Oliver Smithies

65.4k total citations · 44 hit papers
331 papers, 55.5k citations indexed

About

Oliver Smithies is a scholar working on Molecular Biology, Cardiology and Cardiovascular Medicine and Genetics. According to data from OpenAlex, Oliver Smithies has authored 331 papers receiving a total of 55.5k indexed citations (citations by other indexed papers that have themselves been cited), including 170 papers in Molecular Biology, 79 papers in Cardiology and Cardiovascular Medicine and 65 papers in Genetics. Recurrent topics in Oliver Smithies's work include Renin-Angiotensin System Studies (59 papers), Hormonal Regulation and Hypertension (53 papers) and CRISPR and Genetic Engineering (33 papers). Oliver Smithies is often cited by papers focused on Renin-Angiotensin System Studies (59 papers), Hormonal Regulation and Hypertension (53 papers) and CRISPR and Genetic Engineering (33 papers). Oliver Smithies collaborates with scholars based in United States, Canada and Japan. Oliver Smithies's co-authors include Paul Haeberli, Nobuyo Maeda, John H. Krege, Jeffrey B. Hodgin, Kenneth S. Korach, Hyung‐Suk Kim, John F. Couse, John R. Hagaman, Thomas M. Coffman and Beverly H. Koller and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Oliver Smithies

320 papers receiving 52.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A comprehensive set of sequence analysis programs for the VAX

1984 13.8k citations Oliver Smithies et al. profile →
Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults

1955 2.3k citations Oliver Smithies profile →
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

1993 1.5k citations Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
Generation and reproductive phenotypes of mice lacking estrogen receptor β

1998 1.4k citations Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals

1959 1.2k citations Oliver Smithies profile →
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

1995 943 citations Robert Langenbach, Scott G. Morham et al. profile →
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

1995 936 citations Scott G. Morham, Robert Langenbach et al. profile →
Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 837 citations Harvey E. Faber, Oliver Smithies et al. Science profile →
Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 781 citations Beverly H. Koller, Oliver Smithies et al. Science profile →
Elevated blood pressures in mice lacking endothelial nitric oxide synthase

1996 781 citations Nobuyo Maeda, Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
An Animal Model for Cystic Fibrosis Made by Gene Targeting

1992 744 citations Oliver Smithies, Beverly H. Koller et al. Science profile →
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

1985 706 citations Oliver Smithies, Ronald G. Gregg et al. Nature profile →
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.

1998 692 citations Oliver Smithies et al. Journal of Clinical Investigation profile →
Mouse Models of Diabetic Nephropathy

2009 680 citations Thomas M. Coffman, Susan B. Gurley et al. profile →
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2

1997 573 citations William A. Kuziel, Tracey C. Dawson et al. Proceedings of the National Academy of Sciences profile →
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 561 citations Oliver Smithies et al. profile →
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1987 550 citations Thomas Doetschman, Ronald G. Gregg et al. Nature profile →
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney

2006 548 citations Steven D. Crowley, Susan B. Gurley et al. Proceedings of the National Academy of Sciences profile →
Male–female differences in fertility and blood pressure in ACE-deficient mice

1995 546 citations Simon W. M. John, John R. Hagaman et al. Nature profile →
Requirement of Mip-1α for an Inflammatory Response to Viral Infection

1995 526 citations Thomas M. Coffman, Oliver Smithies et al. Science profile →
Genetic control of blood pressure and the angiotensinogen locus.

1995 526 citations John R. Hagaman, J. Charles Jennette et al. Proceedings of the National Academy of Sciences profile →
Zone Electrophoresis in Starch Gels and its Application to Studies of Serum Proteins

1959 525 citations Oliver Smithies Advances in protein chemistry profile →
A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice

1995 516 citations John R. Hagaman, Oliver Smithies et al. Hypertension profile →
Genetic Decreases in Atrial Natriuretic Peptide and Salt-Sensitive Hypertension

1995 511 citations Simon W. M. John, John R. Hagaman et al. Science profile →
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.

1995 499 citations Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A

1997 476 citations Howard A. Rockman, Hyung‐Suk Kim et al. Proceedings of the National Academy of Sciences profile →
Vitamin B ₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice

2017 417 citations Pete A. Williams, Jeffrey M. Harder et al. Science profile →
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β

2002 409 citations Oliver Smithies et al. Science profile →
Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.

