a pilot study. Addiction Science & Clinical Practice. 13(1). 21–21. 27 indexed citations

Jain, Rinku, Kyle V. Butler, Javier Pardo de Santayana y Coloma, Jian Jin, & Aneel K. Aggarwal. (2017). Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase. Scientific Reports. 7(1). 1632–1632. 30 indexed citations

McCorvy, John D., Kyle V. Butler, Brendan Kelly, et al.. (2017). Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs. Nature Chemical Biology. 14(2). 126–134. 131 indexed citations

Butler, Kyle V., Ian A. MacDonald, Nathaniel A. Hathaway, & Jian Jin. (2017). Report and Application of a Tool Compound Data Set. Journal of Chemical Information and Modeling. 57(11). 2699–2706. 4 indexed citations

Butler, Kyle V., Anqi Ma, Wenyu Yu, et al.. (2016). Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. Journal of Medicinal Chemistry. 59(21). 9881–9889. 28 indexed citations

10.

Eram, Mohammad S., Yudao Shen, Magdalena M. Szewczyk, et al.. (2015). A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chemical Biology. 11(3). 772–781. 192 indexed citations

11.

Ma, Anqi, Wenyu Yu, Fengling Li, et al.. (2014). Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8. Journal of Medicinal Chemistry. 57(15). 6822–6833. 74 indexed citations

12.

Xu, Liang, Kyle V. Butler, Jenny Chong, et al.. (2014). Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues. Nucleic Acids Research. 42(9). 5863–5870. 16 indexed citations

13.

Attwater, James, Shunsuke Tagami, Michiko Kimoto, et al.. (2013). Chemical fidelity of an RNA polymerase ribozyme. Chemical Science. 4(7). 2804–2804. 26 indexed citations

14.

Zoeten, Edwin F. de, Liqing Wang, Kyle V. Butler, et al.. (2011). Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3 ⁺ T-Regulatory Cells. Molecular and Cellular Biology. 31(10). 2066–2078. 217 indexed citations

15.

Kalin, Jay H., Kyle V. Butler, Tatiana Akimova, Wayne W. Hancock, & Alan P. Kozikowski. (2011). Second-Generation Histone Deacetylase 6 Inhibitors Enhance the Immunosuppressive Effects of Foxp3+ T-Regulatory Cells. Journal of Medicinal Chemistry. 55(2). 639–651. 92 indexed citations

16.

Butler, Kyle V., Jay H. Kalin, Camille Brochier, et al.. (2010). Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A. Journal of the American Chemical Society. 132(31). 10842–10846. 620 indexed citations breakdown →

17.

Butler, Kyle V., et al.. (2009). Stereoselective HDAC Inhibition from Cysteine‐Derived Zinc‐Binding Groups. ChemMedChem. 4(8). 1292–1301. 6 indexed citations

18.

Kalin, Jay H., Kyle V. Butler, & Alan P. Kozikowski. (2009). Creating zinc monkey wrenches in the treatment of epigenetic disorders. Current Opinion in Chemical Biology. 13(3). 263–271. 17 indexed citations

19.

Kozikowski, Alan P. & Kyle V. Butler. (2008). Chemical Origins of Isoform Selectivity in Histone Deacetylase Inhibitors. Current Pharmaceutical Design. 14(6). 505–528. 100 indexed citations

20.

Butler, Kyle V., et al.. (1967). Nitroimidazole Derivatives. Relationship between Structure and Antitrichomonal Activity. Journal of Medicinal Chemistry. 10(5). 891–897. 36 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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