Kaixian Chen

18.4k total citations · 4 hit papers
437 papers, 13.9k citations indexed

About

Kaixian Chen is a scholar working on Molecular Biology, Organic Chemistry and Computational Theory and Mathematics. According to data from OpenAlex, Kaixian Chen has authored 437 papers receiving a total of 13.9k indexed citations (citations by other indexed papers that have themselves been cited), including 263 papers in Molecular Biology, 110 papers in Organic Chemistry and 81 papers in Computational Theory and Mathematics. Recurrent topics in Kaixian Chen's work include Computational Drug Discovery Methods (81 papers), Protein Structure and Dynamics (36 papers) and Chemical Synthesis and Analysis (25 papers). Kaixian Chen is often cited by papers focused on Computational Drug Discovery Methods (81 papers), Protein Structure and Dynamics (36 papers) and Chemical Synthesis and Analysis (25 papers). Kaixian Chen collaborates with scholars based in China, United States and Singapore. Kaixian Chen's co-authors include Hualiang Jiang, Xiaomin Luo, Weiliang Zhu, Mingyue Zheng, Jianhua Shen, Hong Liu, Cheng Luo, Jian Zhang, Zhaoping Xiong and Xiaohong Liu and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Nucleic Acids Research.

In The Last Decade

Kaixian Chen

431 papers receiving 13.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Predicting protein–protein interactions based only on sequences information

2007 745 citations Xiaomin Luo, Kaixian Chen et al. Proceedings of the National Academy of Sciences profile →
Pushing the Boundaries of Molecular Representation for Drug Discovery with the Graph Attention Mechanism

2019 645 citations Xiaohong Liu, Xiaozhe Wan et al. Journal of Medicinal Chemistry profile →
Halogen Bond: Its Role beyond Drug–Target Binding Affinity for Drug Discovery and Development

2013 332 citations Kaixian Chen et al. Journal of Chemical Information and Modeling profile →
TransformerCPI: improving compound–protein interaction prediction by sequence-based deep learning with self-attention mechanism and label reversal experiments

2020 325 citations Xiaoqin Tan, Xiaohong Liu et al. profile →

Peers

Countries citing papers authored by Kaixian Chen

Since Specialization

Citations

This map shows the geographic impact of Kaixian Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kaixian Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kaixian Chen more than expected).

Fields of papers citing papers by Kaixian Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kaixian Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kaixian Chen. The network helps show where Kaixian Chen may publish in the future.

