David Julius

72.1k total citations · 49 hit papers
137 papers, 56.1k citations indexed

About

David Julius is a scholar working on Sensory Systems, Molecular Biology and Cellular and Molecular Neuroscience. According to data from OpenAlex, David Julius has authored 137 papers receiving a total of 56.1k indexed citations (citations by other indexed papers that have themselves been cited), including 65 papers in Sensory Systems, 62 papers in Molecular Biology and 51 papers in Cellular and Molecular Neuroscience. Recurrent topics in David Julius's work include Ion Channels and Receptors (63 papers), Ion channel regulation and function (37 papers) and Neurobiology and Insect Physiology Research (30 papers). David Julius is often cited by papers focused on Ion Channels and Receptors (63 papers), Ion channel regulation and function (37 papers) and Neurobiology and Insect Physiology Research (30 papers). David Julius collaborates with scholars based in United States, Singapore and Australia. David Julius's co-authors include Allan I. Basbaum, Michael J. Caterina, Makoto Tominaga, Diana M. Bautista, Mark Schumacher, Jon D. Levine, Yifan Cheng, David D. McKemy, Anthony J. Brake and Sven‐Eric Jordt and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

David Julius

134 papers receiving 54.9k citations

Hit Papers

The capsaicin receptor: a heat-activated ion channel in t... 1983 2026 1997 2011 1997 2009 2000 1998 2002 2.0k 4.0k 6.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The capsaicin receptor: a heat-activated ion channel in the pain pathway
    1997 7.1k citations Michael J. Caterina, Makoto Tominaga et al. Nature profile →
  2. Cellular and Molecular Mechanisms of Pain
    2009 3.1k citations Allan I. Basbaum, Diana M. Bautista et al. Cell profile →
  3. Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
    2000 2.8k citations Michael J. Caterina, Allan I. Basbaum et al. Science profile →
  4. The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
    1998 2.5k citations Makoto Tominaga, Michael J. Caterina et al. profile →
  5. Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    2002 2.0k citations David Julius et al. Nature profile →
  6. Molecular mechanisms of nociception
    2001 1.9k citations David Julius, Allan I. Basbaum Nature profile →
  7. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    1999 1.8k citations Peter M. Zygmunt, Jesper Petersson et al. Nature profile →
  8. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    2004 1.5k citations Diana M. Bautista, Huai-hu Chuang et al. Nature profile →
  9. TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
    2006 1.5k citations Diana M. Bautista, Pamela R. Tsuruda et al. Cell profile →
  10. Structure of the TRPV1 ion channel determined by electron cryo-microscopy
    2013 1.3k citations David Julius, Yifan Cheng et al. Nature profile →
  11. A capsaicin-receptor homologue with a high threshold for noxious heat
    1999 1.3k citations Michael J. Caterina, Makoto Tominaga et al. Nature profile →
  12. The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
    2001 1.2k citations Michael J. Caterina, David Julius profile →
  13. The P2Y12 receptor regulates microglial activation by extracellular nucleotides
    2006 1.1k citations David Julius et al. profile →
  14. Identification of the platelet ADP receptor targeted by antithrombotic drugs
    2001 1.1k citations David Julius et al. Nature profile →
  15. The menthol receptor TRPM8 is the principal detector of environmental cold
    2007 1.0k citations Diana M. Bautista, Jan Siemens et al. Nature profile →
  16. TRPA1 mediates formalin-induced pain
    2007 1.0k citations Diana M. Bautista, Jan Siemens et al. Proceedings of the National Academy of Sciences profile →
  17. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
    2001 1.0k citations Huai-hu Chuang, Allan I. Basbaum et al. Nature profile →
  18. Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
    1995 1.0k citations Laurence H. Tecott, David Julius et al. Nature profile →
  19. TRP Channels and Pain
    2013 882 citations David Julius Annual Review of Cell and Developmental Biology profile →
  20. TRPV1 structures in distinct conformations reveal activation mechanisms
    2013 815 citations Yifan Cheng, David Julius et al. Nature profile →
  21. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
    1994 808 citations Anthony J. Brake, David Julius et al. Nature profile →
  22. Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
    1991 807 citations Anthony J. Brake, David Julius et al. Science profile →
  23. Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
    2002 726 citations David Julius et al. Cell profile →
  24. TRP channel activation by reversible covalent modification
    2006 718 citations A. Scott Hinman, Huai-hu Chuang et al. Proceedings of the National Academy of Sciences profile →
  25. Pungent products from garlic activate the sensory ion channel TRPA1
