David E. Clapham

73.2k total citations · 27 hit papers
326 papers, 57.4k citations indexed

About

David E. Clapham is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Cardiology and Cardiovascular Medicine. According to data from OpenAlex, David E. Clapham has authored 326 papers receiving a total of 57.4k indexed citations (citations by other indexed papers that have themselves been cited), including 228 papers in Molecular Biology, 94 papers in Cellular and Molecular Neuroscience and 59 papers in Cardiology and Cardiovascular Medicine. Recurrent topics in David E. Clapham's work include Ion channel regulation and function (126 papers), Ion Channels and Receptors (56 papers) and Cardiac electrophysiology and arrhythmias (54 papers). David E. Clapham is often cited by papers focused on Ion channel regulation and function (126 papers), Ion Channels and Receptors (56 papers) and Cardiac electrophysiology and arrhythmias (54 papers). David E. Clapham collaborates with scholars based in United States, Sweden and Germany. David E. Clapham's co-authors include Grigory Krapivinsky, Eva J. Neer, I. Scott Ramsey, Markus Delling, Betsy Navarro, Kevin Wickman, Anthony J. Harmar, Michael Spedding, George A. Gutman and K. George Chandy and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

David E. Clapham

324 papers receiving 56.3k citations

Hit Papers

International Union of Ph... 1987 2026 2000 2013 2003 2007 2003 1995 2005 2.0k 4.0k 6.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
    2003 6.0k citations David E. Clapham et al. profile →
  2. Calcium Signaling
    2007 3.3k citations David E. Clapham Cell profile →
  3. TRP channels as cellular sensors
    2003 2.1k citations David E. Clapham profile →
  4. Calcium signaling
    1995 1.8k citations David E. Clapham Cell profile →
  5. AN INTRODUCTION TO TRP CHANNELS
    2005 1.2k citations Markus Delling, David E. Clapham et al. profile →
  6. The mitochondrial calcium uniporter is a highly selective ion channel
    2004 1.1k citations Grigory Krapivinsky, David E. Clapham et al. profile →
  7. The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart
    1987 983 citations David E. Clapham et al. profile →
  8. The trp ion channel family
    2001 939 citations David E. Clapham, Loren W. Runnels et al. Nature reviews. Neuroscience profile →
  9. Haemodynamic shear stress activates a K+ current in vascular endothelial cells
    1988 783 citations David E. Clapham et al. profile →
  10. A sperm ion channel required for sperm motility and male fertility
    2001 743 citations Dejian Ren, Betsy Navarro et al. profile →
  11. The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins
    1995 716 citations Grigory Krapivinsky, Luba Krapivinsky et al. profile →
  12. TRPV3 is a calcium-permeable temperature-sensitive cation channel
    2002 698 citations Haoxing Xu, David E. Clapham et al. profile →
  13. G PROTEIN βγ SUBUNITS
    1997 682 citations David E. Clapham et al. profile →
  14. Roles of G protein subunits in transmembrane signalling
    1988 667 citations David E. Clapham et al. profile →
  15. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
    2005 647 citations David E. Clapham et al. profile →
  16. TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain
    2001 639 citations Carsten Strübing, Grigory Krapivinsky et al. Neuron profile →
  17. TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities
    2001 618 citations Loren W. Runnels, Lixia Yue et al. Science profile →
  18. Spiral Calcium Wave Propagation and Annihilation in Xenopus laevis Oocytes
    1991 602 citations David E. Clapham et al. Science profile →
  19. New roles for G-protein (βγ-dimers in transmembrane signalling
    1993 526 citations David E. Clapham et al. profile →
  20. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels
    2006 517 citations Haoxing Xu, Markus Delling et al. profile →
  21. EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex
    2013 516 citations David E. Clapham et al. Science profile →
  22. International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family
    2010 459 citations David E. Clapham et al. profile →
  23. TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes
    2012 419 citations Xian‐Ping Dong, Mohammad Samie et al. Cell profile →
  24. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
    2012 401 citations Paul G. DeCaen, David E. Clapham et al. profile →
  25. Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel
    1994 382 citations Grigory Krapivinsky, David E. Clapham et al. profile →
  26. Rheotaxis Guides Mammalian Sperm
    2013 334 citations Kiyoshi Miki, David E. Clapham profile →
  27. International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels
    2005 316 citations David E. Clapham et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
David E. Clapham 33.0k 17.0k 12.5k 6.1k 5.8k 326 57.4k
Michael J. Berridge 42.2k 1.3× 19.2k 1.1× 7.1k 0.6× 4.2k 0.7× 3.5k 0.6× 210 65.7k
Lutz Birnbaumer 27.5k 0.8× 14.5k 0.8× 9.7k 0.8× 5.5k 0.9× 3.2k 0.6× 556 42.8k
Bernd Nilius 16.3k 0.5× 9.1k 0.5× 19.8k 1.6× 3.7k 0.6× 6.8k 1.2× 412 36.5k
Roger Y. Tsien 70.9k 2.1× 28.4k 1.7× 3.8k 0.3× 4.3k 0.7× 3.1k 0.5× 321 111.4k
David Julius 17.8k 0.5× 18.3k 1.1× 27.1k 2.2× 1.8k 0.3× 6.1k 1.1× 137 56.1k
Florian Läng 36.0k 1.1× 6.7k 0.4× 2.9k 0.2× 5.5k 0.9× 3.9k 0.7× 1.4k 68.2k
Michel Lazdunski 37.0k 1.1× 16.4k 1.0× 5.0k 0.4× 8.9k 1.5× 1.6k 0.3× 573 48.6k
Tullio Pozzan 31.4k 1.0× 14.4k 0.8× 2.7k 0.2× 2.2k 0.4× 1.6k 0.3× 329 45.3k
Solomon H. Snyder 74.9k 2.3× 59.1k 3.5× 4.2k 0.3× 6.5k 1.1× 4.5k 0.8× 1.0k 143.6k
Yasuo Mori 13.6k 0.4× 8.2k 0.5× 7.8k 0.6× 3.0k 0.5× 2.4k 0.4× 478 25.5k

Countries citing papers authored by David E. Clapham

Since Specialization
Citations

This map shows the geographic impact of David E. Clapham's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David E. Clapham with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David E. Clapham more than expected).

