Lesley A. McLaughlin

1.4k citations

27 papers · 1.1k indexed · h-index 20

Pharmacology top 0.5%
Molecular Biology
Oncology top 10%
Computational Theory and Mathematics top 5%
Insect Science top 5%

Co-authors: C. Roland Wolf Colin J. Henderson Mark J. I. Paine Michael J. Sutcliffe Sébastien Ronseaux Jack U. Flanagan Gordon C. K. Roberts Carol A. Kemp
Topics: Pharmacogenetics and Drug Metabolism (19 papers)Drug Transport and Resistance Mechanisms (11 papers)Hormonal Regulation and Hypertension (4 papers)
Cited by: Pharmacology Oncology Insect Science
Journals: Journal of Biological Chemistry PLoS ONE Cancer Research
Partner nations: United Kingdom United States Greece

In The Last Decade

Lesley A. McLaughlin

27 papers receiving 1.1k citations

Peers

Countries citing papers authored by Lesley A. McLaughlin

Since Specialization

Citations

This map shows the geographic impact of Lesley A. McLaughlin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lesley A. McLaughlin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lesley A. McLaughlin more than expected).

Fields of papers citing papers by Lesley A. McLaughlin

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lesley A. McLaughlin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lesley A. McLaughlin. The network helps show where Lesley A. McLaughlin may publish in the future.

