Christine Espiritu

2.4k citations

34 papers · 1.8k indexed · 1 hit paper · h-index 17

Co-authors: Angela M. Lam Holly M. Micolochick Steuer Phillip A. Furman Michaël Otto Shalini Bansal Congrong Niu Michael J. Sofia Meg Keilman
Topics: Hepatitis C virus research (27 papers)Hepatitis B Virus Studies (22 papers)HIV/AIDS drug development and treatment (16 papers)
Cited by: Hepatology Infectious Diseases Epidemiology
Journals: Nature Proceedings of the National Academy of Sciences Journal of Biological Chemistry
Partner nations: United States Belgium Netherlands

In The Last Decade

Christine Espiritu

33 papers receiving 1.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

2010 486 citations Michael J. Sofia, Donghui Bao et al. Journal of Medicinal Chemistry profile →

Peers

Countries citing papers authored by Christine Espiritu

Since Specialization

Citations

This map shows the geographic impact of Christine Espiritu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christine Espiritu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christine Espiritu more than expected).

Fields of papers citing papers by Christine Espiritu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christine Espiritu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christine Espiritu. The network helps show where Christine Espiritu may publish in the future.

Co-authorship network of co-authors of Christine Espiritu

This figure shows the co-authorship network connecting the top 25 collaborators of Christine Espiritu. A scholar is included among the top collaborators of Christine Espiritu based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christine Espiritu. Christine Espiritu is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Control of Hepatitis B Virus with Imdusiran, a Small Interfering RNA Therapeutic 2024 ·ACS Infectious Diseases ·Emily P. Thi,Xin Ye,Nicholas M. Snead,Amy C. H. Lee,Holly M. Micolochick Steuer,(unknown),(unknown),Christine Espiritu,Andrea Cuconati,(unknown),(unknown),(unknown),Bhavna Paratala,Kevin McClintock,Troy O. Harasym,René Rijnbrand,Angela M. Lam,Michael J. Sofia	6
2	Di-fluoro azepane HBV capsid assembly modulators 2023 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Bart Stoops,P.L. Shaffer,Angela M. Lam,Christine Espiritu,Robert Vogel,(unknown),Osvaldo Flores,Scott D. Kuduk	1
3	Diazepinone HBV capsid assembly modulators 2022 ·Bioorganic & Medicinal Chemistry Letters ·Scott D. Kuduk,(unknown),Bart Stoops,P.L. Shaffer,Angela M. Lam,Christine Espiritu,Robert Vogel,(unknown),Osvaldo Flores,George D. Hartman	6
4	Identification of a new class of HBV capsid assembly modulator 2021 ·Bioorganic & Medicinal Chemistry Letters ·Scott D. Kuduk,Bart Stoops,Richard Alexander,Angela M. Lam,Christine Espiritu,Robert Vogel,(unknown),Klaus Klumpp,Osvaldo Flores,George D. Hartman	11
5	Oxadiazepinone HBV capsid assembly modulators 2021 ·Bioorganic & Medicinal Chemistry Letters ·Scott D. Kuduk,Bart Stoops,Angela M. Lam,Christine Espiritu,Robert Vogel,(unknown),Klaus Klumpp,Osvaldo Flores,George D. Hartman	10
6	SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators 2019 ·Bioorganic & Medicinal Chemistry Letters ·Scott D. Kuduk,Angela M. Lam,Christine Espiritu,Robert Vogel,(unknown),Klaus Klumpp,Osvaldo Flores,George D. Hartman	12
7	Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants 2017 ·Antimicrobial Agents and Chemotherapy ·Angela M. Lam,Suping Ren,Christine Espiritu,(unknown),(unknown),Lingjie Zheng,George D. Hartman,Osvaldo Flores,Klaus Klumpp	79
8	Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies 2016 ·Virology ·Vyas Ramanan,Kartik Trehan,(unknown),Joseph M. Luna,(unknown),Christine Espiritu,Timothy P. Sheahan,(unknown),Robert E. Schwartz,Kathleen S. Christine,Charles M. Rice,Alexander van Oudenaarden,Sangeeta N. Bhatia	14
9	SEC14L2 enables pan-genotype HCV replication in cell culture 2015 ·Nature ·Mohsan Saeed,Ursula Andréo,(unknown),Christine Espiritu,Andrea D. Branch,José M. Silva,Charles M. Rice	92
