Christine Espiritu

2.4k total citations · 1 hit paper
34 papers, 1.8k citations indexed

About

Christine Espiritu is a scholar working on Hepatology, Epidemiology and Infectious Diseases. According to data from OpenAlex, Christine Espiritu has authored 34 papers receiving a total of 1.8k indexed citations (citations by other indexed papers that have themselves been cited), including 27 papers in Hepatology, 24 papers in Epidemiology and 18 papers in Infectious Diseases. Recurrent topics in Christine Espiritu's work include Hepatitis C virus research (27 papers), Hepatitis B Virus Studies (22 papers) and HIV/AIDS drug development and treatment (16 papers). Christine Espiritu is often cited by papers focused on Hepatitis C virus research (27 papers), Hepatitis B Virus Studies (22 papers) and HIV/AIDS drug development and treatment (16 papers). Christine Espiritu collaborates with scholars based in United States, Belgium and Netherlands. Christine Espiritu's co-authors include Angela M. Lam, Holly M. Micolochick Steuer, Phillip A. Furman, Michaël Otto, Shalini Bansal, Congrong Niu, Michael J. Sofia, Meg Keilman, Wonsuk Chang and Donghui Bao and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Christine Espiritu

33 papers receiving 1.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

2010 486 citations Michael J. Sofia, Donghui Bao et al. Journal of Medicinal Chemistry profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Christine Espiritu United States	17	1.1k	1.0k	810	502	163	34	1.8k
Congrong Niu United States	18	1.1k 1.0×	1.2k 1.2×	842 1.0×	674 1.3×	179 1.1×	29	2.1k
Angela M. Lam United States	27	1.5k 1.4×	1.4k 1.4×	1.1k 1.3×	913 1.8×	246 1.5×	61	2.7k
Vincent Lévêque United States	28	803 0.7×	643 0.6×	659 0.8×	549 1.1×	219 1.3×	41	1.7k
Holly M. Micolochick Steuer United States	16	957 0.8×	811 0.8×	845 1.0×	489 1.0×	202 1.2×	27	1.6k
Tsuyoshi Adachi Japan	12	694 0.6×	406 0.4×	305 0.4×	370 0.7×	177 1.1×	20	1.2k
Kai Lin United States	25	1.0k 0.9×	919 0.9×	588 0.7×	579 1.2×	78 0.5×	50	2.0k
Preethi Krishnan United States	26	1.5k 1.3×	1.2k 1.2×	734 0.9×	407 0.8×	121 0.7×	58	2.1k
Michael H. Serrano‐Wu United States	18	795 0.7×	633 0.6×	350 0.4×	342 0.7×	307 1.9×	31	1.4k
Rakesh Tripathi United States	20	1.0k 0.9×	859 0.8×	579 0.7×	270 0.5×	61 0.4×	43	1.5k
George Kukolj Canada	33	1.9k 1.7×	1.4k 1.3×	1.2k 1.5×	744 1.5×	317 1.9×	86	3.2k

Countries citing papers authored by Christine Espiritu

Since Specialization

Citations

This map shows the geographic impact of Christine Espiritu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christine Espiritu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christine Espiritu more than expected).

Fields of papers citing papers by Christine Espiritu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christine Espiritu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christine Espiritu. The network helps show where Christine Espiritu may publish in the future.

Co-authorship network of co-authors of Christine Espiritu

This figure shows the co-authorship network connecting the top 25 collaborators of Christine Espiritu. A scholar is included among the top collaborators of Christine Espiritu based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christine Espiritu. Christine Espiritu is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Thi, Emily P., Xin Ye, Nicholas M. Snead, et al.. (2024). Control of Hepatitis B Virus with Imdusiran, a Small Interfering RNA Therapeutic. ACS Infectious Diseases. 10(10). 3640–3649. 6 indexed citations

Stoops, Bart, P.L. Shaffer, Angela M. Lam, et al.. (2023). Di-fluoro azepane HBV capsid assembly modulators. Bioorganic & Medicinal Chemistry Letters. 92. 129350–129350. 1 indexed citations