2000 408 citations Scott G. Morham, Oliver Smithies et al. profile →
Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene.

1995 366 citations Oliver Smithies et al. profile →
A Simple Hemagglutination System Requiring Small Amounts of Red Cells and Antibodies

1966 361 citations Oliver Smithies et al. profile →
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system

1999 353 citations Nobuyuki Takahashi, Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
Cloning Human Fetal γ Globin and Mouse α-Type Globin DNA: Preparation and Screening of Shotgun Collections

1978 326 citations Harvey E. Faber, Oliver Smithies et al. Science profile →
A history of the human fetal globin gene duplication

1981 307 citations Oliver Smithies et al. profile →
Angiotensin-converting enzyme and male fertility

1998 280 citations John R. Hagaman, Oliver Smithies et al. Proceedings of the National Academy of Sciences profile →
The Structure and Evolution of the Human /?-Globin Gene Family

1980 253 citations Oliver Smithies et al. profile →
Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis

1992 244 citations Oliver Smithies, Beverly H. Koller et al. Science profile →
THE EVOLUTION OF MULTIGENE FAMILIES: Human Haptoglobin Genes

1986 212 citations Nobuyo Maeda, Oliver Smithies profile →
Notation for Serum-Protein Groups and the Genes controlling their Inheritance

1956 202 citations Oliver Smithies et al. Nature profile →
Chromosomal Rearrangements and the Evolution of Haptoglobin Genes

1962 198 citations Oliver Smithies et al. Nature profile →
Comparison and combination of the starch-gel and filter-paper electrophoretic methods applied to human sera: two-dimensional electrophoresis

1958 197 citations M. D. Poulik, Oliver Smithies profile →
Genetic Control of some Serum Proteins in Normal Humans

1955 184 citations Oliver Smithies et al. Nature profile →
Variations in Human Serum β-Globulins

1957 148 citations Oliver Smithies Nature profile →
Serum Transferrins

1959 139 citations Oliver Smithies et al. Nature profile →

Peers

Countries citing papers authored by Oliver Smithies

Since Specialization

Citations

This map shows the geographic impact of Oliver Smithies's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Oliver Smithies with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Oliver Smithies more than expected).

Fields of papers citing papers by Oliver Smithies

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Oliver Smithies. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Oliver Smithies. The network helps show where Oliver Smithies may publish in the future.

