Karst Hoogsteen

6.0k total citations · 3 hit papers
66 papers, 4.8k citations indexed

About

Karst Hoogsteen is a scholar working on Organic Chemistry, Molecular Biology and Rheumatology. According to data from OpenAlex, Karst Hoogsteen has authored 66 papers receiving a total of 4.8k indexed citations (citations by other indexed papers that have themselves been cited), including 35 papers in Organic Chemistry, 29 papers in Molecular Biology and 8 papers in Rheumatology. Recurrent topics in Karst Hoogsteen's work include Folate and B Vitamins Research (7 papers), Synthesis and Biological Evaluation (6 papers) and Biochemical and Molecular Research (5 papers). Karst Hoogsteen is often cited by papers focused on Folate and B Vitamins Research (7 papers), Synthesis and Biological Evaluation (6 papers) and Biochemical and Molecular Research (5 papers). Karst Hoogsteen collaborates with scholars based in United States, Canada and Spain. Karst Hoogsteen's co-authors include Martin Poe, Otto D. Hensens, James P. Springer, Myra N. Williams, Byron H. Arison, Jordan Hirshfield, Jerrold M. Liesch, Alfred W. Alberts, Jesse W. Huff and Arthur A. Patchett and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Karst Hoogsteen

66 papers receiving 4.4k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 1.3k citations Otto D. Hensens, Karst Hoogsteen et al. Proceedings of the National Academy of Sciences profile →
The crystal and molecular structure of a hydrogen-bonded complex between 1-methylthymine and 9-methyladenine

1963 343 citations Karst Hoogsteen Acta Crystallographica profile →
The structure of crystals containing a hydrogen-bonded complex of 1-methylthymine and 9-methyladenine

1959 306 citations Karst Hoogsteen Acta Crystallographica profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
Karst Hoogsteen	2.8k	1.4k	881	795	350	66	4.8k
Jeffrey D. Winkler	2.5k 0.9×	3.1k 2.2×	404 0.5×	473 0.6×	182 0.5×	149	6.7k
Kevin T. Chapman	3.5k 1.3×	2.8k 2.0×	403 0.5×	322 0.4×	316 0.9×	82	6.1k
James P. Springer	3.3k 1.2×	3.7k 2.6×	1.0k 1.1×	574 0.7×	302 0.9×	178	7.7k
Xiaoguang Lei	4.5k 1.6×	2.1k 1.5×	947 1.1×	508 0.6×	167 0.5×	208	7.5k
Akiko Itai	2.3k 0.8×	1.6k 1.2×	448 0.5×	156 0.2×	154 0.4×	173	4.9k
A. Ganesan	3.9k 1.4×	2.5k 1.8×	848 1.0×	274 0.3×	152 0.4×	152	6.4k
C. Dale Poulter	8.8k 3.2×	1.8k 1.3×	2.6k 2.9×	514 0.6×	272 0.8×	286	11.0k
George A. Ellestad	3.0k 1.1×	2.4k 1.7×	1.1k 1.2×	397 0.5×	85 0.2×	115	5.8k
Jean‐Yves Lallemand	1.7k 0.6×	1.4k 1.0×	287 0.3×	198 0.2×	205 0.6×	181	4.0k
Scott D. Rychnovsky	2.8k 1.0×	6.8k 4.8×	1.3k 1.4×	1.4k 1.7×	554 1.6×	218	9.2k

Countries citing papers authored by Karst Hoogsteen

Since Specialization

Citations

This map shows the geographic impact of Karst Hoogsteen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karst Hoogsteen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karst Hoogsteen more than expected).

Fields of papers citing papers by Karst Hoogsteen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karst Hoogsteen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karst Hoogsteen. The network helps show where Karst Hoogsteen may publish in the future.

Co-authorship network of co-authors of Karst Hoogsteen

This figure shows the co-authorship network connecting the top 25 collaborators of Karst Hoogsteen. A scholar is included among the top collaborators of Karst Hoogsteen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Karst Hoogsteen. Karst Hoogsteen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Hutchinson, John H., S. Charleson, Jillian F. Evans, et al.. (1995). Thiopyranol[2,3,4-c,d]indoles as Inhibitors of 5-Lipoxygenase, 5-Lipoxygenase-Activating Protein, and Leukotriene C4 Synthase. Journal of Medicinal Chemistry. 38(22). 4538–4547. 34 indexed citations

Lewis, Richard T., Angus M. MacLeod, Kevin J. Merchant, et al.. (1995). Tryptophan-Derived NK1 Antagonists: Conformationally Constrained Heterocyclic Bioisosteres of the Ester Linkage. Journal of Medicinal Chemistry. 38(6). 923–933. 50 indexed citations