Co-authorship network of co-authors of Lesley A. McLaughlin

This figure shows the co-authorship network connecting the top 25 collaborators of Lesley A. McLaughlin. A scholar is included among the top collaborators of Lesley A. McLaughlin based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lesley A. McLaughlin. Lesley A. McLaughlin is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy 2018 ·Clinical Cancer Research ·Annette MacLeod,De Lin,Jeffrey Huang,Lesley A. McLaughlin,Colin J. Henderson,C. Roland Wolf	25
2	Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug–Drug Interaction with Antidepressants 2016 ·Drug Metabolism and Disposition ·(unknown),Lesley A. McLaughlin,Colin J. Henderson,C. Roland Wolf	12
3	The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function 2016 ·Drug Metabolism and Disposition ·Emily E. Scott,C. Roland Wolf,Michal Otyepka,Sara C. Humphreys,James R. Reed,Colin J. Henderson,Lesley A. McLaughlin,Markéta Paloncýová,Veronika Navrátilová,Karel Berka,Pavel Anzenbacher,Upendra P. Dahal,Carlo Barnaba,James A. Brozik,Jeffrey P. Jones,D. Fernando Estrada,Jennifer S. Laurence,(unknown),Wayne L. Backes	36
4	Activation Status of the Pregnane X Receptor Influences Vemurafenib Availability in Humanized Mouse Models 2015 ·Cancer Research ·(unknown),Lesley A. McLaughlin,Colin J. Henderson,C. Roland Wolf	19
5	Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis (cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action 2015 ·Biochemical and Biophysical Research Communications ·Rumen V. Kostov,Elena V. Knatko,Lesley A. McLaughlin,Colin J. Henderson,Suqing Zheng,Jeffrey Huang,Tadashi Honda,Albena T. Dinkova‐Kostova	20
6	Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model 2015 ·Drug Metabolism and Disposition ·Nico Scheer,Yury Kapelyukh,Anja Rode,Stefan Oswald,Diana Busch,Lesley A. McLaughlin,De Lin,Colin J. Henderson,C. Roland Wolf	19
7	Cytochrome b5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo 2015 ·Molecular Pharmacology ·Colin J. Henderson,Lesley A. McLaughlin,Nico Scheer,Lesley A. Stanley,C. Roland Wolf	30
8	HDAC Inhibitors Increase NRF2-Signaling in Tumour Cells and Blunt the Efficacy of Co-Adminstered Cytotoxic Agents 2014 ·PLoS ONE ·Michael McMahon,(unknown),Annette MacLeod,Lesley A. McLaughlin,Colin J. Henderson,C. Roland Wolf	17
9	Deletion of 30 Murine Cytochrome P450 Genes Results In Viable Mice With Compromised Drug Metabolism 2014 ·Drug Metabolism and Disposition ·Nico Scheer,Lesley A. McLaughlin,Anja Rode,(unknown),Colin J. Henderson,C. Roland Wolf	16
10	A Role for Cytochrome b5 in the In Vivo Disposition of Anticancer and Cytochrome P450 Probe Drugs in Mice 2013 ·Drug Metabolism and Disposition ·Colin J. Henderson,Lesley A. McLaughlin,ROBERT FINN,Sébastien Ronseaux,Yury Kapelyukh,C. Roland Wolf	17
11	Evidence That Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System 2013 ·Molecular Pharmacology ·Colin J. Henderson,Lesley A. McLaughlin,C. Roland Wolf	45
12	Deletion of Microsomal Cytochrome b5 Profoundly Affects Hepatic and Extrahepatic Drug Metabolism 2010 ·Molecular Pharmacology ·Lesley A. McLaughlin,Sébastien Ronseaux,ROBERT FINN,Colin J. Henderson,C. Roland Wolf	60
13	Cytochrome b 5 null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis 2010 ·Transgenic Research ·ROBERT FINN,Lesley A. McLaughlin,Catherine Hughes,Chengli Song,Colin J. Henderson,C. Roland Wolf	24
14	Functional Expression and Comparative Characterization of Nine Murine Cytochromes P450 by Fluorescent Inhibition Screening 2008 ·Drug Metabolism and Disposition ·Lesley A. McLaughlin,Leslie J. Dickmann,C. Roland Wolf,Colin J. Henderson	31
15	Characterization of inhibitors and substrates of Anopheles gambiae CYP6Z2 2008 ·Insect Molecular Biology ·Lesley A. McLaughlin,Umar Niazi,Jaclyn Bibby,Jean‐Philippe David,John Vontas,Janet Hemingway,Hilary Ranson,Michael J. Sutcliffe,Mark J. I. Paine	83
16	Defining the in Vivo Role for Cytochrome b5 in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b5 2008 ·Journal of Biological Chemistry ·ROBERT FINN,Lesley A. McLaughlin,Sébastien Ronseaux,Ian Rosewell,J. Brian Houston,Colin J. Henderson,C. Roland Wolf	75
17	Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility 2006 ·Insect Molecular Biology ·Gareth Lycett,Lesley A. McLaughlin,Hilary Ranson,Janet Hemingway,Fotis C. Kafatos,Thanasis G. Loukeris,Mark J. I. Paine	101
18	Residues Glutamate 216 and Aspartate 301 Are Key Determinants of Substrate Specificity and Product Regioselectivity in Cytochrome P450 2D6 2003 ·Journal of Biological Chemistry ·Mark J. I. Paine,Lesley A. McLaughlin,Jack U. Flanagan,Carol A. Kemp,Michael J. Sutcliffe,Gordon C. K. Roberts,C. Roland Wolf	95
19	Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity 2003 ·Biochemical Journal ·Jack U. Flanagan,Lesley A. McLaughlin,Mark J. I. Paine,Michael J. Sutcliffe,Gordon C. K. Roberts,C. Roland Wolf	22
20	MERITS AND LIMITATIONS OF RECOMBINANT MODELS FOR THE STUDY OF HUMAN P450-MEDIATED DRUG METABOLISM AND TOXICITY: AN INTRALABORATORY COMPARISON 1999 ·Drug Metabolism Reviews ·Thomas Friedberg,Michael P. Pritchard,M. Bandera,(unknown),Denggao Yao,Lesley A. McLaughlin,Shaohong Ding,Brian Burchell,C. Roland Wolf	30

About Lesley A. McLaughlin

Lesley A. McLaughlin is a scholar working on Pharmacology, Oncology and Biological Psychiatry, having authored 27 papers that have together received 1.1k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (19 papers), Drug Transport and Resistance Mechanisms (11 papers) and Hormonal Regulation and Hypertension (4 papers). The work is most often cited by research in Pharmacology (610 citations), Oncology (320 citations) and Insect Science (123 citations). Lesley A. McLaughlin has collaborated with scholars based in United Kingdom, United States and Greece. Frequent co-authors include C. Roland Wolf, Colin J. Henderson, Mark J. I. Paine, Michael J. Sutcliffe, Sébastien Ronseaux, Jack U. Flanagan, Gordon C. K. Roberts, Carol A. Kemp, ROBERT FINN and Hilary Ranson. Their work appears in journals such as Journal of Biological Chemistry, PLoS ONE and Cancer Research.

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