A. Robert MacLeod

3.4k citations

26 papers · 2.5k indexed · 1 hit paper · h-index 22

Molecular Biology top 5%
- Epigenetics and DNA Methylation 18
- Cancer-related gene regulation 10
- RNA modifications and cancer 8
- Histone Deacetylase Inhibitors Research 5
- Protein Degradation and Inhibitors 4
- Genomics and Chromatin Dynamics 3
Cancer Research top 10%
Oncology top 10%
Genetics top 10%
Immunology
- interferon and immune responses 2
Hepatology
- Liver physiology and pathology 2

Co-authors: Moshe Szyf Normand Beaulieu Marie‐France Robert Steves Morin Ian C. Chute France Gauthier Annie Barsalou Jeffrey M. Besterman
Cited by: Molecular Biology Cancer Research Oncology
Partner nations: Canada United States France

In The Last Decade

A. Robert MacLeod

26 papers receiving 2.4k citations

Hit Papers

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What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2002 DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

Peers

Countries citing papers authored by A. Robert MacLeod

Since Specialization

Citations

This map shows the geographic impact of A. Robert MacLeod's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by A. Robert MacLeod with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites A. Robert MacLeod more than expected).

Fields of papers citing papers by A. Robert MacLeod

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by A. Robert MacLeod. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by A. Robert MacLeod. The network helps show where A. Robert MacLeod may publish in the future.

