Frank Speleman

26.0k citations

285 papers · 12.9k indexed · 2 hit papers · h-index 60

Impact in

Cancer Research top 0.1%
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
Neurology top 0.2%
- Neuroblastoma Research and Treatments

Papers in

Neurology 112
- Neuroblastoma Research and Treatments 108
Cancer Research 72
- Cancer, Hypoxia, and Metabolism 32
- MicroRNA in disease regulation 22

Co-authors: Jo Vandesompele Nadine Van Roy Pieter Mestdagh Frank Westermann Anne De Paepe Daniel Muth Pieter Van Vlierberghe Katleen De Preter
Journals: Genes Chromosomes and Cancer (24 papers)Cytogenetic and Genome Research (13 papers)PLoS ONE (12 papers)International Journal of Cancer (10 papers)Scientific Reports (8 papers)
Partner nations: Belgium United States Netherlands

In The Last Decade

Frank Speleman

280 papers receiving 12.6k citations

Hit Papers

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miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis 2010 · 1.1k citations

Peers

Countries citing papers authored by Frank Speleman

Since Specialization

Citations

This map shows the geographic impact of Frank Speleman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frank Speleman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frank Speleman more than expected).

Fields of papers citing papers by Frank Speleman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frank Speleman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frank Speleman. The network helps show where Frank Speleman may publish in the future.

