Angela Styhler

900 citations

19 papers · 482 indexed · h-index 14

Impact in

Pharmacology top 10%
- Inflammatory mediators and NSAID effects
- Cholinesterase and Neurodegenerative Diseases
Biochemistry
- Eicosanoids and Hypertension Pharmacology

Papers in ⓘ

Pharmacology 10
- Cholinesterase and Neurodegenerative Diseases 6
- Inflammatory mediators and NSAID effects 3
Biochemistry 4
- Eicosanoids and Hypertension Pharmacology 3

Co-authors: James G. Martin (5 shared papers)Christine Brideau (4 shared papers)Joseph A. Mancini (8 shared papers)Zheng Huang (6 shared papers)Ying Zhang (1 shared paper)William S. Powell (1 shared paper)Chi‐Chung Chan (2 shared papers)Ian W. Rodger (1 shared paper)
Journals: Bioorganic & Medicinal Chemistry Letters (8 papers)Journal of Pharmacology and Experimental Therapeutics (2 papers)American Journal of Respiratory and Critical Care Medicine (2 papers)SLAS DISCOVERY (1 paper)ACS Medicinal Chemistry Letters (1 paper)
Partner nations: Canada United States

In The Last Decade

Angela Styhler

19 papers receiving 466 citations

Peers

Countries citing papers authored by Angela Styhler

Since Specialization

Citations

This map shows the geographic impact of Angela Styhler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Angela Styhler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Angela Styhler more than expected).

Fields of papers citing papers by Angela Styhler

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Angela Styhler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Angela Styhler. The network helps show where Angela Styhler may publish in the future.

Co-authors

The 25 scholars most cited alongside Angela Styhler, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Angela Styhler Line = papers co-authored together Angela Styhler links everyone, so they are left out of the graph.

