Raphael Kopan

32.7k total citations · 9 hit papers
163 papers, 25.2k citations indexed

About

Raphael Kopan is a scholar working on Molecular Biology, Cell Biology and Genetics. According to data from OpenAlex, Raphael Kopan has authored 163 papers receiving a total of 25.2k indexed citations (citations by other indexed papers that have themselves been cited), including 130 papers in Molecular Biology, 26 papers in Cell Biology and 25 papers in Genetics. Recurrent topics in Raphael Kopan's work include Developmental Biology and Gene Regulation (55 papers), Renal and related cancers (31 papers) and Pluripotent Stem Cells Research (17 papers). Raphael Kopan is often cited by papers focused on Developmental Biology and Gene Regulation (55 papers), Renal and related cancers (31 papers) and Pluripotent Stem Cells Research (17 papers). Raphael Kopan collaborates with scholars based in United States, Germany and Japan. Raphael Kopan's co-authors include Ma. Xenia G. Ilagan, Eric H. Schroeter, Jeff S. Mumm, Elaine Fuchs, Jeffrey S. Nye, Alison Goate, Michael S. Wolfe, Dennis J. Selkoe, William J. Ray and Frank Costantini and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Raphael Kopan

160 papers receiving 24.9k citations

Hit Papers

The Canonical Notch Signaling Pathway: Unfoldin... 1995 2026 2005 2015 2009 1999 1998 1995 2000 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
    2009 2.8k citations Raphael Kopan, Ma. Xenia G. Ilagan profile →
  2. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
    1999 1.7k citations Eric H. Schroeter, Raphael Kopan et al. Nature profile →
  3. Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
    1998 1.4k citations Eric H. Schroeter, Raphael Kopan et al. Nature profile →
  4. Signalling downstream of activated mammalian Notch
    1995 1.2k citations Sophie Jarriault, Christel Brou et al. Nature profile →
  5. Notch Signaling: From the Outside In
    2000 809 citations Raphael Kopan et al. profile →
  6. A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1
    2000 693 citations Eric H. Schroeter, Raphael Kopan et al. profile →
  7. AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
    2011 638 citations Raphael Kopan et al. profile →
  8. NOTCH ANDPRESENILIN: Regulated Intramembrane Proteolysis Links Development and Degeneration
    2003 525 citations Raphael Kopan et al. profile →
  9. Patterning a Complex Organ: Branching Morphogenesis and Nephron Segmentation in Kidney Development
    2010 523 citations Raphael Kopan et al. Developmental Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Raphael Kopan United States 77 17.5k 4.0k 3.7k 2.8k 2.7k 163 25.2k
John M. Shelton United States 75 15.7k 0.9× 3.4k 0.8× 2.8k 0.8× 2.8k 1.0× 1.6k 0.6× 152 22.8k
Daniel Metzger France 85 16.5k 0.9× 2.8k 0.7× 2.2k 0.6× 7.1k 2.6× 3.9k 1.4× 200 26.8k
David M. Valenzuela United States 60 11.3k 0.6× 3.3k 0.8× 2.4k 0.7× 1.8k 0.7× 2.4k 0.9× 110 21.8k
En Li United States 57 17.0k 1.0× 1.7k 0.4× 2.5k 0.7× 4.7k 1.7× 1.6k 0.6× 119 22.4k
Mikio Furuse Japan 72 16.9k 1.0× 1.9k 0.5× 4.6k 1.2× 1.2k 0.4× 3.5k 1.3× 160 31.0k
Akira Kikuchi Japan 88 20.4k 1.2× 1.3k 0.3× 6.2k 1.7× 2.3k 0.8× 3.3k 1.2× 463 26.8k
Urban Lendahl Sweden 79 15.4k 0.9× 1.6k 0.4× 2.4k 0.6× 2.2k 0.8× 2.9k 1.1× 215 24.8k
Thomas Braun Germany 82 21.9k 1.3× 2.9k 0.7× 2.2k 0.6× 3.1k 1.1× 1.8k 0.7× 483 31.1k
Xi He United States 74 22.0k 1.3× 1.2k 0.3× 3.6k 1.0× 3.7k 1.4× 4.1k 1.5× 158 28.2k
Andrew Baird United States 79 12.5k 0.7× 1.6k 0.4× 4.3k 1.2× 2.2k 0.8× 1.6k 0.6× 333 21.8k

Countries citing papers authored by Raphael Kopan

Since Specialization
Citations

This map shows the geographic impact of Raphael Kopan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Raphael Kopan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Raphael Kopan more than expected).

