James R. Halpert

12.8k total citations · 2 hit papers
241 papers, 11.3k citations indexed

About

James R. Halpert is a scholar working on Pharmacology, Oncology and Molecular Biology. According to data from OpenAlex, James R. Halpert has authored 241 papers receiving a total of 11.3k indexed citations (citations by other indexed papers that have themselves been cited), including 220 papers in Pharmacology, 79 papers in Oncology and 71 papers in Molecular Biology. Recurrent topics in James R. Halpert's work include Pharmacogenetics and Drug Metabolism (220 papers), Drug Transport and Resistance Mechanisms (62 papers) and Analytical Chemistry and Chromatography (61 papers). James R. Halpert is often cited by papers focused on Pharmacogenetics and Drug Metabolism (220 papers), Drug Transport and Resistance Mechanisms (62 papers) and Analytical Chemistry and Chromatography (61 papers). James R. Halpert collaborates with scholars based in United States, Sweden and China. James R. Halpert's co-authors include Greg R. Harlow, Dmitri R. Davydov, Grażyna D. Szklarz, You Ai He, Tapio Haaparanta, Emily E. Scott, M.D. Burke, Richard T. Mayer, S. Thompson and Clifford R. Elcombe and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Journal of Biological Chemistry.

In The Last Decade

James R. Halpert

241 papers receiving 11.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

1985 1.2k citations James R. Halpert et al. profile →
The genetic determinants of the CYP3A5 polymorphism

2001 560 citations James R. Halpert et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
James R. Halpert United States	56	8.5k	3.7k	3.6k	2.3k	1.7k	241	11.3k
Eric F. Johnson United States	52	6.2k 0.7×	2.7k 0.7×	4.5k 1.2×	2.0k 0.9×	1.1k 0.7×	133	10.4k
R. Scott Obach United States	70	8.1k 1.0×	3.9k 1.1×	4.5k 1.3×	2.8k 1.2×	1.7k 1.0×	215	14.7k
Thomas A. Baillie United States	55	4.4k 0.5×	2.5k 0.7×	4.7k 1.3×	1.4k 0.6×	1.6k 1.0×	210	12.1k
Allan E. Rettie United States	61	8.6k 1.0×	3.3k 0.9×	3.0k 0.8×	1.2k 0.5×	742 0.4×	214	12.9k
Steven Wrighton United States	71	11.1k 1.3×	6.7k 1.8×	3.9k 1.1×	1.5k 0.7×	1.0k 0.6×	172	17.1k
Harry V. Gelboin United States	71	11.0k 1.3×	4.6k 1.2×	6.6k 1.8×	802 0.4×	1.1k 0.7×	288	19.0k
Sidney D. Nelson United States	53	6.5k 0.8×	2.4k 0.6×	2.9k 0.8×	677 0.3×	755 0.5×	213	10.8k
Tetsuya Kamataki Japan	56	7.9k 0.9×	4.0k 1.1×	5.5k 1.5×	567 0.2×	506 0.3×	364	13.7k
Ryo Sato Japan	33	11.8k 1.4×	4.7k 1.3×	6.9k 1.9×	570 0.2×	811 0.5×	125	17.3k
Anthony Y.H. Lu United States	48	5.4k 0.6×	2.4k 0.6×	3.0k 0.8×	593 0.3×	667 0.4×	122	8.8k

Countries citing papers authored by James R. Halpert

Since Specialization

Citations

This map shows the geographic impact of James R. Halpert's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James R. Halpert with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James R. Halpert more than expected).

Fields of papers citing papers by James R. Halpert

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James R. Halpert. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James R. Halpert. The network helps show where James R. Halpert may publish in the future.

Co-authorship network of co-authors of James R. Halpert

This figure shows the co-authorship network connecting the top 25 collaborators of James R. Halpert. A scholar is included among the top collaborators of James R. Halpert based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James R. Halpert. James R. Halpert is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Roberts, Arthur G., Jeffrey Stevens, Grażyna D. Szklarz, et al.. (2022). Four Decades of Cytochrome P450 2B Research: From Protein Adducts to Protein Structures and Beyond. Drug Metabolism and Disposition. 51(1). 111–122. 3 indexed citations

Kitanovic, Smiljka, Teri J. Orr, Daniel Spalink, et al.. (2018). Role of cytochrome P450 2B sequence variation and gene copy number in facilitating dietary specialization in mammalian herbivores. Molecular Ecology. 27(3). 723–736. 19 indexed citations

