Michael J. Sofia

5.4k total citations · 1 hit paper
122 papers, 3.8k citations indexed

About

Michael J. Sofia is a scholar working on Molecular Biology, Hepatology and Epidemiology. According to data from OpenAlex, Michael J. Sofia has authored 122 papers receiving a total of 3.8k indexed citations (citations by other indexed papers that have themselves been cited), including 62 papers in Molecular Biology, 44 papers in Hepatology and 40 papers in Epidemiology. Recurrent topics in Michael J. Sofia's work include Hepatitis C virus research (44 papers), Hepatitis B Virus Studies (36 papers) and HIV/AIDS drug development and treatment (27 papers). Michael J. Sofia is often cited by papers focused on Hepatitis C virus research (44 papers), Hepatitis B Virus Studies (36 papers) and HIV/AIDS drug development and treatment (27 papers). Michael J. Sofia collaborates with scholars based in United States, United Kingdom and China. Michael J. Sofia's co-authors include Phillip A. Furman, Bruce S. Ross, Wonsuk Chang, Angela M. Lam, Michaël Otto, Ralph T. Mosley, Congrong Niu, Holly M. Micolochick Steuer, Shalini Bansal and Suguna Rachakonda and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Michael J. Sofia

121 papers receiving 3.5k citations

Hit Papers

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What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

2010 486 citations Michael J. Sofia, Donghui Bao et al. Journal of Medicinal Chemistry profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
Michael J. Sofia	1.7k	1.2k	1.1k	1.1k	1.0k	122	3.8k
Warren M. Kati	1.6k 1.0×	1.4k 1.2×	724 0.6×	661 0.6×	993 1.0×	81	3.5k
Franck Amblard	1.2k 0.7×	878 0.8×	349 0.3×	1.4k 1.3×	524 0.5×	87	3.0k
Maxwell D. Cummings	1.6k 0.9×	681 0.6×	437 0.4×	577 0.5×	423 0.4×	52	2.9k
Pierre L. Beaulieu	796 0.5×	640 0.6×	767 0.7×	1.3k 1.2×	539 0.5×	79	2.6k
Bertil Samuelsson	1.6k 1.0×	843 0.7×	385 0.3×	1.6k 1.5×	351 0.3×	134	3.6k
Tarek S. Mansour	2.2k 1.3×	590 0.5×	338 0.3×	2.4k 2.3×	490 0.5×	148	5.0k
Phillip A. Furman	1.6k 0.9×	2.3k 2.0×	1.7k 1.5×	735 0.7×	2.7k 2.6×	73	5.3k
Kent D. Stewart	1.3k 0.8×	559 0.5×	300 0.3×	967 0.9×	518 0.5×	91	3.1k
Frank Narjes	564 0.3×	785 0.7×	1.3k 1.1×	580 0.5×	731 0.7×	62	2.2k
Choung U. Kim	1.5k 0.9×	889 0.8×	172 0.2×	1.1k 1.0×	1.6k 1.5×	59	3.3k

Countries citing papers authored by Michael J. Sofia

Since Specialization

Citations

This map shows the geographic impact of Michael J. Sofia's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael J. Sofia with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael J. Sofia more than expected).

Fields of papers citing papers by Michael J. Sofia

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael J. Sofia. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael J. Sofia. The network helps show where Michael J. Sofia may publish in the future.

Co-authorship network of co-authors of Michael J. Sofia

This figure shows the co-authorship network connecting the top 25 collaborators of Michael J. Sofia. A scholar is included among the top collaborators of Michael J. Sofia based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael J. Sofia. Michael J. Sofia is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Mason, Jeremy D., Zhenhua Wu, Rajeev Kumar Singh, et al.. (2025). Development of a Scalable Manufacturing Process for AB-343 Drug Substance: A Potential Candidate for the Treatment of Coronavirus Infections. Organic Process Research & Development. 29(3). 856–871.

