Douglas R. Spitz

28.5k total citations · 6 hit papers
300 papers, 22.1k citations indexed

About

Douglas R. Spitz is a scholar working on Molecular Biology, Cancer Research and Nutrition and Dietetics. According to data from OpenAlex, Douglas R. Spitz has authored 300 papers receiving a total of 22.1k indexed citations (citations by other indexed papers that have themselves been cited), including 162 papers in Molecular Biology, 50 papers in Cancer Research and 35 papers in Nutrition and Dietetics. Recurrent topics in Douglas R. Spitz's work include Glutathione Transferases and Polymorphisms (47 papers), Cancer, Hypoxia, and Metabolism (37 papers) and Redox biology and oxidative stress (36 papers). Douglas R. Spitz is often cited by papers focused on Glutathione Transferases and Polymorphisms (47 papers), Cancer, Hypoxia, and Metabolism (37 papers) and Redox biology and oxidative stress (36 papers). Douglas R. Spitz collaborates with scholars based in United States, Canada and Jordan. Douglas R. Spitz's co-authors include Larry W. Oberley, David Gius, Nükhet Aykin‐Burns, Iman M. Ahmad, Mitchell C. Coleman, Julia Sim, Edouard I. Azzam, Jian Jian Li, Garry R. Buettner and Bryan G. Allen and has published in prestigious journals such as Nature, Cell and Journal of Biological Chemistry.

In The Last Decade

Douglas R. Spitz

292 papers receiving 21.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

2008 881 citations Jeffrey R. Erickson, Mei-ling A. Joiner et al. Cell profile →
Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

2010 735 citations Douglas R. Spitz, David Gius et al. profile →
An assay for superoxide dismutase activity in mammalian tissue homogenates

1989 659 citations Douglas R. Spitz, Larry W. Oberley profile →
SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

2010 647 citations Nükhet Aykin‐Burns, Douglas R. Spitz et al. profile →
Lymph protects metastasizing melanoma cells from ferroptosis

2020 625 citations Michael L. McCormick, Douglas R. Spitz et al. profile →
Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology

2004 559 citations Douglas R. Spitz, Jian Jian Li et al. profile →

Peers

Douglas R. Spitz

PHYSI

PRM

ONCOL

Shinya Toyokuni Japan

Larry W. Oberley United States

Valerian E. Kagan United States

Kôji Uchida Japan

James K. Liao United States

Lawrence J. Marnett United States

Yau‐Huei Wei Taiwan

Balaraman Kalyanaraman United States

Robert E. Gerszten United States

Zheng Dong United States

Shinya Toyokuni Japan

Douglas R. Spitz

11.0k ×0.9

2.6k ×0.7

1.5k ×0.5

PHYSI

3.0k ×1.3

PRM

1.6k ×0.7

ONCOL

Citations per year, relative to Douglas R. Spitz Douglas R. Spitz (= 1×) peers Shinya Toyokuni

Countries citing papers authored by Douglas R. Spitz

Since Specialization

Citations

This map shows the geographic impact of Douglas R. Spitz's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Douglas R. Spitz with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Douglas R. Spitz more than expected).

Fields of papers citing papers by Douglas R. Spitz

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Douglas R. Spitz. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Douglas R. Spitz. The network helps show where Douglas R. Spitz may publish in the future.

Co-authorship network of co-authors of Douglas R. Spitz

This figure shows the co-authorship network connecting the top 25 collaborators of Douglas R. Spitz. A scholar is included among the top collaborators of Douglas R. Spitz based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Douglas R. Spitz. Douglas R. Spitz is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Geasland, Katharine, et al.. (2025). Mitochondrial oxidants promote platelet activation and thrombotic susceptibility in prediabetes. Journal of Clinical Investigation. 136(4).

