Leonard I. Wiebe

4.3k citations

234 papers · 3.4k indexed · h-index 28

Cancer Research top 2%
- Cancer, Hypoxia, and Metabolism 55
Radiology, Nuclear Medicine and Imaging top 1%
- Medical Imaging Techniques and Applications 49
- Radiopharmaceutical Chemistry and Applications 38
Pharmaceutical Science top 1%
- Fluorine in Organic Chemistry 20
Physiology top 2%
Virology top 5%
Infectious Diseases
- HIV/AIDS drug development and treatment 37
Molecular Biology
- Biochemical and Molecular Research 24
Epidemiology
- Cytomegalovirus and herpesvirus research 18
Organic Chemistry
- Synthesis and Characterization of Heterocyclic Compounds 17

Co-authors: Edward E. Knaus Piyush Kumar Alexander McEwan Keykavous Parang Rakesh Kumar James Diakur John R. Mercer Jan Balzarini
Cited by: Cancer Research Radiology, Nuclear Medicine and Imaging Pharmaceutical Science
Journals: Journal of Medicinal Chemistry (14 papers)Nucleosides Nucleotides & Nucleic Acids (11 papers)Nuclear Medicine and Biology (8 papers)
Partner nations: Canada Belgium United States

In The Last Decade

Leonard I. Wiebe

228 papers receiving 3.3k citations

Peers

Countries citing papers authored by Leonard I. Wiebe

Since Specialization

Citations

This map shows the geographic impact of Leonard I. Wiebe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leonard I. Wiebe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leonard I. Wiebe more than expected).

