Oliver Smithies

65.4k total citations · 44 hit papers
331 papers, 55.5k citations indexed

About

Oliver Smithies is a scholar working on Molecular Biology, Cardiology and Cardiovascular Medicine and Genetics. According to data from OpenAlex, Oliver Smithies has authored 331 papers receiving a total of 55.5k indexed citations (citations by other indexed papers that have themselves been cited), including 170 papers in Molecular Biology, 79 papers in Cardiology and Cardiovascular Medicine and 65 papers in Genetics. Recurrent topics in Oliver Smithies's work include Renin-Angiotensin System Studies (59 papers), Hormonal Regulation and Hypertension (53 papers) and CRISPR and Genetic Engineering (33 papers). Oliver Smithies is often cited by papers focused on Renin-Angiotensin System Studies (59 papers), Hormonal Regulation and Hypertension (53 papers) and CRISPR and Genetic Engineering (33 papers). Oliver Smithies collaborates with scholars based in United States, Canada and Japan. Oliver Smithies's co-authors include Paul Haeberli, Nobuyo Maeda, John H. Krege, Jeffrey B. Hodgin, Kenneth S. Korach, Hyung‐Suk Kim, John F. Couse, John R. Hagaman, Thomas M. Coffman and Beverly H. Koller and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Oliver Smithies

