Ernesto Freire

24.0k total citations · 4 hit papers
244 papers, 17.9k citations indexed

About

Ernesto Freire is a scholar working on Molecular Biology, Physical and Theoretical Chemistry and Infectious Diseases. According to data from OpenAlex, Ernesto Freire has authored 244 papers receiving a total of 17.9k indexed citations (citations by other indexed papers that have themselves been cited), including 166 papers in Molecular Biology, 64 papers in Physical and Theoretical Chemistry and 57 papers in Infectious Diseases. Recurrent topics in Ernesto Freire's work include Protein Structure and Dynamics (87 papers), thermodynamics and calorimetric analyses (59 papers) and HIV Research and Treatment (48 papers). Ernesto Freire is often cited by papers focused on Protein Structure and Dynamics (87 papers), thermodynamics and calorimetric analyses (59 papers) and HIV Research and Treatment (48 papers). Ernesto Freire collaborates with scholars based in United States, Japan and Spain. Ernesto Freire's co-authors include Adrián Velázquez‐Campoy, Vincent J. Hilser, Rodney L. Biltonen, Arne Schön, Irene Luque, Dong Xie, Kenneth P. Murphy, Stephanie A. Leavitt, Javier Gómez and Obdulio López Mayorga and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Journal of Biological Chemistry.

In The Last Decade

Ernesto Freire

244 papers receiving 17.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Direct measurement of protein binding energetics by isothermal titration calorimetry

2001 532 citations Stephanie A. Leavitt, Ernesto Freire profile →
Thermodynamics of Structural Stability and Cooperative Folding Behavior in Proteins

1992 510 citations Ernesto Freire et al. profile →
Isothermal titration calorimetry

1990 488 citations Ernesto Freire et al. profile →
Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

2015 458 citations Arne Schön, Ernesto Freire et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Ernesto Freire United States	78	12.3k	3.2k	2.9k	2.8k	2.3k	244	17.9k
S. Swaminathan United States	30	11.7k 0.9×	3.2k 1.0×	736 0.3×	1.3k 0.5×	1.2k 0.5×	54	16.8k
Carlos Simmerling United States	43	20.9k 1.7×	5.3k 1.6×	766 0.3×	2.1k 0.8×	3.6k 1.5×	106	28.3k
Holger Gohlke Germany	49	16.4k 1.3×	3.4k 1.0×	682 0.2×	1.4k 0.5×	4.9k 2.1×	283	23.1k
Alexey V. Onufriev United States	37	13.7k 1.1×	3.4k 1.0×	752 0.3×	1.0k 0.4×	2.5k 1.1×	100	19.0k
Stephen J. Benkovic United States	84	20.8k 1.7×	4.4k 1.4×	606 0.2×	2.0k 0.7×	405 0.2×	457	28.6k
Robert B. Murphy United States	27	13.0k 1.1×	2.1k 0.7×	923 0.3×	1.7k 0.6×	6.8k 2.9×	39	23.0k
W. Minor United States	52	25.8k 2.1×	10.8k 3.4×	1.2k 0.4×	2.4k 0.9×	787 0.3×	233	42.5k
Alexander Wlodawer United States	71	12.7k 1.0×	3.5k 1.1×	266 0.1×	4.0k 1.4×	969 0.4×	371	19.0k
Zbyszek Otwinowski United States	40	27.2k 2.2×	10.4k 3.2×	1.2k 0.4×	2.5k 0.9×	526 0.2×	109	43.4k
Robert Kaptein Netherlands	64	14.1k 1.1×	3.8k 1.2×	1.2k 0.4×	763 0.3×	474 0.2×	347	20.1k

Countries citing papers authored by Ernesto Freire

Since Specialization

Citations

This map shows the geographic impact of Ernesto Freire's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ernesto Freire with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ernesto Freire more than expected).

Fields of papers citing papers by Ernesto Freire

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ernesto Freire. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ernesto Freire. The network helps show where Ernesto Freire may publish in the future.

