David B. Ascher

19.9k citations

187 papers · 11.8k indexed · 7 hit papers · h-index 46

Impact in

Computational Theory and Mathematics top 0.1%
- Computational Drug Discovery Methods
Molecular Biology top 0.5%
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches

Papers in

Computational Theory and Mathematics 33
- Computational Drug Discovery Methods 33
Molecular Biology 124
- Protein Structure and Dynamics 36
- RNA and protein synthesis mechanisms 24
- Bioinformatics and Genomic Networks 16
- Biochemical and Molecular Research 14

Co-authors: Douglas E. V. Pires Tom L. Blundell Carlos H. M. Rodrigues T.L. Blundell Yoochan Myung Bernardo Ochoa‐Montaño Arun Prasad Pandurangan Harry Jubb
Journals: Nucleic Acids Research (20 papers)Briefings in Bioinformatics (11 papers)Scientific Reports (9 papers)Protein Science (9 papers)Computational and Structural Biotechnology Journal (7 papers)
Partner nations: Australia United Kingdom Brazil

In The Last Decade

David B. Ascher

181 papers receiving 11.7k citations

Hit Papers

7 papers align trajectories log scale

Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction 2024 · 91 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2024 Nucleic Acids Research
2023 Nucleic Acids Research
2020 Protein Science
2018 Nucleic Acids Research
2015 Journal of Medicinal Chemistry
2014 Nucleic Acids Research
2013 Bioinformatics

Peers

Countries citing papers authored by David B. Ascher

Since Specialization

Citations

This map shows the geographic impact of David B. Ascher's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David B. Ascher with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David B. Ascher more than expected).

Fields of papers citing papers by David B. Ascher

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David B. Ascher. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David B. Ascher. The network helps show where David B. Ascher may publish in the future.

