Tom S. Chan

2.7k citations

56 papers · 2.2k indexed · h-index 22

Impact in

Biochemistry top 1%
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
Pharmacology top 1%
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection

Papers in

Pharmacology 21
- Pharmacogenetics and Drug Metabolism 20
- Drug-Induced Hepatotoxicity and Protection 7
Biochemistry 6
- Phytochemicals and Antioxidant Activities 5

Co-authors: Peter J. O’Brien Giuseppe Galati Ananth Sekher Pannala Catherine Rice‐Evans Majid Moridani Shirley Teng Donald Tweedie Bin Wu
Journals: Drug Metabolism and Disposition (7 papers)Free Radical Biology and Medicine (3 papers)Cytogenetic and Genome Research (3 papers)Chemico-Biological Interactions (3 papers)Free Radical Research (2 papers)
Partner nations: United States Canada Germany

In The Last Decade

Tom S. Chan

55 papers receiving 2.1k citations

Peers

Countries citing papers authored by Tom S. Chan

Since Specialization

Citations

This map shows the geographic impact of Tom S. Chan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tom S. Chan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tom S. Chan more than expected).

Fields of papers citing papers by Tom S. Chan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tom S. Chan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tom S. Chan. The network helps show where Tom S. Chan may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Tom S. Chan, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Tom S. Chan Line = papers co-authored together Tom S. Chan links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Identification of selective inhibitors of uridine 5'-diphospho-glucuronosyltransferase (UGT) 1A3 and UGT1A8 and their application in UGT reaction phenotyping studies in human liver and intestinal microsomes Drug Metabolism and Disposition ·Ting Wang, Stuart Bondurant, Qin Yu-gang, Mitchell E. Taub, Tom S. Chan	2025	0
2	A novel system to determine activity of individual uridine 5′-diphospho-glucuronosyltransferase (UGT) isoforms: Recombinant UGT-beads Journal of Biological Chemistry ·Ting Wang, Mitchell E. Taub, Tom S. Chan	2024	4
3	Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin Pharmaceutical Research ·Tom S. Chan, Wangchen Sonam, Bachir Latli, Twadu Ali Saeed, 順子相馬, 正剛木野, 健一土井尻, Aaron M. Teitelbaum, Ting Wang, Ayoub El Abidi, Mitchell E. Taub	2023	4
4	Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor European Journal of Drug Metabolism and Pharmacokinetics ·Michael Desch, Glen Wunderlich, Lonica Andreea, Yang Soon Jung, Karl‐Heinz Liesenfeld, Tom S. Chan, Holger Rosenbrock, Regina Sennewald, Joonas Nurmela, Sascha Keller, Sven Wind	2021	6
5	The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [14C]-BI 425809 in Healthy Males Clinical Drug Investigation ·Javier Sabugo-Luis, Michael Desch, 岳人関, Glen Wunderlich, 和夫花輪, Christina Schlecker, Aaron M. Teitelbaum, Twadu Ali Saeed, Tom S. Chan	2021	3
6	Evaluation of Erythromycin as a Tool to Assess CYP3A Contribution of Low Clearance Compounds in a Long-Term Hepatocyte Culture Drug Metabolism and Disposition ·Tom S. Chan, 健一土井尻, 正剛木野, Mitchell E. Taub	2020	11
7	Human Liver Microsomes Immobilized on Magnetizable Beads: A Novel Approach to Study In Vitro Drug Metabolism Drug Metabolism and Disposition ·Alexander M. Horspool, Ting Wang, 健一土井尻, Mitchell E. Taub, Tom S. Chan	2020	12
8	Upregulation of Krebs cycle and anaerobic glycolysis activity early after onset of liver ischemia PLoS ONE ·Tom S. Chan, Shamir Cassim, Valérie‐Ann Raymond, Sven Gottschalk, Grégory Merlen, Claudia Zwingmann, Pascal Lapierre, Zi-Zhao Ding, C. David Mazer, Marc Bilodeau	2018	30
9	Bridging In Vitro and In Vivo Metabolism and Transport of Faldaprevir in Human Using a Novel Cocultured Human Hepatocyte System, HepatoPac Drug Metabolism and Disposition ·Diane Ramsden, Donald Tweedie, Tom S. Chan, Mitchell E. Taub, Yongmei Li	2013	56
10	Herbal monoterpene alcohols inhibit propofol metabolism and prolong anesthesia time Life Sciences ·Baiq Anina Ariyani Nilasari, Nandita Shangari, Tom S. Chan, L. L. K., Peter J. O’Brien	2006	29
11	Glyoxal markedly compromises hepatocyte resistance to hydrogen peroxide Biochemical Pharmacology ·Nandita Shangari, Tom S. Chan, Marija Popović, Peter J. O’Brien	2006	26
12	Coenzyme Q1 depletes NAD(P)H and impairs recycling of ascorbate in astrocytes Brain Research ·Magdalena Dragan, S. Jeffrey Dixon, Ewa Jaworski, Tom S. Chan, Peter J. O’Brien, John X. Wilson	2006	14
13	Sulfation and Glucuronidation of Phenols: Implications in Coenyzme Q Metabolism Methods in enzymology on CD-ROM/Methods in enzymology ·Nandita Shangari, Tom S. Chan, Peter J. O’Brien	2005	30
14	Coenzyme Q Cytoprotective Mechanisms Methods in enzymology on CD-ROM/Methods in enzymology ·Tom S. Chan, John X. Wilson, Peter J. O’Brien	2004	13
15	Hepatocyte metabolism of coenzyme Q₁ (ubiquinone‐5) to its sulfate conjugate decreases its antioxidant activity BioFactors ·Tom S. Chan, Peter J. O’Brien	2003	8
16	Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and suceptibility to a mitochondrial toxin Molecular and Cellular Biochemistry ·Mohammad Abdollahı, Tom S. Chan, Vangala V. Subrahmanyam, Peter J. O’Brien	2003	85
17	N-OXIDATION OF AROMATIC AMINES BY INTRACELLULAR OXIDASES Drug Metabolism Reviews ·Arno G. Siraki, Tom S. Chan, Giuseppe Galati, Shirley Teng, Peter J. O’Brien	2002	30
18	Idiosyncratic NSAID drug induced oxidative stress Chemico-Biological Interactions ·Giuseppe Galati, Shahrzad Tafazoli, Omid Sabzevari, Tom S. Chan, Peter J. O’Brien	2002	114
19	Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity Chemico-Biological Interactions ·Majid Moridani, Fiama Graciela Villamar Bravo, Tom S. Chan, Shirley Teng, K Beard, Peter J. O’Brien	2001	15
20	Antibodies to the Carboxyl Terminus of Mouse Interferon-γ Neutralize its Immunoregulatory and Antiviral Activities Journal of Interferon Research ·Marlyn P. Langford, Douglas A. Weigent, Tom S. Chan, Howard M. Johnson, G J Stanton	1987	6