Fath, Melissa A., Charles Searby, Jeffrey M. Stolwijk, et al.. (2023). Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer. Antioxidants. 12(11). 2005–2005. 7 indexed citations

Sonkar, Vijay K., Alicia S. Eustes, Azaj Ahmed, et al.. (2022). Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging. Arteriosclerosis Thrombosis and Vascular Biology. 43(1). 79–91. 29 indexed citations

Zhang, Chunyun, Michael L. McCormick, Douglas R. Spitz, et al.. (2021). The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice. Toxicological Sciences. 186(1). 102–117. 6 indexed citations

O’Leary, Brianne R., Juan Du, Ehab H. Sarsour, et al.. (2020). Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity. Cancer Research. 80(7). 1401–1413. 30 indexed citations

Park, Julien H., Janine Reunert, Michael L. McCormick, et al.. (2019). SOD1 deficiency: a novel syndrome distinct from amyotrophic lateral sclerosis. Brain. 142(8). 2230–2237. 62 indexed citations

Alexander, Matthew S., Justin G. Wilkes, Garry R. Buettner, et al.. (2018). Pharmacologic Ascorbate Reduces Radiation-Induced Normal Tissue Toxicity and Enhances Tumor Radiosensitization in Pancreatic Cancer. Cancer Research. 78(24). 6838–6851. 89 indexed citations

Rashmi, Ramachandran, Xiaojing Huang, John M. Floberg, et al.. (2018). Radioresistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism. Cancer Research. 78(6). 1392–1403. 68 indexed citations

Mapuskar, Kranti A., Kyle H. Flippo, Joshua D. Schoenfeld, et al.. (2017). Mitochondrial Superoxide Increases Age-Associated Susceptibility of Human Dermal Fibroblasts to Radiation and Chemotherapy. Cancer Research. 77(18). 5054–5067. 31 indexed citations

10.

Du, Juan, John A. Cieslak, Jessemae L. Welsh, et al.. (2015). Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer. Cancer Research. 75(16). 3314–3326. 89 indexed citations

11.

O’Leary, Brianne R., Melissa A. Fath, Andrew M. Bellizzi, et al.. (2015). Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research. 21(7). 1741–1751. 57 indexed citations

12.

Allen, Bryan G., Sudershan K. Bhatia, John M. Buatti, et al.. (2013). Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts. Clinical Cancer Research. 19(14). 3905–3913. 178 indexed citations

13.

Bey, Erik A., Kathryn E. Reinicke, Melissa C. Srougi, et al.. (2013). Catalase Abrogates β-Lapachone–Induced PARP1 Hyperactivation–Directed Programmed Necrosis in NQO1-Positive Breast Cancers. Molecular Cancer Therapeutics. 12(10). 2110–2120. 84 indexed citations

14.

Duru, Nadire, Ming Fan, Demet Candas, et al.. (2012). HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells. Clinical Cancer Research. 18(24). 6634–6647. 169 indexed citations

15.

Love-Homan, Laurie, et al.. (2012). Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism. PLoS ONE. 7(10). e48175–e48175. 63 indexed citations

16.

Fath, Melissa A., et al.. (2011). Enhancement of Carboplatin-Mediated Lung Cancer Cell Killing by Simultaneous Disruption of Glutathione and Thioredoxin Metabolism. Clinical Cancer Research. 17(19). 6206–6217. 100 indexed citations

17.

Erickson, Jeffrey R., Mei-ling A. Joiner, Xiaoqun Guan, et al.. (2008). A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation. Cell. 133(3). 462–474. 881 indexed citations breakdown →

18.

Li, Ling, et al.. (2005). The Role of Low Molecular Weight Thiols in T Lymphocyte Proliferation and IL-2 Secretion. The Journal of Immunology. 175(12). 7965–7972. 72 indexed citations

19.

Bradbury, C. Matthew, Douglas R. Spitz, & David Gius. (2001). Thioredoxin reductase is a novel cytoplasmic signaling factor regulating radiation-induced AP-1 DNA-binding activity and gene expression via active cysteine residues. Free Radical Biology and Medicine. 31(10). 128. 1 indexed citations

20.

Oberley, Larry W. & Douglas R. Spitz. (1984). [61] Assay of superoxide dismutase activity in tumor tissue. Methods in enzymology on CD-ROM/Methods in enzymology. 105. 457–464. 378 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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