    2005 672 citations Diana M. Bautista, A. Scott Hinman et al. Proceedings of the National Academy of Sciences profile →
  26. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
    2017 639 citations Joel Castro, Stuart M. Brierley et al. Cell profile →
  27. TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
    2016 637 citations David Julius, Yifan Cheng et al. Nature profile →
  28. Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
    1993 626 citations David Julius et al. Nature profile →
  29. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
    2007 608 citations Marcello Trevisani, Jan Siemens et al. Proceedings of the National Academy of Sciences profile →
  30. Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor
    1984 601 citations David Julius, Anthony J. Brake et al. Cell profile →
  31. Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
    1988 586 citations David Julius et al. Science profile →
  32. Acid potentiation of the capsaicin receptor determined by a key extracellular site
    2000 520 citations Makoto Tominaga, David Julius et al. Proceedings of the National Academy of Sciences profile →
  33. Structure of the TRPA1 ion channel suggests regulatory mechanisms
    2015 518 citations Candice E. Paulsen, Yifan Cheng et al. Nature profile →
  34. Expression cloning of an ATP receptor from mouse neuroblastoma cells.
    1993 506 citations David Julius et al. Proceedings of the National Academy of Sciences profile →
  35. A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
    2003 431 citations David Julius et al. Science profile →
  36. Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells
    2011 423 citations David Julius, Allan I. Basbaum et al. profile →
  37. Glycosylation and processing of prepro-α-factor through the yeast secretory pathway
    1984 367 citations David Julius et al. Cell profile →
  38. Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase
    1983 355 citations David Julius, Anthony J. Brake et al. Cell profile →
  39. Molecular basis of infrared detection by snakes
    2010 334 citations Elena O. Gracheva, Julio F. Cordero-Morales et al. Nature profile →
  40. International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels
    2005 316 citations David Julius et al. profile →
  41. Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation
    1989 297 citations David Julius et al. Science profile →
  42. A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
    2011 267 citations Christopher J. Bohlen, Allan I. Basbaum et al. Nature profile →
  43. TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids
    2013 262 citations Julio F. Cordero-Morales, David Julius et al. profile →
  44. Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
    2016 238 citations Joel Castro, Stuart M. Brierley et al. Nature profile →
  45. X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
    2014 237 citations Isabelle Baconguis, Christopher J. Bohlen et al. Cell profile →
  46. Structure of the human TRPM4 ion channel in a lipid nanodisc
    2017 207 citations Henriette Elisabeth Autzen, Alexander Myasnikov et al. Science profile →
  47. Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
    2021 144 citations David Julius, Yifan Cheng et al. Cell profile →
  48. Irritant-evoked activation and calcium modulation of the TRPA1 receptor
    2020 123 citations Jianhua Zhao, John V. Lin King et al. Nature profile →
  49. Gut enterochromaffin cells drive visceral pain and anxiety
    2023 95 citations Joel Castro, Archana Venkataraman et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
David Julius United States 77 27.1k 18.3k 18.1k 17.8k 6.1k 137 56.1k
Makoto Tominaga Japan 70 17.0k 0.6× 7.8k 0.4× 10.3k 0.6× 7.8k 0.4× 4.4k 0.7× 402 30.8k
David E. Clapham United States 117 12.5k 0.5× 17.0k 0.9× 5.5k 0.3× 33.0k 1.9× 5.8k 0.9× 326 57.4k
Bernd Nilius Belgium 104 19.8k 0.7× 9.1k 0.5× 6.3k 0.3× 16.3k 0.9× 6.8k 1.1× 412 36.5k
Allan I. Basbaum United States 103 10.7k 0.4× 21.0k 1.1× 26.7k 1.5× 11.7k 0.7× 1.9k 0.3× 296 46.1k
Michael J. Caterina United States 51 15.3k 0.6× 7.3k 0.4× 9.6k 0.5× 6.0k 0.3× 3.0k 0.5× 94 24.2k
Ardem Patapoutian United States 82 13.3k 0.5× 8.8k 0.5× 14.1k 0.8× 12.5k 0.7× 2.9k 0.5× 112 33.2k
Jon D. Levine United States 92 8.1k 0.3× 11.5k 0.6× 19.3k 1.1× 9.1k 0.5× 1.4k 0.2× 581 36.3k
Michael J. Berridge United Kingdom 96 7.1k 0.3× 19.2k 1.0× 7.8k 0.4× 42.2k 2.4× 3.5k 0.6× 210 65.7k
Clifford J. Woolf United States 127 5.9k 0.2× 23.1k 1.3× 39.2k 2.2× 15.3k 0.9× 1.4k 0.2× 379 69.4k
Lutz Birnbaumer United States 110 9.7k 0.4× 14.5k 0.8× 4.6k 0.3× 27.5k 1.5× 3.2k 0.5× 556 42.8k

Countries citing papers authored by David Julius

Since Specialization
Citations

This map shows the geographic impact of David Julius's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Julius with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Julius more than expected).

