Hirosato Ebiike

1.3k citations

31 papers · 1.0k indexed · h-index 14

Co-authors: Yuko Aoki Kazuo Achiwa Kiyoaki Sakata Nobuo Shimma Kenji Morikami Toshihiko Fujii Yasuhiko Shiratori Ken‐ichi Kawasaki
Topics: Asymmetric Synthesis and Catalysis (6 papers)PI3K/AKT/mTOR signaling in cancer (5 papers)Chemical synthesis and alkaloids (5 papers)
Cited by: Organic Chemistry Toxicology Molecular Biology
Journals: Cancer Research Clinical Cancer Research Journal of Medicinal Chemistry
Partner nations: Japan United States Switzerland

In The Last Decade

Hirosato Ebiike

31 papers receiving 976 citations

Peers

Countries citing papers authored by Hirosato Ebiike

Since Specialization

Citations

This map shows the geographic impact of Hirosato Ebiike's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hirosato Ebiike with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hirosato Ebiike more than expected).

Fields of papers citing papers by Hirosato Ebiike

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hirosato Ebiike. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hirosato Ebiike. The network helps show where Hirosato Ebiike may publish in the future.

Co-authorship network of co-authors of Hirosato Ebiike

This figure shows the co-authorship network connecting the top 25 collaborators of Hirosato Ebiike. A scholar is included among the top collaborators of Hirosato Ebiike based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hirosato Ebiike. Hirosato Ebiike is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents 2016 ·Bioorganic & Medicinal Chemistry ·Hatsuo Kawada,Hirosato Ebiike,Masao Tsukazaki,(unknown),(unknown),(unknown),Kenji Morikami,(unknown),Miyuki Yoshida,Kotaro Ogawa,Nobuo Shimma,Takuo Tsukuda,Jun Ohwada	6
2	Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability 2015 ·Bioorganic & Medicinal Chemistry ·Hatsuo Kawada,Hirosato Ebiike,Masao Tsukazaki,(unknown),(unknown),(unknown),Kenji Morikami,(unknown),Miyuki Yoshida,Kotaro Ogawa,(unknown),Takuo Tsukuda,Jun Ohwada	9
3	The Fibroblast Growth Factor Receptor Genetic Status as a Potential Predictor of the Sensitivity to CH5183284/Debio 1347, a Novel Selective FGFR Inhibitor 2014 ·Molecular Cancer Therapeutics ·Yoshito Nakanishi,(unknown),Toshiyuki Tsukaguchi,Toshihiko Fujii,Kiyoaki Sakata,Hitoshi Sase,(unknown),Kenji Morikami,Hidetoshi Shindoh,Toshiyuki Mio,Hirosato Ebiike,Naoki Taka,Yuko Aoki,Nobuya Ishii	101
4	Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation 2012 ·Bioorganic & Medicinal Chemistry Letters ·Hatsuo Kawada,Hirosato Ebiike,Masao Tsukazaki,(unknown),Kenji Morikami,(unknown),Miyuki Yoshida,Kotaro Ogawa,Nobuo Shimma,Takuo Tsukuda,Jun Ohwada	13
5	The Selective Class I PI3K Inhibitor CH5132799 Targets Human Cancers Harboring Oncogenic PIK3CA Mutations 2011 ·Clinical Cancer Research ·Hiroshi Tanaka,Miyuki Yoshida,Hiromi Tanimura,Toshihiko Fujii,Kiyoaki Sakata,Yukako Tachibana,Jun Ohwada,Hirosato Ebiike,Shino Kuramoto,Keiichi Morita,Yasushi Yoshimura,Toshikazu Yamazaki,Nobuya Ishii,Osamu Kondoh,Yuko Aoki	79
6	Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799 2011 ·Bioorganic & Medicinal Chemistry Letters ·Jun Ohwada,Hirosato Ebiike,Hatsuo Kawada,Masao Tsukazaki,(unknown),Takuya Miyazaki,Kenji Morikami,(unknown),Miyuki Yoshida,Osamu Kondoh,Shino Kuramoto,Kotaro Ogawa,Yuko Aoki,Nobuo Shimma	56
7	Synthesis and structure–activity relationships of novel benzofuran farnesyltransferase inhibitors 2009 ·Bioorganic & Medicinal Chemistry Letters ·Kohsuke Asoh,(unknown),(unknown),Tatsuo Ohtsuka,Miyako Masubuchi,Ken‐ichi Kawasaki,Hirosato Ebiike,Yasuhiko Shiratori,Takaaki A. Fukami,Osamu Kondoh,Toshiyuki Tsukaguchi,(unknown),Yuko Aoki,Nobuo Shimma,Masahiro Sakaitani	39
8	Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3 2003 ·Bioorganic & Medicinal Chemistry Letters ·Ken‐ichi Kawasaki,Miyako Masubuchi,Kenji Morikami,Satoshi Sogabe,(unknown),Hirosato Ebiike,Satoshi Niizuma,(unknown),Toshihiko Fujii,Kiyoaki Sakata,Hidetoshi Shindoh,Yasuhiko Shiratori,Yuko Aoki,Tatsuo Ohtsuka,Nobuo Shimma	90
