Dwight Macdonald

1.7k citations

40 papers · 1.2k indexed · h-index 18

Impact in

Pharmacology top 2%
- Cholinesterase and Neurodegenerative Diseases
Organic Chemistry top 5%
- Chemical synthesis and alkaloids
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods

Papers in

Pharmacology 20
- Cholinesterase and Neurodegenerative Diseases 13
Toxicology 4
- Bioactive Compounds and Antitumor Agents 4

Co-authors: Zheng Huang Annette Robichaud France Laliberté Susana Liu Panagiota B. Stamatiou Chi‐Chung Chan S.-L. Catherine Jin Marco Conti
Journals: Bioorganic & Medicinal Chemistry Letters (9 papers)Journal of Medicinal Chemistry (4 papers)Journal of the American Chemical Society (3 papers)Tetrahedron Letters (3 papers)Canadian Journal of Chemistry (3 papers)
Partner nations: Canada United States Netherlands

In The Last Decade

Dwight Macdonald

38 papers receiving 1.1k citations

Peers

Countries citing papers authored by Dwight Macdonald

Since Specialization

Citations

This map shows the geographic impact of Dwight Macdonald's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dwight Macdonald with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dwight Macdonald more than expected).

Fields of papers citing papers by Dwight Macdonald

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dwight Macdonald. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dwight Macdonald. The network helps show where Dwight Macdonald may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Dwight Macdonald, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Dwight Macdonald Line = papers co-authored together Dwight Macdonald links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR Nature Communications ·Loes M. Stevers, M. Wolter, Graeme W. Carlile, Dwight Macdonald, Luc Richard, Yuichi Ikuhara, John W. Hanrahan, David Y. Thomas, Sai Kumar Chakka, Mark L. Peterson, Helmut Thomas, Luc Brunsveld, Christian Ottmann	2022	20
2	Design and synthesis of potent, isoxazole-containing renin inhibitors Bioorganic & Medicinal Chemistry Letters ·P E de Nicola, Wendy Rita Felicie, Elizabeth Cauchon, Austin Chen, Amandine Chefson, Yves Ducharme, Jean‐Pierre Falgueyret, Sébastien Gagné, Erich L. Grimm, Yongxin Han, Robert Houle, В.В. ЯМИЛОВА, Jean-François Lévesque, Dwight Macdonald, Bruce Mackay, D. I. Nazarenko, M. David Percival, Yeeman K. Ramtohul, Hans F. M. Reijnders, Sylvie Toulmond	2012	9
3	The discovery and synthesis of potent zwitterionic inhibitors of renin Bioorganic & Medicinal Chemistry Letters ·Renée Aspiotis, Austin Chen, Elizabeth Cauchon, Daniel Dubé, Jean‐Pierre Falgueyret, Sébastien Gagné, Michel Gallant, Erich L. Grimm, Robert Houle, Hélène Jûteau, В.В. ЯМИЛОВА, Xiaoqian Liu, Jean-François Lévesque, Dwight Macdonald, D. I. Nazarenko, M. David Percival, Patrick Roy, S.M. Soisson, Tom Wu	2011	7
4	Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents Bioorganic & Medicinal Chemistry Letters ·Jean-François Lévesque, Kelly Bleasby, Amandine Chefson, Austin Chen, Daniel Dubé, Yves Ducharme, P E de Nicola, Sébastien Gagné, Michel Gallant, Erich L. Grimm, Michael J. Hafey, Yongxin Han, Robert Houle, В.В. ЯМИЛОВА, Xiaoqian Liu, Dwight Macdonald, Bruce Mackay, Robert Papp, Richard A. Tschirret-Guth	2011	9
5	Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study Bioorganic & Medicinal Chemistry Letters ·Austin Chen, Daniel Dubé, Alan Usher, Sébastien Gagné, Michel Gallant, نیره سلمانی, Erich L. Grimm, Robert Houle, В.В. ЯМИЛОВА, Xiaoqian Liu, P. Manjaly, Dwight Macdonald, Bruce Mackay, David Martín, D. I. Nazarenko, David Powell, Jean-François Lévesque	2010	12
6	Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors Bioorganic & Medicinal Chemistry Letters ·В.В. ЯМИЛОВА, Nathalie Chauret, David Claveau, Stephen H. Day, Denis Deschênes, Daniel Dubé, Michel Gallant, Yves Girard, Zheng Huang, France Laliberté, Jean-François Lévesque, Susana Liu, Dwight Macdonald, Joseph A. Mancini, P. Masson, Donald W. Nicholson, Deborah A. Nicoll‐Griffith, Myriam Salem, Angela Styhler, Robert N. Young	2009	2
7	Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein Bioorganic & Medicinal Chemistry Letters ·Dwight Macdonald, Christine Brideau, Chi Chung Chan, Jean‐Pierre Falgueyret, Richard Frenette, Jocelyne Guay, John H. Hutchinson, Hélène Perrier, Lingfen Hong, Denis Riendeau, Philip Tagari, Michel Thérien, Robert N. Young, Yves Girard	2008	13
8	Interspecies in vitro metabolism of the phosphodiesterase‐4 (PDE4) inhibitor L‐454,560 Journal of Mass Spectrometry ·Kevin P. Bateman, Laird A. Trimble, Nathalie Chauret, José Silva, Stephen H. Day, Dwight Macdonald, Daniel Dubé, Michel Gallant, Anthony Mastracchio, Hélène Perrier, Yves Girard, Deborah A. Nicoll‐Griffith	2006	12
9	Neuroanatomical and pharmacological assessment of Fos expression induced in the rat brain by the phosphodiesterase-4 inhibitor 6-(4-pyridylmethyl)-8-(3-nitrophenyl) quinoline Neuropharmacology ·Y Bureau, Mohamad Hassan Rahimi Rad, Zhang Duan, France Laliberté, Craig S. Moore, ABHINAV KUMAR, Zheng Huang, Dwight Macdonald, Daigen Xu, George S. Robertson	2006	16
10	Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors Bioorganic & Medicinal Chemistry Letters ·В.В. ЯМИЛОВА, Denis Deschênes, Daniel Dubé, Alan Usher, Michel Gallant, Dwight Macdonald, Puja Novia Nasution, Hélène Perrier, S. Charleson, Zheng Huang, France Laliberté, Susana Liu, Joseph A. Mancini, P. Masson, Myriam Salem, Angela Styhler, Yves Girard	2006	3
11	Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis Journal of Clinical Investigation ·Annette Robichaud, Panagiota B. Stamatiou, S.-L. Catherine Jin, K Cherniawsky, Dwight Macdonald, France Laliberté, Susana Liu, Zheng Huang, Marco Conti, Chi‐Chung Chan	2002	24
12	Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis Journal of Clinical Investigation ·Annette Robichaud, Panagiota B. Stamatiou, S.-L. Catherine Jin, K Cherniawsky, Dwight Macdonald, France Laliberté, Susana Liu, Zheng Huang, Marco Conti, Chi‐Chung Chan	2002	238
13	The next generation of PDE4 inhibitors Current Opinion in Chemical Biology ·Zheng Huang, Yves Ducharme, Dwight Macdonald, Annette Robichaud	2001	100
14	Substituted furans as inhibitors of the PDE4 enzyme Bioorganic & Medicinal Chemistry Letters ·Hélène Perrier, Christopher I. Bayly, France Laliberté, Zheng Huang, Muhammad M Salameh, Annette Robichaud, Yves Girard, Dwight Macdonald	1999	10
15	Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma Canadian Journal of Physiology and Pharmacology ·Thomas R. Jones, M. McAuliffe, C. S. McFarlane, H. Piechuta, Dwight Macdonald, Ian W. Rodger	1998	18
16	Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization Biochemistry ·Jean‐Pierre Falgueyret, Danielle Denis, Dwight Macdonald, John H. Hutchinson, Avraham Wolfensohn	1995	22
17	Thiopyranol[2,3,4-c,d]indoles as Inhibitors of 5-Lipoxygenase, 5-Lipoxygenase-Activating Protein, and Leukotriene C4 Synthase Journal of Medicinal Chemistry ·John H. Hutchinson, S. Charleson, Jillian F. Evans, Jean‐Pierre Falgueyret, Karst Hoogsteen, Thomas R. Jones, Stacia Kargman, Dwight Macdonald, C. S. McFarlane	1995	34
18	Thiopyrano[2,3,4-cd]indoles as 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2-[2-[1-(4-Chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic Acid Journal of Medicinal Chemistry ·John H. Hutchinson, Denis Riendeau, Christine Brideau, Chi-Chung Chan, Jean‐Pierre Falgueyret, Jocelyne Guay, Tom R. Jones, Wiwit Nugroho, Dwight Macdonald	1994	14
19	Total synthesis of (+)-ikarugamycin. 2. Elaboration of the macrocyclic lactam and tetramic acid substructures and complete assembly of the antibiotic Journal of the American Chemical Society ·Leo A. Paquette, Dwight Macdonald, Lawrence G. Anderson	1990	31
20	Structure of pithecolobine. II Canadian Journal of Chemistry ·K. Wiesner, Dwight Macdonald, Saran Lal A Mokan Dasan, Jody C. Warren	1968	13