Co-authorship network of co-authors of Oliver Smithies

This figure shows the co-authorship network connecting the top 25 collaborators of Oliver Smithies. A scholar is included among the top collaborators of Oliver Smithies based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Oliver Smithies. Oliver Smithies is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling 2021 ·Communications Biology ·Masao Kakoki, (unknown), John R. Hagaman, Ruriko Grant, (unknown), Joan M. Taylor, J. Charles Jennette, Oliver Smithies, (unknown)	9
2	Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system 2018 ·Scientific Reports ·(unknown), (unknown), Mark Baguma‐Nibasheka, Robert A. Rose, Lucile Miquerol, Oliver Smithies, Nobuyo Maeda, Kishore B.S. Pasumarthi	12
3	Vitamin B ₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice breakdown → 2017 ·Science ·Pete A. Williams, Jeffrey M. Harder, Nicole E. Foxworth, Kelly E. Cochran, Vivek M. Philip, Vittorio Porciatti, Oliver Smithies, Simon W. M. John	417
4	Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase 2016 ·Proceedings of the National Academy of Sciences ·Albert S. Chang, Ruriko Grant, Hirofumi Tomita, Hyung‐Suk Kim, Oliver Smithies, Masao Kakoki	31
5	Decreased Beta-Adrenergic Responsiveness Following Hypertrophy Occurs Only in Cardiomyocytes that Also Re-Express Beta-Myosin Heavy Chain 2009 ·European Journal of Heart Failure ·Kumar Pandya, Kristine Porter, Howard A. Rockman, Oliver Smithies	9
6	Salt-Sensitive Blood Pressure in Mice With Increased Expression of Aldosterone Synthase 2007 ·Hypertension ·Natalia Makhanova, John R. Hagaman, Hyung‐Suk Kim, Oliver Smithies	60
7	Disturbed Homeostasis in Sodium-Restricted Mice Heterozygous and Homozygous for Aldosterone Synthase Gene Disruption 2006 ·Hypertension ·Natalia Makhanova, Maria Luisa S. Sequeira-Lόpez, R. Ariel Gómez, Hyung‐Suk Kim, Oliver Smithies	47
8	Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney breakdown → 2006 ·Proceedings of the National Academy of Sciences ·Steven D. Crowley, Susan B. Gurley, M Herrera, Phillip Ruiz, Robert Griffiths, (unknown), Hyung‐Suk Kim, Oliver Smithies, Thu H. Le, Thomas M. Coffman	548
9	Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice 2006 ·Journal of Clinical Investigation ·Manyu Li, Della Yee, Terry Magnuson, Oliver Smithies, Kathleen M. Caron	79
10	Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene 2005 ·Cardiovascular Research ·Toshio Nishikimi, (unknown), Naohiko Takahashi, (unknown), H Matsuoka, Oliver Smithies, Nobuaki Maeda	25
11	E-Prostanoid-3 Receptors Mediate the Proinflammatory Actions of Prostaglandin E2 in Acute Cutaneous Inflammation 2004 ·The Journal of Immunology ·Jennifer L. Goulet, Amy J. Pace, (unknown), Robert S. Byrum, MyTrang Nguyen, Stephen L. Tilley, Scott G. Morham, Robert Langenbach, Jeffrey L. Stock, John D. McNeish, Oliver Smithies, Thomas M. Coffman, Beverly H. Koller	51
12	Altering the Expression in Mice of Genes by Modifying Their 3′ Regions 2004 ·Developmental Cell ·Masao Kakoki, Yau-Sheng Tsai, Hyung‐Suk Kim, Seigo Hatada, Dominic J. Ciavatta, Nobuyuki Takahashi, Larry W. Arnold, Nobuyo Maeda, Oliver Smithies	43
13	Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm 2003 ·Surgery ·Jeffrey H. Fair, Bruce A. Cairns, (unknown), Jian Wang, Anthony A. Meyer, Hyung L. Kim, Seigo Hatada, Oliver Smithies, Larysa Pevny	47
14	The Influence of Chromosomal Location on the Expression of Two Transgenes in Mice 1999 ·Journal of Biological Chemistry ·Seigo Hatada, William A. Kuziel, Oliver Smithies, Nobuyo Maeda	25
15	Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2 breakdown → 1997 ·Proceedings of the National Academy of Sciences ·William A. Kuziel, (unknown), Tracey C. Dawson, (unknown), Oliver Smithies, Klaus Ley, Nobuyo Maeda	573
16	Deletion and Replacement of the Mouse Adult β-Globin Genes by a “Plug and Socket” Repeated Targeting Strategy 1994 ·Molecular and Cellular Biology ·Peter J. Detloff, (unknown), Simon W. M. John, W. Ronald Shehee, Robert Langenbach, Nobuyo Maeda, Oliver Smithies	50
17	ISLET ALLOGRAFT, ISLET XENOGRAFT, AND SKIN ALLOGRAFT SURVIVAL IN CD8 1993 ·Transplantation ·Niraj M. Desai, Hamid Bassiri, (unknown), (unknown), Oliver Smithies, Clyde F. Barker, Ali Naji, James F. Markmann	34
18	Targetted correction of a mutant HPRT gene in mouse embryonic stem cells breakdown → 1987 ·Nature ·Thomas Doetschman, Ronald G. Gregg, Nobuyo Maeda, Martin Hooper, David W. Melton, Simon Thompson, Oliver Smithies	550
19	Assignment of the gene for beta-2-microglobulin to human chromosome 15 1976 ·Cytogenetic and Genome Research ·Raju Kucherlapati, Harvey E. Faber, M. D. Poulik, F.H. Ruddle, Oliver Smithies	2
20	Zone Electrophoresis in Starch Gels and its Application to Studies of Serum Proteins breakdown → 1959 ·Advances in protein chemistry ·Oliver Smithies	525

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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