Christian Frezza

41.3k total citations · 9 hit papers
139 papers, 16.1k citations indexed

About

Christian Frezza is a scholar working on Molecular Biology, Cancer Research and Pulmonary and Respiratory Medicine. According to data from OpenAlex, Christian Frezza has authored 139 papers receiving a total of 16.1k indexed citations (citations by other indexed papers that have themselves been cited), including 102 papers in Molecular Biology, 66 papers in Cancer Research and 14 papers in Pulmonary and Respiratory Medicine. Recurrent topics in Christian Frezza's work include Cancer, Hypoxia, and Metabolism (59 papers), Mitochondrial Function and Pathology (39 papers) and Epigenetics and DNA Methylation (28 papers). Christian Frezza is often cited by papers focused on Cancer, Hypoxia, and Metabolism (59 papers), Mitochondrial Function and Pathology (39 papers) and Epigenetics and DNA Methylation (28 papers). Christian Frezza collaborates with scholars based in United Kingdom, Germany and United States. Christian Frezza's co-authors include Luca Scorrano, Sara Cipolat, Eyal Gottlieb, Edoardo Gaude, Marco Sciacovelli, Ana S.H. Costa, Michael P. Murphy, Bart De Strooper, Dylan G. Ryan and Luke O'neill and has published in prestigious journals such as Nature, Cell and Nucleic Acids Research.

In The Last Decade

Christian Frezza

135 papers receiving 16.0k citations

Hit Papers

Succinate Dehydrogenase Supports Metabolic ... 2006 2026 2012 2019 2016 2006 2007 2013 2006 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
    2016 1.6k citations Ana S.H. Costa, Dylan G. Ryan et al. profile →
  2. OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
    2006 1.3k citations Christian Frezza, Sara Cipolat et al. profile →
  3. Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts
    2007 973 citations Christian Frezza, Sara Cipolat et al. profile →
  4. Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency
    2013 957 citations Christian Frezza, Sara Cipolat et al. profile →
  5. Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
    2006 587 citations Sara Cipolat, Christian Frezza et al. profile →
  6. A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury
    2016 560 citations Christian Frezza, Thomas Krieg et al. Cell Metabolism profile →
  7. Serine is a natural ligand and allosteric activator of pyruvate kinase M2
    2012 497 citations Christian Frezza et al. profile →
  8. Crosstalk between mechanotransduction and metabolism
    2020 290 citations Christian Frezza et al. profile →
  9. Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation
    2025 22 citations Alva M. Casey, Dylan G. Ryan et al. Nature Metabolism profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Christian Frezza United Kingdom 61 11.4k 4.2k 2.0k 1.8k 1.5k 139 16.1k
Christian M. Metallo United States 51 8.2k 0.7× 4.8k 1.1× 1.1k 0.5× 1.6k 0.9× 1.3k 0.9× 125 12.3k
Bennett Van Houten United States 71 12.3k 1.1× 2.4k 0.6× 824 0.4× 1.6k 0.9× 1.2k 0.8× 232 16.8k
Anne N. Murphy United States 60 8.3k 0.7× 1.9k 0.5× 1.1k 0.6× 2.5k 1.4× 1.8k 1.1× 130 13.2k
Eyal Gottlieb United Kingdom 63 14.6k 1.3× 8.6k 2.0× 2.1k 1.1× 1.8k 1.0× 2.1k 1.4× 135 20.8k
Zoltàn Arany United States 61 9.0k 0.8× 3.1k 0.7× 1.1k 0.6× 4.7k 2.6× 1.7k 1.1× 174 16.1k
Harald Mischak Germany 81 13.1k 1.1× 1.3k 0.3× 2.0k 1.0× 1.5k 0.8× 1.1k 0.7× 441 23.5k
Hans R. Waterham Netherlands 69 12.8k 1.1× 1.2k 0.3× 1.6k 0.8× 2.1k 1.2× 1.0k 0.7× 300 15.8k
Shigeomi Shimizu Japan 58 12.5k 1.1× 1.5k 0.4× 1.8k 0.9× 1.9k 1.0× 4.9k 3.2× 146 18.5k
Stephen W. G. Tait United Kingdom 49 10.0k 0.9× 1.8k 0.4× 3.5k 1.8× 925 0.5× 3.4k 2.2× 87 15.5k
Quan Chen China 58 7.6k 0.7× 1.3k 0.3× 1.1k 0.6× 1.3k 0.7× 4.0k 2.6× 266 12.4k

Countries citing papers authored by Christian Frezza

Since Specialization
Citations

This map shows the geographic impact of Christian Frezza's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christian Frezza with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christian Frezza more than expected).