320 papers receiving 52.6k citations

Hit Papers

A comprehensive set of se... 1955 2026 1978 2002 1984 1955 1993 1998 1959 4.0k 8.0k 12.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. A comprehensive set of sequence analysis programs for the VAX
    1984 13.8k citations Oliver Smithies et al. profile →
  2. Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults
    1955 2.3k citations Oliver Smithies profile →
  3. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
    1993 1.5k citations Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
  4. Generation and reproductive phenotypes of mice lacking estrogen receptor β
    1998 1.4k citations Joel F. Mahler, Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
  5. An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals
    1959 1.2k citations Oliver Smithies profile →
  6. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    1995 943 citations Robert Langenbach, Scott G. Morham et al. Cell profile →
  7. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
    1995 936 citations Scott G. Morham, Robert Langenbach et al. Cell profile →
  8. Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning
    1977 837 citations Harvey E. Faber, Oliver Smithies et al. Science profile →
  9. Elevated blood pressures in mice lacking endothelial nitric oxide synthase
    1996 781 citations Nobuyo Maeda, Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
  10. Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
    1990 781 citations Beverly H. Koller, Philippa Marrack et al. Science profile →
  11. An Animal Model for Cystic Fibrosis Made by Gene Targeting
    1992 744 citations Oliver Smithies, Beverly H. Koller et al. Science profile →
  12. Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
    1985 706 citations Oliver Smithies, Raju Kucherlapati et al. profile →
  13. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.
    1998 692 citations Oliver Smithies et al. Journal of Clinical Investigation profile →
  14. Mouse Models of Diabetic Nephropathy
    2009 680 citations Thomas M. Coffman, Susan B. Gurley et al. profile →
  15. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
    1997 573 citations William A. Kuziel, Tracey C. Dawson et al. Proceedings of the National Academy of Sciences profile →
  16. TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
    1993 561 citations Oliver Smithies et al. Cell profile →
  17. Targetted correction of a mutant HPRT gene in mouse embryonic stem cells
    1987 550 citations Nobuyo Maeda, Oliver Smithies et al. profile →
  18. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
    2006 548 citations Steven D. Crowley, Susan B. Gurley et al. Proceedings of the National Academy of Sciences profile →
  19. Male–female differences in fertility and blood pressure in ACE-deficient mice
    1995 546 citations Simon W. M. John, John R. Hagaman et al. profile →
  20. Requirement of Mip-1α for an Inflammatory Response to Viral Infection
    1995 526 citations Thomas M. Coffman, Oliver Smithies et al. Science profile →
  21. Genetic control of blood pressure and the angiotensinogen locus.
    1995 526 citations John R. Hagaman, Thomas M. Coffman et al. Proceedings of the National Academy of Sciences profile →
  22. Zone Electrophoresis in Starch Gels and its Application to Studies of Serum Proteins
    1959 525 citations Oliver Smithies Advances in protein chemistry profile →
  23. A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice
    1995 516 citations John R. Hagaman, Oliver Smithies et al. Hypertension profile →
  24. Genetic Decreases in Atrial Natriuretic Peptide and Salt-Sensitive Hypertension
    1995 511 citations Simon W. M. John, John R. Hagaman et al. Science profile →
  25. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
    1995 499 citations Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
  26. Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A
    1997 476 citations Howard A. Rockman, Hyung‐Suk Kim et al. Proceedings of the National Academy of Sciences profile →
  27. Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice
    2017 417 citations Pete A. Williams, Jeffrey M. Harder et al. Science profile →
  28. Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
    2002 409 citations Oliver Smithies et al. Science profile →
  29. Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.
    2000 408 citations Patricia C. Chulada, Joel F. Mahler et al. profile →
  30. Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene.
    1995 366 citations Oliver Smithies et al. profile →
  31. A Simple Hemagglutination System Requiring Small Amounts of Red Cells and Antibodies
    1966 361 citations Oliver Smithies et al. profile →
  32. The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
    1999 353 citations Nobuyuki Takahashi, Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
  33. Cloning Human Fetal γ Globin and Mouse α-Type Globin DNA: Preparation and Screening of Shotgun Collections
    1978 326 citations Harvey E. Faber, Oliver Smithies et al. Science profile →
  34. A history of the human fetal globin gene duplication
    1981 307 citations Oliver Smithies et al. Cell profile →
  35. Angiotensin-converting enzyme and male fertility
    1998 280 citations John R. Hagaman, Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
  36. The Structure and Evolution of the Human /?-Globin Gene Family
    1980 253 citations Oliver Smithies et al. profile →
  37. Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis
    1992 244 citations Oliver Smithies, Beverly H. Koller et al. Science profile →
  38. THE EVOLUTION OF MULTIGENE FAMILIES: Human Haptoglobin Genes
    1986 212 citations Nobuyo Maeda, Oliver Smithies profile →
  39. Notation for Serum-Protein Groups and the Genes controlling their Inheritance
    1956 202 citations Oliver Smithies et al. profile →
  40. Chromosomal Rearrangements and the Evolution of Haptoglobin Genes
    1962 198 citations Oliver Smithies et al. profile →
  41. Comparison and combination of the starch-gel and filter-paper electrophoretic methods applied to human sera: two-dimensional electrophoresis
    1958 197 citations M. D. Poulik, Oliver Smithies profile →
  42. Genetic Control of some Serum Proteins in Normal Humans
    1955 184 citations Oliver Smithies et al. profile →
  43. Variations in Human Serum β-Globulins
    1957 148 citations Oliver Smithies profile →
  44. Serum Transferrins
    1959 139 citations Oliver Smithies et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Oliver Smithies 26.5k 11.4k 7.4k 6.0k 5.5k 331 55.5k
Aldons J. Lusis 30.8k 1.2× 9.0k 0.8× 6.3k 0.9× 10.5k 1.7× 6.5k 1.2× 617 63.9k
Piotr Chomczyński 26.5k 1.0× 6.1k 0.5× 2.5k 0.3× 7.1k 1.2× 3.5k 0.6× 54 51.9k
Nicoletta Sacchi 26.0k 1.0× 6.0k 0.5× 2.4k 0.3× 7.6k 1.3× 3.0k 0.5× 150 50.8k
Florian Läng 36.0k 1.4× 4.0k 0.4× 5.5k 0.8× 5.2k 0.9× 4.3k 0.8× 1.4k 68.2k
Philip Cohen 67.4k 2.5× 4.5k 0.4× 3.0k 0.4× 8.8k 1.5× 3.7k 0.7× 489 89.2k
Michael B. Sporn 44.7k 1.7× 8.0k 0.7× 1.8k 0.2× 8.4k 1.4× 3.9k 0.7× 512 73.5k
Harvey F. Lodish 49.1k 1.9× 6.7k 0.6× 3.9k 0.5× 8.7k 1.4× 3.0k 0.5× 646 82.0k
Christopher K. Glass 61.4k 2.3× 17.9k 1.6× 2.4k 0.3× 19.3k 3.2× 7.0k 1.3× 375 96.6k
Joseph L. Goldstein 51.8k 2.0× 6.7k 0.6× 5.8k 0.8× 9.2k 1.5× 13.7k 2.5× 405 100.1k
Nahum Sonenberg 77.5k 2.9× 8.7k 0.8× 10.2k 1.4× 9.1k 1.5× 1.2k 0.2× 673 97.8k

Countries citing papers authored by Oliver Smithies

Since Specialization
Citations

This map shows the geographic impact of Oliver Smithies's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Oliver Smithies with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Oliver Smithies more than expected).

Fields of papers citing papers by Oliver Smithies

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Oliver Smithies. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Oliver Smithies. The network helps show where Oliver Smithies may publish in the future.