Leeson, Paul D., Robert W. Carling, Kevin W. Moore, et al.. (1992). 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor. Journal of Medicinal Chemistry. 35(11). 1954–1968. 162 indexed citations

Trost, Barry M., et al.. (1992). Cyclorearrangement and cycloolefination of keto-bis-sulfones. A sulfone analog of a pinacol reduction-rearrangement. Journal of the American Chemical Society. 114(13). 5432–5434. 19 indexed citations

Chabala, John C., Virginia B. Waits, Theodore J. Ikeler, et al.. (1991). 1-(Substituted)benzyl-5-aminoimidazole-4-carboxamides are potent orally active inhibitors ofTrypanosoma cruzi in mice. Cellular and Molecular Life Sciences. 47(1). 51–53. 8 indexed citations

Mathre, David J., Todd K. Jones, Lyndon C. Xavier, et al.. (1991). A practical enantioselective synthesis of .alpha.,.alpha.-diaryl-2-pyrrolidinemethanol. Preparation and chemistry of the corresponding oxazaborolidines. The Journal of Organic Chemistry. 56(2). 751–762. 180 indexed citations

Cottrell, Ian F., et al.. (1991). A synthesis of 1-azabicyclo[2.2.1]heptane-3-carboxylic acid esters in enantiomerically pure form. Journal of the Chemical Society Perkin Transactions 1. 1091–1091. 13 indexed citations

Bélanger-Gariépy, F., Karst Hoogsteen, Vijay Kumar Sharma, & James D. Wuest. (1991). Multidentate Lewis acids. Synthesis and structure of complex aluminum chloride alkoxides. Inorganic Chemistry. 30(22). 4140–4145. 19 indexed citations

Rupprecht, Kathleen M., Joshua Boger, Karst Hoogsteen, Robert B. Nachbar, & James P. Springer. (1991). Controlling the stereochemistry of the ring junction in hexahydrodibenzofurans. The Journal of Organic Chemistry. 56(21). 6180–6188. 29 indexed citations

10.

Leblanc, Yves, et al.. (1991). Synthesis of 2-amino C-glucosides and 2-amino C-glucosides spiroketals. Tetrahedron Letters. 32(38). 5021–5024. 24 indexed citations

11.

GAUTHIER, J. Y., Thomas R. Jones, Éric Champion, et al.. (1990). Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leukotriene D4 receptor antagonist. Journal of Medicinal Chemistry. 33(10). 2841–2845. 25 indexed citations

12.

Navia, Manuel A., Brian M. McKeever, James P. Springer, et al.. (1989). Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.. Proceedings of the National Academy of Sciences. 86(1). 7–11. 205 indexed citations

13.

Poe, Martin, et al.. (1984). Mouse submaxillary gland renin. Purification and properties of minor forms, which include several differently processed forms of the major gene product and a second gene product.. Journal of Biological Chemistry. 259(13). 8358–8362. 7 indexed citations

14.

Navia, Manuel A., James P. Springer, Martin Poe, Joshua Boger, & Karst Hoogsteen. (1984). Preliminary X-ray crystallographic data on mouse submaxillary gland renin and renin-inhibitor complexes.. Journal of Biological Chemistry. 259(20). 12714–12717. 17 indexed citations

15.

Poe, Martin, et al.. (1981). Models for the Binding of Methotrexate to Escherichia coli Dihydrofolate Reductase. Molecular Pharmacology. 20(1). 154–158. 2 indexed citations

16.

Poe, Martin, Otto D. Hensens, & Karst Hoogsteen. (1979). 5-Methyl-5,6,7,8-tetrahydrofolic acid. Conformation of the tetrahydropyrazine ring.. Journal of Biological Chemistry. 254(21). 10881–10884. 10 indexed citations

17.

Poe, Martin, et al.. (1977). Calculations by Complete Neglect of Differential Overlap (CNDO/2) on Dihydrofolic Acid: Role of N(5) in Reduction by Dihydrofolate Reductase. Molecular Pharmacology. 13(6). 1111–1115. 8 indexed citations

18.

Shigeura, Harold T., et al.. (1975). Metabolic studies on diphenylsulfone derivatives in chick macrophages. Biochemical Pharmacology. 24(6). 687–691. 10 indexed citations

19.

Arison, Byron H. & Karst Hoogsteen. (1970). Nuclear magnetic resonance spectral studies on actinomycin D. Preliminary observations on the effect of complex formation with 5'-deoxyguanylic acid. Biochemistry. 9(20). 3976–3983. 52 indexed citations

20.

Hoogsteen, Karst. (1963). The crystal structure of 1-methylthymine. Acta Crystallographica. 16(1). 28–38. 104 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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