Co-authorship network of co-authors of Ernesto Freire

This figure shows the co-authorship network connecting the top 25 collaborators of Ernesto Freire. A scholar is included among the top collaborators of Ernesto Freire based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ernesto Freire. Ernesto Freire is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Wang, Shusheng, Stephanie A. Ketcham, Arne Schön, et al.. (2013). Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis. Molecular Biology of the Cell. 24(22). 3522–3533. 53 indexed citations

Brown, Richard, et al.. (2013). Optimizing Biologics Stability Testing. Genetic Engineering & Biotechnology News. 33(16). 26–27. 1 indexed citations

Aneja, Rachna, Diogo Rodrigo Magalhães Moreira, Karyn McFadden, et al.. (2012). Non‐natural Peptide Triazole Antagonists of HIV‐1 Envelope gp120. ChemMedChem. 8(2). 322–328. 12 indexed citations

Freire, Ernesto, Arne Schön, & Adrián Velázquez‐Campoy. (2009). Chapter 5 Isothermal Titration Calorimetry. Methods in enzymology on CD-ROM/Methods in enzymology. 455. 127–155. 130 indexed citations

Aguilar, R. Claudio, Silvia A. Longhi, Sean Kim, et al.. (2006). Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins. Proceedings of the National Academy of Sciences. 103(11). 4116–4121. 86 indexed citations

Murali, Ramachandran, Xin Cheng, Alan Berezov, et al.. (2005). Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107. Proceedings of the National Academy of Sciences. 102(31). 10970–10975. 38 indexed citations

Hidaka, Koushi, Tooru Kimura, Yoshio Hayashi, et al.. (2005). Evaluation of Peptidomimetic Inhibitors against Malarial Protease Plasmepsin. 2004. 527–530. 1 indexed citations

Leavitt, Stephanie A., et al.. (2004). Interactions of HIV-1 Proteins gp120 and Nef with Cellular Partners Define a Novel Allosteric Paradigm. Current Protein and Peptide Science. 5(1). 1–8. 34 indexed citations

Hidaka, Koushi, Tooru Kimura, Yoshio Hayashi, et al.. (2003). Substrate Transition-State Analogue Inhibitors of Plasmepsin II as Antimalarial Drugs. 2002. 297–300. 1 indexed citations

10.

Ohtaka, Hiroyasu, Adrián Velázquez‐Campoy, Dong Xie, & Ernesto Freire. (2002). Overcoming drug resistance in HIV‐1 chemotherapy: The binding thermodynamics of Amprenavir and TMC‐126 to wild‐type and drug‐resistant mutants of the HIV‐1 protease. Protein Science. 11(8). 1908–1916. 87 indexed citations

11.

Freire, Ernesto, et al.. (1995). Precise Scanning Calorimeter for Studying Thermal Properties of Biological Macromolecules in Dilute Solution. Analytical Biochemistry. 232(1). 79–85. 164 indexed citations

12.

Freire, Ernesto. (1995). [6] Thermal denaturation methods in the study of protein folding. Methods in enzymology on CD-ROM/Methods in enzymology. 259. 144–168. 86 indexed citations

13.

Freire, Ernesto. (1994). [23] Statistical thermodynamic analysis of differential scanning calorimetry data: Structural deconvolution of heat capacity function of proteins. Methods in enzymology on CD-ROM/Methods in enzymology. 240. 502–530. 53 indexed citations

14.

Haynie, Donald T. & Ernesto Freire. (1994). Thermodynamic strategies for stabilizing intermediate states of proteins. Biopolymers. 34(2). 261–272. 5 indexed citations

15.

Hilser, Vincent J., et al.. (1993). Analysis of Thermally Induced Protein Folding/Unfolding Transitions Using Free Solution Capillary Electrophoresis. Analytical Biochemistry. 208(1). 125–131. 35 indexed citations

16.

Pace, C. Nick, et al.. (1992). Temperature and guanidine hydrochloride dependence of the structural stability of ribonuclease T1. Biochemistry. 31(45). 11196–11202. 32 indexed citations

17.

Xie, Dong, Vinod Bhakuni, & Ernesto Freire. (1991). Calorimetric determination of the energetics of the molten globule intermediate in protein folding: apo-.alpha.-lactalbumin. Biochemistry. 30(44). 10673–10678. 107 indexed citations

18.

Freire, Ernesto, et al.. (1990). Linked thermal and solute perturbation analysis of cooperative domain interactions in proteins. Structural stability of diphtheria toxin. Biochemistry. 29(37). 8677–8683. 57 indexed citations

19.

Freire, Ernesto, et al.. (1989). Thermodynamics of intersubunit interactions in cholera toxin upon binding to the oligosaccharide portion of its cell surface receptor, ganglioside GM1. Biochemistry. 28(12). 5019–5024. 149 indexed citations

20.

Masserini, Massimo, Paola Palestini, & Ernesto Freire. (1989). Influence of glycolipid oligosaccharide and long-chain base composition on the thermotropic properties of dipalmitoylphosphatidylcholine large unilamellar vesicles containing gangliosides. Biochemistry. 28(12). 5029–5034. 63 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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