Fields of papers citing papers by David Julius

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Julius. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Julius. The network helps show where David Julius may publish in the future.

Co-authorship network of co-authors of David Julius

This figure shows the co-authorship network connecting the top 25 collaborators of David Julius. A scholar is included among the top collaborators of David Julius based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David Julius. David Julius is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Venkataraman, Archana, et al.. (2025). A cellular basis for heightened gut sensitivity in females. Science. 390(6779). 1285–1291.
2.
Yue, Wendy W. S., Kouki K Touhara, Kenichi Toma, Xin Duan, & David Julius. (2024). Endogenous opioid signalling regulates spinal ependymal cell proliferation. Nature. 634(8033). 407–414. 3 indexed citations
3.
Yue, Wendy W. S., Lin Yuan, João M. Bráz, Allan I. Basbaum, & David Julius. (2022). TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons. eLife. 11. 35 indexed citations
4.
Zhao, Jianhua, John V. Lin King, Candice E. Paulsen, Yifan Cheng, & David Julius. (2020). Irritant-evoked activation and calcium modulation of the TRPA1 receptor. Nature. 585(7823). 141–145. 123 indexed citations breakdown →
5.
Dang, Shangyu, Daniel Asarnow, Yongqiang Wang, et al.. (2019). Structural insight into TRPV5 channel function and modulation. Proceedings of the National Academy of Sciences. 116(18). 8869–8878. 85 indexed citations
6.
Autzen, Henriette Elisabeth, Alexander Myasnikov, Melody G. Campbell, et al.. (2017). Structure of the human TRPM4 ion channel in a lipid nanodisc. Science. 359(6372). 228–232. 207 indexed citations breakdown →
7.
Baconguis, Isabelle, Christopher J. Bohlen, April Goehring, David Julius, & Eric Gouaux. (2014). X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel. Cell. 156(4). 717–729. 237 indexed citations breakdown →
8.
Cordero-Morales, Julio F., Elena O. Gracheva, & David Julius. (2011). Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proceedings of the National Academy of Sciences. 108(46). E1184–91. 184 indexed citations
9.
Basbaum, Allan I., Diana M. Bautista, Grégory Scherrer, & David Julius. (2009). Cellular and Molecular Mechanisms of Pain. Cell. 139(2). 267–284. 3109 indexed citations breakdown →
10.
Bautista, Diana M., et al.. (2008). Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proceedings of the National Academy of Sciences. 105(50). 20015–20020. 67 indexed citations
11.
Trevisani, Marcello, Jan Siemens, Serena Materazzi, et al.. (2007). 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proceedings of the National Academy of Sciences. 104(33). 13519–13524. 608 indexed citations breakdown →
12.
Hinman, A. Scott, Huai-hu Chuang, Diana M. Bautista, & David Julius. (2006). TRP channel activation by reversible covalent modification. Proceedings of the National Academy of Sciences. 103(51). 19564–19568. 718 indexed citations breakdown →
13.
Marasco, Paul D., Pamela R. Tsuruda, Diana M. Bautista, David Julius, & Kenneth C. Catania. (2006). Neuroanatomical evidence for segregation of nerve fibers conveying light touch and pain sensation in Eimer’s organ of the mole. Proceedings of the National Academy of Sciences. 103(24). 9339–9344. 14 indexed citations
14.
Julius, David & Lawrence C Katz. (2004). A Nobel for Smell. Cell. 119(6). 747–752. 8 indexed citations
15.
Julius, David, et al.. (2003). A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity. Science. 300(5623). 1284–1288. 431 indexed citations breakdown →
16.
Caterina, Michael J., et al.. (1999). A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 398(6726). 436–441. 1255 indexed citations breakdown →
17.
Zygmunt, Peter M., Jesper Petersson, David A. Andersson, et al.. (1999). Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature. 400(6743). 452–457. 1767 indexed citations breakdown →
18.
Melck, Dominique, Tiziana Bisogno, Luciano De Petrocellis, et al.. (1999). Unsaturated Long-Chain N-Acyl-vanillyl-amides (N-AVAMs): Vanilloid Receptor Ligands That Inhibit Anandamide-Facilitated Transport and Bind to CB1 Cannabinoid Receptors. Biochemical and Biophysical Research Communications. 262(1). 275–284. 161 indexed citations
19.
Brake, Anthony J. & David Julius. (1996). SIGNALING BY EXTRACELLULAR NUCLEOTIDES. Annual Review of Cell and Developmental Biology. 12(1). 519–541. 106 indexed citations
20.
Tecott, Laurence H. & David Julius. (1993). A new wave of serotonin receptors. Current Opinion in Neurobiology. 3(3). 310–315. 29 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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