John Wai

5.0k citations

30 papers · 1.7k · 1 hit paper · h-index 17

Impact in

Virology top 1%
- HIV Research and Treatment
Infectious Diseases top 2%
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions

Papers in

Organic Chemistry 15
- Synthesis and Biological Evaluation 4
- Synthesis and Reactions of Organic Compounds 4
- Synthetic Organic Chemistry Methods 4
- Synthesis and Reactivity of Heterocycles 4
Molecular Biology 14
- Biochemical and Molecular Research 7

Co-authors: J. M. HOFFMAN (7 shared papers)Thorsten E. Fisher (13 shared papers)Daria J. Hazuda (6 shared papers)Walfred S. Saari (5 shared papers)Marc Witmer (3 shared papers)Mark E. Goldman (4 shared papers)Abigail Wolfe (3 shared papers)William A. Schleif (6 shared papers)
Journals: Journal of Medicinal Chemistry (7 papers)Bioorganic & Medicinal Chemistry Letters (5 papers)Tetrahedron Letters (3 papers)Proceedings of the National Academy of Sciences (2 papers)Journal of Bacteriology (1 paper)
Partner nations: United States China Hong Kong

In The Last Decade

John Wai

29 papers receiving 1.7k citations

Hit Papers

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A mechanistic insight leads to a greatly improved osmium-catalyzed asymmetric dihydroxylation process 1989 · 180 citations

Peers

Countries citing papers authored by John Wai

Since Specialization

Citations

This map shows the geographic impact of John Wai's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Wai with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Wai more than expected).

Fields of papers citing papers by John Wai

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Wai. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Wai. The network helps show where John Wai may publish in the future.

