Keefe T. Chan

2.6k total citations · 1 hit paper
25 papers, 1.7k citations indexed

About

Keefe T. Chan is a scholar working on Molecular Biology, Cell Biology and Oncology. According to data from OpenAlex, Keefe T. Chan has authored 25 papers receiving a total of 1.7k indexed citations (citations by other indexed papers that have themselves been cited), including 11 papers in Molecular Biology, 11 papers in Cell Biology and 7 papers in Oncology. Recurrent topics in Keefe T. Chan's work include Cellular Mechanics and Interactions (9 papers), Cell Adhesion Molecules Research (6 papers) and Melanoma and MAPK Pathways (3 papers). Keefe T. Chan is often cited by papers focused on Cellular Mechanics and Interactions (9 papers), Cell Adhesion Molecules Research (6 papers) and Melanoma and MAPK Pathways (3 papers). Keefe T. Chan collaborates with scholars based in Australia, United States and Finland. Keefe T. Chan's co-authors include Anna Huttenlocher, Christa L. Cortesio, Richard B. Pearson, Jian Kang, James E. Bear, David A. Bennin, Sarah J. Creed, Elaine Sanij, Natalie Brajanovski and Jiachen Xuan and has published in prestigious journals such as Journal of Biological Chemistry, The Journal of Experimental Medicine and The Journal of Cell Biology.

In The Last Decade

Keefe T. Chan

23 papers receiving 1.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

2021 214 citations Jian Kang, Natalie Brajanovski et al. Signal Transduction and Targeted Therapy profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Keefe T. Chan Australia	20	951	549	301	287	238	25	1.7k
Emilia Turco Italy	27	1.7k 1.8×	632 1.2×	426 1.4×	374 1.3×	364 1.5×	67	2.6k
Pengcheng Zhou China	19	1.0k 1.1×	343 0.6×	316 1.0×	262 0.9×	198 0.8×	34	1.6k
Sandra Iden Germany	20	890 0.9×	562 1.0×	238 0.8×	158 0.6×	116 0.5×	33	1.7k
Julie Milanini France	15	1.3k 1.3×	317 0.6×	395 1.3×	139 0.5×	542 2.3×	19	2.0k
Katsuhito Takahashi Japan	26	1.2k 1.3×	561 1.0×	159 0.5×	143 0.5×	225 0.9×	61	2.1k
Kwai Wa Cheng United States	29	1.7k 1.8×	906 1.7×	410 1.4×	205 0.7×	447 1.9×	41	2.8k
Evangelia A. Papakonstanti Greece	24	860 0.9×	300 0.5×	257 0.9×	158 0.6×	113 0.5×	33	1.7k
Chenran Wang United States	18	831 0.9×	264 0.5×	237 0.8×	114 0.4×	316 1.3×	35	1.6k
Edward Monosov United States	17	1.4k 1.4×	371 0.7×	508 1.7×	285 1.0×	584 2.5×	18	2.4k

Countries citing papers authored by Keefe T. Chan

Since Specialization

Citations

This map shows the geographic impact of Keefe T. Chan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keefe T. Chan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keefe T. Chan more than expected).

Fields of papers citing papers by Keefe T. Chan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keefe T. Chan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keefe T. Chan. The network helps show where Keefe T. Chan may publish in the future.

Co-authorship network of co-authors of Keefe T. Chan

This figure shows the co-authorship network connecting the top 25 collaborators of Keefe T. Chan. A scholar is included among the top collaborators of Keefe T. Chan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Keefe T. Chan. Keefe T. Chan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Thio, Niko, Ada Koo, Adrian Wong, et al.. (2025). Exploiting dysregulated iron homeostasis to eradicate persistent high-grade serous ovarian cancer. Cell Death Discovery. 11(1). 423–423.

Ahn, Antonio, Michael Taylor, Keefe T. Chan, et al.. (2023). INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors. Cancer Discovery. 14(3). 446–467. 62 indexed citations

Zhu, Haoran, Keefe T. Chan, Anna Trigos, et al.. (2022). Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation. eLife. 11. 24 indexed citations

Kang, Jian, Natalie Brajanovski, Keefe T. Chan, et al.. (2021). Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy. Signal Transduction and Targeted Therapy. 6(1). 323–323. 214 indexed citations breakdown →

Kusnadi, Eric, Anna Trigos, Carleen Cullinane, et al.. (2020). Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis. The EMBO Journal. 39(21). e105111–e105111. 28 indexed citations

Yan, Shunfei, Jiachen Xuan, Natalie Brajanovski, et al.. (2020). The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer. British Journal of Cancer. 124(3). 616–627. 29 indexed citations

Zhu, Haoran, et al.. (2020). Oncogene-induced senescence: From biology to therapy. Mechanisms of Ageing and Development. 187. 111229–111229. 81 indexed citations

Chan, Keefe T., Haoran Zhu, Jian Kang, et al.. (2019). A functional genetic screen defines the AKT-induced senescence signaling network. Cell Death and Differentiation. 27(2). 725–741. 47 indexed citations

Yan, Shunfei, Daniel Frank, Jinbae Son, et al.. (2017). The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer. International Journal of Molecular Sciences. 18(1). 210–210. 19 indexed citations

10.

Chan, Keefe T., Lassi Paavolainen, Katherine M. Hannan, et al.. (2016). Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence. Assay and Drug Development Technologies. 14(7). 416–428. 8 indexed citations

11.

Quin, Jaclyn, Keefe T. Chan, Jennifer R. Devlin, et al.. (2016). Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling. Oncotarget. 7(31). 49800–49818. 79 indexed citations

12.

Creed, Sarah J., Caroline P. Le, Mohd Ali Hassan, et al.. (2015). β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion. Breast Cancer Research. 17(1). 62 indexed citations

13.

Chan, Keefe T., Stephen Jones, Hailey E. Brighton, et al.. (2013). Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin. PubMed. 2(2). e25805–e25805. 11 indexed citations

14.

Liu, Wenjin, Kimberly B. Monahan, Adam D. Pfefferle, et al.. (2012). LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma. Cancer Cell. 21(6). 751–764. 96 indexed citations

15.

Chan, Keefe T., David W. Roadcap, Nicholas Holoweckyj, & James E. Bear. (2012). Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin. Biochemical Journal. 444(1). 89–96. 30 indexed citations

16.

Chan, Keefe T., Sarah J. Creed, & James E. Bear. (2011). Unraveling the enigma: progress towards understanding the coronin family of actin regulators. Trends in Cell Biology. 21(8). 481–488. 136 indexed citations

17.

Chan, Keefe T., David A. Bennin, & Anna Huttenlocher. (2010). Regulation of Adhesion Dynamics by Calpain-mediated Proteolysis of Focal Adhesion Kinase (FAK). Journal of Biological Chemistry. 285(15). 11418–11426. 171 indexed citations

18.

Cortesio, Christa L., Keefe T. Chan, Benjamin J. Perrin, et al.. (2008). Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. The Journal of Cell Biology. 180(5). 957–971. 157 indexed citations

19.

Chan, Keefe T., Christa L. Cortesio, & Anna Huttenlocher. (2007). Integrins in Cell Migration. Methods in enzymology on CD-ROM/Methods in enzymology. 426. 47–67. 31 indexed citations

20.

Lokuta, Mary A., David A. Bennin, Paul A. Nuzzi, et al.. (2007). Type Iγ PIP Kinase Is a Novel Uropod Component that Regulates Rear Retraction during Neutrophil Chemotaxis. Molecular Biology of the Cell. 18(12). 5069–5080. 57 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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