9	Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors 2002 ·Chemistry & Biology ·Satoshi Sogabe,Miyako Masubuchi,Kiyoaki Sakata,Takaaki A. Fukami,Kenji Morikami,Yasuhiko Shiratori,Hirosato Ebiike,Ken‐ichi Kawasaki,Yuko Aoki,Nobuo Shimma,A. D’Arcy,Fritz K. Winkler,David W. Banner,Tatsuo Ohtsuka	107
10	Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2 2002 ·Bioorganic & Medicinal Chemistry Letters ·Hirosato Ebiike,Miyako Masubuchi,Pingli Liu,Ken‐ichi Kawasaki,Kenji Morikami,Satoshi Sogabe,(unknown),Toshihiko Fujii,Kiyoaki Sakata,Hidetoshi Shindoh,Yasuhiko Shiratori,Yuko Aoki,Tatsuo Ohtsuka,Nobuo Shimma	66
11	Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N -myristoyltransferase. Part 1 2001 ·Bioorganic & Medicinal Chemistry Letters ·Miyako Masubuchi,Ken‐ichi Kawasaki,Hirosato Ebiike,Yoshihiko Ikeda,Shinji Tsujii,Satoshi Sogabe,Toshihiko Fujii,Kiyoaki Sakata,Yasuhiko Shiratori,Yuko Aoki,Tatsuo Ohtsuka,Nobuo Shimma	103
12	Asymmetric Synthesis of (R)-Nilvadipine and (S)-NB 818 via Regioselective Bromination of Chiral 1,4-Dihydropyridines as a Key Step and Enzymatic Resolution of Racemic 2-Hydroxymethyl-1,4-dihydropyridine Derivatives. 1997 ·Chemical and Pharmaceutical Bulletin ·Hirosato Ebiike,(unknown),(unknown),(unknown),Kazuo Achiwa	3
13	Asymmetric Synthesis of (S)-(+)- and (R)-(-)-NZ-105 through the Modified Michaelis-Arbuzov Rearrangement as a Key Step. 1996 ·Chemical and Pharmaceutical Bulletin ·Tatsuhisa Kato,(unknown),Hirosato Ebiike,Kazuo Achiwa	10
14	Determination of the Absolute Configuration of Biologically Active (S)-(-)-NB 818 and Its Structural Correlation with the Stereoselectivity of the Channel Blocking Action. 1994 ·Chemical and Pharmaceutical Bulletin ·(unknown),Hirosato Ebiike,Kazuo Achiwa	3
15	Lipase-catalyzed asymmetric hydrolysis and regioselective bromination of 1,4-dihydropyridine. Synthesis of (R)-(=)-nilvadipine 1994 ·Tetrahedron Asymmetry ·Hirosato Ebiike,Kazuo Achiwa	5
16	Enzymatic synthesis of optically active 2-carbamoyl-oxymethyl-1,4-dihydropyridines, (R)-(+)- and (S)-(−)-NB 818 1992 ·Tetrahedron Asymmetry ·Hirosato Ebiike,(unknown),Kazuo Achiwa	12
17	Lipase-catalyzed enantioselective hydrolysis of 4-alkyl-1,4-dihydropyridine derivatives: synthesis of (+)- and (-)-methyl 2-(phenylthio)ethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate(PCA 4248). 1992 ·Chemical and Pharmaceutical Bulletin ·Hirosato Ebiike,Kazuaki Maruyama,Kazuo Achiwa	12
18	Drastic solvent effect on lipase-catalyzed enantioselective hydrolysis of prochiral 1,4-dihydropyridines 1992 ·Tetrahedron Letters ·Yoshihiko Hirose,(unknown),(unknown),(unknown),Hirosato Ebiike,Kazuo Achiwa	78
19	Design of Lipase-catalyzed Asymmetric Reactions in Organic Solvents and Their Application to the Syhthesis of Optically Active Medicines. 1991 ·Journal of Synthetic Organic Chemistry Japan ·Masakazu Murata,Hirosato Ebiike,Kazuo Achiwa	4
20	Synthesis and inhibitory activity of isoindolinone derivatives on thromboxane A2 analog (U-46619)-induced vasocontraction. 1990 ·Chemical and Pharmaceutical Bulletin ·Yukio Kato,Hirosato Ebiike,Kazuo Achiwa,Naoki Ashizawa,Toshio Kurihara,Fujio Kobayashi	46

About Hirosato Ebiike

Hirosato Ebiike is a scholar working on Organic Chemistry, Molecular Biology and Genetics, having authored 31 papers that have together received 1.0k indexed citations. Recurring topics across this work include Asymmetric Synthesis and Catalysis (6 papers), PI3K/AKT/mTOR signaling in cancer (5 papers) and Chemical synthesis and alkaloids (5 papers). The work is most often cited by research in Organic Chemistry (480 citations), Toxicology (32 citations) and Molecular Biology (605 citations). Hirosato Ebiike has collaborated with scholars based in Japan, United States and Switzerland. Frequent co-authors include Yuko Aoki, Kazuo Achiwa, Kiyoaki Sakata, Nobuo Shimma, Kenji Morikami, Toshihiko Fujii, Yasuhiko Shiratori, Ken‐ichi Kawasaki, Miyako Masubuchi and Tatsuo Ohtsuka. Their work appears in journals such as Cancer Research, Clinical Cancer Research and Journal of Medicinal Chemistry.

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