Cole, Andrew G., Steven G. Kultgen, Nagraj Mani, et al.. (2024). Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836. Journal of Medicinal Chemistry. 67(18). 16773–16795. 4 indexed citations

Mesaros, Eugen F., Andrew G. Cole, Steven G. Kultgen, et al.. (2024). Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators. ACS Medicinal Chemistry Letters. 15(9). 1627–1634. 2 indexed citations

Lam, Angela M., Muhammad Sheraz, Fei Liu, et al.. (2024). Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161. Viruses. 16(3). 323–323. 5 indexed citations

Yuen, Man‐Fung, Elina Berliba, Wattana Sukeepaisarnjaroen, et al.. (2022). Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB‐506 from Phase 1 studies in healthy subjects and those with hepatitis B. Hepatology Communications. 6(12). 3457–3472. 17 indexed citations

Mani, Nagraj, et al.. (2019). Inhibition of HBV replication by N-hydroxyisoquinolinedione and N-hydroxypyridinedione ribonuclease H inhibitors. Antiviral Research. 164. 70–80. 30 indexed citations

Sofia, Michael J.. (2016). Enter Sofosbuvir: The Path to Curing HCV. Cell. 167(1). 25–29. 7 indexed citations

Appleby, T.C., Jason K. Perry, Eisuke Murakami, et al.. (2015). Structural basis for RNA replication by the hepatitis C virus polymerase. Science. 347(6223). 771–775. 254 indexed citations

Sofia, Michael J.. (2014). Beyond sofosbuvir: What opportunity exists for a better nucleoside/nucleotide to treat hepatitis C?. Antiviral Research. 107. 119–124. 31 indexed citations

10.

Du, Jinfa, Donghui Bao, Ying Jiang, et al.. (2012). β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study. Bioorganic & Medicinal Chemistry Letters. 22(18). 5924–5929. 13 indexed citations

11.

Liu, Jian, Jinfa Du, Peiyuan Wang, et al.. (2012). A 2′-Deoxy-2′-Fluoro-2′-C-Methyl Uridine Cyclopentyl Carbocyclic Analog and Its Phosphoramidate Prodrug as Inhibitors of HCV NS5B Polymerase. Nucleosides Nucleotides & Nucleic Acids. 31(4). 277–285. 10 indexed citations

12.

Murakami, Eisuke, Tatiana Tolstykh, Haiying Bao, et al.. (2010). Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977. Journal of Biological Chemistry. 285(45). 34337–34347. 234 indexed citations

13.

Shi, Shuhao, Shirong Zhu, Samuel W. Gerritz, et al.. (2009). Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 19(22). 6477–6480. 3 indexed citations

14.

Silbaugh, Steven A., Peter W. Stengel, Sandra L. Cockerham, et al.. (2000). Pharmacologic actions of the second generation leukotriene B 4 receptor antagonist LY293111: in vivo pulmonary studies. Naunyn-Schmiedeberg s Archives of Pharmacology. 361(4). 397–404. 14 indexed citations

15.

Silva, Domingos J., et al.. (2000). Synthesis and biological evaluation of analogues of bacterial lipid I. Bioorganic & Medicinal Chemistry Letters. 10(24). 2811–2813. 11 indexed citations

16.

Silbaugh, Steven A., Peter W. Stengel, Sandra L. Cockerham, et al.. (1996). Aerosolized LTB4 produces delayed onset increases in pulmonary gas trapping. Prostaglandins Leukotrienes and Essential Fatty Acids. 54(2). 115–121. 1 indexed citations

17.

Sawyer, J. Scott, Michael J. Sofia, Paul E. Floreancig, et al.. (1993). Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. Journal of Medicinal Chemistry. 36(24). 3982–3984. 8 indexed citations

18.

Marder, Philip, Richard M. Schultz, Stephen M. Spaethe, Michael J. Sofia, & David K. Herron. (1992). Flow cytometric evaluation of the effects of leukotriene B4 receptor antagonists (LY255283 and SC-41930) on calcium mobilization and integrin expression of activated human neutrophils. Prostaglandins Leukotrienes and Essential Fatty Acids. 46(4). 265–270. 16 indexed citations

19.

Schultz, Richard M., Philip Marder, Stephen M. Spaethe, David K. Herron, & Michael J. Sofia. (1991). Effects of two leukotriene B4 (LTB4) receptor antagonists (LY255283 and SC-41930) on LTB4-induced human neutrophil adhesion and superoxide production. Prostaglandins Leukotrienes and Essential Fatty Acids. 43(4). 267–271. 10 indexed citations

20.

Karanewsky, Donald S., Michael C. Badia, Carl P. Ciosek, et al.. (1990). Phosphorus-containing inhibitors of HMG-CoA reductase. I. 4-[(2-Arylethyl)hydroxyphosphinyl]-3-hydroxybutanoic acids: a new class of cell selective inhibitors of cholesterol biosynthesis. Journal of Medicinal Chemistry. 33(11). 2952–2956. 42 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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