Claudio Hetz

52.7k total citations · 13 hit papers
200 papers, 23.9k citations indexed

About

Claudio Hetz is a scholar working on Cell Biology, Epidemiology and Molecular Biology. According to data from OpenAlex, Claudio Hetz has authored 200 papers receiving a total of 23.9k indexed citations (citations by other indexed papers that have themselves been cited), including 140 papers in Cell Biology, 93 papers in Epidemiology and 89 papers in Molecular Biology. Recurrent topics in Claudio Hetz's work include Endoplasmic Reticulum Stress and Disease (134 papers), Autophagy in Disease and Therapy (90 papers) and Prion Diseases and Protein Misfolding (25 papers). Claudio Hetz is often cited by papers focused on Endoplasmic Reticulum Stress and Disease (134 papers), Autophagy in Disease and Therapy (90 papers) and Prion Diseases and Protein Misfolding (25 papers). Claudio Hetz collaborates with scholars based in Chile, United States and France. Claudio Hetz's co-authors include Éric Chevet, Randal J. Kaufman, Feroz R. Papa, Kezhong Zhang, Laurie H. Glimcher, Claudio Soto, Smita Saxena, Bertrand Mollereau, Diego Rojas‐Rivera and Heather P. Harding and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Claudio Hetz

196 papers receiving 23.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

2012 3.1k citations Claudio Hetz Nature Reviews Molecular Cell Biology profile →
Mechanisms, regulation and functions of the unfolded protein response

2020 1.7k citations Claudio Hetz, Kezhong Zhang et al. Nature Reviews Molecular Cell Biology profile →
The Unfolded Protein Response and Cell Fate Control

2017 1.1k citations Claudio Hetz et al. profile →
Targeting the unfolded protein response in disease

2013 736 citations Claudio Hetz, Éric Chevet et al. profile →
ER stress and the unfolded protein response in neurodegeneration

2017 713 citations Claudio Hetz et al. profile →
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease

2018 678 citations Younis Hazari, Claudio Hetz et al. profile →
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

2005 674 citations Claudio Hetz et al. profile →
In Vitro Generation of Infectious Scrapie Prions

2005 611 citations Claudio Hetz, Claudio Soto et al. profile →
Proteostasis control by the unfolded protein response

2015 563 citations Claudio Hetz, Éric Chevet et al. profile →
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

2014 534 citations Claudio Hetz et al. profile →
Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases

2021 473 citations Claudio Hetz et al. profile →
The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

2011 464 citations Claudio Hetz et al. profile →
Endoplasmic Reticulum Stress and the Hallmarks of Cancer

2016 424 citations Hery Urra, Tony Avril et al. profile →

Peers

Countries citing papers authored by Claudio Hetz

Since Specialization

Citations

This map shows the geographic impact of Claudio Hetz's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Claudio Hetz with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Claudio Hetz more than expected).

Fields of papers citing papers by Claudio Hetz

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Claudio Hetz. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Claudio Hetz. The network helps show where Claudio Hetz may publish in the future.