Co-authors

The 25 scholars most cited alongside Frank Speleman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Frank Speleman Line = papers co-authored together Frank Speleman links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma iScience ·Stéphane Van Haver, Yujie Fan, Sarah-Lee Bekaert, Celine Everaert, Wouter Van Loocke, Vittorio Zanzani, Joke Deschildre, Inés Fernández-Maestre, Adrianna Amaro, Vanessa Vermeirssen, Katleen De Preter, Ting Zhou, Alex Kentsis, Lorenz Studer, Frank Speleman, Stephen S. Roberts	2023	2
2	From DNA Copy Number Gains and Tumor Dependencies to Novel Therapeutic Targets for High-Risk Neuroblastoma Journal of Personalized Medicine ·Bieke Decaesteker, Kaat Durinck, Nadine Van Roy, Bram De Wilde, Christophe Van Neste, Stéphane Van Haver, Stephen S. Roberts, Katleen De Preter, Vanessa Vermeirssen, Frank Speleman	2021	2
3	DREAM target reactivation by core transcriptional regulators supports neuroblastoma growth Molecular & Cellular Oncology ·Bieke Decaesteker, Katleen De Preter, Frank Speleman	2019	2
4	SMARTer single cell total RNA sequencing Nucleic Acids Research ·Karen Verboom, Celine Everaert, Nathalie Bolduc, Kenneth J. Livak, Nurten Yigit, Dries Rombaut, Jasper Anckaert, Simon Ming‐Yuen Lee, Morten T. Venø, Jørgen Kjems, Frank Speleman, Pieter Mestdagh, Jo Vandesompele	2019	35
5	LDHA in Neuroblastoma Is Associated with Poor Outcome and Its Depletion Decreases Neuroblastoma Growth Independent of Aerobic Glycolysis Clinical Cancer Research ·Carmen Dorneburg, Matthias Fischer, Thomas F.E. Barth, Wolfgang Mueller‐Klieser, Barbara Hero, Judith Gecht, Daniel R. Carter, Katleen De Preter, Benjamin Mayer, Lisa Christner, Frank Speleman, Glenn M. Marshall, Klaus‐Michael Debatin, Christian Beltinger	2018	54
6	In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors Scientific Reports ·Suzanne Vanhauwaert, Bieke Decaesteker, Sara De Brouwer, Carina Leonelli, Kaat Durinck, Pieter Mestdagh, Jo Vandesompele, Karen Sermon, Geertrui Denecker, Christophe Van Neste, Frank Speleman, Katleen De Preter	2018	7
7	Genetisch geïnspireerde toekomstperspectieven voor de therapie van het neuroblastoom Ghent University Academic Bibliography (Ghent University) ·Bram De Wilde, Tom Van Maerken, Katleen De Preter, Nadine Van Roy, Geneviève Laureys, Jo Vandesompele, Frank Speleman	2014	1
8	The MYCN/miR-26a-5p/LIN28B regulatory axis controls MYCN-driven LIN28B upregulation in neuroblastoma Ghent University Academic Bibliography (Ghent University) ·Anneleen Beckers, Andrew D. Ludwig, Gert Van Peer, Daniel R. Carter, Belamy B. Cheung, Sara De Brouwer, Jo Vandesompele, Katleen De Preter, Jason M. Shohet, Frank Speleman	2014	1
9	Histone Chaperone CHAF1A Inhibits Differentiation and Promotes Aggressive Neuroblastoma Cancer Research ·Eveline Barbieri, Katleen De Preter, Mario Capasso, Zaowen Chen, Danielle M. Hsu, Gian Paolo Tonini, Steve Lefever, John Hicks, Rogier Versteeg, Andrea Pession, Frank Speleman, Eugene S. Kim, Jason M. Shohet	2013	44
10	MiR-137 is epigenetically silenced in MYCN amplified neuroblastomas and targets the polycomb repressive complex 2 (PRC2) component EZH2 Ghent University Academic Bibliography (Ghent University) ·Anneleen Beckers, Maté Ongenaert, Anneleen Decock, Candy Kumps, Filip Pattyn, Pieter Mestdagh, Johannes H. Schulte, Frank Speleman, Katleen De Preter	2012	1
11	Functional Analysis of the p53 Pathway in Neuroblastoma Cells Using the Small-Molecule MDM2 Antagonist Nutlin-3 Molecular Cancer Therapeutics ·Tom Van Maerken, Ali Rihani, Daniel Dreidax, Sarah De Clercq, Nurten Yigit, Jean‐Christophe Marine, Frank Westermann, Anne De Paepe, Jo Vandesompele, Frank Speleman	2011	61
12	High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma Clinical Cancer Research ·Johannes H. Schulte, Hagen S. Bachmann, Bent Brockmeyer, Katleen De Preter, André Oberthür, Sandra Ackermann, Yvonne Kahlert, Kristian W. Pajtler, Jessica Theißen, Frank Westermann, Jo Vandesompele, Frank Speleman, Frank Berthold, Angelika Eggert, Benedikt Brors, Barbara Hero, Alexander Schramm, Matthias Fischer	2011	72
13	The Quassinoid Derivative NBT-272 Targets Both the AKT and ERK Signaling Pathways in Embryonal Tumors Molecular Cancer Therapeutics ·Deborah Castelletti, Giulio Fiaschetti, Valeria Di Dato, Urs Ziegler, Candy Kumps, Katleen De Preter, Massimo Zollo, Frank Speleman, Tarek Shalaby, Daniela De Martino, Thorsten Berg, Angelika Eggert, Alexandre Arcaro, Michael A. Grotzer	2010	11
14	Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature Clinical Cancer Research ·Katleen De Preter, Joëlle Vermeulen, Benedikt Brors, Olivier Delattre, Angelika Eggert, Matthias Fischer, Isabelle Janoueix‐Lerosey, Cinzia Lavarino, John M. Maris, Jaume Mora, Akira Nakagawara, André Oberthuer, Miki Ohira, Gudrun Schleiermacher, Alexander Schramm, Johannes H. Schulte, Qun Wang, Frank Westermann, Frank Speleman, Jo Vandesompele	2010	65
15	Meta-mining of Neuroblastoma and Neuroblast Gene Expression Profiles Reveals Candidate Therapeutic Compounds Clinical Cancer Research ·Katleen De Preter, Sara De Brouwer, Tom Van Maerken, Filip Pattyn, Alexander Schramm, Angelika Eggert, Jo Vandesompele, Frank Speleman	2009	37
16	High-throughput stem-loop RT-PCR miRNA expression profiling using minute amounts of input RNA Ghent University Academic Bibliography (Ghent University) ·Pieter Mestdagh, Tom Feys, Nathalie Bernard‐Marissal, Simone M Guenther, Caifu Chen, Vladimı́r Beneš, Frank Speleman, Jo Vandesompele	2008	1
17	Integrative genomics in neuroblastoma research Ghent University Academic Bibliography (Ghent University) ·Frank Speleman, Katleen De Preter, Evi Michels, Jasmien Hoebeeck, Filip Pattyn, Joëlle Vermeulen, Nadine Van Roy, Anne De Paepe, Geneviève Laureys, Jo Vandesompele	2007	1
18	Small-Molecule MDM2 Antagonists as a New Therapy Concept for Neuroblastoma Cancer Research ·Tom Van Maerken, Frank Speleman, Joëlle Vermeulen, Irina Lambertz, Sarah De Clercq, Els De Smet, Nurten Yigit, Vicky Coppens, Jan Philippé, Anne De Paepe, Jean‐Christophe Marine, Jo Vandesompele	2006	120
19	Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma (vol 101, pg 103, 2002) Ghent University Academic Bibliography (Ghent University) ·J. Helen Leonard, Anthony L. Cook, Mireille Van Gele, Gm Boyle, Kj Inglis, Frank Speleman, Richard A. Sturm	2004	3
20	Molecular characterization of a t(2;3)(p23;q26): A recurrent translocation involving the EVI1 gene Ghent University Academic Bibliography (Ghent University) ·Bruce Poppe, Nurten Yigit, Peter Marynen, A Hagemeijer, Heidi Van Limbergen, Barbara Smet, Anne De Paepe, Frank Speleman	2001	2

About Frank Speleman

Frank Speleman is a scholar working on Neurology, Cancer Research, Hematology, Genetics and Molecular Biology, having authored 285 papers that have together received 12.9k indexed citations. Recurring topics across this work include Neuroblastoma Research and Treatments (108 papers), Genomic variations and chromosomal abnormalities (40 papers), Cancer, Hypoxia, and Metabolism (32 papers), RNA modifications and cancer (25 papers), MicroRNA in disease regulation (22 papers), Lung Cancer Research Studies (20 papers), Chromosomal and Genetic Variations (20 papers) and Acute Myeloid Leukemia Research (17 papers). The work is most often cited by research in Cancer Research (4.6k citations), Neurology (3.5k citations), Molecular Biology (7.9k citations), Oncology (2.2k citations) and Genetics (2.1k citations). Frank Speleman has collaborated with scholars based in Belgium, United States and Netherlands. Frequent co-authors include Jo Vandesompele, Nadine Van Roy, Pieter Mestdagh, Frank Westermann, Anne De Paepe, Daniel Muth, Pieter Van Vlierberghe, Katleen De Preter, Geneviève Laureys and An De Weer. Their work appears in journals such as Genes Chromosomes and Cancer, Cytogenetic and Genome Research, PLoS ONE, International Journal of Cancer and Scientific Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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