Co-authorship network

The 25 scholars most cited alongside A. Robert MacLeod, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with A. Robert MacLeod Line = papers co-authored together A. Robert MacLeod links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target Massih Ningarhari,Stefano Caruso,Théo Z. Hirsch,Quentin Bayard,Andrea Franconi,Anne‐Laure Védié,Bénédicte Noblet,Jean‐Frédéric Blanc,Giuliana Amaddeo,Nathalie Ganne‐Carrié,Marianne Ziol,Valérie Paradis,Catherine Guettier,Julien Caldéraro,Guillaume Morcrette,Youngsoo Kim,A. Robert MacLeod,Jean‐Charles Nault,Sandra Rebouissou,Jessica Zucman‐Rossi	2020	73
2	Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups Frédéric Gaudette,Stéphane Raeppel,Hannah Nguyen,Normand Beaulieu,Carole Beaulieu,Isabelle Dupont,A. Robert MacLeod,Jeffrey M. Besterman,Arkadii Vaisburg	2010	16
3	Identification of a novel series of potent RON receptor tyrosine kinase inhibitors Stéphane Raeppel,Frédéric Gaudette,Michael R. Mannion,Stephen Claridge,Oscar Saavedra,Ljubomir Isakovic,Robert Déziel,Normand Beaulieu,Carole Beaulieu,Isabelle Dupont,Hannah Nguyen,Jinru Wang,A. Robert MacLeod,Christiane R. Maroun,Jeffrey M. Besterman,Arkadii Vaisburg	2010	11
4	N3-Arylmalonamides: A new series of thieno[3,2-b]pyridine based inhibitors of c-Met and VEGFR2 tyrosine kinases Oscar Saavedra,Stephen Claridge,Lijie Zhan,Franck Raeppel,Marie‐Claude Granger,Stéphane Raeppel,Michael R. Mannion,Frédéric Gaudette,Nancy Zhou,Ljubomir Isakovic,Naomy Bernstein,Robert Déziel,Hannah Nguyen,Normand Beaulieu,Carole Beaulieu,Isabelle Dupont,Jinru Wang,A. Robert MacLeod,Jeffrey M. Besterman,Arkadii Vaisburg	2009	24
5	SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes Oscar M. Saavedra,Ljubomir Isakovic,David B. Llewellyn,Lijie Zhan,Naomy Bernstein,Stephen Claridge,Franck Raeppel,Arkadii Vaisburg,Nadine H. Elowe,Andrea J. Petschner,Jubrail Rahil,Norman Beaulieu,A. Robert MacLeod,Daniel Delorme,Jeffrey M. Besterman,Amal Wahhab	2009	35
6	Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors Ljubomir Isakovic,Oscar M. Saavedra,David B. Llewellyn,Stephen Claridge,Lijie Zhan,Naomy Bernstein,Arkadii Vaisburg,Nadine H. Elowe,Andrea J. Petschner,Jubrail Rahil,Norman Beaulieu,France Gauthier,A. Robert MacLeod,Daniel Delorme,Jeffrey M. Besterman,Amal Wahhab	2009	44
7	MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo Marielle Fournel,Claire Bonfils,Yu Hou,Pu Yan,Marie-Claude Trachy-Bourget,Ann Kalita,Jianhong Liu,Aihua Lu,Nancy Z. Zhou,Marie‐France Robert,Jeffrey Gillespie,Jinru Wang,Hélène Ste-Croix,Jubrail Rahil,Sylvain Lefèbvre,Oscar Moradei,Daniel Delorme,A. Robert MacLeod,Jeffrey M. Besterman,Zuomei Li	2008	271
8	N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1) Martin Allan,Sukhdev Manku,Éric Therrien,Natalie Nguyen,Sylvia Styhler,Marie‐France Robert,Anne-Christine Goulet,Andrea J. Petschner,Gabi Rahil,A. Robert MacLeod,Robert Déziel,Jeffrey M. Besterman,Hannah Nguyen,Amal Wahhab	2008	69
9	Overcoming Resistance to Interferon-Induced Apoptosis of Renal Carcinoma and Melanoma Cells by DNA Demethylation Frederic J. Reu,Soo In Bae,Leonid Cherkassky,Douglas W. Leaman,Daniel J. Lindner,Normand Beaulieu,A. Robert MacLeod,Ernest C. Borden	2006	97
10	Release of Methyl CpG Binding Proteins and Histone Deacetylase 1 from the Estrogen Receptor α (ER) Promoter upon Reactivation in ER-Negative Human Breast Cancer Cells Dipali Sharma,Julie Blum,Xiaowei Yang,Normand Beaulieu,A. Robert MacLeod,Nancy E. Davidson	2005	128
11	(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors Arkadii Vaisburg,Naomy Bernstein,Sylvie Fréchette,Martin Allan,Elie Abou-Khalil,Silvana Leit,Oscar Moradei,Giliane Bouchain,Jinru Wang,Soon Hyung Woo,Marielle Fournel,Pu Yan,Marie-Claude Trachy-Bourget,Ann Kalita,Carole Beaulieu,Zuomei Li,A. Robert MacLeod,Jeffrey M. Besterman,Daniel Delorme	2003	21
12	A phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly David J. Stewart,Ross C. Donehower,Elizabeth A. Eisenhauer,Nancy Wainman,Ajit Shah,Claire Bonfils,A. Robert MacLeod,Jeffrey M. Besterman,Gregory K. Reid	2003	77
13	Development of Potential Antitumor Agents. Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivatives as Histone Deacetylase Inhibitors Giliane Bouchain,Silvana Leit,Sylvie Fréchette,Elie Abou Khalil,Rico Lavoie,Oscar Moradei,Soon Hyung Woo,Marielle Fournel,Pu Yan,Ann Kalita,Marie-Claude Trachy-Bourget,Carole Beaulieu,Zuomei Li,Marie‐France Robert,A. Robert MacLeod,Jeffrey M. Besterman,Daniel Delorme	2003	52
14	DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cellsbreakdown → Marie‐France Robert,Steves Morin,Normand Beaulieu,France Gauthier,Ian C. Chute,Annie Barsalou,A. Robert MacLeod	2002	507
15	An Essential Role for DNA Methyltransferase DNMT3B in Cancer Cell Survival Normand Beaulieu,Steves Morin,Ian C. Chute,Marie‐France Robert,Hannah Nguyen,A. Robert MacLeod	2002	124
16	Characterization of the Human DNA Methyltransferase Splice Variant Dnmt1b Claire Bonfils,Normand Beaulieu,Eric Y. Chan,Judith Cotton-Montpetit,A. Robert MacLeod	2000	33
17	Down-regulation of Human DNA-(Cytosine-5) Methyltransferase Induces Cell Cycle Regulators p16 and p21WAF/Cip1 by Distinct Mechanisms Marielle Fournel,Przemysław Sapieha,Normand Beaulieu,Jeffrey M. Besterman,A. Robert MacLeod	1999	93
18	Regulation of DNA Methylation by the Ras Signaling Pathway A. Robert MacLeod,Julie Rouleau,Moshe Szyf	1995	161
19	Expression of Antisense to DNA Methyltransferase mRNA Induces DNA Demethylation and Inhibits Tumorigenesis A. Robert MacLeod,Moshe Szyf	1995	140
20	Regulation of the DNA Methyltransferase by the Ras-AP-1 Signaling Pathway Julie Rouleau,A. Robert MacLeod,Moshe Szyf	1995	119

About A. Robert MacLeod

A. Robert MacLeod is a scholar working on Aging, Molecular Biology and Hepatology, having authored 26 papers that have together received 2.5k indexed citations. Recurring topics across this work include Epigenetics and DNA Methylation (18 papers), Cancer-related gene regulation (10 papers), RNA modifications and cancer (8 papers), Histone Deacetylase Inhibitors Research (5 papers), Protein Degradation and Inhibitors (4 papers), Genomics and Chromatin Dynamics (3 papers), interferon and immune responses (2 papers) and Liver physiology and pathology (2 papers). The work is most often cited by research in Molecular Biology (2.2k citations), Cancer Research (233 citations) and Oncology (353 citations). A. Robert MacLeod has collaborated with scholars based in Canada, United States and France. Frequent co-authors include Moshe Szyf, Normand Beaulieu, Marie‐France Robert, Steves Morin, Ian C. Chute, France Gauthier, Annie Barsalou, Jeffrey M. Besterman, Marielle Fournel and Claire Bonfils.

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