Co-authorship network of co-authors of Claudio Hetz

This figure shows the co-authorship network connecting the top 25 collaborators of Claudio Hetz. A scholar is included among the top collaborators of Claudio Hetz based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Claudio Hetz. Claudio Hetz is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	ER stress signaling at the interphase between MASH and HCC 2024 ·Hepatology ·Younis Hazari, Éric Chevet, Béatrice Bailly‐Maitre, Claudio Hetz	3
2	Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets 2023 ·Molecular & Cellular Proteomics ·Kizito‐Tshitoko Tshilenge, (unknown), Joanna Bons, Akos A. Gerencser, Nathan Basisty, Sicheng Song, Jacob Rose, (unknown), Swati Naphade, (unknown), (unknown), (unknown), (unknown), Anja Holtz, Claudio Hetz, Sean D. Mooney, Birgit Schilling, Lisa Ellerby	18
3	A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation in a cellular model of Huntington’s disease 2021 ·PLoS ONE ·(unknown), José Luis Ordóñez, (unknown), Philippe Pihán, Alfredo Sagredo, Ulises Ahumada-Castro, Andrés Barriga, (unknown), César Cárdenas, René L. Vidal, Claudio Hetz, Carla Delporte	12
4	The UPRosome – decoding novel biological outputs of IRE1α function 2020 ·Journal of Cell Science ·Hery Urra, Philippe Pihán, Claudio Hetz	33
5	Mechanisms, regulation and functions of the unfolded protein response breakdown → 2020 ·Nature Reviews Molecular Cell Biology ·Claudio Hetz, Kezhong Zhang, Randal J. Kaufman	1665
6	Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion 2019 ·Cancers ·(unknown), Chloé Sauzay, Hery Urra, Claudio Hetz, Éric Chevet, Tony Avril	72
7	Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease 2018 ·Neurobiology of Disease ·Gabriela Mercado, Valentina Castillo, Paulina Soto, (unknown), Jeffrey M. Axten, S. Pablo Sardi, Jeroen J.M. Hoozemans, Claudio Hetz	128
8	Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases 2018 ·Seminars in Cancer Biology ·Matías González-Quiroz, Hery Urra, (unknown), Claudio Hetz	8
9	Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives 2017 ·Science Signaling ·Joanna Obacz, Tony Avril, Pierre‐Jean Le Reste, Hery Urra, Véronique Quillien, Claudio Hetz, Éric Chevet	102
10	The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics 2017 ·Frontiers in Oncology ·Amado Carreras‐Sureda, Philippe Pihán, Claudio Hetz	37
11	Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury 2016 ·Scientific Reports ·Maritza Oñate, Alejandra Catenaccio, Gabriela Martínez, Donna Armentano, Geoffrey Parsons, Bredford Kerr, Claudio Hetz, Felipe A. Court	74
12	A Molecular Reporter for Monitoring Autophagic Flux in Nervous System In Vivo 2016 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Karen Castillo, (unknown), Maritza Oñate, Claudio Hetz	10
13	Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis 2014 ·Autophagy ·Melissa Nassif, Vicente Valenzuela, Diego Rojas‐Rivera, René L. Vidal, Soledad Matus, Karen Castillo, (unknown), Guido Kroemer, Beth Levine, Claudio Hetz	86
14	ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders 2014 ·Virus Research ·Mauricio Torres, José Manuel Matamala, Claudia Duran‐Aniotz, Víctor Hugo Cornejo, Andrew Foley, Claudio Hetz	27
15	Protein disulfide isomerases in neurodegeneration: From disease mechanisms to biomedical applications 2012 ·FEBS Letters ·Catherine I. Andreu, Ute Woehlbier, Mauricio Torres, Claudio Hetz	90
16	Activation of the unfolded protein response enhances motor recovery after spinal cord injury 2012 ·Cell Death and Disease ·(unknown), Eileen Collyer, Donna Armentano, Geoffrey Parsons, Felipe A. Court, Claudio Hetz	120
17	The unfolded protein response: controlling cell fate decisions under ER stress and beyond breakdown → 2012 ·Nature Reviews Molecular Cell Biology ·Claudio Hetz	3115
18	Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore 2011 ·Journal of Neuroscience ·(unknown), Nicolás W. Martínez, Soonmoon Yoo, Juan Sebastián Jara, Sebastián Zamorano, Claudio Hetz, Jeffery L. Twiss, Jaime Álvarez, Felipe A. Court	179
19	Correction: Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress 2011 ·PLoS ONE ·Mauricio Torres, Karen Castillo, (unknown), (unknown), Claudio Soto, Claudio Hetz	3
20	Abnormal calcium homeostasis and protein folding stress at the ER 2011 ·Communicative & Integrative Biology ·Mauricio Torres, (unknown), Claudio Soto, Claudio Hetz	30

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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