David J. Cowan

1.2k citations

12 papers · 831 indexed · 1 hit paper · h-index 10

Co-authors: Robert W. Wiethe Steven A. Kliewer Shimoga R. Prakash Jürgen M. Lehmann Jeffery E. Cobb Timothy M. Willson Linda B. Moore J. David Becherer
Topics: Phosphodiesterase function and regulation (3 papers)Synthesis and Catalytic Reactions (2 papers)Protein Kinase Regulation and GTPase Signaling (2 papers)
Cited by: Biochemistry Molecular Biology Physiology
Journals: Journal of Medicinal Chemistry The Journal of Organic Chemistry Bioorganic & Medicinal Chemistry Letters
Partner nations: United States Netherlands United Kingdom

In The Last Decade

David J. Cowan

12 papers receiving 787 citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

1996 569 citations Timothy M. Willson, Jeffery E. Cobb et al. Journal of Medicinal Chemistry profile →

Peers

Countries citing papers authored by David J. Cowan

Since Specialization

Citations

This map shows the geographic impact of David J. Cowan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David J. Cowan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David J. Cowan more than expected).

Fields of papers citing papers by David J. Cowan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David J. Cowan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David J. Cowan. The network helps show where David J. Cowan may publish in the future.

Co-authorship network of co-authors of David J. Cowan

This figure shows the co-authorship network connecting the top 25 collaborators of David J. Cowan. A scholar is included among the top collaborators of David J. Cowan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David J. Cowan. David J. Cowan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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12 of 12 papers shown

#	Work	Indexed citations
1	Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration 2017 ·Bioorganic & Medicinal Chemistry Letters ·Steven M. Sparks,Paul K. Spearing,(unknown),David J. Cowan,Channa Jayawickreme,Grace Chen,Thomas J. Rimele,(unknown),(unknown),Shane Roller	6
2	Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist 2017 ·Bioorganic & Medicinal Chemistry Letters ·Steven M. Sparks,Christopher Aquino,(unknown),Jon L. Collins,David J. Cowan,(unknown),(unknown),Donald L. Hertzog,Xi Liang,(unknown),Josephine Yuen,Grace Chen,Channa Jayawickreme,(unknown),(unknown),(unknown),Thomas J. Rimele,Shane Roller,Sean Ross	22
3	Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38 2015 ·Journal of Medicinal Chemistry ·J. David Becherer,Eric E. Boros,Tiffany Carpenter,David J. Cowan,David N. Deaton,Curt D. Haffner,Michael R. Jeune,István Káldor,(unknown),Frank Preugschat,Tara Rheault,(unknown),Barry G. Shearer,Todd Shearer,Lisa M. Shewchuk,Terrence L. Smalley,Eugene L. Stewart,J. Darren Stuart,John C. Ulrich	44
4	Enzymatic- and Iridium-Catalyzed Asymmetric Synthesis of a Benzothiazepinylphosphonate Bile Acid Transporter Inhibitor 2013 ·The Journal of Organic Chemistry ·David J. Cowan,Jon L. Collins,Mark B. Mitchell,John A. Ray,Peter W. Sutton,Amy A. Sarjeant,Eric E. Boros	15
5	The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist 2009 ·Acta Crystallographica Section D Biological Crystallography ·Kevin P. Madauss,William Burkhart,Thomas G. Consler,David J. Cowan,William Gottschalk,Aaron B. Miller,Steven A. Short,Thuy Tran,Shawn P. Williams	25
6	Hantzsch Synthesis of Pyrazolo[1‘,2‘:1,2]pyrazolo[3,4-b]pyridines: Partial Agonists of the Calcitonin Receptor 2005 ·The Journal of Organic Chemistry ·Eric E. Boros,David J. Cowan,Richard F. Cox,(unknown),Michael H. Rabinowitz,James B. Thompson,(unknown)	13
7	Substrate Specificity and Novel Selective Inhibitors of TNF-α Converting Enzyme (TACE) from Two-Dimensional Substrate Mapping 2005 ·Combinatorial Chemistry & High Throughput Screening ·Millard H. Lambert,(unknown),Theresa Seaton,Daniel B. Kassel,(unknown),(unknown),(unknown),Janet Warner,(unknown),(unknown),David J. Cowan,Michael D. Gaul,Kimberly G. Petrov,Michael H. Rabinowitz,Robert W. Wiethe,J. David Becherer,Darryl McDougald,David L. Musso,Robert Andrews,Marcia L. Moss	21
8	Design of Selective and Soluble Inhibitors of Tumor Necrosis Factor-α Converting Enzyme (TACE) 2001 ·Journal of Medicinal Chemistry ·Michael H. Rabinowitz,Robert Andrews,J. David Becherer,D. Mark Bickett,(unknown),James G. Conway,David J. Cowan,Micheal D. Gaul,(unknown),Millard H. Lambert,M. Anthony Leesnitzer,Darryl McDougald,Marcia L. Moss,David L. Musso,Michèle Rizzolio	57
9	The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinedionesbreakdown → 1996 ·Journal of Medicinal Chemistry ·Timothy M. Willson,Jeffery E. Cobb,David J. Cowan,Robert W. Wiethe,(unknown),Shimoga R. Prakash,(unknown),Linda B. Moore,Steven A. Kliewer,Jürgen M. Lehmann	569
10	Phosphodiesterase Type IV Inhibition. Structure-Activity Relationships of 1,3-Disubstituted Pyrrolidines 1995 ·Journal of Medicinal Chemistry ·Paul L. Feldman,Marcus F. Brackeen,David J. Cowan,Brian E. Marron,Frank J. Schoenen,Jeffrey A. Stafford,Edward M. Suh,Paul L. Domanico,(unknown)	16
11	Design and Synthesis of Conformationally Constrained Analogs of 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as Potent Inhibitors of cAMP-Specific Phosphodiesterase 1995 ·Journal of Medicinal Chemistry ·Marcus F. Brackeen,David J. Cowan,Jeffrey A. Stafford,Frank J. Schoenen,(unknown),Paul L. Domanico,(unknown),(unknown),Margrith W. Verghese,(unknown)	35
12	Phosphodiesterase type IV (PDE IV) inhibition. Synthesis and evaluation of a series of 1,3,4-trisubstituted pyrrolidines 1995 ·Bioorganic & Medicinal Chemistry Letters ·Jeffrey A. Stafford,(unknown),Paul L. Feldman,(unknown),David J. Cowan,Paul L. Domanico,M. Anthony Leesnitzer,(unknown),Stephen A. Stimpson,(unknown),Rayomand J. Unwalla,Margrith W. Verghese	8

About David J. Cowan

David J. Cowan is a scholar working on Biochemistry, Physiology and Sensory Systems, having authored 12 papers that have together received 831 indexed citations. Recurring topics across this work include Phosphodiesterase function and regulation (3 papers), Synthesis and Catalytic Reactions (2 papers) and Protein Kinase Regulation and GTPase Signaling (2 papers). The work is most often cited by research in Biochemistry (83 citations), Molecular Biology (637 citations) and Physiology (35 citations). David J. Cowan has collaborated with scholars based in United States, Netherlands and United Kingdom. Frequent co-authors include Robert W. Wiethe, Steven A. Kliewer, Shimoga R. Prakash, Jürgen M. Lehmann, Jeffery E. Cobb, Timothy M. Willson, Linda B. Moore, J. David Becherer, Michael H. Rabinowitz and Eric E. Boros. Their work appears in journals such as Journal of Medicinal Chemistry, The Journal of Organic Chemistry and Bioorganic & Medicinal Chemistry Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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