Brunhilde Wirth

19.5k citations

177 papers · 11.4k indexed · 2 hit papers · h-index 54

Impact in

Genetics top 0.02%
- Neurogenetic and Muscular Disorders Research
- Genetics and Neurodevelopmental Disorders
- Connective tissue disorders research
Molecular Biology top 0.5%
- RNA modifications and cancer
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Cancer-related gene regulation

Papers in

Genetics 127
- Neurogenetic and Muscular Disorders Research 127
- Genetics and Neurodevelopmental Disorders 13
- Genetic and Kidney Cyst Diseases 7
Molecular Biology 146
- RNA modifications and cancer 99
- RNA Research and Splicing 47
- Muscle Physiology and Disorders 17
- Cancer-related gene regulation 11

Co-authors: Eric Hahnen Elliot J. Androphy Christian L. Lorson Klaus Zerres Sabine Rudnik‐Schöneborn Thomas F. Wienker Markus Rießland Markus Feldkötter
Journals: Human Molecular Genetics (17 papers)Human Genetics (11 papers)The American Journal of Human Genetics (10 papers)Genomics (9 papers)European Journal of Human Genetics (6 papers)
Partner nations: Germany United States United Kingdom

In The Last Decade

Brunhilde Wirth

173 papers receiving 11.1k citations

Hit Papers

align trajectories log scale

Quantitative Analyses of SMN1 and SMN2 Based on Real-Time LightCycler PCR: Fast and Highly Reliable Carrier Testing and Prediction of Severity of Spinal Muscular Atrophy 2002 · 772 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2002 The American Journal of Human Genetics
1999 Proceedings of the National Academy of Sciences

Peers

Countries citing papers authored by Brunhilde Wirth

Since Specialization

Citations

This map shows the geographic impact of Brunhilde Wirth's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brunhilde Wirth with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brunhilde Wirth more than expected).

Fields of papers citing papers by Brunhilde Wirth

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brunhilde Wirth. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brunhilde Wirth. The network helps show where Brunhilde Wirth may publish in the future.

Co-authors

The 25 scholars most cited alongside Brunhilde Wirth, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Brunhilde Wirth Line = papers co-authored together Brunhilde Wirth links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy Science Advances ·Marta Zaninello, B. Tönshoff, Hendrik Nolte, Shichuan Ding, T. Alexander Aleinikoff, Esther Barth, Ines Klein, H. Yang, Kiszka, Hongqiao Qiao, Brunhilde Wirth, Helmar C. Lehmann, Jean-Michel Cioni, Thomas Langer, Elena I. Rugarli	2024	5
2	Functional Insights in PLS3-Mediated Osteogenic Regulation Cells ·Sofía Hevia Tagle, R.D. Margarette Harden, R. Neueder, Xingyang Li, Gerard Pals, M. Carola Zillikens, Elisabeth M. W. Eekhoff, Nathalie Bravenboer, Qingbin Zhang, Matthias Hammerschmidt, Brunhilde Wirth, Dimitra Micha	2024	0
3	Histone variant H3.5 in testicular cell differentiation and its interactions with histone chaperones Scientific Reports ·周晓风, Elaine Crawley, Brunhilde Wirth, E. Oetjen, C.A. Dimitriadis, Luis Alberto Sancesario Pérez, 增一郝, Е.Е. РУСЛЯКОВА, Jann‐Frederik Cremers, Daniel Gödde, Stephan Degener, Jan Postberg	2024	0
4	Oral functions in adult persons with spinal muscular atrophy compared to a healthy control group: a prospective cross-sectional study with a multimodal approach Orphanet Journal of Rare Diseases ·宏次朗笹井, W. Schuphan, E W FAIR, Boo-Hu Wang, Brunhilde Wirth, Raoul Heller, سهام لطفي عبد الفتاح, Tim Hagenacker, Bert Braumann, Gilbert Wunderlich	2024	1
5	Long-Term SMN- and Ncald-ASO Combinatorial Therapy in SMA Mice and NCALD-ASO Treatment in hiPSC-Derived Motor Neurons Show Protective Effects International Journal of Molecular Sciences ·Heng Wang, Aji Kusumo Atmojo, Karen Ling, Sören Höhn, Frank Rigo, C. Frank Bennett, Brunhilde Wirth	2023	7
6	Mitochondrial Dysfunction in Spinal Muscular Atrophy International Journal of Molecular Sciences ·Sören Höhn, Valentina Piano, Brunhilde Wirth	2022	28
7	Autophagy regulates neuronal excitability by controlling cAMP /protein kinase A signaling at the synapse The EMBO Journal ·Siegfried R�sch, Frederik Tellkamp, Simon Heß, Fan Yang, Luh Putu Windaresa, D C Hugh, Gabriela Paola Sánchez Mandujano, Milad Mohammadi, Elodie De Bruyckere, Emmanouela Kallergi, 刘海俐, Vassiliki Nikoletopoulou, Brunhilde Wirth, Jörg Isensee, Tim Hucho, Dmytro Puchkov, Dirk Isbrandt, Marcus Krüeger, Peter Kloppenburg, Natalia L. Kononenko	2022	31
8	The Proteome Signatures of Fibroblasts from Patients with Severe, Intermediate and Mild Spinal Muscular Atrophy Show Limited Overlap Cells ·Sharon J. Brown, Rachel Kline, Silvia A. Synowsky, Sally L. Shirran, Ian Holt, Oluwafemi O. Olawoyind, Peter Claus, Brunhilde Wirth, Thomas M. Wishart, Heidi R. Fuller	2022	6
9	Infants Diagnosed with Spinal Muscular Atrophy and 4 SMN2 Copies through Newborn Screening – Opportunity or Burden? Journal of Neuromuscular Diseases ·Wolfgang Müller‐Felber, Katharina Vill, Oliver Schwartz, Dieter Gläser, Uta Nennstiel, Brunhilde Wirth, Siegfried Burggraf, Wulf Röschinger, Marc Becker, Jürgen Durner, Katja Eggermann, Christine Müller, Iris Hannibal, B. Olgemöller, Ulrike Schara, Astrid Blaschek, Heike Kölbel	2020	42
10	Identification of Evolutionarily Conserved Exons as Regulated Targets for the Splicing Activator Tra2β in Development PLoS Genetics ·Sushma Nagaraja Grellscheid, Caroline Dalgliesh, Markus Storbeck, Andrew Best, Yilei Liu, Junmei Li, Ylva Mende, Ingrid Ehrmann, Tomaž Curk, Glenda Cea¬-Barcia, Cyril F. Bourgeois, James Stévenin, D. Grellscheid, Michael S. Jackson, Brunhilde Wirth, David J. Elliott	2011	61
11	Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy Human Molecular Genetics ·Stéphane Fourcade, Montserrat Ruíz, Cristina Guilera, Eric Hahnen, Lars Brichta, Alba Naudí, Manuel Portero-Otı́n, G. Dacremont, Nathalie Cartier, Ronald J. A. Wanders, Stephan Kemp, Jean‐Louis Mandel, Brunhilde Wirth, Reinald Pamplona, Patrick Aubourg, Aurora Pujol	2010	76
12	Plastin 3 Is a Protective Modifier of Autosomal Recessive Spinal Muscular Atrophy Science ·Gabriela Oprea, Sandra Kröber, Michelle L. McWhorter, Wilfried Rossoll, Stefan Müller, Michael Krawczak, Gary J. Bassell, Christine E. Beattie, Brunhilde Wirth	2008	393
13	Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition Human Molecular Genetics ·Jan Hauke, Markus Rießland, Sebastian Lunke, Ilker Y. Eyüpoglu, Ingmar Blümcke, Assam El‐Osta, Brunhilde Wirth, Eric Hahnen	2008	111
14	Drug discovery for spinal muscular atrophy Expert Opinion on Drug Discovery ·Brunhilde Wirth, Markus Rießland, Eric Hahnen	2007	3
15	The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells Human Genetics ·Markus Rießland, Lars Brichta, Eric Hahnen, Brunhilde Wirth	2006	104
16	X-linked lethal infantile (XL)-SMA: new clinical information, variant phenotypes, and candidate disease gene studies. mediaTUM (Technical University of Munich) ·Mary Ellen Ahearn, Devin Dressman, Kemal O. Yariz, Elicia Estrella, Enas R. Alwaily, A Meindl, Francesc Palau, 毅谷田貝, 경민 도, Brunhilde Wirth, J J G M Gerritsen, Bukish Natalia, Cheah Fook Choe, Galina Krasteva	2004	1
17	Missense Mutations in Exon 6 of the Survival Motor Neuron Gene in Patients with Spinal Muscular Atrophy (SMA) Human Molecular Genetics ·Eric Hahnen, Jutta Schönling, Sabine Rudnik‐Schöneborn, A Gulley, Klaus Zerres, Brunhilde Wirth	1997	89
18	Evidence of autosomal dominant mutations in childhood-onset proximal spinal muscular atrophy. PubMed Central ·Sabine Rudnik‐Schöneborn, Brunhilde Wirth, Klaus Zerres	1994	11
19	A new polymorphic probe on 5q11.2-13.3: ECB306Bgl2.1 (D5S215) Nucleic Acids Research ·Klaus Rüther, Brunhilde Wirth	1992	3
20	Late Manifestation of Autosomal-Recessive Polycystic Kidney Disease in Two Sisters American Journal of Nephrology ·Hartmut P.H. Neumann, Klaus Zerres, Xuehui Huang, G. Wolff, Hans E. Schaefer, Andreas Gal, Brunhilde Wirth, GU Renfu, Klaus Haag, P. Schollmeyer	1988	11

About Brunhilde Wirth

Brunhilde Wirth is a scholar working on Genetics, Molecular Biology, Genetics, Surgery and Neurology, having authored 177 papers that have together received 11.4k indexed citations. Recurring topics across this work include Neurogenetic and Muscular Disorders Research (127 papers), RNA modifications and cancer (99 papers), RNA Research and Splicing (47 papers), Congenital Anomalies and Fetal Surgery (37 papers), Muscle Physiology and Disorders (17 papers), Genetics and Neurodevelopmental Disorders (13 papers), Cancer-related gene regulation (11 papers) and Genetic and Kidney Cyst Diseases (7 papers). The work is most often cited by research in Genetics (8.2k citations), Molecular Biology (9.0k citations), Surgery (3.4k citations), Genetics (1.5k citations) and Neurology (582 citations). Brunhilde Wirth has collaborated with scholars based in Germany, United States and United Kingdom. Frequent co-authors include Eric Hahnen, Elliot J. Androphy, Christian L. Lorson, Klaus Zerres, Sabine Rudnik‐Schöneborn, Thomas F. Wienker, Markus Rießland, Markus Feldkötter, Lars Brichta and Arthur H.M. Burghes. Their work appears in journals such as Human Molecular Genetics, Human Genetics, The American Journal of Human Genetics, Genomics and European Journal of Human Genetics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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