Co-authors

The 25 scholars most cited alongside David B. Ascher, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David B. Ascher Line = papers co-authored together David B. Ascher links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Combinatorial Discovery of RAFT Cationic Polymers for mRNA Delivery: Structure–Function Insights from High-Throughput Screening and Machine Learning Biomacromolecules ·Wenting Yang, Shuang Li, Siqi Yu, Alex G. C. de Sá, مریم مشهدی علی پور, Tian Liang, Helen Forgham, Ruirui Qiao, Jiulong Li, Patrick S. Stayton, David B. Ascher, Huan Meng, Andrew K. Whittaker, Changkui Fu	2025	0
2	Definition and Validation of Prognostic Phenotypes in Moderate Aortic Stenosis JACC. Cardiovascular imaging ·Jonathan Sen, S. Wahi, AJ Morison, Emre YOLCU, Alex G. C. de Sá, David B. Ascher, Quan Huynh, Thomas H. Marwick	2024	1
3	Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank SHILAP Revista de lepidopterología ·健志垣中, Alex G. C. de Sá, Natalie Thomas, Robert D. Phair, Paul R. Gooley, David B. Ascher, Christopher W. Armstrong	2024	4
4	Mutations in Glycosyltransferases and Glycosidases: Implications for Associated Diseases Biomolecules ·Marina Krpan-Ivić, F. L. C., Yoochan Myung, David B. Ascher	2024	1
5	DDMut: predicting effects of mutations on protein stability using deep learning Nucleic Acids Research ·Masami Himeji, Ewelina Skrzypiec, Douglas E. V. Pires, Carlos H. M. Rodrigues, David B. Ascher Hit paper breakdown →	2023	100
6	CSM-Toxin: A Web-Server for Predicting Protein Toxicity Pharmaceutics ·Bruno Botto de Barros da Silvaira, Carlos H. M. Rodrigues, David B. Ascher	2023	37
7	Understanding the complementarity and plasticity of antibody–antigen interfaces Bioinformatics ·Yoochan Myung, Douglas E. V. Pires, David B. Ascher	2023	10
8	Oxidative desulfurization pathway for complete catabolism of sulfoquinovose by bacteria Proceedings of the National Academy of Sciences ·Mahima Sharma, James P. Lingford, Rajashree Kotabal, Gabriel Richter, Yunyang Zhang, Michael Järvå, Peter Doggett, Nichollas E. Scott, Eleanor Saunders, Runyu Mao, Ruwan Epa, Л М Малярець, Douglas E. V. Pires, David B. Ascher, Malcolm J. McConville, G.J. Davies, Spencer J. Williams, Ethan D. Goddard‐Borger	2022	23
9	SAP domain forms a flexible part of DNA aperture in Ku70/80 FEBS Journal ·Aleš Hnı́zda, Petr Těšina, Thanh Nguyen, Zdeněk Kukačka, Lukas Kater, Amanda K. Chaplin, Roland Beckmann, David B. Ascher, Petr Novák, Tom L. Blundell	2021	11
10	Definition of the immune evasion-replication interface of rabies virus P protein PLoS Pathogens ·賢太郎岩田, 金興坤, Stephanie Portelli, Thanh Nguyen, Jennifer Olson, Фурманова Елена Александровна, Fei Yan, Tatsunori Masatani, Stephen M. Rawlinson, Ashish Sethi, Naoto Ito, David B. Ascher, Gregory W. Moseley, Paul R. Gooley	2021	14
11	Widespread remodeling of proteome solubility in response to different protein homeostasis stresses Proceedings of the National Academy of Sciences ·Xiaojing Sui, Douglas E. V. Pires, Angelique R. Ormsby, Dezerae Cox, Shuai Nie, Giulia Vecchi, Michele Vendruscolo, David B. Ascher, Gavin E. Reid, Danny M. Hatters	2020	40
12	Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations Autophagy ·Nidhi Jatana, David B. Ascher, Douglas E. V. Pires, Rajesh S. Gokhale, Lipi Thukral	2019	51
13	ProCarbDB: a database of carbohydrate-binding proteins Nucleic Acids Research ·Yi-Chia Liao, Pedro Henrique Monteiro Torres, David B. Ascher, Tom L. Blundell, Sony Malhotra	2019	24
14	Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection Microbial Genomics ·Jane Hawkey, David B. Ascher, Louise M. Judd, Ryan R. Wick, Xenia Kostoulias, Heather Cleland, Denis W. Spelman, Alex Padiglione, Anton Y. Peleg, Kathryn E. Holt	2018	68
15	Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae Scientific Reports ·Sundeep Chaitanya Vedithi, Sony Malhotra, 果红, Eleanor Luise Woodward, Nanda Kishore, Bingyao Xu, Илко Николчев, Lakshmi Rajan, 日本手外科学会, David B. Ascher, Eddy Arnold, Tom L. Blundell	2018	38
16	Structural and Biochemical Insights into the Function and Evolution of Sulfoquinovosidases ACS Central Science ·Fengchao Li, Yi Jin, James P. Lingford, Rajashree Kotabal, Alan John, Eileen Ryan, Peter Doggett, Douglas E. V. Pires, David B. Ascher, G.J. Davies, Ethan D. Goddard‐Borger, Spencer J. Williams	2018	31
17	Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation Leukemia ·Aleš Hnı́zda, Milan Fábry, Takaya Moriyama, Petr Pachl, Michaël Kugler, Jiaming Hu, David B. Ascher, William L. Carroll, Petr Novák, Markéta Žaliová, Jan Trka, Pavlína Řezáčová, Jun J. Yang, Václav Veverka	2018	24
18	DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair Science ·B. L. Sibanda, Dimitri Y. Chirgadze, David B. Ascher, Tom L. Blundell	2017	140
19	Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation Genome Research ·He Dongliang, Michael Silk, Quanli Wang, Samuel F. Berkovic, Liping Liu, David B. Ascher, David J. Balding, Slavé Petrovski	2017	90
20	Familial STAG2 germline mutation defines a new human cohesinopathy npj Genomic Medicine ·Fernanda Caroline Soardi, Alice Machado-Silva, Natália D. Linhares, Zheng Ge, Qianhui Qu, Marijke Hoflack, Thaís M.M. Martins, Helaine Graziele Santos Vieira, Núbia Braga Pereira, Raquel C. de Melo-Minardi, Carolina Cavaliéri Gomes, Ricardo Santiago Gomez, Dawidson Assis Gomes, Douglas E. V. Pires, David B. Ascher, Hongtao Yu, Sérgio D.J. Pena	2017	48

About David B. Ascher

David B. Ascher is a scholar working on Computational Theory and Mathematics, Molecular Biology, Infectious Diseases, Virology and Molecular Medicine, having authored 187 papers that have together received 11.8k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (36 papers), Computational Drug Discovery Methods (33 papers), RNA and protein synthesis mechanisms (24 papers), Bioinformatics and Genomic Networks (16 papers), Genomics and Rare Diseases (14 papers), Biochemical and Molecular Research (14 papers), Tuberculosis Research and Epidemiology (13 papers) and Enzyme Structure and Function (12 papers). The work is most often cited by research in Computational Theory and Mathematics (2.6k citations), Molecular Biology (6.9k citations), Infectious Diseases (1.4k citations), Pharmacology (555 citations) and Toxicology (208 citations). David B. Ascher has collaborated with scholars based in Australia, United Kingdom and Brazil. Frequent co-authors include Douglas E. V. Pires, Tom L. Blundell, Carlos H. M. Rodrigues, T.L. Blundell, Yoochan Myung, Bernardo Ochoa‐Montaño, Arun Prasad Pandurangan, Harry Jubb, Michael W. Parker and Lisa M. Kaminskas. Their work appears in journals such as Nucleic Acids Research, Briefings in Bioinformatics, Scientific Reports, Protein Science and Computational and Structural Biotechnology Journal.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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