Leah L. Frye

16.4k total citations · 3 hit papers
32 papers, 11.8k citations indexed

About

Leah L. Frye is a scholar working on Molecular Biology, Organic Chemistry and Computational Theory and Mathematics. According to data from OpenAlex, Leah L. Frye has authored 32 papers receiving a total of 11.8k indexed citations (citations by other indexed papers that have themselves been cited), including 17 papers in Molecular Biology, 8 papers in Organic Chemistry and 7 papers in Computational Theory and Mathematics. Recurrent topics in Leah L. Frye's work include Steroid Chemistry and Biochemistry (8 papers), Computational Drug Discovery Methods (7 papers) and Protein Structure and Dynamics (5 papers). Leah L. Frye is often cited by papers focused on Steroid Chemistry and Biochemistry (8 papers), Computational Drug Discovery Methods (7 papers) and Protein Structure and Dynamics (5 papers). Leah L. Frye collaborates with scholars based in United States, United Kingdom and Australia. Leah L. Frye's co-authors include Richard A. Friesner, Thomas A. Halgren, Robert B. Murphy, Jeremy R. Greenwood, Paul C. Sanschagrin, Daniel T. Mainz, Matthew P. Repasky, W. Thomas Pollard, Jay L. Banks and John C. Shelley and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Cancer Research.

In The Last Decade

Leah L. Frye

28 papers receiving 11.6k citations

Hit Papers

Extra Precision Glide:  Docking and Scoring Incorporating... 2004 2026 2011 2018 2006 2004 2007 1000 2.0k 3.0k 4.0k 5.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Extra Precision Glide:  Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes
    2006 5.4k citations Richard A. Friesner, Robert B. Murphy et al. Journal of Medicinal Chemistry profile →
  2. Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening
    2004 4.0k citations Thomas A. Halgren, Robert B. Murphy et al. Journal of Medicinal Chemistry profile →
  3. Epik: a software program for pK a prediction and protonation state generation for drug-like molecules
    2007 1.6k citations John C. Shelley, Leah L. Frye et al. Journal of Computer-Aided Molecular Design profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Leah L. Frye United States 18 7.1k 3.8k 2.9k 1.4k 1.3k 32 11.8k
Jay L. Banks United States 6 8.3k 1.2× 4.7k 1.2× 3.0k 1.0× 1.5k 1.1× 1.4k 1.0× 8 13.4k
Daniel T. Mainz United States 9 9.0k 1.3× 4.8k 1.3× 3.4k 1.2× 1.7k 1.2× 1.6k 1.2× 11 14.7k
Jeremy R. Greenwood United States 27 6.8k 1.0× 3.2k 0.9× 2.9k 1.0× 1.2k 0.8× 1.2k 0.9× 67 12.1k
Tyler Day United States 22 6.1k 0.9× 2.7k 0.7× 1.9k 0.7× 1.0k 0.7× 1.0k 0.8× 24 10.4k
Matthew P. Repasky United States 18 9.5k 1.3× 5.3k 1.4× 3.7k 1.3× 1.9k 1.3× 1.6k 1.2× 20 15.6k
Kaixian Chen China 58 7.5k 1.1× 3.5k 0.9× 2.9k 1.0× 1.3k 0.9× 932 0.7× 437 13.9k
Andrew L. Hopkins United Kingdom 30 9.1k 1.3× 5.0k 1.3× 1.9k 0.7× 1.4k 1.0× 960 0.7× 63 14.2k
Peter S. Shenkin United States 19 7.4k 1.0× 3.4k 0.9× 2.1k 0.7× 1.1k 0.7× 989 0.7× 28 11.1k
Mee Shelley Canada 16 5.5k 0.8× 3.0k 0.8× 2.0k 0.7× 975 0.7× 848 0.6× 37 9.0k
Jason K. Perry United States 28 5.5k 0.8× 3.1k 0.8× 1.9k 0.6× 993 0.7× 925 0.7× 60 10.3k

Countries citing papers authored by Leah L. Frye

Since Specialization
Citations

This map shows the geographic impact of Leah L. Frye's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leah L. Frye with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leah L. Frye more than expected).

Fields of papers citing papers by Leah L. Frye

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leah L. Frye. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leah L. Frye. The network helps show where Leah L. Frye may publish in the future.