Co-authorship network of co-authors of Oliver Smithies

This figure shows the co-authorship network connecting the top 25 collaborators of Oliver Smithies. A scholar is included among the top collaborators of Oliver Smithies based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Oliver Smithies. Oliver Smithies is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Williams, Pete A., Jeffrey M. Harder, Nicole E. Foxworth, et al.. (2017). Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science. 355(6326). 756–760. 417 indexed citations breakdown →
2.
Chang, Albert S., Ruriko Grant, Hirofumi Tomita, et al.. (2016). Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences. 113(44). 12538–12543. 31 indexed citations
3.
Koller, Beverly H., Philippa Marrack, John W. Kappler, & Oliver Smithies. (2010). Pillars Article: Normal Development of Mice Deficient in β2M, MHC Class I Proteins, and CD8+ T Cells. Science. 248: 1227–1230. The Journal of Immunology. 184(9). 4592–4595. 3 indexed citations
4.
Pandya, Kumar, Kristine Porter, Howard A. Rockman, & Oliver Smithies. (2009). Decreased Beta-Adrenergic Responsiveness Following Hypertrophy Occurs Only in Cardiomyocytes that Also Re-Express Beta-Myosin Heavy Chain. European Journal of Heart Failure. 11(7). 648–652. 9 indexed citations
5.
Scott, Nicola, Leigh J. Ellmers, John G. Lainchbury, et al.. (2009). Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1792(12). 1175–1184. 31 indexed citations
6.
Makhanova, Natalia, John R. Hagaman, Hyung‐Suk Kim, & Oliver Smithies. (2007). Salt-Sensitive Blood Pressure in Mice With Increased Expression of Aldosterone Synthase. Hypertension. 51(1). 134–140. 60 indexed citations
7.
Crowley, Steven D., Susan B. Gurley, M Herrera, et al.. (2006). Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proceedings of the National Academy of Sciences. 103(47). 17985–17990. 548 indexed citations breakdown →
8.
Makhanova, Natalia, Maria Luisa S. Sequeira-Lόpez, R. Ariel Gómez, Hyung‐Suk Kim, & Oliver Smithies. (2006). Disturbed Homeostasis in Sodium-Restricted Mice Heterozygous and Homozygous for Aldosterone Synthase Gene Disruption. Hypertension. 48(6). 1151–1159. 47 indexed citations
9.
Li, Manyu, Della Yee, Terry Magnuson, Oliver Smithies, & Kathleen M. Caron. (2006). Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. Journal of Clinical Investigation. 116(10). 2653–2662. 79 indexed citations
10.
Goulet, Jennifer L., Amy J. Pace, Robert S. Byrum, et al.. (2004). E-Prostanoid-3 Receptors Mediate the Proinflammatory Actions of Prostaglandin E2 in Acute Cutaneous Inflammation. The Journal of Immunology. 173(2). 1321–1326. 51 indexed citations
11.
Kakoki, Masao, Yau-Sheng Tsai, Hyung‐Suk Kim, et al.. (2004). Altering the Expression in Mice of Genes by Modifying Their 3′ Regions. Developmental Cell. 6(4). 597–606. 43 indexed citations
12.
Sequeira-Lόpez, Maria Luisa S., et al.. (2004). Renin Cells Are Precursors for Multiple Cell Types that Switch to the Renin Phenotype When Homeostasis Is Threatened. Developmental Cell. 6(5). 719–728. 210 indexed citations
13.
Norwood, Victoria F., Scott G. Morham, & Oliver Smithies. (2000). Postnatal development and progression of renal dysplasia in cyclooxygenase-2 null mice. Kidney International. 58(6). 2291–2300. 81 indexed citations
14.
Hatada, Seigo, William A. Kuziel, Oliver Smithies, & Nobuyo Maeda. (1999). The Influence of Chromosomal Location on the Expression of Two Transgenes in Mice. Journal of Biological Chemistry. 274(2). 948–955. 25 indexed citations
15.
Kuziel, William A., et al.. (1997). Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proceedings of the National Academy of Sciences. 94(22). 12053–12058. 573 indexed citations breakdown →
16.
Morham, Scott G., et al.. (1996). Targeted Disruption of the Mouse Topoisomerase I Gene by Camptothecin Selection. Molecular and Cellular Biology. 16(12). 6804–6809. 147 indexed citations
17.
Langenbach, Robert, Scott G. Morham, Howard F. Tiano, et al.. (1995). Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 83(3). 483–492. 943 indexed citations breakdown →
18.
Detloff, Peter J., Simon W. M. John, W. Ronald Shehee, et al.. (1994). Deletion and Replacement of the Mouse Adult β-Globin Genes by a “Plug and Socket” Repeated Targeting Strategy. Molecular and Cellular Biology. 14(10). 6936–6943. 50 indexed citations
19.
Kucherlapati, Raju, Harvey E. Faber, M. D. Poulik, F.H. Ruddle, & Oliver Smithies. (1976). Assignment of the gene for beta-2-microglobulin to human chromosome 15. Cytogenetic and Genome Research. 16(1-5). 178–180. 2 indexed citations
20.
Smithies, Oliver. (1959). Zone Electrophoresis in Starch Gels and its Application to Studies of Serum Proteins. Advances in protein chemistry. 14. 65–113. 525 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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