10	High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein 2015 ·Proceedings of the National Academy of Sciences ·Klaus Klumpp,Angela M. Lam,Christine Lukacs,Robert Vogel,Suping Ren,Christine Espiritu,Ruth Baydo,Kateri Atkins,Jan Abendroth,Guochun Liao,Andrey Efimov,George D. Hartman,Osvaldo Flores	122
11	Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design 2013 ·Journal of Medicinal Chemistry ·Jinfa Du,(unknown),Ralph T. Mosley,Shalini Bansal,Haiying Bao,Christine Espiritu,Angela M. Lam,Eisuke Murakami,Congrong Niu,Holly M. Micolochick Steuer,Phillip A. Furman,Michael J. Sofia	31
12	β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study 2012 ·Bioorganic & Medicinal Chemistry Letters ·Jinfa Du,Donghui Bao,(unknown),Ying Jiang,P. Ganapati Reddy,Hai‐Ren Zhang,Bruce S. Ross,Shalini Bansal,Haiying Bao,Christine Espiritu,Angela M. Lam,Eisuke Murakami,Congrong Niu,Holly M. Micolochick Steuer,Phillip A. Furman,Michaël Otto,Michael J. Sofia	13
13	A 2′-Deoxy-2′-Fluoro-2′-C-Methyl Uridine Cyclopentyl Carbocyclic Analog and Its Phosphoramidate Prodrug as Inhibitors of HCV NS5B Polymerase 2012 ·Nucleosides Nucleotides & Nucleic Acids ·Jian Liu,Jinfa Du,Peiyuan Wang,Dhanapalan Nagarathnam,Christine Espiritu,Haiying Bao,Eisuke Murakami,Phillip A. Furman,Michael J. Sofia	10
14	Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661 2011 ·Antiviral Research ·Phillip A. Furman,Eisuke Murakami,Congrong Niu,Angela M. Lam,Christine Espiritu,Shalini Bansal,Haiying Bao,Tatiana Tolstykh,Holly M. Micolochick Steuer,Meg Keilman,Véronique Zennou,Nigel Bourne,Ronald L. Veselenak,Wonsuk Chang,Bruce S. Ross,Jinfa Du,Michaël Otto,Michael J. Sofia	36
15	Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938 2011 ·Nucleosides Nucleotides & Nucleic Acids ·(unknown),Jinfa Du,Hai‐Ren Zhang,Wonsuk Chang,Bruce S. Ross,Ying Jiang,Donghui Bao,Christine Espiritu,Meg Keilman,Holly M. Micolochick Steuer,Phillip A. Furman,Michael J. Sofia	3
16	In vitro Selection of HCV Replicons with Reduced Sensitivity to PSI-352938, A Cyclicphosphate Prodrug of β-d-2′-α-F-2′-β-C-Methylguanosine 2011 ·Antiviral Research ·Angela M. Lam,Christine Espiritu,Shalini Bansal,Holly M. Micolochick Steuer,Véronique Zennou,Michaël Otto,Phillip A. Furman	2
17	2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938 2010 ·Bioorganic & Medicinal Chemistry Letters ·P. Ganapati Reddy,Donghui Bao,Wonsuk Chang,(unknown),Jinfa Du,Dhanapalan Nagarathnam,Suguna Rachakonda,Bruce S. Ross,Hai‐Ren Zhang,Shalini Bansal,Christine Espiritu,Meg Keilman,Angela M. Lam,Congrong Niu,Holly M. Micolochick Steuer,Phillip A. Furman,Michaël Otto,Michael J. Sofia	43
18	Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977 2010 ·Journal of Biological Chemistry ·Eisuke Murakami,Tatiana Tolstykh,Haiying Bao,Congrong Niu,Holly M. Micolochick Steuer,Donghui Bao,Wonsuk Chang,Christine Espiritu,Shalini Bansal,Angela M. Lam,Michaël Otto,Michael J. Sofia,Phillip A. Furman	234
19	Rpn5 Is a Conserved Proteasome Subunit and Required for Proper Proteasome Localization and Assembly 2003 ·Journal of Biological Chemistry ·Hsueh-Chi S. Yen,Christine Espiritu,Eric C. Chang	31
20	New Insights into the Mechanism of Inhibition of p53 by Simian Virus 40 Large T Antigen 1999 ·Molecular and Cellular Biology ·Hilary M. Sheppard,(unknown),Christine Espiritu,Andrea Gatti,Xuan Liu	49

About Christine Espiritu

Christine Espiritu is a scholar working on Hepatology, Infectious Diseases and Epidemiology, having authored 34 papers that have together received 1.8k indexed citations. Recurring topics across this work include Hepatitis C virus research (27 papers), Hepatitis B Virus Studies (22 papers) and HIV/AIDS drug development and treatment (16 papers). The work is most often cited by research in Hepatology (1.1k citations), Infectious Diseases (810 citations) and Epidemiology (1.0k citations). Christine Espiritu has collaborated with scholars based in United States, Belgium and Netherlands. Frequent co-authors include Angela M. Lam, Holly M. Micolochick Steuer, Phillip A. Furman, Michaël Otto, Shalini Bansal, Congrong Niu, Michael J. Sofia, Meg Keilman, Wonsuk Chang and Donghui Bao. Their work appears in journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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