Lee, Sung Chang, B. Bennett, Wen‐Xu Hong, et al.. (2013). Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins. Proceedings of the National Academy of Sciences. 110(13). E1203–11. 119 indexed citations

Wilderman, P. Ross, et al.. (2013). Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida. Toxicology and Applied Pharmacology. 274(3). 393–401. 14 indexed citations

Sineva, Elena V., Jessica Rumfeldt, James R. Halpert, & Dmitri R. Davydov. (2013). A Large-Scale Allosteric Transition in Cytochrome P450 3A4 Revealed by Luminescence Resonance Energy Transfer (LRET). PLoS ONE. 8(12). e83898–e83898. 25 indexed citations

Davydov, Dmitri R., Jessica Rumfeldt, Elena V. Sineva, et al.. (2011). Peripheral Ligand-binding Site in Cytochrome P450 3A4 Located with Fluorescence Resonance Energy Transfer (FRET). Journal of Biological Chemistry. 287(9). 6797–6809. 60 indexed citations

Halpert, James R.. (2011). Structure and Function of Cytochromes P450 2B: From Mechanism-Based Inactivators to X-Ray Crystal Structures and Back. Drug Metabolism and Disposition. 39(7). 1113–1121. 29 indexed citations

Davydov, Dmitri R., Elena V. Sineva, Srinivas Sistla, et al.. (2009). Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: The effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1797(3). 378–390. 47 indexed citations

Kumar, Santosh, Long Sun, Hong Liu, B. K. Muralidhara, & James R. Halpert. (2006). Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide. Protein Engineering Design and Selection. 19(12). 547–554. 43 indexed citations

10.

He, You Ai, et al.. (2002). Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling. Archives of Biochemistry and Biophysics. 409(1). 92–101. 65 indexed citations

11.

Klekotka, Paul, Toby H. Richardson, Eric F. Johnson, & James R. Halpert. (1995). Inactivation of Escherichia coli-expressed rabbit cytochrome P-450 2C enzymes by 17 beta-substituted steroids.. Journal of Pharmacology and Experimental Therapeutics. 274(3). 1450–1455. 2 indexed citations

12.

He, You, You Ai He, & James R. Halpert. (1995). Escherichia coli Expression of Site-Directed Mutants of Cytochrome P450 2B1 from Six Substrate Recognition Sites: Substrate Specificity and Inhibitor Selectivity Studies. Chemical Research in Toxicology. 8(4). 574–579. 61 indexed citations

13.

Laethem, Ronald M., James R. Halpert, & Dennis R. Koop. (1994). Epoxidation of arachidonic acid as an active-site probe of cytochrome P-450 2B isoforms. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1206(1). 42–48. 30 indexed citations

14.

He, You-Ai, Zongshu Luo, Paul Klekotka, Vicki L. Burnett, & James R. Halpert. (1994). Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites. Biochemistry. 33(14). 4419–4424. 56 indexed citations

15.

Ryan, Robert P., Scott Grimm, Karen M. Kedzie, James R. Halpert, & R.M. Philpot. (1993). Cloning, Sequencing, and Functional Studies of Phenobarbital-Inducible Forms of Cytochrome P450 2B and 4B Expressed in Rabbit Kidney. Archives of Biochemistry and Biophysics. 304(2). 454–463. 15 indexed citations

16.

Stevens, Jeffrey, et al.. (1991). Mechanism-based inactivation of bovine adrenal cytochromes P450, C-21, and P450 17.alpha. by 17.beta.-substituted steroids. Biochemistry. 30(15). 3649–3658. 10 indexed citations

17.

Kedzie, Karen M., Richard M. Philpot, & James R. Halpert. (1991). Functional expression of mammalian cytochromes P450IIB in the yeast Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 291(1). 176–186. 19 indexed citations

18.

Halpert, James R. & Jeffrey Stevens. (1991). Cytochrome P-450 as a Target of Biological Reactive Intermediates. Advances in experimental medicine and biology. 283. 105–109. 2 indexed citations

19.

Graves, Penelope E., Laurence S. Kaminsky, & James R. Halpert. (1987). Evidence for functional and structural multiplicity of pregnenolone-16.alpha.-carbonitrile-inducible cytochrome P-450 isozymes in rat liver microsomes. Biochemistry. 26(13). 3887–3894. 52 indexed citations

20.

Duignan, David B., I.G. Sipes, Thomas B. Leonard, & James R. Halpert. (1986). Purification and characterization of the dog hepatic cytochrome P-450 isozyme(s) responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl. Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States). 10 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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