Nobuo Shimma

3.7k citations

56 papers · 3.0k indexed · 1 hit paper · h-index 26

Oncology top 2%
Molecular Biology top 10%
Organic Chemistry top 2%
Epidemiology top 10%
Pulmonary and Respiratory Medicine top 10%

Co-authors: Hideo Ishitsuka Isao UMEDA Masanori Miwa Masako Ura Noriaki Sawada M Nishida T Ishikawa Kazushige Mori
Topics: Cancer therapeutics and mechanisms (11 papers)Synthesis and Biological Evaluation (7 papers)Antifungal resistance and susceptibility (7 papers)
Cited by: Oncology Organic Chemistry Hepatology
Journals: Journal of Biological Chemistry Cancer Research Scientific Reports
Partner nations: Japan Switzerland United States

In The Last Decade

Nobuo Shimma

56 papers receiving 2.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

1998 1.0k citations Masanori Miwa, Masako Ura et al. profile →

Peers

Countries citing papers authored by Nobuo Shimma

Since Specialization

Citations

This map shows the geographic impact of Nobuo Shimma's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Nobuo Shimma with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Nobuo Shimma more than expected).

Fields of papers citing papers by Nobuo Shimma

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Nobuo Shimma. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Nobuo Shimma. The network helps show where Nobuo Shimma may publish in the future.

