Haoxing Xu

25.7k total citations · 10 hit papers
97 papers, 12.5k citations indexed

About

Haoxing Xu is a scholar working on Physiology, Molecular Biology and Sensory Systems. According to data from OpenAlex, Haoxing Xu has authored 97 papers receiving a total of 12.5k indexed citations (citations by other indexed papers that have themselves been cited), including 53 papers in Physiology, 42 papers in Molecular Biology and 26 papers in Sensory Systems. Recurrent topics in Haoxing Xu's work include Calcium signaling and nucleotide metabolism (53 papers), Ion Channels and Receptors (26 papers) and Ion channel regulation and function (25 papers). Haoxing Xu is often cited by papers focused on Calcium signaling and nucleotide metabolism (53 papers), Ion Channels and Receptors (26 papers) and Ion channel regulation and function (25 papers). Haoxing Xu collaborates with scholars based in United States, China and Japan. Haoxing Xu's co-authors include David E. Clapham, Dejian Ren, Xiaoli Zhang, Xian‐Ping Dong, Xiping Cheng, Markus Delling, Dongbiao Shen, Qiong Gao, Mohammad Samie and Wuyang Wang and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Haoxing Xu

94 papers receiving 12.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

2015 1.1k citations Diego L. Medina, Simone Di Paola et al. Nature Cell Biology profile →
Lysosomal Physiology

2015 794 citations Haoxing Xu, Dejian Ren profile →
TRPV3 is a calcium-permeable temperature-sensitive cation channel

2002 698 citations Haoxing Xu, David E. Clapham et al. profile →
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels

2006 517 citations Haoxing Xu, Markus Delling et al. profile →
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

2010 484 citations Xian‐Ping Dong, Xiang Wang et al. profile →
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

2016 433 citations Xiaoli Zhang, Xiping Cheng et al. profile →
TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

2012 419 citations Xiang Wang, Xiaoli Zhang et al. Cell profile →
Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

2012 386 citations Xiang Wang, Xinran Li et al. profile →
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

2017 251 citations Haoxing Xu et al. profile →
Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes

2022 136 citations Meiqin Hu, Ping Li et al. Cell profile →

Peers

Haoxing Xu

PHYSI

EPIDE

Michael X. Zhu United States

Jan B. Parys Belgium

Shmuel Muallem United States

H. Llewelyn Roderick United Kingdom

Ole H. Petersen United Kingdom

Ludwig Missiaen Belgium

Humbert De Smedt Belgium

Paolo Pinton Italy

Grzegorz Grynkiewicz Poland

Geert Bultynck Belgium

Michael X. Zhu United States

Haoxing Xu

6.2k ×1.4

2.9k ×0.6

PHYSI

6.5k ×1.9

599 ×0.3

EPIDE

1.2k ×0.5

Citations per year, relative to Haoxing Xu Haoxing Xu (= 1×) peers Michael X. Zhu

Countries citing papers authored by Haoxing Xu

Since Specialization

Citations

This map shows the geographic impact of Haoxing Xu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Haoxing Xu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Haoxing Xu more than expected).

Fields of papers citing papers by Haoxing Xu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Haoxing Xu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Haoxing Xu. The network helps show where Haoxing Xu may publish in the future.

Co-authorship network of co-authors of Haoxing Xu

This figure shows the co-authorship network connecting the top 25 collaborators of Haoxing Xu. A scholar is included among the top collaborators of Haoxing Xu based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Haoxing Xu. Haoxing Xu is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Zhang, Heng, Xiaoying Chen, Qingxia Ma, et al.. (2025). Discovery and structural basis of endogenous and exogenous inhibitors of the proton-activated-chloride channel. Cell Reports. 44(7). 115998–115998. 1 indexed citations

Zhao, Jie, Qingya Shen, Xin Li, et al.. (2025). Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS. Nature Structural & Molecular Biology. 32(5). 896–904.

Yang, Chuanyan, Mei Hu, Yiyao Liu, et al.. (2023). Characterization of the role of TMEM175 in an in vitro lysosomal H⁺ fluxes model. FEBS Journal. 290(19). 4641–4659. 6 indexed citations

Hu, Meiqin, Jingzhi Chen, Siyu Liu, & Haoxing Xu. (2022). The Acid Gate in the Lysosome. Autophagy. 19(4). 1368–1370. 49 indexed citations

Hu, Meiqin, Ping Li, Ce Wang, et al.. (2022). Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes. Cell. 185(13). 2292–2308.e20. 136 indexed citations breakdown →

Yue, Lixia & Haoxing Xu. (2021). TRP channels in health and disease at a glance. Journal of Cell Science. 134(13). 26 indexed citations

Yang, Xi, Yun-Yu Liu, Phyllis I. Hanson, et al.. (2021). A conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation. PLoS Biology. 19(7). e3001361–e3001361. 32 indexed citations

Yu, Lu, Xiaoli Zhang, Dan Li, et al.. (2020). Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models. Science Advances. 6(6). eaaz2736–eaaz2736. 39 indexed citations

Linsley, Jeremy W., Xiaoli Zhang, Haoxing Xu, et al.. (2020). Stac protein regulates release of neuropeptides. Proceedings of the National Academy of Sciences. 117(47). 29914–29924. 9 indexed citations

10.

Li, Ping, Meiqin Hu, Ce Wang, et al.. (2020). LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses. Proceedings of the National Academy of Sciences. 117(46). 29155–29165. 50 indexed citations

11.

Zhang, Xiaoli, W. Chen, Ping Li, et al.. (2019). Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels. eLife. 8. 42 indexed citations

12.

Zhang, Xiaoli, Lu Yu, & Haoxing Xu. (2016). Lysosome calcium in ROS regulation of autophagy. Autophagy. 12(10). 1954–1955. 102 indexed citations

13.

Krishna, Shefali, Wilhelm Palm, Yongchan Lee, et al.. (2016). PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment. Developmental Cell. 38(5). 536–547. 88 indexed citations

14.

Medina, Diego L., Simone Di Paola, Ivana Peluso, et al.. (2015). Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nature Cell Biology. 17(3). 288–299. 1060 indexed citations breakdown →

15.

Cheng, Xiping, Xiaoli Zhang, Qiong Gao, et al.. (2014). The intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy. Nature Medicine. 20(10). 1187–1192. 97 indexed citations

16.

Li, Xinran, Xiang Wang, Xiaoli Zhang, et al.. (2013). Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics. Proceedings of the National Academy of Sciences. 110(52). 21165–21170. 116 indexed citations

17.

Xu, Haoxing, Markus Delling, Linyu Li, Xian‐Ping Dong, & David E. Clapham. (2007). Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint–waddler mice. Proceedings of the National Academy of Sciences. 104(46). 18321–18326. 169 indexed citations

18.

Rojas, Asheebo, Jianping Wu, Hailan Piao, et al.. (2005). Determinant Role of Membrane Helices in KATP Channel Gating. The Journal of Membrane Biology. 204(1). 1–10. 4 indexed citations

19.

Ren, Dejian, Betsy Navarro, Haoxing Xu, et al.. (2001). A Prokaryotic Voltage-Gated Sodium Channel. Science. 294(5550). 2372–2375. 381 indexed citations

20.

Cui, Ningren, et al.. (2001). Modulation of the heteromeric Kir4.1–Kir5.1 channels by P at physiological levels. Journal of Cellular Physiology. 189(2). 229–236. 22 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact