David E. Cane

23.6k total citations · 3 hit papers
330 papers, 18.6k citations indexed

About

David E. Cane is a scholar working on Molecular Biology, Pharmacology and Organic Chemistry. According to data from OpenAlex, David E. Cane has authored 330 papers receiving a total of 18.6k indexed citations (citations by other indexed papers that have themselves been cited), including 246 papers in Molecular Biology, 216 papers in Pharmacology and 94 papers in Organic Chemistry. Recurrent topics in David E. Cane's work include Microbial Natural Products and Biosynthesis (212 papers), Plant biochemistry and biosynthesis (156 papers) and Carbohydrate Chemistry and Synthesis (51 papers). David E. Cane is often cited by papers focused on Microbial Natural Products and Biosynthesis (212 papers), Plant biochemistry and biosynthesis (156 papers) and Carbohydrate Chemistry and Synthesis (51 papers). David E. Cane collaborates with scholars based in United States, Japan and United Kingdom. David E. Cane's co-authors include Chaitan Khosla, David W. Christianson, Haruo Ikeda, Rajesh S. Gokhale, Alice Y. Chen, Christopher T. Walsh, Satoshi Ōmura, Chi Ching Yang, Mamoru Komatsu and Jiaoyang Jiang and has published in prestigious journals such as Nature, Science and Chemical Reviews.

In The Last Decade

David E. Cane

330 papers receiving 18.1k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli

2001 598 citations David E. Cane, Chaitan Khosla et al. profile →
Terpene synthases are widely distributed in bacteria

2014 404 citations Yuuki Yamada, Mamoru Komatsu et al. Proceedings of the National Academy of Sciences profile →
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

2010 399 citations Mamoru Komatsu, David E. Cane et al. Proceedings of the National Academy of Sciences profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
David E. Cane	14.0k	12.6k	3.8k	2.8k	1.9k	330	18.6k
David H. Sherman	8.5k 0.6×	8.6k 0.7×	3.8k 1.0×	3.2k 1.1×	1.5k 0.8×	357	15.1k
Ben Shen	9.7k 0.7×	8.1k 0.6×	3.5k 0.9×	2.3k 0.8×	1.1k 0.6×	304	14.5k
Paul R. Jensen	8.3k 0.6×	9.5k 0.8×	4.9k 1.3×	6.9k 2.5×	1.0k 0.5×	334	20.5k
C. Richard Hutchinson	6.7k 0.5×	6.9k 0.6×	2.5k 0.7×	1.8k 0.6×	1.9k 1.0×	208	10.2k
Christian Hertweck	11.0k 0.8×	12.8k 1.0×	5.1k 1.3×	3.8k 1.3×	5.3k 2.8×	473	23.1k
Heinz G. Floss	6.1k 0.4×	5.0k 0.4×	2.9k 0.8×	1.5k 0.5×	1.0k 0.5×	331	10.4k
Craig A. Townsend	6.9k 0.5×	4.7k 0.4×	2.4k 0.6×	997 0.4×	1.5k 0.8×	270	11.4k
Haruo Seto	7.0k 0.5×	4.3k 0.3×	3.2k 0.9×	1.3k 0.5×	826 0.4×	405	11.2k
Peter F. Leadlay	8.4k 0.6×	8.4k 0.7×	3.4k 0.9×	2.1k 0.8×	1.6k 0.8×	260	12.8k
Ikuro Abe	7.5k 0.5×	5.6k 0.4×	1.9k 0.5×	2.0k 0.7×	1.6k 0.8×	372	11.1k

Countries citing papers authored by David E. Cane

Since Specialization

Citations

This map shows the geographic impact of David E. Cane's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David E. Cane with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David E. Cane more than expected).

Fields of papers citing papers by David E. Cane

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David E. Cane. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David E. Cane. The network helps show where David E. Cane may publish in the future.