Co-authorship network of co-authors of Kaixian Chen

This figure shows the co-authorship network connecting the top 25 collaborators of Kaixian Chen. A scholar is included among the top collaborators of Kaixian Chen based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kaixian Chen. Kaixian Chen is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Panax notoginseng saponins ameliorate LPS-induced acute lung injury by promoting STAT6-mediated M2-like macrophage polarization 2025 ·Phytomedicine ·(unknown), Hanyang Zhao, Wen‐Yuan Lin, Wenxiang Fan, Tongxi Zhuang, Xu Wang, Qi Li, Xiaohui Wei, Zhengtao Wang, Kaixian Chen, Li Yang, Lili Ding	4
2	The First Discovery of Marine Polyoxygenated Cembranolides as Potential Agents for the Treatment of Ulcerative Colitis 2024 ·Journal of Medicinal Chemistry ·(unknown), Yang Jin, (unknown), (unknown), (unknown), (unknown), Kaixian Chen, Yili Sun, Yue‐Wei Guo, Jia Li, Xu‐Wen Li	5
3	Structure-Based Design and Discovery of a Potent and Cell-Active LC3A/B Covalent Inhibitor 2024 ·Journal of Medicinal Chemistry ·(unknown), (unknown), Shijie Fan, Xueyuan Li, (unknown), (unknown), Daohai Du, Yuanyuan Zhang, Kaixian Chen, Wei Fu, Cheng Luo	3
4	Iridoids and derivatives from Catalpa ovata with their antioxidant activities 2023 ·Fitoterapia ·Liuqiang Zhang, Longlong Wu, Jingwen Liu, Kaixian Chen, Yiming Li	3
5	OTTM: an automated classification tool for translational drug discovery from omics data 2023 ·Briefings in Bioinformatics ·(unknown), Bei Zhang, Siqi Wang, Ye Lü, Kaixian Chen, Cheng Luo, Aihua Sun, Hao Zhang	1
6	Rh(III)-catalyzed late-stage C-H alkenylation and macrolactamization for the synthesis of cyclic peptides with unique Trp(C7)-alkene crosslinks 2023 ·Chinese Chemical Letters ·Shulei Hu, Yu Zhang, Xiong Xie, (unknown), Kaixian Chen, Hong Liu, Jiang Wang	4
7	Structure–Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists 2023 ·ACS Medicinal Chemistry Letters ·(unknown), (unknown), Changfa Zhang, Zhaoming Su, Bin Shan, Rui Li, (unknown), Keke Zhang, (unknown), Jingyi Zhou, Xiaojie Lu, Kaixian Chen, Mingyue Zheng, Sulin Zhang, Hui Hou	2
8	Comprehensive quality evaluation of processed Scrophulariae Radix from different regions of China using HPLC coupled with chemometrics methods 2023 ·Phytochemical Analysis ·Mina Zhang, Kaixian Chen, Pan Wang, Liuqiang Zhang, Yiming Li	5
9	Loops Mediate Agonist-Induced Activation of the Stimulator of Interferon Genes Protein 2023 ·Journal of Chemical Information and Modeling ·Rui Li, (unknown), Xinheng He, (unknown), Zehong Zhang, Hualiang Jiang, Kaixian Chen, Xi Cheng	1
10	L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression 2022 ·Journal for ImmunoTherapy of Cancer ·(unknown), Xiaobo Wang, Bing Li, (unknown), Ruina Wang, Hongru Tao, Junchi Hu, Yu Jin, Hualiang Jiang, Kaixian Chen, Cheng Luo, Yongjun Dang, Yuanyuan Zhang	17
11	Discovery of High-Affinity Inhibitors of the BPTF Bromodomain 2021 ·Journal of Medicinal Chemistry ·Tian Lu, Haibo Lu, Z. H. Duan, Jun Wang, Jie Han, Sen-Hao Xiao, (unknown), Hao Jiang, Yu Chen, Feng Yang, Qi Li, Dongying Chen, (unknown), Bo Li, Hualiang Jiang, Kaixian Chen, Wenchao Lu, Hua Lin, Cheng Luo	12
12	DrugSpaceX: a large screenable and synthetically tractable database extending drug space 2020 ·Nucleic Acids Research ·Tianbiao Yang, Zhaojun Li, Yingjia Chen, (unknown), Guangchao Wang, Zunyun Fu, Xiaoyu Ding, Xiaoqin Tan, Jihui Zhao, Xiaomin Luo, Kaixian Chen, Hualiang Jiang, Mingyue Zheng	26
13	Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering 2020 ·iScience ·Ke Li, Xiaohong Liu, (unknown), (unknown), Yanfang Shen, (unknown), Xiaodong Shi, Wenji Su, Weiren Cui, Zhiqiang Duan, Letian Kuai, Hongfang Yang, Alexander L. Satz, Kaixian Chen, Hualiang Jiang, Mingyue Zheng, Xuanjia Peng, Xiaojie Lu	16
14	p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization 2019 ·Theranostics ·(unknown), Jiacheng Li, Jing Huang, Pan Xu, (unknown), Y. Liu, Yu Liang, Yaxi Yang, (unknown), Hualiang Jiang, Kaixian Chen, Yongjun Dang, Yuanyuan Zhang, Cheng Luo, (unknown)	73
15	Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening 2019 ·RSC Advances ·Hongru Tao, Jun Wang, Wenchao Lu, Rukang Zhang, Yiqian Xie, Yu‐Chih Liu, Rongfeng Liu, Liyan Yue, Kaixian Chen, Hualiang Jiang, Yuanyuan Zhang, Xiaohui Xu, Cheng Luo	8
16	Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues 2017 ·Organic & Biomolecular Chemistry ·Hao Jiang, Jing Xing, Chen Wang, Hao Zhang, Liyan Yue, Xiaozhe Wan, Wei Chen, Hong Ding, Yiqian Xie, Hongru Tao, Zhifeng Chen, Hualiang Jiang, Kaixian Chen, Shijie Chen, Mingyue Zheng, Yuanyuan Zhang, Cheng Luo	29
17	Iron Deprivation Suppresses Hepatocellular Carcinoma Growth in Experimental Studies 2011 ·Clinical Cancer Research ·Qian Ba, Miao Hao, He Huang, Junmei Hou, Shichao Ge, Zhuzhen Zhang, Jun Yin, Ruiai Chu, Hualiang Jiang, Fudi Wang, Kaixian Chen, Hong Liu, Hui Wang	56
18	A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db / db mice 2007 ·Proceedings of the National Academy of Sciences ·(unknown), Jiayu Liao, Na Li, Caihong Zhou, Qing Liu, Guangxing Wang, Rui Zhang, Song Zhang, (unknown), Kaixian Chen, Xin Xie, Fajun Nan, Andrew A. Young, Ming‐Wei Wang	143
19	Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives 2007 ·Acta Pharmacologica Sinica ·Haihong Li, (unknown), Jinzhi Tan, Lili Chen, Hong Liu, Xiaomin Luo, Xu Shen, Liping Lin, Kaixian Chen, Jian Ding, Hualiang Jiang	14
20	Design, synthesis, antitumor evaluations and molecular modeling studies of novel 3,5-substituted indolin-2-one derivatives 2007 ·Acta Pharmacologica Sinica ·(unknown), (unknown), Jinzhi Tan, (unknown), Hong Liu, Xiaomin Luo, Xu Shen, Liping Lin, Kaixian Chen, Jian Ding, Hualiang Jiang	2

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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