Heather E. Ryan

6.1k total citations · 5 hit papers
13 papers, 5.1k citations indexed

About

Heather E. Ryan is a scholar working on Cancer Research, Molecular Biology and Oncology. According to data from OpenAlex, Heather E. Ryan has authored 13 papers receiving a total of 5.1k indexed citations (citations by other indexed papers that have themselves been cited), including 11 papers in Cancer Research, 7 papers in Molecular Biology and 4 papers in Oncology. Recurrent topics in Heather E. Ryan's work include Cancer, Hypoxia, and Metabolism (11 papers), High Altitude and Hypoxia (3 papers) and Mitochondrial Function and Pathology (3 papers). Heather E. Ryan is often cited by papers focused on Cancer, Hypoxia, and Metabolism (11 papers), High Altitude and Hypoxia (3 papers) and Mitochondrial Function and Pathology (3 papers). Heather E. Ryan collaborates with scholars based in United States, Switzerland and Germany. Heather E. Ryan's co-authors include Randall S. Johnson, Max Gassmann, Melissa C. Knight, Tatsuya Kobayashi, Ernestina Schipani, David Elson, William McNulty, Keith R. Laderoute, Nobuhito Goda and Bahram Khadivi and has published in prestigious journals such as Genes & Development, The EMBO Journal and Molecular and Cellular Biology.

In The Last Decade

Heather E. Ryan

12 papers receiving 5.0k citations

Hit Papers

HIF-1alpha is required for solid tumor formation and embr... 1998 2026 2007 2016 1998 2000 2000 2001 2001 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. HIF-1alpha is required for solid tumor formation and embryonic vascularization
    1998 1.3k citations Heather E. Ryan The EMBO Journal profile →
  2. Loss of PTEN facilitates HIF-1-mediated gene expression
    2000 688 citations Wayne Zundel, Cornelia Schindler et al. Genes & Development profile →
  3. Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.
    2000 678 citations Heather E. Ryan, William McNulty et al. PubMed profile →
  4. Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival
    2001 656 citations Ernestina Schipani, Heather E. Ryan et al. Genes & Development profile →
  5. Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells
    2001 500 citations Tiffany N. Seagroves, Heather E. Ryan et al. Molecular and Cellular Biology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Heather E. Ryan United States 12 3.4k 3.1k 745 661 565 13 5.1k
Dorit Shweiki Israel 7 2.2k 0.6× 3.7k 1.2× 764 1.0× 359 0.5× 396 0.7× 13 5.9k
Gin-Wen Chang United Kingdom 13 3.8k 1.1× 3.8k 1.2× 692 0.9× 744 1.1× 584 1.0× 18 5.7k
Sandra W. Leung United States 7 4.9k 1.5× 4.4k 1.4× 806 1.1× 1.2k 1.8× 1.1k 1.9× 7 7.5k
Eric Metzen Germany 30 4.5k 1.3× 3.8k 1.2× 590 0.8× 1.3k 2.0× 1.1k 2.0× 51 6.8k
Ingo Flamme Germany 32 2.2k 0.7× 4.1k 1.3× 677 0.9× 559 0.8× 397 0.7× 49 6.1k
Ng Shyh‐Chang China 23 2.7k 0.8× 4.5k 1.5× 716 1.0× 282 0.4× 640 1.1× 44 6.3k
José Luís Rosa Spain 43 980 0.3× 3.6k 1.2× 817 1.1× 588 0.9× 386 0.7× 121 5.3k
Aimee Y. Yu United States 14 2.8k 0.8× 2.4k 0.8× 296 0.4× 901 1.4× 833 1.5× 16 4.9k
Lori E. Kotch United States 17 1.8k 0.5× 1.8k 0.6× 245 0.3× 532 0.8× 451 0.8× 19 3.5k
Susan E. Crawford United States 31 1.1k 0.3× 3.7k 1.2× 832 1.1× 659 1.0× 442 0.8× 92 5.9k

Countries citing papers authored by Heather E. Ryan

Since Specialization
Citations

This map shows the geographic impact of Heather E. Ryan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Heather E. Ryan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Heather E. Ryan more than expected).

Fields of papers citing papers by Heather E. Ryan

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Heather E. Ryan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Heather E. Ryan. The network helps show where Heather E. Ryan may publish in the future.

Co-authorship network of co-authors of Heather E. Ryan

This figure shows the co-authorship network connecting the top 25 collaborators of Heather E. Ryan. A scholar is included among the top collaborators of Heather E. Ryan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Heather E. Ryan. Heather E. Ryan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

13 of 13 papers shown
1.
Sharma, Archana, Sanjit K. Roy, Heather E. Ryan, et al.. (2025). Mouse pancreatic tumor organoids reveal synergistic efficacy of low-dose anticancer drug and radiation combinations. Frontiers in Medicine. 12. 1661521–1661521.
2.
Ryan, Heather E.. (2006). Oxidative stress and apoptosis: a new treatment paradigm in cancer. Frontiers in bioscience. 11(1). 300–300. 178 indexed citations
3.
Ryan, Heather E., et al.. (2003). Gene Expression Profiling of the Hypoxia Signaling Pathway in Hypoxia-Inducible Factor 1α Null Mouse Embryonic Fibroblasts. Gene Expression. 11(3). 181–197. 96 indexed citations
4.
Goda, Nobuhito, et al.. (2002). Hypoxia-Inducible Factor 1α Is Essential for Cell Cycle Arrest during Hypoxia. Molecular and Cellular Biology. 23(1). 359–369. 427 indexed citations
5.
Scheid, Annette, Roland H. Wenger, Leonhard Schäffer, et al.. (2002). Physiologically low oxygen concentrations determined in fetal skin regulate hypoxia‐inducible factor 1 and transforming growth factor β3. The FASEB Journal. 16(3). 411–413. 54 indexed citations
6.
Laderoute, Keith R., Joy M. Calaoagan, Cindy Gustafson‐Brown, et al.. (2002). The Response of c-Jun/AP-1 to Chronic Hypoxia Is Hypoxia-Inducible Factor 1α Dependent. Molecular and Cellular Biology. 22(8). 2515–2523. 84 indexed citations
7.
Schipani, Ernestina, et al.. (2001). Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival. Genes & Development. 15(21). 2865–2876. 656 indexed citations breakdown →
8.
Seagroves, Tiffany N., Heather E. Ryan, Han Lu, et al.. (2001). Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells. Molecular and Cellular Biology. 21(10). 3436–3444. 500 indexed citations breakdown →
9.
Garayoa, Mercedes, Alfredo Martı́nez, Sunmin Lee, et al.. (2000). Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis. Molecular Endocrinology. 14(6). 848–862. 209 indexed citations
10.
Ryan, Heather E., et al.. (2000). Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.. PubMed. 60(15). 4010–5. 678 indexed citations breakdown →
11.
Ryan, Heather E., et al.. (2000). Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing.. PubMed. 60(21). 6189–95. 211 indexed citations
12.
Zundel, Wayne, Cornelia Schindler, Daphne A. Haas‐Kogan, et al.. (2000). Loss of PTEN facilitates HIF-1-mediated gene expression. Genes & Development. 14(4). 391–396. 688 indexed citations breakdown →
13.
Ryan, Heather E.. (1998). HIF-1alpha is required for solid tumor formation and embryonic vascularization. The EMBO Journal. 17(11). 3005–3015. 1306 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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