Gene LeSage

6.5k citations

84 papers · 4.6k indexed · h-index 42

Impact in

Hepatology top 0.2%
- Liver physiology and pathology
- Liver Diseases and Immunity
- Liver Disease and Transplantation
Oncology top 2%
- Drug Transport and Resistance Mechanisms

Papers in

Hepatology 23
- Liver physiology and pathology 16
- Liver Diseases and Immunity 6
Oncology 47
- Drug Transport and Resistance Mechanisms 44

Co-authors: Gianfranco Alpini Shannon Glaser Jo Lynne Phinizy Heather Francis Yoshiyuki Ueno Noriatsu Kanno Domenico Alvaro Leonardo Baiocchi
Journals: Gastroenterology (19 papers)American Journal of Physiology-Gastrointestinal and Liver Physiology (13 papers)Hepatology (11 papers)Journal of Hepatology (5 papers)Journal of Biological Chemistry (4 papers)
Partner nations: United States Italy China

In The Last Decade

Gene LeSage

84 papers receiving 4.5k citations

Peers

Countries citing papers authored by Gene LeSage

Since Specialization

Citations

This map shows the geographic impact of Gene LeSage's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gene LeSage with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gene LeSage more than expected).

Fields of papers citing papers by Gene LeSage

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gene LeSage. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gene LeSage. The network helps show where Gene LeSage may publish in the future.