Fields of papers citing papers by Raphael Kopan

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Raphael Kopan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Raphael Kopan. The network helps show where Raphael Kopan may publish in the future.

Co-authorship network of co-authors of Raphael Kopan

This figure shows the co-authorship network connecting the top 25 collaborators of Raphael Kopan. A scholar is included among the top collaborators of Raphael Kopan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Raphael Kopan. Raphael Kopan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Kovall, Rhett A., et al.. (2024). Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity. PLoS Genetics. 20(12). e1011486–e1011486.
2.
Pode‐Shakked, Naomi, Nambirajan Sundaram, Ruth Schreiber, et al.. (2023). RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis. Nature Communications. 14(1). 8159–8159. 14 indexed citations
3.
Schuh, Meredith P., et al.. (2023). Characterizing post-branching nephrogenesis in the neonatal rabbit. Scientific Reports. 13(1). 19234–19234.
4.
Hass, Matthew R., Praneet Chaturvedi, Sarah Stein, et al.. (2020). Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. PLoS Biology. 18(10). e3000850–e3000850. 16 indexed citations
5.
Kovall, Rhett A., Brian Gebelein, David Sprinzak, & Raphael Kopan. (2017). The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force. Developmental Cell. 41(3). 228–241. 280 indexed citations
6.
Townsend, R. Reid, et al.. (2016). The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development. Journal of Investigative Dermatology. 136(6). 1106–1115. 16 indexed citations
7.
Volovelsky, Oded & Raphael Kopan. (2016). Making new kidneys. Current Opinion in Organ Transplantation. 21(6). 574–580. 6 indexed citations
8.
Demitrack, Elise S., Theresa M. Keeley, Alexis J. Carulli, et al.. (2015). Notch signaling regulates gastric antral LGR 5 stem cell function. The EMBO Journal. 34(20). 2522–2536. 80 indexed citations
9.
Ilagan, Ma. Xenia G. & Raphael Kopan. (2014). Monitoring Notch Activation in Cultured Mammalian Cells: Transcriptional Reporter Assays. Methods in molecular biology. 1187. 143–154. 2 indexed citations
10.
Yockey, Laura J., Shadmehr Demehri, Mustafa Turkoz, et al.. (2013). The Absence of a Microbiota Enhances TSLP Expression in Mice with Defective Skin Barrier but Does Not Affect the Severity of their Allergic Inflammation. Journal of Investigative Dermatology. 133(12). 2714–2721. 27 indexed citations
11.
Chillakuri, Chandramouli, Devon Sheppard, Ma. Xenia G. Ilagan, et al.. (2013). Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands. Cell Reports. 5(4). 861–867. 38 indexed citations
12.
Tu, Xiaolin, Jianquan Chen, Joohyun Lim, et al.. (2012). Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1. PLoS Genetics. 8(3). e1002577–e1002577. 78 indexed citations
13.
14.
Zhao, Guojun, Zhenyi Liu, Ma. Xenia G. Ilagan, & Raphael Kopan. (2010). γ-Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin. Journal of Neuroscience. 30(5). 1648–1656. 68 indexed citations
15.
Cras‐Méneur, Corentin, Lin Li, Raphael Kopan, & M. Alan Permutt. (2009). Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes & Development. 23(17). 2088–2101. 43 indexed citations
16.
Cheng, Hui‐Teng, Mijin Kim, M. Todd Valerius, et al.. (2007). Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development. 134(4). 801–811. 262 indexed citations
17.
Yang, Xudong, Taisuke Tomita, Mary Wines-Samuelson, et al.. (2006). Notch1 Signaling Influences V2 Interneuron and Motor Neuron Development in the Spinal Cord. Developmental Neuroscience. 28(1-2). 102–117. 53 indexed citations
18.
Ong, Chin‐Tong, Hui‐Teng Cheng, Li‐Wei Chang, et al.. (2005). Target Selectivity of Vertebrate Notch Proteins. Journal of Biological Chemistry. 281(8). 5106–5119. 183 indexed citations
19.
Jarriault, Sophie, Christel Brou, Frédérique Logeat, et al.. (1995). Signalling downstream of activated mammalian Notch. Nature. 377(6547). 355–358. 1190 indexed citations breakdown →
20.
Stoler, Andrea, Raphael Kopan, Madeleine Duvic, & Elaine Fuchs. (1988). Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation.. The Journal of Cell Biology. 107(2). 427–446. 327 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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