Fields of papers citing papers by Leonard I. Wiebe

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leonard I. Wiebe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leonard I. Wiebe. The network helps show where Leonard I. Wiebe may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Leonard I. Wiebe, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Leonard I. Wiebe Line = papers co-authored together Leonard I. Wiebe links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agents Redox Biology ·智一下田,Diana Diaz‐Dussan,André Ribeiro da Silva,Dawn Macdonald,Patrick N. Nation,Xiaohong Yang,Ali İhsan Özcan,Nabila Gohar,A. Bart Smolders,Mayumi Haneda,Ravin Narain,Ismail Hassan Ismail,Leonard I. Wiebe,Piyush Kumar,Michael Weinfeld	2022	24
2	The Chemistry and Radiochemistry of Hypoxia-Specific, Radiohalogenated Nitroaromatic Imaging Probes Seminars in Nuclear Medicine ·Piyush Kumar,David Magida,Leonard I. Wiebe	2015	24
3	In Vitro and In Vivo Evaluation of [ ¹⁸ F]F-GAZ, a Novel Oxygen-Mimetic Azomycin-Glucose Conjugate, for Imaging Hypoxic Tumor Cancer Biotherapy and Radiopharmaceuticals ·Melinda Wuest,Piyush Kumar,Monica Wang,Jennifer Yang,Mayra Dahimi Barbarita Zamora Paredes,Leonard I. Wiebe	2012	7
4	Synthesis, radiofluorination, and hypoxia-selective studies of FRAZ: A configurational and positional analogue of the clinical hypoxia marker, [18F]-FAZA Bioorganic & Medicinal Chemistry ·Piyush Kumar,Hernández Abello,Alexander McEwan,Leonard I. Wiebe	2010	8
5	Confocal laser scanning microscopy (CLSM) based evidence for cell permeation by mono-4-(N-6-deoxy-6-amino-β-cyclodextrin)-7-nitrobenzofuran (NBD-β-CyD) International Journal of Pharmaceutics ·Hai Wei,Weizhong Zheng,James Diakur,Leonard I. Wiebe	2010	14
6	A One-Pot Synthesis of 1-α- And 1-β-D-Arabinofuranosyl-2-Nitroimidazoles: Synthons to the Markers of Tumor Hypoxia Nucleosides Nucleotides & Nucleic Acids ·Hernández Abello,Piyush Kumar,Alexander McEwan,Leonard I. Wiebe	2005	2
7	[131I]Iodoazomycin arabinoside for low-dose-rate isotope radiotherapy: radiolabeling, stability, long-term whole-body clearance and radiation dosimetry estimates in mice Nuclear Medicine and Biology ·Piyush Kumar,Nuntana Champa,Qiaopan Jia,Alexander McEwan,Leonard I. Wiebe	2005	10
8	Molecular Imaging and Treatment of Malignant Gliomas Following Adenoviral Transfer of the Herpes Simplex Virus-Thymidine Kinase Gene and the Somatostatin Receptor Subtype 2 Gene Cancer Biotherapy and Radiopharmaceuticals ·Winda Haeriyoko,Paulo Monteiro,Rob C. Hoeben,Martijn J. W. E. Rabelink,Leonard I. Wiebe,David T. Curiel,Akseli Hemminki,Eric P. Krenning,Marion de Jong	2004	11
9	Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells Nuclear Medicine and Biology ·Mend Mariwany,Weili Duan,Lihua Xu,Aihua Zhou,H. Y. E. Boo,Edward E. Knaus,Alexander McEwan,Leonard I. Wiebe	2004	18
10	Dose‐dependent pharmacokinetics of 1‐(2‐Deoxy‐β‐D‐ ribofuranosyl)‐2,4‐difluoro‐5‐iodobenzene: A potential mimic of 5‐iodo‐2′‐deoxyuridine Biopharmaceutics & Drug Disposition ·Chiara Mazzanti,Hernández Abello,Wei Sun,Edward E. Knaus,Leonard I. Wiebe	2003	3
11	Clinical pharmacokinetics of 123I-IAZA in healthy volunteers Nuclear Medicine Communications ·Daria Stypinski,Leonard I. Wiebe,Alexander McEwan,Rico Schmidt,Y.K. Tam,John R. Mercer	1999	14
12	A rapid and simple assay to determine the blood and urine concentrations of 1-(5-[123/125I]iodo-5-deoxyarabinofuranosyl)-2-nitroimidazole, a hypoxic cell marker Journal of Pharmaceutical and Biomedical Analysis ·Daria Stypinski,Leonard I. Wiebe,Chen Bai	1998	6
13	Synthesis,In VitroAnti-HIV Activity, and Biological Stability of 5′-O-Myristoyl Analogue Derivatives of 3′-Fluoro-2′,3′-Dideoxythymidine (FLT) as Potential Bifunctional Prodrugs of FLT Nucleosides and Nucleotides ·Keykavous Parang,Edward E. Knaus,Leonard I. Wiebe	1998	18
14	Targeted Radiotherapy of Multicell Neuroblastoma Spheroids with High Specific Activity [125I]Meta-Iodobenzylguanidine International Journal of Radiation OncologyBiologyPhysics ·Wilson Roa,Gerald G. Miller,Alexander McEwan,S.A. McQuarrie,Rakesh Nagampally,Jonn Wu,Leonard I. Wiebe	1998	9
15	The cytostatic activity of 5‐(1‐azidovinyl)‐2′‐deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene‐transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (λ = 254 nm) exposure FEBS Letters ·Jan Balzarini,Graciela Andreï,Rakesh Kumar,Jocimar Dias,Leonard I. Wiebe,Erik De Clercq	1995	10
16	Synthesis, in vitro Biological Stability, and Anti-HIV Activity of 5-Halo-6-alkoxy(or azido)-5,6-dihydro-3'-azido-3'-deoxythymidine Diastereomers as Potential Prodrugs to 3'-Azido-3'-deoxythymidine (AZT) Journal of Medicinal Chemistry ·Rakesh Kumar,Lili Wang,Leonard I. Wiebe,Edward E. Knaus	1994	20
17	The synthesis of N-acetyl-4-S-cysteaminyl [U-14C]phenol as a basis for the development of an antimelanoma and melanoma-radioimaging agent Applied Radiation and Isotopes ·Takashi Iwashina,Kowichi Jimbow,Leonard I. Wiebe	1994	2
18	Synthesis and tumor uptake of 5-bromine-82- and 5-iodine-131-labeled 5-halo-1-(2-fluoro-2-deoxy-.beta.-D-ribofuranosyl)uracils Journal of Medicinal Chemistry ·John R. Mercer,Li Xu,Edward E. Knaus,Leonard I. Wiebe	1989	23
19	Advances in Scintillation Counting Septa In Sutures,Mohannad Mofawaz,Leonard I. Wiebe	1983	40
20	Liquid scintillation counting of positron emitters Transactions of the American Nuclear Society ·S.A. McQuarrie,A.A. Noujaim,Mohannad Mofawaz,Leonard I. Wiebe	1981	0

About Leonard I. Wiebe

Leonard I. Wiebe is a scholar working on Pharmaceutical Science, Cancer Research and Radiology, Nuclear Medicine and Imaging, having authored 234 papers that have together received 3.4k indexed citations. Recurring topics across this work include Cancer, Hypoxia, and Metabolism (55 papers), Medical Imaging Techniques and Applications (49 papers), Radiopharmaceutical Chemistry and Applications (38 papers), HIV/AIDS drug development and treatment (37 papers), Biochemical and Molecular Research (24 papers), Fluorine in Organic Chemistry (20 papers), Cytomegalovirus and herpesvirus research (18 papers) and Synthesis and Characterization of Heterocyclic Compounds (17 papers). The work is most often cited by research in Cancer Research (988 citations), Radiology, Nuclear Medicine and Imaging (1.1k citations) and Pharmaceutical Science (260 citations). Leonard I. Wiebe has collaborated with scholars based in Canada, Belgium and United States. Frequent co-authors include Edward E. Knaus, Piyush Kumar, Alexander McEwan, Keykavous Parang, Rakesh Kumar, James Diakur, John R. Mercer, Jan Balzarini, J. D. Chapman and Gui‐Fang Huang. Their work appears in journals such as Journal of Medicinal Chemistry, Nucleosides Nucleotides & Nucleic Acids, Nuclear Medicine and Biology, Canadian Journal of Chemistry and Applied Radiation and Isotopes.

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