Co-authorship network of co-authors of Nobuo Shimma

This figure shows the co-authorship network connecting the top 25 collaborators of Nobuo Shimma. A scholar is included among the top collaborators of Nobuo Shimma based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Nobuo Shimma. Nobuo Shimma is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity 2013 ·Cancer Research ·Nobuya Ishii,Naoki Harada,Eric W. Joseph,Kazuhiro Ohara,Takaaki Miura,Hiroshi Sakamoto,Yutaka Matsuda,Yasushi Tomii,(unknown),Hitoshi Iikura,Toshihiro Aoki,Nobuo Shimma,Mikio Arisawa,Yoshihiro Sowa,Poulikos I. Poulikakos,Neal Rosen,Yuko Aoki,Toshiyuki Sakai	128
2	Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors 2013 ·Bioorganic & Medicinal Chemistry ·Atsushi Suda,Ken‐ichi Kawasaki,Susumu Komiyama,Yoshiaki Isshiki,(unknown),Sung‐Jin Kim,(unknown),Kiyoshi Hasegawa,Takaaki A. Fukami,Shigeo Sato,Takaaki Miura,Naomi Ono,Toshikazu Yamazaki,Ryoichi Saitoh,Nobuo Shimma,Yasuhiko Shiratori,Takuo Tsukuda	36
3	An orally available, small-molecule interferon inhibits viral replication 2012 ·Scientific Reports ·Hideyuki Konishi,Koichi Okamoto,(unknown),Hitoshi Yoshino,(unknown),(unknown),Yuichi Hirata,(unknown),Hiroshi Sakamoto,Natsuko Hada,Asao Katsume,Michinori Kohara,Kazumi Morikawa,Takuo Tsukuda,Nobuo Shimma,Graham R. Foster,William Alazawi,Yuko Aoki,Mikio Arisawa,Masayuki Sudoh	39
4	Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors 2011 ·Bioorganic & Medicinal Chemistry Letters ·Atsushi Suda,Hiroshi Koyano,Tadakatsu Hayase,(unknown),Ken‐ichi Kawasaki,Susumu Komiyama,Kiyoshi Hasegawa,Takaaki A. Fukami,Shigeo Sato,Takaaki Miura,Naomi Ono,Toshikazu Yamazaki,Ryoichi Saitoh,Nobuo Shimma,Yasuhiko Shiratori,Takuo Tsukuda	23
5	Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments 2011 ·ChemMedChem ·Leo A. Hardegger,Bernd Kuhn,(unknown),Lilli Anselm,(unknown),M. Stihle,Bernard Gsell,Ralf Thoma,Joachim Diez,Jörg Benz,Jean‐Marc Plancher,Guido Hartmann,Yoshiaki Isshiki,Kenji Morikami,Nobuo Shimma,Wolfgang Haap,David W. Banner,François Diederich	105
6	Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design 2011 ·Bioorganic & Medicinal Chemistry Letters ·Takaaki Miura,Takaaki A. Fukami,Kiyoshi Hasegawa,Naomi Ono,Atsushi Suda,(unknown),(unknown),Sung‐Jin Kim,(unknown),Yuko Aoki,Nobuo Shimma,Takuo Tsukuda,Yasuhiko Shiratori	28
7	Synthesis and structure–activity relationships of novel benzofuran farnesyltransferase inhibitors 2009 ·Bioorganic & Medicinal Chemistry Letters ·Kohsuke Asoh,(unknown),(unknown),Tatsuo Ohtsuka,Miyako Masubuchi,Ken‐ichi Kawasaki,Hirosato Ebiike,Yasuhiko Shiratori,Takaaki A. Fukami,Osamu Kondoh,Toshiyuki Tsukaguchi,(unknown),Yuko Aoki,Nobuo Shimma,Masahiro Sakaitani	39
8	Design and synthesis of novel prodrugs of 2′-deoxy-2′-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues 2007 ·Bioorganic & Medicinal Chemistry Letters ·Yasunori Kohchi,Kazuo Hattori,Nobuhiro Oikawa,(unknown),Yoshiaki Isshiki,(unknown),(unknown),(unknown),Masanori Miwa,(unknown),Masako Ura,(unknown),Hisafumi Okabe,Hideo Ishitsuka,Nobuo Shimma	5
9	Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors 2002 ·Chemistry & Biology ·Satoshi Sogabe,Miyako Masubuchi,Kiyoaki Sakata,Takaaki A. Fukami,Kenji Morikami,Yasuhiko Shiratori,Hirosato Ebiike,Ken‐ichi Kawasaki,Yuko Aoki,Nobuo Shimma,A. D’Arcy,Fritz K. Winkler,David W. Banner,Tatsuo Ohtsuka	107
10	Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2 2002 ·Bioorganic & Medicinal Chemistry Letters ·Hirosato Ebiike,Miyako Masubuchi,Pingli Liu,Ken‐ichi Kawasaki,Kenji Morikami,Satoshi Sogabe,(unknown),Toshihiko Fujii,Kiyoaki Sakata,Hidetoshi Shindoh,Yasuhiko Shiratori,Yuko Aoki,Tatsuo Ohtsuka,Nobuo Shimma	66
11	Synthesis and Antifungal Activities of Novel 1,3-β-d-Glucan Synthase Inhibitors. Part 2 2001 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),(unknown),(unknown),Takeshi Murata,Masao Tsukazaki,Osamu Kondoh,Toshikazu Yamazaki,Yasuko Satoh,(unknown),Toshiyuki Tsukaguchi,Kazuko Kobayashi,(unknown),(unknown),Ikuo Horii,Nobuo Shimma	10
12	Identification of a Novel Inhibitor Specific to the Fungal Chitin Synthase 2000 ·Journal of Biological Chemistry ·Masayuki Sudoh,Toshikazu Yamazaki,(unknown),Mikio Taniguchi,Nobuo Shimma,Mikio Arisawa,Hisafumi Yamada‐Okabe	42
13	Synthesis and structure–activity relationships of novel fungal chitin synthase inhibitors 2000 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Mikio Taniguchi,Isao UMEDA,Kazuo Hattori,(unknown),Yasunori Kohchi,Yoshiaki Isshiki,(unknown),(unknown),(unknown),Hisafumi Okabe,Masayuki Sudoh,Toshikazu Yamazaki,Nobuo Shimma	35
14	Discovery and Development of Novel Anticancer Drug Capecitabine 1999 ·YAKUGAKU ZASSHI ·Hideo Ishitsuka,Nobuo Shimma,Ikuo Horii	19
15	Synthesis of novel antifungal agents (2) 1998 ·Bioorganic & Medicinal Chemistry Letters ·Takuo Tsukuda,Masami Watanabe,(unknown),Kazuo Hattori,(unknown),Nobuo Shimma	2
16	Cyclothialidine, a novel DNA gyrase inhibitor. II. Isolation, charactenzation and structure elucidation. 1994 ·The Journal of Antibiotics ·Tsutomu Kamiyama,Nobuo Shimma,Tatsuo Ohtsuka,Noboru Nakayama,Yoshiko Itezono,(unknown),Junko Watanabe,Kazuteru Yokose	18
17	Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp. NR0489. III. Structural elucidation. 1993 ·The Journal of Antibiotics ·Tatsuo Ohtsuka,Noboru Nakayama,Yoshiko Itezono,Nobuo Shimma,(unknown),Kazuteru Yokose	13
18	Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp. NR0489. II. Isolation, characterization and biological activities. 1993 ·The Journal of Antibiotics ·Tatsuo Ohtsuka,(unknown),Noboru Nakayama,Yoshiko Itezono,Nobuo Shimma,(unknown),(unknown),Mikio Arisawa,Kazuteru Yokose,Haruo Seto	30
19	A new series of natural antifungals that inhibit P450 lanosterol C-14 demethylase. I. Taxonomy, fermentation, isolation and structural elucidation. 1992 ·The Journal of Antibiotics ·Shoko Matsukuma,Tatsuo Ohtsuka,(unknown),(unknown),Takashi Sano,(unknown),Noboru Nakayama,Yoshiko Itezono,Morio Fujiu,Nobuo Shimma,Kazuteru Yokose,Tôru Okuda	36
20	Comparative studies on the antirhinovirus activity and the mode of action of the rhinovirus capsid binding agents, chalcone amides 1990 ·Antiviral Research ·(unknown),Nobuo Shimma,Hideo Ishitsuka	49

About Nobuo Shimma

Nobuo Shimma is a scholar working on Organic Chemistry, Toxicology and Molecular Biology, having authored 56 papers that have together received 3.0k indexed citations. Recurring topics across this work include Cancer therapeutics and mechanisms (11 papers), Synthesis and Biological Evaluation (7 papers) and Antifungal resistance and susceptibility (7 papers). The work is most often cited by research in Oncology (1.1k citations), Organic Chemistry (807 citations) and Hepatology (179 citations). Nobuo Shimma has collaborated with scholars based in Japan, Switzerland and United States. Frequent co-authors include Hideo Ishitsuka, Isao UMEDA, Masanori Miwa, Masako Ura, Noriaki Sawada, M Nishida, T Ishikawa, Kazushige Mori, Yuko Aoki and Yasuhiko Shiratori. Their work appears in journals such as Journal of Biological Chemistry, Cancer Research and Scientific Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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