Co-authorship network of co-authors of Leah L. Frye

This figure shows the co-authorship network connecting the top 25 collaborators of Leah L. Frye. A scholar is included among the top collaborators of Leah L. Frye based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Leah L. Frye. Leah L. Frye is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Leffler, Abba E., Evelyne M. Houang, Andrew T. Placzek, et al.. (2025). Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations. ACS Medicinal Chemistry Letters. 16(3). 444–453. 1 indexed citations
2.
Carney, Daniel W., Michiko Tawada, Jumpei Aida, et al.. (2025). Discovery of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 Main Protease through Computer-Aided Drug Design. Journal of Medicinal Chemistry. 68(20). 21330–21345.
3.
4.
Wang, Hui, Christian Atsriku, Andrew T. Placzek, et al.. (2025). Abstract 4376: Preclinical characterization of SGR-4174, a potent and selective SOS1 inhibitor for the treatment of pan KRAS mutant cancers in combination with KRAS pathway inhibitors. Cancer Research. 85(8_Supplement_1). 4376–4376. 1 indexed citations
5.
Frye, Leah L., et al.. (2024). Code and Data Repository for Microgrid Planner: An Open-Source Software Platform. INFORMS journal on computing.
6.
Carney, Daniel W., Abba E. Leffler, Jeffrey A. Bell, et al.. (2024). Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity. Bioorganic & Medicinal Chemistry. 103. 117577–117577. 4 indexed citations
7.
Frye, Leah L., Sathesh Bhat, Karen Akinsanya, & Robert Abel. (2021). From computer-aided drug discovery to computer-driven drug discovery. Drug Discovery Today Technologies. 39. 111–117. 45 indexed citations
8.
Ivetac, Anthony, et al.. (2012). Locating a Plausible Binding Site for an Open-Channel Blocker, GlyH-101, in the Pore of the Cystic Fibrosis Transmembrane Conductance Regulator. Molecular Pharmacology. 82(6). 1042–1055. 35 indexed citations
9.
Acharya, Priyamvada, Cajetan Dogo‐Isonagie, Judith M. LaLonde, et al.. (2011). Structure-Based Identification and Neutralization Mechanism of Tyrosine Sulfate Mimetics That Inhibit HIV-1 Entry. ACS Chemical Biology. 6(10). 1069–1077. 29 indexed citations
10.
Ivetac, Anthony, et al.. (2010). Identification of Possible Binding Sites for the CFTR Pore Blocker, GlyH-101. Biophysical Journal. 98(3). 323a–323a. 1 indexed citations
11.
Shelley, John C., et al.. (2007). Epik: a software program for pK a prediction and protonation state generation for drug-like molecules. Journal of Computer-Aided Molecular Design. 21(12). 681–691. 1585 indexed citations breakdown →
12.
Halgren, Thomas A., Robert B. Murphy, Richard A. Friesner, et al.. (2004). Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening. Journal of Medicinal Chemistry. 47(7). 1750–1759. 4026 indexed citations breakdown →
13.
Last-Barney, K, Walter Davidson, Mario Cardozo, et al.. (2001). Binding Site Elucidation of Hydantoin-Based Antagonists of LFA-1 Using Multidisciplinary Technologies:  Evidence for the Allosteric Inhibition of a Protein−Protein Interaction. Journal of the American Chemical Society. 123(24). 5643–5650. 109 indexed citations
14.
Goldstein, Alex & Leah L. Frye. (1997). Synthesis and Bioevaluation of Δ7-5-Desaturase Inhibitors, an Enzyme Late in the Biosynthesis of the Fungal Sterol Ergosterol. Journal of Medicinal Chemistry. 40(22). 3706–3706. 1 indexed citations
15.
Thompson, Richele J., et al.. (1997). The design, synthesis and transmembrane transport studies of a biomimetic sterol-based ion channel. Bioorganic & Medicinal Chemistry. 5(10). 1893–1901. 12 indexed citations
16.
Anderson, J. Ansel, Deborah A. Leonard, Kevin P. Cusack, & Leah L. Frye. (1995). 15-Substituted Lanosterols: Post-transcriptional Suppressors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase. Archives of Biochemistry and Biophysics. 316(1). 190–196. 11 indexed citations
17.
Cioffi, Christopher L., et al.. (1995). Synthesis of 24.xi.-Squalamine, an Anti-Infective Steroidal Polyamine. The Journal of Organic Chemistry. 60(16). 5121–5126. 42 indexed citations
18.
Frye, Leah L., Kevin P. Cusack, & Deborah A. Leonard. (1993). 32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis. Journal of Medicinal Chemistry. 36(3). 410–416. 22 indexed citations
19.
Frye, Leah L. & Cecil H. Robinson. (1990). Synthesis of potential mechanism-based inactivators of lanosterol 14.alpha.-methyl demethylase. The Journal of Organic Chemistry. 55(5). 1579–1584. 19 indexed citations
20.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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