Silvana Leit

1.3k total citations
19 papers, 810 citations indexed

About

Silvana Leit is a scholar working on Molecular Biology, Organic Chemistry and Oncology. According to data from OpenAlex, Silvana Leit has authored 19 papers receiving a total of 810 indexed citations (citations by other indexed papers that have themselves been cited), including 14 papers in Molecular Biology, 8 papers in Organic Chemistry and 5 papers in Oncology. Recurrent topics in Silvana Leit's work include Protein Degradation and Inhibitors (9 papers), Histone Deacetylase Inhibitors Research (9 papers) and Peptidase Inhibition and Analysis (4 papers). Silvana Leit is often cited by papers focused on Protein Degradation and Inhibitors (9 papers), Histone Deacetylase Inhibitors Research (9 papers) and Peptidase Inhibition and Analysis (4 papers). Silvana Leit collaborates with scholars based in United States, Italy and Canada. Silvana Leit's co-authors include Leo A. Paquette, Zuomei Li, Jeffrey M. Besterman, Marielle Fournel, Sylvie Fréchette, Marie-Claude Trachy-Bourget, Jubrail Rahil, Daniel Delorme, Oscar Moradei and Éric Therrien and has published in prestigious journals such as Nature, Journal of the American Chemical Society and Cancer Research.

In The Last Decade

Silvana Leit

19 papers receiving 776 citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Silvana Leit United States 14 599 307 200 77 48 19 810
Robert B. Garland United States 15 463 0.8× 479 1.6× 159 0.8× 74 1.0× 37 0.8× 26 925
Peter Chua Canada 11 443 0.7× 323 1.1× 111 0.6× 49 0.6× 29 0.6× 14 766
Christoph M. Dehnhardt United States 18 641 1.1× 312 1.0× 135 0.7× 45 0.6× 38 0.8× 22 938
Michael Friedmann United States 14 520 0.9× 258 0.8× 112 0.6× 72 0.9× 39 0.8× 19 735
Rainer Metternich Switzerland 17 312 0.5× 570 1.9× 94 0.5× 55 0.7× 80 1.7× 28 973
Jidong Zhu China 14 752 1.3× 198 0.6× 146 0.7× 106 1.4× 40 0.8× 34 1.1k
Laura L. Rokosz United States 14 379 0.6× 167 0.5× 227 1.1× 178 2.3× 38 0.8× 26 660
Ligang Qian United States 14 311 0.5× 341 1.1× 91 0.5× 51 0.7× 41 0.9× 19 649
Hank La United States 14 428 0.7× 120 0.4× 221 1.1× 68 0.9× 40 0.8× 23 792
Darin E. Jones United States 20 297 0.5× 373 1.2× 69 0.3× 73 0.9× 39 0.8× 44 796

Countries citing papers authored by Silvana Leit

Since Specialization
Citations

This map shows the geographic impact of Silvana Leit's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Silvana Leit with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Silvana Leit more than expected).

Fields of papers citing papers by Silvana Leit

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Silvana Leit. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Silvana Leit. The network helps show where Silvana Leit may publish in the future.

Co-authorship network of co-authors of Silvana Leit

This figure shows the co-authorship network connecting the top 25 collaborators of Silvana Leit. A scholar is included among the top collaborators of Silvana Leit based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Silvana Leit. Silvana Leit is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