Fields of papers citing papers by Christian Frezza

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christian Frezza. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christian Frezza. The network helps show where Christian Frezza may publish in the future.

Co-authorship network of co-authors of Christian Frezza

This figure shows the co-authorship network connecting the top 25 collaborators of Christian Frezza. A scholar is included among the top collaborators of Christian Frezza based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christian Frezza. Christian Frezza is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Casey, Alva M., Dylan G. Ryan, Hiran A. Prag, et al.. (2025). Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation. Nature Metabolism. 7(3). 493–507. 22 indexed citations breakdown →
2.
Klein, Ines, Frederik Dethloff, Patrick Giavalisco, et al.. (2025). Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity. Nature Metabolism. 7(2). 297–320. 8 indexed citations
3.
Seidel, Eric, Christina Schmidt, Adriano B. Chaves‐Filho, et al.. (2025). An atlas of ferroptosis-induced secretomes. Cell Death and Differentiation. 32(11). 1986–2008. 3 indexed citations
4.
Podrini, Christine, Davide Stefanoni, Gianfranco Distefano, et al.. (2024). Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression. EMBO Molecular Medicine. 16(6). 1379–1403. 5 indexed citations
5.
Mottahedin, Amin, Hiran A. Prag, Christina Schmidt, et al.. (2023). Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke. Redox Biology. 59. 102600–102600. 33 indexed citations
6.
Nigro, Elisa Agnese, Laura Cassina, Christine Podrini, et al.. (2023). Primary cilia sense glutamine availability and respond via asparagine synthetase. Nature Metabolism. 5(3). 385–397. 20 indexed citations
7.
Harris, Rebecca, Ming Yang, Christina Schmidt, et al.. (2022). Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells. The Journal of Cell Biology. 221(7). 11 indexed citations
8.
Petruzzelli, Michele, Miriam Ferrer, Martijn J. Schuijs, et al.. (2022). Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia. Cancers. 14(4). 963–963. 15 indexed citations
9.
Lundahl, Mimmi L. E., Dylan G. Ryan, Niamh C. Williams, et al.. (2022). Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses. eLife. 11. 58 indexed citations
10.
Maleszewska, Monika, Swati Parekh, Ming Yang, et al.. (2022). Hypoxia promotes osteogenesis by facilitating acetyl‐CoA ‐mediated mitochondrial–nuclear communication. The EMBO Journal. 41(23). e111239–e111239. 24 indexed citations
11.
Lalou, Claude, Monica De Luise, Benoı̂t Rousseau, et al.. (2021). Lung Tumor Growth Promotion by Tobacco-Specific Nitrosamines Involves the β2-Adrenergic Receptors-Dependent Stimulation of Mitochondrial REDOX Signaling. Antioxidants and Redox Signaling. 36(7-9). 525–549. 3 indexed citations
12.
Dugourd, Aurélien, Christoph Kuppe, Marco Sciacovelli, et al.. (2021). Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses. Molecular Systems Biology. 17(1). e9730–e9730. 90 indexed citations
13.
Fendt, Sarah‐Maria, Christian Frezza, & Ayelet Erez. (2020). Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy. Cancer Discovery. 10(12). 1797–1807. 189 indexed citations
14.
Ryan, Dylan G., Christian Frezza, & Luke O'neill. (2020). TCA cycle signalling and the evolution of eukaryotes. Current Opinion in Biotechnology. 68. 72–88. 45 indexed citations
15.
Jang, Cholsoon, Sheng Hui, Xianfeng Zeng, et al.. (2019). Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metabolism. 30(3). 594–606.e3. 175 indexed citations
16.
Connor, Thomas M., Simon Hoer, Andrew J. Mallett, et al.. (2017). Mutations in mitochondrial DNA causing tubulointerstitial kidney disease. PLoS Genetics. 13(3). e1006620–e1006620. 40 indexed citations
17.
Hilvo, Mika, Inês de Santiago, Peddinti Gopalacharyulu, et al.. (2016). Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas. Cancer Research. 76(4). 796–804. 70 indexed citations
18.
Zecchini, Vincent, Basetti Madhu, Roslin Russell, et al.. (2014). Nuclear ARRB 1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. The EMBO Journal. 33(12). 1365–1382. 51 indexed citations
19.
Morais, Vanessa A., Patrik Verstreken, Joél Smet, et al.. (2009). Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Molecular Medicine. 1(2). 99–111. 326 indexed citations
20.
Frezza, Christian, Sara Cipolat, & Luca Scorrano. (2007). Measuring Mitochondrial Shape Changes and Their Consequences on Mitochondrial Involvement During Apoptosis. Methods in molecular biology. 372. 405–420. 23 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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