Bruce Α. Freeman

57.0k citations

297 papers · 46.5k indexed · 14 hit papers · h-index 100

Impact in

Biochemistry top 0.01%
- Eicosanoids and Hypertension Pharmacology
- Sulfur Compounds in Biology
Physiology top 0.01%
- Nitric Oxide and Endothelin Effects

Papers in

Biochemistry 94
- Eicosanoids and Hypertension Pharmacology 82
Physiology 121
- Nitric Oxide and Endothelin Effects 103

Co-authors: Joseph S. Beckman Rafael Radí Crapo Jd Jake Y. Chen Pamela A. Marshall James D. Crapo Margaret M. Tarpey Francisco J. Schöpfer
Journals: Free Radical Biology and Medicine (41 papers)Journal of Biological Chemistry (39 papers)Archives of Biochemistry and Biophysics (16 papers)American Journal of Physiology-Lung Cellular and Molecular Physiology (13 papers)Proceedings of the National Academy of Sciences (13 papers)
Partner nations: United States Uruguay Germany

In The Last Decade

Bruce Α. Freeman

296 papers receiving 45.4k citations

Hit Papers

14 papers align trajectories log scale

Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase 2002 · 553 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2002 Science
2001 Circulation
1998 Nature
1997 Circulation
1996 Journal of Clinical Investigation
1996 Archives of Biochemistry and Biophysics
1995 Journal of Clinical Investigation
1994 Journal of Biological Chemistry
1994 Proceedings of the National Academy of Sciences
1991 Archives of Biochemistry and Biophysics
1991 Journal of Biological Chemistry
1990 Proceedings of the National Academy of Sciences
1982 PubMed
1981 Journal of Biological Chemistry

Peers

Countries citing papers authored by Bruce Α. Freeman

Since Specialization

Citations

This map shows the geographic impact of Bruce Α. Freeman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bruce Α. Freeman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bruce Α. Freeman more than expected).

