Beth Pietrak

3.1k total citations · 1 hit paper
22 papers, 1.1k citations indexed

About

Beth Pietrak is a scholar working on Molecular Biology, Physiology and Computational Theory and Mathematics. According to data from OpenAlex, Beth Pietrak has authored 22 papers receiving a total of 1.1k indexed citations (citations by other indexed papers that have themselves been cited), including 15 papers in Molecular Biology, 8 papers in Physiology and 7 papers in Computational Theory and Mathematics. Recurrent topics in Beth Pietrak's work include Alzheimer's disease research and treatments (8 papers), Computational Drug Discovery Methods (7 papers) and Protein Structure and Dynamics (6 papers). Beth Pietrak is often cited by papers focused on Alzheimer's disease research and treatments (8 papers), Computational Drug Discovery Methods (7 papers) and Protein Structure and Dynamics (6 papers). Beth Pietrak collaborates with scholars based in United States, United Kingdom and Belgium. Beth Pietrak's co-authors include Nicholas D. Adams, Ralph J. DeBerardinis, Chendong Yang, Pamela Swain, Lei Jiang, Seth J. Parker, Lance S. Terada, Alexander A. Shestov, Benjamin Schwartz and Christian M. Metallo and has published in prestigious journals such as Nature, Nature Communications and Biochemistry.

In The Last Decade

Beth Pietrak

22 papers receiving 1.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

2016 432 citations Lei Jiang, Alexander A. Shestov et al. Nature profile →

Peers

Countries citing papers authored by Beth Pietrak

Since Specialization

Citations

This map shows the geographic impact of Beth Pietrak's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Beth Pietrak with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Beth Pietrak more than expected).

Fields of papers citing papers by Beth Pietrak

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Beth Pietrak. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Beth Pietrak. The network helps show where Beth Pietrak may publish in the future.

Co-authorship network of co-authors of Beth Pietrak

This figure shows the co-authorship network connecting the top 25 collaborators of Beth Pietrak. A scholar is included among the top collaborators of Beth Pietrak based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Beth Pietrak. Beth Pietrak is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Title	Journal	Authors	Indexed citations
1	Structural basis for the oligomerization-facilitated NLRP3 activation	Nature Communications	Xiaodi Yu, Rosalie Matico et al.	25
2	Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein–Protein Interaction Modulator with the Potential of Treating Hematological Malignancies	Journal of Medicinal Chemistry	Fedor Romanov‐Michailidis, Chien‐Chi Hsiao et al.	16
3	Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery	Scientific Reports	Rosalie Matico, Lawrence M. Szewczuk et al.	2
4	Reductive carboxylation supports redox homeostasis during anchorage-independent growth breakdown →	Nature	Lei Jiang, Alexander A. Shestov et al.	432
5	Crystallographic Structure of a Small Molecule SIRT1 Activator/Enzyme Complex	Biophysical Journal	Huizhen Zhao, Yong Jiang et al.	6
6	Mutant IDH1 Enhances the Production of 2-Hydroxyglutarate Due to Its Kinetic Mechanism	Biochemistry	Alan R. Rendina, Beth Pietrak et al.	64
7	Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors	Bioorganic & Medicinal Chemistry Letters	Hong Zhu, Mary Beth Young et al.	14
8	A conformational constraint improves a β-secretase inhibitor but for an unexpected reason	Bioorganic & Medicinal Chemistry Letters	Ivory D. Hills, M. Katharine Holloway et al.	11
9	Discovery of aminoheterocycles as a novel β-secretase inhibitor class: pH dependence on binding activity part 1	Bioorganic & Medicinal Chemistry Letters	Shawn J. Stachel, Craig A. Coburn et al.	49
10	Evaluating scoring functions for docking and designing β-secretase inhibitors	Bioorganic & Medicinal Chemistry Letters	M. Katharine Holloway, Georgia B. McGaughey et al.	17
11	β-Secretase (BACE-1) inhibitors: Accounting for 10s loop flexibility using rigid active sites	Bioorganic & Medicinal Chemistry Letters	Georgia B. McGaughey, Dennis Colussi et al.	35
12	BACE-1 inhibition by a series of ψ[CH2NH] reduced amide isosteres	Bioorganic & Medicinal Chemistry Letters	Craig A. Coburn, Shawn J. Stachel et al.	45
13	Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation	Bioorganic & Medicinal Chemistry Letters	Shaun R. Stauffer, Matthew G. Stanton et al.	37
14	P2–069: Nonhuman primate model for prediction of human Aβ effects. Targeting γ–secretase: Effects of enzyme inhibition vs. modulation of cleavage specificity on CSF and plasma Aβ in conscious rhesus monkeys	Alzheimer s & Dementia	Maria S. Michener, Marie A. Holahan et al.	4
15	Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model.	Journal of Medicinal Chemistry	Shawn J. Stachel, Craig A. Coburn et al.	1
16	Macrocyclic Inhibitors of β-Secretase: Functional Activity in an Animal Model	Journal of Medicinal Chemistry	Shawn J. Stachel, Craig A. Coburn et al.	67
17	Conformationally biased P3 amide replacements of β-secretase inhibitors	Bioorganic & Medicinal Chemistry Letters	Shawn J. Stachel, Craig A. Coburn et al.	55
18	Biochemical and cell-based assays for characterization of BACE-1 inhibitors	Analytical Biochemistry	Beth Pietrak, Ming‐Chih Crouthamel et al.	37
19	A presenilin‐independent aspartyl protease prefers the γ‐42 site cleavage	Journal of Neurochemistry	Ming‐Tain Lai, Ming‐Chih Crouthamel et al.	23
20	Quinolinate Phosphoribosyltransferase: Kinetic Mechanism for a Type II PRTase	Biochemistry	Hong Cao, Beth Pietrak et al.	24

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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