Yoshihiko Kotake

2.0k total citations · 1 hit paper
22 papers, 1.5k citations indexed

About

Yoshihiko Kotake is a scholar working on Molecular Biology, Organic Chemistry and Biotechnology. According to data from OpenAlex, Yoshihiko Kotake has authored 22 papers receiving a total of 1.5k indexed citations (citations by other indexed papers that have themselves been cited), including 14 papers in Molecular Biology, 11 papers in Organic Chemistry and 4 papers in Biotechnology. Recurrent topics in Yoshihiko Kotake's work include Synthetic Organic Chemistry Methods (6 papers), Cancer therapeutics and mechanisms (4 papers) and Marine Sponges and Natural Products (4 papers). Yoshihiko Kotake is often cited by papers focused on Synthetic Organic Chemistry Methods (6 papers), Cancer therapeutics and mechanisms (4 papers) and Marine Sponges and Natural Products (4 papers). Yoshihiko Kotake collaborates with scholars based in Japan and United States. Yoshihiko Kotake's co-authors include Koji Sagane, Yoshiharu Mizui, Takashi Owa, Mai Uesugi, Masao Iwata, Hajime Shimizu, Yasushi Ishihama, Yuko Mimori‐Kiyosue, Jun Niijima and Akira Yokoi and has published in prestigious journals such as Angewandte Chemie International Edition, Cancer Research and Journal of Medicinal Chemistry.

In The Last Decade

Yoshihiko Kotake

20 papers receiving 1.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Splicing factor SF3b as a target of the antitumor natural product pladienolide

2007 500 citations Yoshihiko Kotake, Koji Sagane et al. Nature Chemical Biology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Yoshihiko Kotake Japan	14	1.1k	481	181	124	100	22	1.5k
Alexandre A. Pletnev United States	16	1.0k 0.9×	781 1.6×	344 1.9×	52 0.4×	69 0.7×	23	1.8k
Siavosh Mahboobi Germany	26	1.0k 0.9×	858 1.8×	369 2.0×	113 0.9×	120 1.2×	76	1.8k
Yijun Huang China	17	565 0.5×	696 1.4×	130 0.7×	97 0.8×	115 1.1×	26	1.2k
Edwin J. Iwanowicz United States	20	574 0.5×	560 1.2×	97 0.5×	37 0.3×	75 0.8×	43	1.0k
Juiwanna Kushner United States	22	697 0.6×	389 0.8×	140 0.8×	54 0.4×	64 0.6×	31	1.1k
Stacy Remiszewski United States	18	910 0.8×	341 0.7×	211 1.2×	107 0.9×	45 0.5×	24	1.2k
Tsuneji Suzuki Japan	10	995 0.9×	302 0.6×	353 2.0×	62 0.5×	47 0.5×	18	1.3k
Kanami Yamazaki Japan	17	892 0.8×	238 0.5×	334 1.8×	46 0.4×	203 2.0×	27	1.4k
Mikel P. Moyer United States	19	2.1k 1.8×	371 0.8×	193 1.1×	45 0.4×	141 1.4×	28	2.5k
Nadim Jessani United States	9	909 0.8×	426 0.9×	388 2.1×	106 0.9×	222 2.2×	10	1.3k

Countries citing papers authored by Yoshihiko Kotake

Since Specialization

Citations

This map shows the geographic impact of Yoshihiko Kotake's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Yoshihiko Kotake with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Yoshihiko Kotake more than expected).

Fields of papers citing papers by Yoshihiko Kotake

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Yoshihiko Kotake. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Yoshihiko Kotake. The network helps show where Yoshihiko Kotake may publish in the future.

Co-authorship network of co-authors of Yoshihiko Kotake

This figure shows the co-authorship network connecting the top 25 collaborators of Yoshihiko Kotake. A scholar is included among the top collaborators of Yoshihiko Kotake based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Yoshihiko Kotake. Yoshihiko Kotake is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

1.

Kamiyama, Hiroshi, Koji Sagane, Hiroshi Azuma, et al.. (2025). Target Identification of Marine Natural Product Odoamide:Odoamide Induces Apoptotic Cell Death by Targeting ATPase Na⁺/K⁺ Transporting Subunit Alpha 1 (ATP1A1). ChemBioChem. 26(6). e202400762–e202400762.

2.

Uehara, Taisuke, Yukinori Minoshima, Koji Sagane, et al.. (2017). Selective degradation of splicing factor CAPERα by anticancer sulfonamides. Nature Chemical Biology. 13(6). 675–680. 279 indexed citations

3.