Co-authors

The 25 scholars most cited alongside Gene LeSage, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Gene LeSage Line = papers co-authored together Gene LeSage links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway Pflügers Archiv - European Journal of Physiology ·罗郑, J. Philippe York, Li Wang, Chaofeng Yang, Aijun Zhang, Heather Francis, Paul Webb, Wallace L. McKeehan, Gianfranco Alpini, Gene LeSage, David D. Moore, Xuefeng Xia	2013	29
2	Toll-Like Receptor 9 Is Required for Opioid-Induced Microglia Apoptosis PLoS ONE ·Lei He, Hui Li, Lin Chen, Jun‐Ying Miao, Yulin Jiang, Yi Zhang, Zuoxiang Xiao, Gregory P. Hanley, Ulfa Septi Muslimah, Xiumei Zhang, Gene LeSage, Ying Peng, Deling Yin	2011	35
3	Critical Role of Toll-Like Receptor 9 in Morphine and Mycobacterium tuberculosis–Induced Apoptosis in Mice PLoS ONE ·Lin Chen, Wanliang Shi, Hui Li, Xiuli Sun, Xionglin Fan, Gene LeSage, Yi Li, Yi Zhang, U Lulu Shadin, Ying Zhang, Deling Yin	2010	19
4	Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice Neuroscience Letters ·Yi Zhang, Hui Li, Yi Li, Xiuli Sun, Meng‐Yang Zhu, Gregory P. Hanley, Gene LeSage, Deling Yin	2010	67
5	Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis Neuropharmacology ·Nanchang Xie, Hui Li, 卓藤浪, Gene LeSage, Lin Chen, Shengjun Wang, Yi Zhang, Lingyi Chi, Kenneth E. Ferslew, Lei He, Chi Zhao-fu, Deling Yin	2010	46
6	Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3β pathway Bioorganic & Medicinal Chemistry ·Lin Chen, Yi Zhang, Xiuli Sun, Hui Li, Gene LeSage, Surah Grumet, Xiumei Zhang, Xinbing Wei, Yulin Jiang, Deling Yin	2009	24
7	AF17 Competes with AF9 for Binding to Dot1a to Up-regulate Transcription of Epithelial Na+ Channel α Journal of Biological Chemistry ·Mary Rose Reisenauer, Marc H. Anderson, Le Huang, Zhijing Zhang, Qiaoling Zhou, Bruce C. Kone, Andrew P. Morris, Gene LeSage, Stuart E. Dryer, Wenzheng Zhang	2009	44
8	The α₂-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats American Journal of Physiology-Cell Physiology ·Heather Francis, Gene LeSage, Sharon DeMorrow, Domenico Alvaro, Yoshiyuki Ueno, Julie Venter, Shannon Glaser, Maria Grazia Mancino, Luca Marucci, A. Benedetti, Gianfranco Alpini	2007	28
9	Aldosterone-sensitive repression of ENaCα transcription by a histone H3 lysine-79 methyltransferase American Journal of Physiology-Cell Physiology ·Wenzheng Zhang, Xuefeng Xia, Diana Jalal, Laura V. López-Gutiérrez, William Xu, Gene LeSage, Bruce C. Kone	2005	54
10	cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway Journal of Hepatology ·Heather Francis, Shannon Glaser, Yoshiyuki Ueno, Gene LeSage, Luca Marucci, A. Benedetti, Silvia Taffetani, Marco Marzioni, Domenico Alvaro, Julie Venter, Ramona Reichenbach, Giammarco Fava, Jo Lynne Phinizy, Gianfranco Alpini	2004	106
11	Gastrin reverses established cholangiocyte proliferation and enhanced secretin‐stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca²⁺‐dependent PKC isoforms Liver International ·Shannon Glaser, Domenico Alvaro, Yoshiyuki Ueno, Heather Francis, Marco Marzioni, Jo Lynne Phinizy, Juliana Franceschi, Maria Grazia Mancino, Julie Venter, Gene LeSage, Gianfranco Alpini	2003	24
12	Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats Journal of Hepatology ·Leonardo Baiocchi, Gianfranco Alpini, Shannon Glaser, M. Angélico, Domenico Alvaro, Heather Francis, Marco Marzioni, Jo Lynne Phinizy, Barbara Barbaro, Gene LeSage	2003	12
13	Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase–dependent pathway in rats Gastroenterology ·Gianfranco Alpini, Shannon Glaser, Domenico Alvaro, Yoshiyuki Ueno, Marco Marzioni, Heather Francis, Leonardo Baiocchi, Tonino Stati, Barbara Barbaro, Jo Lynne Phinizy, Jeremy Mauldin, Gene LeSage	2002	60
14	Regulation of cholangiocyte bile secretion Journal of Hepatology ·Leonardo Baiocchi, Gene LeSage, Shannon Glaser, Gianfranco Alpini	1999	33
15	Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct–ligated rats Gastroenterology ·Gene LeSage, Domenico Alvaro, A. Benedetti, Shannon Glaser, Luca Marucci, Leonardo Baiocchi, Pradeep H. Tawade, Alessandra Caligiuri, Jo Lynne Phinizy, Rebecca Rodgers, Heather Francis, Gianfranco Alpini	1999	131
16	Acute Carbon Tetrachloride Feeding Selectively Damages Large, But Not Small, Cholangiocytes From Normal Rat Liver Hepatology ·Gene LeSage, A. Benedetti, De Kai Ba, Luca Marucci, Ziga Tretjak, Alessandra Caligiuri, Rebecca Rodgers, Jo Lynne Phinizy, Leonardo Baiocchi, Heather Francis, John Lasater, William Hustace Hubbard, Gianfranco Alpini	1999	98
17	Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver American Journal of Physiology-Gastrointestinal and Liver Physiology ·Gene LeSage, Shannon Glaser, Luca Marucci, A. Benedetti, Jo Lynne Phinizy, Rebecca Rodgers, Alessandra Caligiuri, Lyagin Leonid Mikhailovich, Ziga Tretjak, Flora Henderson, Leigh A. Holcomb, Gianfranco Alpini	1999	109
18	Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver Gastroenterology ·Gianfranco Alpini, Stuart K. Roberts, Pau Peña Muñoz, Yoshiyuki Ueno, Siddeswar Gubba, Yoshihide Oshima, Gene LeSage, N. F. LaRusso	1996	182
19	Ursodeoxycholic acid in the treatment of primary biliary cirrhosis Gastroenterology ·Keith D. Lindor, E. Rolland Dickson, William P. Baldus, Roberta A. Jorgensen, Jürgen Ludwig, Paul A. Murtaugh, Jay M. Harrison, Russell H. Wiesner, Monte L. Anderson, Stephen M. Lange, Gene LeSage, Steven S. Rossi, Alan F. Hofmann	1994	375
20	Demonstration of vesicular-dependent bile flow in the sucrose-loaded rat Gastroenterology ·Gene LeSage, W. Robertson, Soleimanpour Asl Mehrdad	1990	10

About Gene LeSage

Gene LeSage is a scholar working on Hepatology, Oncology, Surgery, Behavioral Neuroscience and Gastroenterology, having authored 84 papers that have together received 4.6k indexed citations. Recurring topics across this work include Drug Transport and Resistance Mechanisms (44 papers), Pediatric Hepatobiliary Diseases and Treatments (39 papers), Liver physiology and pathology (16 papers), Neuropeptides and Animal Physiology (13 papers), Immune Response and Inflammation (11 papers), Liver Disease Diagnosis and Treatment (10 papers), Liver Diseases and Immunity (6 papers) and Receptor Mechanisms and Signaling (6 papers). The work is most often cited by research in Hepatology (2.1k citations), Oncology (1.5k citations), Surgery (2.3k citations), Epidemiology (1.0k citations) and Biological Psychiatry (66 citations). Gene LeSage has collaborated with scholars based in United States, Italy and China. Frequent co-authors include Gianfranco Alpini, Shannon Glaser, Jo Lynne Phinizy, Heather Francis, Yoshiyuki Ueno, Noriatsu Kanno, Domenico Alvaro, Leonardo Baiocchi, Rebecca Rodgers and Marco Marzioni. Their work appears in journals such as Gastroenterology, American Journal of Physiology-Gastrointestinal and Liver Physiology, Hepatology, Journal of Hepatology and Journal of Biological Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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