Co-authorship network of co-authors of David E. Cane

This figure shows the co-authorship network connecting the top 25 collaborators of David E. Cane. A scholar is included among the top collaborators of David E. Cane based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David E. Cane. David E. Cane is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Li, Xiuyuan, Natalia Sevillano, L.N. Deis, et al.. (2018). Structure–Function Analysis of the Extended Conformation of a Polyketide Synthase Module. Journal of the American Chemical Society. 140(21). 6518–6521. 32 indexed citations

Xie, Xinqiang, et al.. (2017). Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay. Journal of the American Chemical Society. 139(28). 9507–9510. 17 indexed citations

Xie, Xinqiang, et al.. (2017). Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis. Journal of the American Chemical Society. 139(8). 3283–3292. 20 indexed citations

Xie, Xinqiang, Chaitan Khosla, & David E. Cane. (2017). Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases. Journal of the American Chemical Society. 139(17). 6102–6105. 17 indexed citations

Robbins, Thomas, Yuchen Liu, David E. Cane, & Chaitan Khosla. (2016). Structure and mechanism of assembly line polyketide synthases. Current Opinion in Structural Biology. 41. 10–18. 103 indexed citations

Yamada, Yuuki, David E. Cane, & Haruo Ikeda. (2012). Diversity and Analysis of Bacterial Terpene Synthases. Methods in enzymology on CD-ROM/Methods in enzymology. 515. 123–162. 45 indexed citations

Hu, Yunfeng, Wayne Chou, Russell Hopson, & David E. Cane. (2011). Genome Mining in Streptomyces clavuligerus: Expression and Biochemical Characterization of Two New Cryptic Sesquiterpene Synthases. Chemistry & Biology. 18(1). 32–37. 66 indexed citations

Takamatsu, Satoshi, et al.. (2010). Characterization of a silent sesquiterpenoid biosynthetic pathway in Streptomyces avermitilis controlling epi ‐isozizaene albaflavenone biosynthesis and isolation of a new oxidized epi ‐isozizaene metabolite. Microbial Biotechnology. 4(2). 184–191. 55 indexed citations

Liu, Tiangang, Xin Lin, Xiufen Zhou, Zixin Deng, & David E. Cane. (2008). Mechanism of Thioesterase-Catalyzed Chain Release in the Biosynthesis of the Polyether Antibiotic Nanchangmycin. Chemistry & Biology. 15(5). 449–458. 40 indexed citations

10.

Chen, Alice Y., David E. Cane, & Chaitan Khosla. (2007). Structure-Based Dissociation of a Type I Polyketide Synthase Module. Chemistry & Biology. 14(7). 784–792. 64 indexed citations

11.

Tang, Yinyan, Alice Y. Chen, Chu‐Young Kim, David E. Cane, & Chaitan Khosla. (2007). Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B Synthase. Chemistry & Biology. 14(8). 931–943. 137 indexed citations

12.

Jiang, Jiaoyang, Xiaofei He, & David E. Cane. (2007). Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme. Nature Chemical Biology. 3(11). 711–715. 201 indexed citations

13.

Tang, Yinyan, Chu‐Young Kim, Irimpan I. Mathews, David E. Cane, & Chaitan Khosla. (2006). The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences. 103(30). 11124–11129. 226 indexed citations

14.

Liu, Tiangang, Delin You, Chiara R. Valenzano, et al.. (2006). Identification of NanE as the Thioesterase for Polyether Chain Release in Nanchangmycin Biosynthesis. Chemistry & Biology. 13(9). 945–955. 55 indexed citations

15.

Cane, David E.. (2004). Back to Basics. Chemistry & Biology. 11(6). 741–743. 1 indexed citations

16.

Cane, David E., Fumitaka Kudo, Kenji Kinoshita, & Chaitan Khosla. (2002). Precursor-Directed Biosynthesis. Chemistry & Biology. 9(1). 131–142. 50 indexed citations

17.

Tsai, Shiou‐Chuan, Larry J. W. Miercke, J. Krucinski, et al.. (2001). Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel. Proceedings of the National Academy of Sciences. 98(26). 14808–14813. 179 indexed citations

18.

Chen, Huawei, Sarah E. O’Connor, David E. Cane, & Christopher T. Walsh. (2001). Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit. Chemistry & Biology. 8(9). 899–912. 65 indexed citations

19.

Cane, David E.. (1999). Isoprenoids including carotenoids and steroids. Elsevier eBooks. 61 indexed citations

20.

Cane, David E., et al.. (1991). Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition—elimination reactions. Philosophical Transactions of the Royal Society B Biological Sciences. 332(1263). 123–129. 24 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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