About Tom S. Chan

Tom S. Chan is a scholar working on Pharmacology, Biochemistry, Biochemistry, Clinical Biochemistry and Oncology, having authored 56 papers that have together received 2.2k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (20 papers), Drug Transport and Resistance Mechanisms (12 papers), Free Radicals and Antioxidants (7 papers), Drug-Induced Hepatotoxicity and Protection (7 papers), Coenzyme Q10 studies and effects (5 papers), Phytochemicals and Antioxidant Activities (5 papers), Pharmacological Effects and Toxicity Studies (5 papers) and Biochemical and Molecular Research (4 papers). The work is most often cited by research in Biochemistry (508 citations), Pharmacology (327 citations), Toxicology (72 citations), Molecular Biology (895 citations) and Organic Chemistry (369 citations). Tom S. Chan has collaborated with scholars based in United States, Canada and Germany. Frequent co-authors include Peter J. O’Brien, Giuseppe Galati, Ananth Sekher Pannala, Catherine Rice‐Evans, Majid Moridani, Shirley Teng, Donald Tweedie, Peter J. O’Brien, Bin Wu and Nandita Shangari. Their work appears in journals such as Drug Metabolism and Disposition, Free Radical Biology and Medicine, Cytogenetic and Genome Research, Chemico-Biological Interactions and Free Radical Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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