David Fox

3.3k citations

39 papers · 2.0k indexed · h-index 24

Impact in

Organic Chemistry top 5%
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
Molecular Biology top 10%
- DNA Repair Mechanisms
- Phosphodiesterase function and regulation
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering

Papers in ⓘ

Molecular Biology 22
- Phosphodiesterase function and regulation 7
- DNA Repair Mechanisms 6
- RNA and protein synthesis mechanisms 4
Organic Chemistry 17
- Synthetic Organic Chemistry Methods 5
- Coordination Chemistry and Organometallics 5
- Asymmetric Synthesis and Catalysis 4

Co-authors: Rachel E. Klevit (3 shared papers)Timothy Gallagher (4 shared papers)Mark E. Gurney (4 shared papers)Peter S. Brzović (2 shared papers)Alex B. Burgin (3 shared papers)Julian Blagg (1 shared paper)Barry Kenny (1 shared paper)Stephen A. Ballard (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (5 papers)Tetrahedron Letters (3 papers)Tetrahedron (3 papers)Nature Communications (3 papers)Journal of Biological Chemistry (3 papers)
Partner nations: United States United Kingdom Japan

In The Last Decade

David Fox

39 papers receiving 1.9k citations

Peers

Countries citing papers authored by David Fox

Since Specialization

Citations

This map shows the geographic impact of David Fox's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Fox with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Fox more than expected).

Fields of papers citing papers by David Fox

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Fox. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Fox. The network helps show where David Fox may publish in the future.