Kuduk, Scott D., Bart Stoops, P.L. Shaffer, et al.. (2022). Diazepinone HBV capsid assembly modulators. Bioorganic & Medicinal Chemistry Letters. 72. 128823–128823. 6 indexed citations

Kuduk, Scott D., Bart Stoops, Richard Alexander, et al.. (2021). Identification of a new class of HBV capsid assembly modulator. Bioorganic & Medicinal Chemistry Letters. 39. 127848–127848. 11 indexed citations

Kuduk, Scott D., Bart Stoops, Angela M. Lam, et al.. (2021). Oxadiazepinone HBV capsid assembly modulators. Bioorganic & Medicinal Chemistry Letters. 52. 128353–128353. 10 indexed citations

Kuduk, Scott D., Angela M. Lam, Christine Espiritu, et al.. (2019). SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators. Bioorganic & Medicinal Chemistry Letters. 29(16). 2405–2409. 12 indexed citations

Lam, Angela M., Suping Ren, Christine Espiritu, et al.. (2017). Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants. Antimicrobial Agents and Chemotherapy. 61(8). 79 indexed citations

Ramanan, Vyas, Kartik Trehan, Joseph M. Luna, et al.. (2016). Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies. Virology. 494. 236–247. 14 indexed citations

Saeed, Mohsan, Ursula Andréo, Christine Espiritu, et al.. (2015). SEC14L2 enables pan-genotype HCV replication in cell culture. Nature. 524(7566). 471–475. 92 indexed citations

10.

Klumpp, Klaus, Angela M. Lam, Christine Lukacs, et al.. (2015). High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein. Proceedings of the National Academy of Sciences. 112(49). 15196–15201. 122 indexed citations

11.

Du, Jinfa, Ralph T. Mosley, Shalini Bansal, et al.. (2013). Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design. Journal of Medicinal Chemistry. 57(5). 1826–1835. 31 indexed citations

12.

Du, Jinfa, Donghui Bao, Ying Jiang, et al.. (2012). β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study. Bioorganic & Medicinal Chemistry Letters. 22(18). 5924–5929. 13 indexed citations

13.

Liu, Jian, Jinfa Du, Peiyuan Wang, et al.. (2012). A 2′-Deoxy-2′-Fluoro-2′-C-Methyl Uridine Cyclopentyl Carbocyclic Analog and Its Phosphoramidate Prodrug as Inhibitors of HCV NS5B Polymerase. Nucleosides Nucleotides & Nucleic Acids. 31(4). 277–285. 10 indexed citations

14.

Furman, Phillip A., Eisuke Murakami, Congrong Niu, et al.. (2011). Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661. Antiviral Research. 91(2). 120–132. 36 indexed citations

15.

Du, Jinfa, Hai‐Ren Zhang, Wonsuk Chang, et al.. (2011). Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938. Nucleosides Nucleotides & Nucleic Acids. 30(11). 886–896. 3 indexed citations

16.

Lam, Angela M., Christine Espiritu, Shalini Bansal, et al.. (2011). In vitro Selection of HCV Replicons with Reduced Sensitivity to PSI-352938, A Cyclicphosphate Prodrug of β-d-2′-α-F-2′-β-C-Methylguanosine. Antiviral Research. 90(2). A22–A22. 2 indexed citations

17.

Reddy, P. Ganapati, Donghui Bao, Wonsuk Chang, et al.. (2010). 2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938. Bioorganic & Medicinal Chemistry Letters. 20(24). 7376–7380. 43 indexed citations

18.

Murakami, Eisuke, Tatiana Tolstykh, Haiying Bao, et al.. (2010). Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977. Journal of Biological Chemistry. 285(45). 34337–34347. 234 indexed citations

19.

Yen, Hsueh-Chi S., Christine Espiritu, & Eric C. Chang. (2003). Rpn5 Is a Conserved Proteasome Subunit and Required for Proper Proteasome Localization and Assembly. Journal of Biological Chemistry. 278(33). 30669–30676. 31 indexed citations

20.

Sheppard, Hilary M., et al.. (1999). New Insights into the Mechanism of Inhibition of p53 by Simian Virus 40 Large T Antigen. Molecular and Cellular Biology. 19(4). 2746–2753. 49 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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