About Dwight Macdonald

Dwight Macdonald is a scholar working on Pharmacology, Toxicology, Organic Chemistry, Pharmacology and Molecular Biology, having authored 40 papers that have together received 1.2k indexed citations. Recurring topics across this work include Phosphodiesterase function and regulation (15 papers), Cholinesterase and Neurodegenerative Diseases (13 papers), Receptor Mechanisms and Signaling (9 papers), Chemical synthesis and alkaloids (5 papers), Bioactive Compounds and Antitumor Agents (4 papers), Synthesis and Reactions of Organic Compounds (3 papers), Carbohydrate Chemistry and Synthesis (3 papers) and Chemical Synthesis and Analysis (2 papers). The work is most often cited by research in Pharmacology (391 citations), Organic Chemistry (343 citations), Molecular Biology (769 citations), Physiology (195 citations) and Immunology (149 citations). Dwight Macdonald has collaborated with scholars based in Canada, United States and Netherlands. Frequent co-authors include Zheng Huang, Annette Robichaud, France Laliberté, Susana Liu, Panagiota B. Stamatiou, Chi‐Chung Chan, S.-L. Catherine Jin, Marco Conti, Yves Ducharme and Lawrence G. Anderson. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, Journal of the American Chemical Society, Tetrahedron Letters and Canadian Journal of Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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