Huang, Kuan‐Chun, Zhihong Chen, Yimin Jiang, et al.. (2016). Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61. Molecular Cancer Therapeutics. 15(6). 1208–1216. 55 indexed citations

4.

Yamane, Yoshinobu, Setsuo Funasaka, Keigo Tanaka, et al.. (2014). Synthesis and structure–activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorganic & Medicinal Chemistry. 22(19). 5513–5529. 3 indexed citations

5.

Yokoi, Akira, Yoshihiko Kotake, Kentaro Takahashi, et al.. (2011). Biological validation that SF3b is a target of the antitumor macrolide pladienolide. FEBS Journal. 278(24). 4870–4880. 140 indexed citations

6.

Okamoto, Kiyoshi, Daisuke Ito, Kazuki Miyazaki, et al.. (2011). Microregional antitumor activity of a small-molecule hypoxia-inducible factor 1 inhibitor. International Journal of Molecular Medicine. 29(4). 541–549. 9 indexed citations

7.

Kotake, Yoshihiko. (2009). Chemical Approaches to a Novel Antitumor Natural Product Pladienolide. Journal of Synthetic Organic Chemistry Japan. 67(11). 1144–1151.

8.

Kotake, Yoshihiko, Daisuke Kaida, Yoshiharu Mizui, & Minoru Yoshida. (2008). [Discovery of splicing inhibitors and its impact on drug development].. PubMed. 53(1). 28–35. 2 indexed citations

9.

Iwata, Masao, Toshimitsu Uenaka, Yoichi Ozawa, et al.. (2007). E7107: Antitumor activity on human SCLC and cervical cancer xenografts in relation to its potential predictive markers of response.. Cancer Research. 67. 5608–5608. 1 indexed citations

10.

Itoh, Daisuke, Mitsuo Nagai, Jun Niijima, et al.. (2007). Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D. Angewandte Chemie International Edition. 46(46). 8734–8734. 4 indexed citations

11.

Kotake, Yoshihiko, Koji Sagane, Takashi Owa, et al.. (2007). Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nature Chemical Biology. 3(9). 570–575. 500 indexed citations breakdown →

12.

Itoh, Daisuke, Mitsuo Nagai, Jun Niijima, et al.. (2007). Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D. Angewandte Chemie. 119(23). 4428–4433. 13 indexed citations

13.

Asai, Naoki, Yoshihiko Kotake, Jun Niijima, et al.. (2007). Stereochemistry of Pladienolide B. The Journal of Antibiotics. 60(6). 364–369. 30 indexed citations

14.

Itoh, Daisuke, Mitsuo Nagai, Jun Niijima, et al.. (2007). Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D. Angewandte Chemie International Edition. 46(23). 4350–4355. 73 indexed citations

15.

Niijima, Jun, Yoshihiko Kotake, Mitsuo Nagai, et al.. (2004). E7107, a new 7-urethane derivative of pladienolide D: Discovery of a novel antitumor agent. Cancer Research. 64. 691–691. 18 indexed citations

16.

Kamata, Junichi, Yoshihiko Kotake, Jun Niijima, et al.. (2004). Synthesis and Evaluation of Novel Pyrimido-Acridone, -Phenoxadine, and -Carbazole as Topoisomerase II Inhibitors. Chemical and Pharmaceutical Bulletin. 52(9). 1071–1081. 27 indexed citations

17.

Nakamura, Katsuji, Toshimitsu Uenaka, Takeshi Nagasu, et al.. (2003). A novel carbazole topoisomerase II poison, ER‐37328: potent tumoricidal activity against human solid tumors in vitro and in vivo. Cancer Science. 94(1). 119–124. 15 indexed citations

18.

Nakamura, Katsuji, Hiroyuki Sugumi, Atsumi Yamaguchi, et al.. (2002). Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.. PubMed. 1(3). 169–75. 21 indexed citations

19.

Yoshino, Hiroshi, Norihiro Ueda, Jun Niijima, et al.. (1992). Novel sulfonamides as potential, systemically active antitumor agents. Journal of Medicinal Chemistry. 35(13). 2496–2497. 208 indexed citations

20.

Kimura, Eiichi, Yoshihiko Kotake, Tohru Koike, Mitsuhiko Shionoya, & Motoo Shiro. (1990). A novel cyclam appended with 3-hydroxypridine. An Ambident donor ligand comprising a pyridyl N and a pyridinolate O- donor. Inorganic Chemistry. 29(24). 4991–4996. 29 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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