19 of 19 papers shown
1.
Svensson, Robert, Scott Boiko, Beth Browning, et al.. (2025). Abstract 2894: NTX-452: a non-covalent, potent, selective and highly efficacious WRN inhibitor with best-in-class potential for the treatment of MSI-H tumors. Cancer Research. 85(8_Supplement_1). 2894–2894. 2 indexed citations
2.
Leit, Silvana, Jeremy R. Greenwood, Sayan Mondal, et al.. (2022). Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis. Bioorganic & Medicinal Chemistry Letters. 73. 128891–128891. 10 indexed citations
3.
Leit, Silvana, David L. Laughton, Suzanne L. Jacques, et al.. (2022). Abstract 589: Discovery of NTX-001, a potent Cbl-b inhibitor with antitumor activity in syngeneic models. Cancer Research. 82(12_Supplement). 589–589. 1 indexed citations
4.
Brachène, Alexandra Coomans de, Ângela Castela, Anne Op De Beeck, et al.. (2020). Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta‐cell protection in type 1 diabetes. Diabetes Obesity and Metabolism. 22(10). 1827–1836. 26 indexed citations
5.
Jia, Wei, Silvana Leit, Jun Kuai, et al.. (2019). An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature. 568(7753). 566–570. 122 indexed citations
6.
Tessier, Pierre, David Smil, Amal Wahhab, et al.. (2009). Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19(19). 5684–5688. 45 indexed citations
7.
Smil, David, Sukhdev Manku, Silvana Leit, et al.. (2008). Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19(3). 688–692. 73 indexed citations
8.
Wahhab, Amal, David Smil, Alain Ajamian, et al.. (2008). Sulfamides as novel histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19(2). 336–340. 26 indexed citations
9.
Moradei, Oscar, Sylvie Fréchette, Isabelle Paquin, et al.. (2007). Novel Aminophenyl Benzamide-Type Histone Deacetylase Inhibitors with Enhanced Potency and Selectivity. Journal of Medicinal Chemistry. 50(23). 5543–5546. 137 indexed citations
10.
Vaisburg, Arkadii, Naomy Bernstein, Sylvie Fréchette, et al.. (2003). (2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 14(1). 283–287. 21 indexed citations
11.
Bouchain, Giliane, Silvana Leit, Sylvie Fréchette, et al.. (2003). Development of Potential Antitumor Agents. Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivatives as Histone Deacetylase Inhibitors. Journal of Medicinal Chemistry. 46(5). 820–830. 52 indexed citations
12.
Woo, Soon Hyung, Sylvie Fréchette, Giliane Bouchain, et al.. (2002). Structurally Simple Trichostatin A-Like Straight Chain Hydroxamates as Potent Histone Deacetylase Inhibitors. Journal of Medicinal Chemistry. 45(13). 2877–2885. 53 indexed citations
13.
Fournel, Marielle, Marie-Claude Trachy-Bourget, Ann Kalita, et al.. (2002). Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors.. PubMed. 62(15). 4325–30. 72 indexed citations
14.
Bouchain, Giliane, Sylvie Fréchette, Soon Hyung Woo, et al.. (2001). Design and synthesis of a novel class of histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 11(21). 2847–2850. 52 indexed citations
15.
Paquette, Leo A., et al.. (2001). Direct Synthesis of Previously Inaccessible Bridgehead Azabicyclics by Intramolecular Cyclization of α-Sulfonamido and α-Sulfonimido Radicals. The Journal of Organic Chemistry. 66(10). 3564–3573. 22 indexed citations
16.
Leit, Silvana, et al.. (2000). Radical and Anionic Response of N-(Bromomethanesulfonyl)-Substituted α,α‘-Bridged Piperidine Substrates. The Journal of Organic Chemistry. 65(21). 7119–7123. 7 indexed citations
17.
Leit, Silvana & Leo A. Paquette. (1999). Intramolecular Cyclization of Radicals Generated from α-Halomethylsulfonamides. The Journal of Organic Chemistry. 64(25). 9225–9229. 20 indexed citations
18.
Paquette, Leo A. & Silvana Leit. (1999). The First Examples of Bridgehead Bicyclic Sultams. Journal of the American Chemical Society. 121(35). 8126–8127. 64 indexed citations
19.
Moradei, Oscar, et al.. (1993). Amine-Induced Deacylation of Carbohydrate Derivatives Under Anhydrous Conditions. Journal of Carbohydrate Chemistry. 12(1). 13–22. 5 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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