Co-authors

The 25 scholars most cited alongside John Wai, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with John Wai Line = papers co-authored together John Wai links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 30 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes Proceedings of the National Academy of Sciences ·Jay A. Grobler, Kara A. Stillmock, Binghua Hu, Marc Witmer, Peter J. Felock, Amy S. Espeseth, Abigail Wolfe, Melissa S. Egbertson, Michele Bourgeois, Jeffrey Y. Melamed, John Wai, Steve Young, Joseph P. Vacca, Daria J. Hazuda	2002	321
2	Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity. Proceedings of the National Academy of Sciences ·Mark E. Goldman, Jack H. Nunberg, J A O'Brien, J C Quintero, William A. Schleif, Kurt Freund, Stanley L. Gaul, Walfred S. Saari, John Wai, J. M. HOFFMAN	1991	256
3	Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells Journal of Medicinal Chemistry ·Linghang Zhuang, John Wai, Mark W. Embrey, Thorsten E. Fisher, Melissa S. Egbertson, Linda S. Payne, James P. Guare, Joseph P. Vacca, Daria J. Hazuda, Peter J. Felock, Abigail Wolfe, Kara A. Stillmock, Marc Witmer, Gregory Moyer, William A. Schleif, Lori J. Gabryelski, Yvonne Leonard, Joseph J. Lynch, Stuart R. Michelson, Steven D. Young	2003	219
4	A mechanistic insight leads to a greatly improved osmium-catalyzed asymmetric dihydroxylation process Journal of the American Chemical Society ·John Wai, István E. Markó, John S. Svendsen, M. G. Finn, Eric N. Jacobsen, K. Barry Sharpless Hit paper breakdown →	1989	180
5	Inhibition of HIV-1 Ribonuclease H by a Novel Diketo Acid, 4-[5-(Benzoylamino)thien-2-yl]-2,4-dioxobutanoic Acid Journal of Biological Chemistry ·Cathryn A. Shaw-Reid, Vandna Munshi, Pia Graham, Abigail Wolfe, Marc Witmer, Renee Danzeisen, David B. Olsen, Steven S. Carroll, Mark W. Embrey, John Wai, Michael D. Miller, James L. Cole, Daria J. Hazuda	2003	135
6	2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors Journal of Medicinal Chemistry ·Walfred S. Saari, J. M. HOFFMAN, John Wai, Thorsten E. Fisher, C. S. ROONEY, Anthony M. Smith, C. M. Thomas, Mark E. Goldman, J A O'Brien	1991	101
7	Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogs of 3-aminopyridin-2(1H)-one Journal of Medicinal Chemistry ·Walfred S. Saari, John Wai, Thorsten E. Fisher, C. M. Thomas, J. M. HOFFMAN, C. S. ROONEY, Anthony M. Smith, James H. Jones, Dona L. Bamberger	1992	75
8	Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogs Journal of Medicinal Chemistry ·J. M. HOFFMAN, Anthony M. Smith, Clarence S. Rooney, Thorsten E. Fisher, John Wai, Craig Thomas, Dona L. Bamberger, James L. Barnes, Theresa M. Williams	1993	69
9	Documenting the scope of the catalytic asymmetric dihydroxylation Tetrahedron Letters ·Braj B. Lohray, Thomas H. Kalantar, B. Moon Kim, Christine Y. Park, Tomoyuki Shibata, John Wai, K. Barry Sharpless	1989	69
10	Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogs Journal of Medicinal Chemistry ·J. M. HOFFMAN, John Wai, Craig Thomas, Rhonda B. Levin, Julie A. O’Brien, Mark E. Goldman	1992	44
11	A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors Bioorganic & Medicinal Chemistry Letters ·James P. Guare, John Wai, Robert Gomez, Neville J. Anthony, Samson M. Jolly, Amanda R. Cortes, Joseph P. Vacca, Peter J. Felock, Kara A. Stillmock, William A. Schleif, Gregory Moyer, Lori J. Gabryelski, Lixia Jin, I‐Wu Chen, Daria J. Hazuda, Steven D. Young	2006	37
12	Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one Journal of Medicinal Chemistry ·John Wai, Theresa M. Williams, Dona L. Bamberger, Thorsten E. Fisher, J. M. HOFFMAN, Ronald J. Hudcosky, Suzanne C. MacTough, Clarence S. Rooney, Walfred S. Saari	1993	37
13	8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors Bioorganic & Medicinal Chemistry Letters ·Thorsten E. Fisher, Bo-Young Kim, Donnette D. Staas, Terry A. Lyle, Steven D. Young, Joseph P. Vacca, Matthew M. Zrada, Daria J. Hazuda, Peter J. Felock, William A. Schleif, Lori J. Gabryelski, M. Reza Anari, Christopher J. Kochansky, John Wai	2007	31
14	Synthesis and biological activity of ras farnesyl protein transferase inhibitors. Tetrapeptide analogs with amino methyl and carbon linkages Bioorganic & Medicinal Chemistry ·John Wai, Dona L. Bamberger, Thorsten E. Fisher, Samuel Graham, Robert L. Smith, W. Wayt Gibbs, Scott D. Mosser, Allen Oliff, David L. Pompliano, Elaine Rands, Nancy E. Kohl	1994	23
15	Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors Bioorganic & Medicinal Chemistry Letters ·John Wai, Bo Young Kim, Thorsten E. Fisher, Linghang Zhuang, Mark W. Embrey, Peter Williams, Donnette D. Staas, Chris Culberson, Terry A. Lyle, Joseph P. Vacca, Daria J. Hazuda, Peter J. Felock, William A. Schleif, Lori J. Gabryelski, Lixia Jin, I‐Wu Chen, Joan D. Ellis, Rama Mallai, Steven D. Young	2007	21
16	Stereoselective total synthesis of the marine sesterterpenoid (±)-palauolide Canadian Journal of Chemistry ·Edward Piers, John Wai	1994	21
17	P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes 1 1Abbreviations: FTI, farnesyl-protein transferase inhibitor; FTase, farnesyl-protein transferase; and LC-MS, liquid chromatography-mass spectrometry. Biochemical Pharmacology ·Masato Chiba, Cuyue Tang, William Neway, Theresa M. Williams, S. J. DESOLMS, Christopher J Dinsmore, John Wai, Jiunn H. Lin	2001	19
18	Fatty acids: XXIII. A rapid method for the preparation of C₁₈ furanoid fatty ester involving dry‐column chromatography Journal of the American Oil Chemists Society ·Marcel S. F. Lie Ken Jie, Hak-Kim Chan, John Wai, S. Sinha	1981	13
19	Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates Journal of Medicinal Chemistry ·Leanna R. Staben, Jinhua Chen, Josefa dela Cruz-Chuh, Geoff Del Rosario, Mary Ann T. Go, Jun Guo, S. Cyrus Khojasteh, Katherine R. Kozak, Guangmin Li, Carl Ng, Gail D. Lewis Phillips, Thomas H. Pillow, Rebecca K. Rowntree, John Wai, BinQing Wei, Keyang Xu, Zijin Xu, Shang‐Fan Yu, Donglu Zhang, Peter S. Dragovich	2020	13
20	An efficient synthesis of γ-alkylated E-olefin dipeptide isosteres Tetrahedron Letters ·John Wai, Thorsten E. Fisher, Mark W. Embrey	1995	11

About John Wai

John Wai is a scholar working on Organic Chemistry, Molecular Biology, Infectious Diseases, Virology and Epidemiology, having authored 30 papers that have together received 1.7k indexed citations. Recurring topics across this work include HIV/AIDS drug development and treatment (11 papers), HIV Research and Treatment (8 papers), Biochemical and Molecular Research (7 papers), Pneumocystis jirovecii pneumonia detection and treatment (4 papers), Synthesis and Biological Evaluation (4 papers), Synthesis and Reactions of Organic Compounds (4 papers), Synthetic Organic Chemistry Methods (4 papers) and Synthesis and Reactivity of Heterocycles (4 papers). The work is most often cited by research in Virology (768 citations), Infectious Diseases (936 citations), Organic Chemistry (828 citations), Molecular Biology (649 citations) and Toxicology (21 citations). John Wai has collaborated with scholars based in United States, China and Hong Kong. Frequent co-authors include J. M. HOFFMAN, Thorsten E. Fisher, Daria J. Hazuda, Walfred S. Saari, Marc Witmer, Mark E. Goldman, Abigail Wolfe, William A. Schleif, Peter J. Felock and Joseph P. Vacca. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, Proceedings of the National Academy of Sciences and Journal of Bacteriology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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