All Works

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19 of 19 papers shown

#	Work
1	Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor Journal of Pharmacology and Experimental Therapeutics ·David Claveau, S L Chen, Stephen J. O’Keefe, Dennis M. Zaller, Angela Styhler, S. Liu, Zheng Huang, Donald W. Nicholson, Joseph A. Mancini	2004	79
2	The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor ACS Medicinal Chemistry Letters ·Yves Ducharme, Marc Blouin, Christine Brideau, Anne Châteauneuf, Yves Gareau, Erich L. Grimm, Hélène Jûteau, Sébastien Laliberté, Bruce Mackay, Frédéric Massé, Marc Ouellet, Myriam Salem, Angela Styhler, Richard W. Friesen	2010	70
3	The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B₄ in a novel human whole blood assay British Journal of Pharmacology ·Christine Brideau, Carlo van Staden, Angela Styhler, Ian W. Rodger, Chi‐Chung Chan	1999	60
4	Synthesis of 5-oxo-6,8, 11, 14-eicosatetraenoic acid by human monocytes and lymphocytes Journal of Leukocyte Biology ·Ying Zhang, Angela Styhler, William S. Powell	1996	39
5	In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663) Bioorganic & Medicinal Chemistry Letters ·Nathalie Chauret, James A. Yergey, Christine Brideau, Richard W. Friesen, Joseph A. Mancini, Denis Riendeau, José M. Silva, Angela Styhler, Laird A. Trimble, Deborah A. Nicoll‐Griffith	2001	36
6	Antiproliferative effect of prostaglandin E2 in cultured guinea pig tracheal smooth muscle cells American Journal of Physiology-Lung Cellular and Molecular Physiology ·C. Florio, James G. Martin, Angela Styhler, S. Heisler	1994	33
7	Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2 Bioorganic & Medicinal Chemistry Letters ·Denis Riendeau, Myriam Salem, Angela Styhler, Marc Ouellet, Joseph A. Mancini, Chun Sing Li	2004	21
8	Increased Maximal Pulmonary Response to Methacholine and Airway Smooth Muscle in Immature Compared with Mature Rabbits American Journal of Respiratory and Critical Care Medicine ·Robert S. Tepper, Tao Du, Angela Styhler, Mara S. Ludwig, James G. Martin	1995	19
9	Increased Maximal Pulmonary Response to Methacholine and Airway Smooth Muscle in Immature Compared with Mature Rabbits American Journal of Respiratory and Critical Care Medicine ·Robert S. Tepper, Tao Du, Angela Styhler, Mara S. Ludwig, James G. Martin	1995	18
10	A comparison of breathlessness during spontaneous asthma and histamine-induced bronchoconstriction. PubMed ·Denise M. Boudreau, Angela Styhler, Katherine Gray‐Donald, James G. Martin	1995	17
11	Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy Bioorganic & Medicinal Chemistry Letters ·David Powell, W. Cameron Black, Kelly Bleasby, Chi‐Chung Chan, Denis Deschênes, Marc Gagnon, R.A. Gordon, Jocelyne Guay, Sébastien Guiral, Michael J. Hafey, Zheng Huang, Élise Isabel, Yves Leblanc, Angela Styhler, Lijing Xu, Lei Zhang, Renata M. Oballa	2011	15
12	Peripheral Phosphodiesterase 4 Inhibition Produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) Prevents Experimental Autoimmune Encephalomyelitis Journal of Pharmacology and Experimental Therapeutics ·Craig S. Moore, N. Earl, Richard Frenette, Angela Styhler, Joseph A. Mancini, Donald W. Nicholson, Andrea L.O. Hebb, Trevor Owens, George S. Robertson	2006	14
13	A Multiplexed Cell Assay in HepG2 Cells for the Identification of Delta-5, Delta-6, and Delta-9 Desaturase and Elongase Inhibitors SLAS DISCOVERY ·Lei Zhang, Yeeman K. Ramtohul, Sébastien Gagné, Angela Styhler, Hao Wang, Jocelyne Guay, Zheng Huang	2010	14
14	Optimization and structure–activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: Identification of MK-0873, a potent and effective PDE4 inhibitor Bioorganic & Medicinal Chemistry Letters ·Daniel Guay, Louise Boulet, Richard W. Friesen, Mario Girard, Pierre Hamel, Zheng Huang, France Laliberté, Sébastien Laliberté, Joseph A. Mancini, Eric S. Muise, Doug Pon, Angela Styhler	2008	13
15	Substituted 2-Pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors Bioorganic & Medicinal Chemistry Letters ·Yves Ducharme, Richard W. Friesen, Marc Blouin, Bernard Côté, Daniel Dubé, Diane Ethier, Richard Frenette, France Laliberté, Joseph A. Mancini, P. Masson, Angela Styhler, Robert N. Young, Yves Girard	2003	12
16	Mechanical Responses of Tracheal Tissue In Vitro: Dependance on the Tissue Preparation Employed and Relationship to Smooth Muscle Content Pulmonary Pharmacology ·Chiara Florio, Angela Styhler, Seymour Heisler, James G. Martin	1996	10
17	Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors Bioorganic & Medicinal Chemistry Letters ·Bernard Côté, Richard Frenette, Sylvie Prescott, Marc Blouin, Christine Brideau, Yves Ducharme, Richard W. Friesen, France Laliberté, P. Masson, Angela Styhler, Yves Girard	2003	7
18	Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors Bioorganic & Medicinal Chemistry Letters ·Patrick Lacombe, Denis Deschênes, Daniel Dubé, Laurence Dubé, Michel Gallant, Dwight Macdonald, Antony Mastracchio, Hélène Perrier, S. Charleson, Zheng Huang, France Laliberté, Susana Liu, Joseph A. Mancini, P. Masson, Myriam Salem, Angela Styhler, Yves Girard	2006	3
19	Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors Bioorganic & Medicinal Chemistry Letters ·Patrick Lacombe, Nathalie Chauret, David Claveau, Stephen H. Day, Denis Deschênes, Daniel Dubé, Michel Gallant, Yves Girard, Zheng Huang, France Laliberté, Jean-François Lévesque, Susana Liu, Dwight Macdonald, Joseph A. Mancini, P. Masson, Donald W. Nicholson, Deborah A. Nicoll‐Griffith, Myriam Salem, Angela Styhler, Robert N. Young	2009	2

About Angela Styhler

Angela Styhler is a scholar working on Pharmacology, Biochemistry, Physiology, Physiology and Anesthesiology and Pain Medicine, having authored 19 papers that have together received 482 indexed citations. Recurring topics across this work include Phosphodiesterase function and regulation (8 papers), Cholinesterase and Neurodegenerative Diseases (6 papers), Asthma and respiratory diseases (6 papers), Receptor Mechanisms and Signaling (4 papers), Eicosanoids and Hypertension Pharmacology (3 papers), Respiratory and Cough-Related Research (3 papers), Inflammatory mediators and NSAID effects (3 papers) and Mast cells and histamine (2 papers). The work is most often cited by research in Pharmacology (137 citations), Biochemistry (42 citations), Physiology (132 citations), Organic Chemistry (120 citations) and Immunology (78 citations). Angela Styhler has collaborated with scholars based in Canada and United States. Frequent co-authors include James G. Martin, Christine Brideau, Joseph A. Mancini, Zheng Huang, Ying Zhang, William S. Powell, Chi‐Chung Chan, Ian W. Rodger, Carlo van Staden and Richard W. Friesen. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Journal of Pharmacology and Experimental Therapeutics, American Journal of Respiratory and Critical Care Medicine, SLAS DISCOVERY and ACS Medicinal Chemistry Letters.

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