Joseph E. Coyle

2.3k citations

13 papers · 1.1k indexed · 1 hit paper · h-index 12

Impact in

Cancer Research top 5%
- Cancer, Hypoxia, and Metabolism
Molecular Biology top 10%
- Protein Structure and Dynamics
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Heat shock proteins research

Papers in ⓘ

Developmental Neuroscience 1
Physical and Theoretical Chemistry 2
- thermodynamics and calorimetric analyses 2

Co-authors: Finn P. Holding (3 shared papers)Dimitar B. Nikolov (2 shared papers)Liang Zheng (1 shared paper)Achuthanunni Chokkathukalam (1 shared paper)Barbara Chaneton (1 shared paper)Petra Hillmann (1 shared paper)Marc O’Reilly (1 shared paper)Oliver D.K. Maddocks (1 shared paper)
Journals: SLAS DISCOVERY (1 paper)ACS Medicinal Chemistry Letters (1 paper)Journal of Biological Chemistry (1 paper)Review of Scientific Instruments (1 paper)Journal of Medicinal Chemistry (1 paper)
Partner nations: United States United Kingdom Switzerland

In The Last Decade

Joseph E. Coyle

13 papers receiving 1.1k citations

Hit Papers

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2 2012 · 497 citations

Peers

Countries citing papers authored by Joseph E. Coyle

Since Specialization

Citations

This map shows the geographic impact of Joseph E. Coyle's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Joseph E. Coyle with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Joseph E. Coyle more than expected).

Fields of papers citing papers by Joseph E. Coyle

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Joseph E. Coyle. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Joseph E. Coyle. The network helps show where Joseph E. Coyle may publish in the future.

Co-authors

The 25 scholars most cited alongside Joseph E. Coyle, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Joseph E. Coyle Line = papers co-authored together Joseph E. Coyle links everyone, so they are left out of the graph.

All Works

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13 of 13 papers shown

#	Work
1	Serine is a natural ligand and allosteric activator of pyruvate kinase M2 Nature ·Barbara Chaneton, Petra Hillmann, Liang Zheng, Agnés C. L. Martin, Oliver D.K. Maddocks, Achuthanunni Chokkathukalam, Joseph E. Coyle, Andris Jankevics, Finn P. Holding, Karen H. Vousden, Christian Frezza, Marc O’Reilly, Eyal Gottlieb Hit paper breakdown →	2012	497
2	Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency Journal of Medicinal Chemistry ·Christopher W. Murray, Maria G. Carr, Owen Callaghan, Gianni Chessari, Miles Congreve, Suzanna Cowan, Joseph E. Coyle, Robert Downham, Eva Figueroa, Martyn Frederickson, Brent Graham, Rachel McMenamin, Alistair O’Brien, Sahil Patel, Theresa R. Phillips, Glyn Williams, Andrew Woodhead, Alison J.‐A. Woolford	2010	144
3	Structure of GABARAP in Two Conformations Neuron ·Joseph E. Coyle, Seema Qamar, Kanagalaghatta R. Rajashankar, Dimitar B. Nikolov	2002	127
4	Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function Nature Chemical Biology ·S. Saalau-Bethell, Andrew Woodhead, Gianni Chessari, Maria G. Carr, Joseph E. Coyle, Brent Graham, Steven D. Hiscock, Christopher W. Murray, Puja Pathuri, Sharna J. Rich, Caroline J. Richardson, Pamela A. Williams, Harren Jhoti	2012	85
5	Higher throughput calorimetry: opportunities, approaches and challenges Current Opinion in Structural Biology ·Francisco Eduardo Torres, Michael I. Recht, Joseph E. Coyle, Richard H. Bruce, Glyn Williams	2010	74
6	Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain Journal of Biological Chemistry ·Alison E. Ashcroft, Achim Brinker, Joseph E. Coyle, Frank Weber, Markus Kaiser, Luis Moroder, Mark R. Parsons, Joachim Jäger, Ulrich Hartl, Manajit Hayer‐Hartl, Sheena E. Radford	2002	31
7	Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket ChemMedChem ·S. Saalau-Bethell, Valério Berdini, Anne Cleasby, Miles Congreve, Joseph E. Coyle, Victoria Lock, Christopher W. Murray, Alistair O’Brien, Sharna J. Rich, Tracey Sambrook, M. Vinković, Jeff Yon, Harren Jhoti	2014	31
8	GABARAP: Lessons for Synaptogenesis The Neuroscientist ·Joseph E. Coyle, Dimitar B. Nikolov	2003	27
9	Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase ACS Medicinal Chemistry Letters ·Christopher N. Johnson, Valério Berdini, Lijs Beke, Pascal Bonnet, Dirk Brehmer, Joseph E. Coyle, Phillip J. Day, Martyn Frederickson, Eddy Freyne, Ron Gilissen, C. Hamlett, Steven Howard, Lieven Meerpoel, Rachel McMenamin, Sahil Patel, David C. Rees, Andrew Sharff, François Sommen, Tongfei Wu, Joannes T. M. Linders	2014	25
10	Application of Native ESI-MS to Characterize Interactions between Compounds Derived from Fragment-Based Discovery Campaigns and Two Pharmaceutically Relevant Proteins SLAS DISCOVERY ·Agni F. M. Gavriilidou, Finn P. Holding, Joseph E. Coyle, Renato Zenobi	2018	18
11	Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate Biochemistry ·Agni F. M. Gavriilidou, Finn P. Holding, Daniel Mayer, Joseph E. Coyle, Dmitry B. Veprintsev, Renato Zenobi	2018	18
12	An All-Metal Vacuum Valve Review of Scientific Instruments ·Sanborn C. Brown, Joseph E. Coyle	1952	13
13	Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase fromErwinia chrysanthemi Acta Crystallographica Section D Biological Crystallography ·Tino Krell, Joseph E. Coyle, Malcolm J. Horsburgh, J.R. Coggins, Adrian J. Lapthorn	1997	8

About Joseph E. Coyle

Joseph E. Coyle is a scholar working on Developmental Neuroscience, Physical and Theoretical Chemistry, Physiology, Spectroscopy and Molecular Biology, having authored 13 papers that have together received 1.1k indexed citations. Recurring topics across this work include Enzyme Structure and Function (3 papers), Protein Structure and Dynamics (3 papers), Cancer, Hypoxia, and Metabolism (2 papers), Computational Drug Discovery Methods (2 papers), Analytical Chemistry and Chromatography (2 papers), Biochemical and Molecular Research (2 papers), thermodynamics and calorimetric analyses (2 papers) and Mass Spectrometry Techniques and Applications (2 papers). The work is most often cited by research in Cancer Research (321 citations), Molecular Biology (787 citations), Biochemistry (70 citations), Computational Theory and Mathematics (151 citations) and Physical and Theoretical Chemistry (49 citations). Joseph E. Coyle has collaborated with scholars based in United States, United Kingdom and Switzerland. Frequent co-authors include Finn P. Holding, Dimitar B. Nikolov, Liang Zheng, Achuthanunni Chokkathukalam, Barbara Chaneton, Petra Hillmann, Marc O’Reilly, Oliver D.K. Maddocks, Eyal Gottlieb and Karen H. Vousden. Their work appears in journals such as SLAS DISCOVERY, ACS Medicinal Chemistry Letters, Journal of Biological Chemistry, Review of Scientific Instruments and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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