Fields of papers citing papers by David E. Clapham

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David E. Clapham. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David E. Clapham. The network helps show where David E. Clapham may publish in the future.

Co-authorship network of co-authors of David E. Clapham

This figure shows the co-authorship network connecting the top 25 collaborators of David E. Clapham. A scholar is included among the top collaborators of David E. Clapham based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David E. Clapham. David E. Clapham is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Gao, Shuai, William C. Valinsky, Qian Qu, et al.. (2020). Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na + channels in nanodisc. Proceedings of the National Academy of Sciences. 117(25). 14187–14193. 38 indexed citations
2.
Chung, Jean‐Ju, Kiyoshi Miki, Doory Kim, et al.. (2017). CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility. eLife. 6. 115 indexed citations
3.
Naylor, C.E., Claire Bagnéris, Paul G. DeCaen, et al.. (2016). Molecular basis of ion permeability in a voltage‐gated sodium channel. The EMBO Journal. 35(8). 820–830. 87 indexed citations
4.
Sah, Rajan, Pietro Mesirca, Jonathan N. Rosen, et al.. (2013). Ion channel-kinase TRPM 7 is required for maintaining cardiac automaticity. Proceedings of the National Academy of Sciences. 110(32). E3037–46. 84 indexed citations
5.
Sah, Rajan, Pietro Mesirca, Xenos Mason, et al.. (2013). The Ion Channel-Kinase, TRPM7, is Required for Cardiac Automaticity. Biophysical Journal. 104(2). 379a–379a. 1 indexed citations
6.
Squillace, Rachel M., David F. Miller, Scott Wardwell, et al.. (2011). Antitumor Activity of Ridaforolimus and Potential Cell-Cycle Determinants of Sensitivity in Sarcoma and Endometrial Cancer Models. Molecular Cancer Therapeutics. 10(10). 1959–1968. 40 indexed citations
7.
Cheng, Xiping, Jie Jin, Dongbiao Shen, et al.. (2010). TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation. Cell. 141(2). 331–343. 253 indexed citations
8.
Jiang, Dawei, Linlin Zhao, & David E. Clapham. (2009). Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca 2+ /H + Antiporter. Science. 326(5949). 144–147. 422 indexed citations
9.
Smyth, Cyril J. & David E. Clapham. (2008). Use of immunoprecipitates to obtain monospecific immunoglobulins to nuclease 1 of Tradescantia. Hereditas. 96(1). 69–75. 1 indexed citations
10.
Fujinami, Shun, Takako Sato, James S. Trimmer, et al.. (2007). The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. Microbiology. 153(12). 4027–4038. 17 indexed citations
11.
Xu, Haoxing, Markus Delling, Linyu Li, Xian‐Ping Dong, & David E. Clapham. (2007). Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint–waddler mice. Proceedings of the National Academy of Sciences. 104(46). 18321–18326. 169 indexed citations
12.
Arnold, Sara von, Peter V. Bozhkov, David E. Clapham, et al.. (2005). Propagation of Norway spruce via somatic embryogenesis. 2 indexed citations
13.
Clapham, David E.. (2005). The meaning of housing. Policy Press eBooks. 2 indexed citations
14.
Clapham, David E.. (2003). Symmetry, Selectivity, and the 2003 Nobel Prize. Cell. 115(6). 641–646. 7 indexed citations
15.
Krapivinsky, Grigory, Luba Krapivinsky, Anton Ivanov, et al.. (2003). The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1. Neuron. 40(4). 775–784. 365 indexed citations
16.
Ren, Dejian, Betsy Navarro, Haoxing Xu, et al.. (2001). A Prokaryotic Voltage-Gated Sodium Channel. Science. 294(5550). 2372–2375. 381 indexed citations
17.
Clapham, David E., Loren W. Runnels, & Carsten Strübing. (2001). The trp ion channel family. Nature reviews. Neuroscience. 2(6). 387–396. 939 indexed citations breakdown →
18.
Hsu, Shyue‐Fang, Peta J. O’Connell, Vitaly A. Klyachko, et al.. (2001). Fundamental Ca2+ Signaling Mechanisms in Mouse Dendritic Cells: CRAC Is the Major Ca2+ Entry Pathway. The Journal of Immunology. 166(10). 6126–6133. 79 indexed citations
19.
Stehno‐Bittel, Lisa, Carmen Pérez-Terzic, Andreas Lückhoff, & David E. Clapham. (1996). Nuclear ion channels and regulation of the nuclear pore.. PubMed. 51. 195–207. 14 indexed citations
20.
Clapham, David E., et al.. (1990). A comparison of the roles of purified G protein subunits in the activation of the cardiac muscarinic K+ channel.. PubMed. 45. 29–41. 11 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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