Co-authors

The 25 scholars most cited alongside David Fox, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David Fox Line = papers co-authored together David Fox links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 39 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex Proceedings of the National Academy of Sciences ·Peter S. Brzović, Jennifer R. Keeffe, Hiroyuki Nishikawa, Κ. Miyamoto, David Fox, Mamoru Fukuda, Tomohiko Ohta, Rachel E. Klevit	2003	278
2	Structural basis for RNA replication by the hepatitis C virus polymerase Science ·T.C. Appleby, Jason K. Perry, Eisuke Murakami, Ona Barauskas, Joy Y. Feng, Aesop Cho, David Fox, Diana Wetmore, Mary E. McGrath, Adrian S. Ray, Michael J. Sofia, S. Swaminathan, Thomas E. Edwards	2015	254
3	Pharmacological Options in the Treatment of Benign Prostatic Hyperplasia Journal of Medicinal Chemistry ·Barry Kenny, Stephen A. Ballard, Julian Blagg, David Fox	1997	145
4	Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer Nature Communications ·James P. O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel E. Davis, David McMillan, T.L. Arakaki, Alex B. Burgin, David Fox, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P. Cossins, Tim Bourne, Alastair D. G. Lawson	2019	81
5	Rif1 provides a new DNA‐binding interface for the Bloom syndrome complex to maintain normal replication The EMBO Journal ·Dongyi Xu, Parameswary A. Muniandy, Elisabetta Leo, Jinhu Yin, Saravanabhavan Thangavel, Xi Shen, Miki Ii, Keli Agama, Rong Guo, David Fox, Amom Ruhikanta Meetei, Lauren E. Wilson, Huy Nguyen, Nan-ping Weng, Steven J. Brill, Lei Li, Alessandro Vindigni, Yves Pommier, Michael M. Seidman, Weidong Wang	2010	78
6	Structural basis for the design of selective phosphodiesterase 4B inhibitors Cellular Signalling ·David Fox, Alex B. Burgin, Mark E. Gurney	2013	78
7	Enantioselective synthesis of pumiliotoxin 251D. A strategy employing an allene-based electrophile-mediated cyclization Journal of the American Chemical Society ·David Fox, David Lathbury, Mary F. Mahon, Kieran C. Molloy, Timothy Gallagher	1991	71
8	Asymmetric Synthesis of Cyclic Ethers by Rearrangement of Oxonium Ylides Generated from Chiral Copper Carbenoids Tetrahedron Letters ·J. Stephen Clark, Mark Fretwell, Gavin A. Whitlock, Christopher J. Burns, David Fox	1998	68
9	Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF Nature Communications ·David McMillan, C. Martinez-Fleites, John Porter, David Fox, Rachel E. Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair D. G. Lawson, Tim Bourne, James P. O’Connell	2021	63
10	Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice Neuropsychopharmacology ·Chong Zhang, Ying Xu, Anirudh Chowdhary, David Fox, Mark E. Gurney, Han‐Ting Zhang, Benjamin D. Auerbach, Richard Salvi, Mingxin Yang, Gaowen Li, James M. O’Donnell	2018	61
11	RecQL5 Promotes Genome Stabilization through Two Parallel Mechanisms—Interacting with RNA Polymerase II and Acting as a Helicase Molecular and Cellular Biology ·M. Nurul Islam, David Fox, Rong Guo, Takemi Enomoto, Weidong Wang	2010	61
12	A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network Molecular Cell ·Zhijiang Yan, Rong Guo, Manikandan Paramasivam, Weiping Shen, Ling Chen, David Fox, Yucai Wang, Anneke B. Oostra, Julia Kuehl, Duck-Yeon Lee, Minoru Takata, Maureen E. Hoatlin, Detlev Schindler, Hans Joenje, Johan P. de Winter, Lei Li, Michael M. Seidman, Weidong Wang	2012	58
13	Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders Journal of Medicinal Chemistry ·Mark E. Gurney, Richard A. Nugent, Xuesheng Mo, Janice A. Sindac, Timothy J. Hagen, David Fox, James M. O’Donnell, Chong Zhang, Ying Xu, Han‐Ting Zhang, Vincent E. Groppi, Marc B. Bailie, Ronald E. White, Donna L. Romero, A. Samuel Vellekoop, Joel R. Walker, M. D. Surman, Lei Zhu, Robert F. Campbell	2019	56
14	Carbon-carbon bond formation catalyzed by lithium perchlorate in dichloromethane Tetrahedron Letters ·Manfred T. Reetz, David Fox	1993	53
15	A rapid injection NMR study of the chelation controlled Mukaiyama aldol addition: TiCl4 versus LiClO4 as the Lewis acid Tetrahedron ·Manfred T. Reetz, Burkhard Raguse, C. F. Marth, Helmut Hügel, Thorsten Bach, David Fox	1992	53
16	Discovery of triazines as selective PDE4B versus PDE4D inhibitors Bioorganic & Medicinal Chemistry Letters ·Timothy J. Hagen, Xuesheng Mo, Alex B. Burgin, David Fox, Zheng Zhang, Mark E. Gurney	2014	42
17	Asymmetric synthesis via electrophile-mediated cyclisations Tetrahedron ·David Fox, Timothy Gallagher	1990	41
18	Design of Second Generation Phosphodiesterase 5 Inhibitors Current Topics in Medicinal Chemistry ·Michael Palmer, Andrew Bell, David Fox, David Brown	2007	39
19	A Variant of the Breast Cancer Type 2 Susceptibility Protein (BRC) Repeat Is Essential for the RECQL5 Helicase to Interact with RAD51 Recombinase for Genome Stabilization Journal of Biological Chemistry ·M. Nurul Islam, Nicolas Paquet, David Fox, Eloïse Dray, Xiao-Feng Zheng, Hannah L. Klein, Patrick Sung, Weidong Wang	2012	38
20	Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences Journal of Biological Chemistry ·David Fox, Isolde Le Trong, Ponni Rajagopal, Peter S. Brzović, Ronald E. Stenkamp, Rachel E. Klevit	2008	36

About David Fox

David Fox is a scholar working on Molecular Biology, Organic Chemistry, Pharmacology, Oncology and Epidemiology, having authored 39 papers that have together received 2.0k indexed citations. Recurring topics across this work include Phosphodiesterase function and regulation (7 papers), DNA Repair Mechanisms (6 papers), Synthetic Organic Chemistry Methods (5 papers), Coordination Chemistry and Organometallics (5 papers), Cholinesterase and Neurodegenerative Diseases (5 papers), Asymmetric Synthesis and Catalysis (4 papers), RNA and protein synthesis mechanisms (4 papers) and Microbial Natural Products and Biosynthesis (3 papers). The work is most often cited by research in Organic Chemistry (564 citations), Molecular Biology (1.1k citations), Pharmacology (192 citations), Oncology (237 citations) and Hepatology (68 citations). David Fox has collaborated with scholars based in United States, United Kingdom and Japan. Frequent co-authors include Rachel E. Klevit, Timothy Gallagher, Mark E. Gurney, Peter S. Brzović, Alex B. Burgin, Julian Blagg, Barry Kenny, Stephen A. Ballard, Κ. Miyamoto and Manfred T. Reetz. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, Tetrahedron, Nature Communications and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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