Fields of papers citing papers by Bruce Α. Freeman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bruce Α. Freeman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bruce Α. Freeman. The network helps show where Bruce Α. Freeman may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Bruce Α. Freeman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Bruce Α. Freeman Line = papers co-authored together Bruce Α. Freeman links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Fatty acid nitroalkenes regulate intestinal lipid absorption Journal of Lipid Research ·Francisco J. Schöpfer, Lihong Teng, K. Raju Jampani, Graciana de Assis Cunha Manoel, Alison B. Kohan, Bruce Α. Freeman, Marco Fazzari	2025	1
2	Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease Redox Biology ·Francisco Jiménez, 翟力, Irene Caravita, Katherine C. Wood, Julia Xu, Bruce Α. Freeman, Francisco J. Schöpfer, Adam C. Straub	2023	6
3	Immunomodulatory actions of a kynurenine-derived endogenous electrophile Science Advances ·B. Sakintuna, Vanessa Tavares da Silva Fontes, Steven R. Woodcock, Tomasz Brzóska, Samit Ghosh, Sonia R. Salvatore, Fei Chang, Nicholas K.H. Khoo, Matthew D. Dunn, M Boscolo Berto, Shuai Yuan, Adam C. Straub, Stacy G. Wendell, Gregory J. Kato, Bruce Α. Freeman, Solomon F. Ofori‐Acquah, Prithu Sundd, Francisco J. Schöpfer, Darío A. Vitturi	2022	14
4	Synthesis of 9- and 12-nitro conjugated linoleic acid: Regiospecific isomers of naturally occurring conjugated nitrodienes Tetrahedron Letters ·Steven R. Woodcock, Sonia R. Salvatore, Bruce Α. Freeman, Francisco J. Schöpfer	2021	3
5	Electrophilic nitro-fatty acids suppress psoriasiform dermatitis: STAT3 inhibition as a contributory mechanism Redox Biology ·葉志冠, Meaghan E. Killeen, Tina L. Sumpter, Laura K. Ferris, Louis D. Falo, Bruce Α. Freeman, Francisco J. Schöpfer, Alicia R. Mathers	2021	17
6	Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO2) and nitroalkene (RNO2) substituents Redox Biology ·Marco Fazzari, Steven R. Woodcock, Pascal Rowart, Karina Ricart, Jack R. Lancaster, Rakesh P. Patel, Darío A. Vitturi, Bruce Α. Freeman, Francisco J. Schöpfer	2021	12
7	Electrophilic nitroalkene-tocopherol derivatives: synthesis, physicochemical characterization and evaluation of anti-inflammatory signaling responses Scientific Reports ·弘志境, Robert Sweetland, MISSING-VALUE MISSING-VALUE, Lucía Turell, Andrés Kamaid, Nicholas K.H. Khoo, Francisco J. Schöpfer, Bruce Α. Freeman, Carlos Escande, Carlos Batthyány, Gerardo Ferrer‐Sueta, Gloria V. López	2018	12
8	Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes Free Radical Biology and Medicine ·Meghan Delmastro-Greenwood, Kara S. Hughan, Darío A. Vitturi, Sonia R. Salvatore, George Grimes, L. E. King, Sruti Shiva, Francisco J. Schöpfer, Mark T. Gladwin, Bruce Α. Freeman, Stacy G. Wendell	2015	76
9	15-Hydroxyprostaglandin Dehydrogenase Generation of Electrophilic Lipid Signaling Mediators from Hydroxy Ω-3 Fatty Acids Journal of Biological Chemistry ·Stacy G. Wendell, Franca Golin-Bisello, Sally E. Wenzel, Robert W. Sobol, Fernando Holguín, Bruce Α. Freeman	2015	28
10	Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase Proceedings of the National Academy of Sciences ·Rebecca L. Charles, Olena Rudyk, Oleksandra Prysyazhna, Caroline Hyernart, Jun Yang, Christophe Morisseau, Bruce D. Hammock, Bruce Α. Freeman, Philip Eaton	2014	83
11	Protective Effects of 10-nitro-oleic Acid in a Hypoxia-Induced Murine Model of Pulmonary Hypertension American Journal of Respiratory Cell and Molecular Biology ·Anna Klinke, Destiana Avionita, Michaela Pekarová, Thorben Ravekes, Kai Friedrichs, Subramaniam Tavintharan, Малышков Григорий Борисович, Lukáš Kubala, Hana Kolářová, Gabriela Ambrožová, Ralph T. Schermuly, Steven R. Woodcock, Bruce Α. Freeman, Stephan Rosenkranz, Stephan Baldus, Volker Rudolph, Tanja K. Rudolph	2014	58
12	Electrophilic Fatty Acid Species Inhibit 5-Lipoxygenase and Attenuate Sepsis-Induced Pulmonary Inflammation Antioxidants and Redox Signaling ·Khader Awwad, Etzioni David, Timo Frömel, J P Maton, J. Isaak, Ann‐Kathrin Häfner, Jessica Roos, Bettina Hofmann, Heinrich Heide, Gerd Geißlinger, Dieter Steinhilber, Bruce Α. Freeman, Thorsten J. Maier, Ingrid Fleming	2013	48
13	Nitrated oleic acid up-regulates PPARγ and attenuates experimental inflammatory bowel disease Free Radical Biology and Medicine ·Sara Borniquel, Emmelie Å. Jansson, Marsha P. Cole, Bruce Α. Freeman, Jon O. Lundberg	2009	81
14	Nitro-fatty Acid Metabolome: Saturation, Desaturation, β-Oxidation, and Protein Adduction Journal of Biological Chemistry ·Volker Rudolph, Francisco J. Schöpfer, Nicholas K.H. Khoo, Tanja K. Rudolph, Marsha P. Cole, Steven R. Woodcock, Gustavo Bonacci, Alison L. Groeger, Franca Golin-Bisello, Yuki Masami, Paul R.S. Baker, Bruce Α. Freeman	2008	101
15	Red cell membrane and plasma linoleic acid nitration products: Synthesis, clinical identification, and quantitation Proceedings of the National Academy of Sciences ·Paul R.S. Baker, Francisco J. Schöpfer, Scott Sweeney, Bruce Α. Freeman	2004	173
16	Hypercapnia via Reduced Rate and Tidal Volume Contributes to Lipopolysaccharide-induced Lung Injury American Journal of Respiratory and Critical Care Medicine ·John D. Lang, Mario Figueroa, Haotian Wu, Mutay Aslan, Yuliang Liu, Phillip Chumley, Bruce Α. Freeman	2004	76
17	Endothelial transcytosis of myeloperoxidase confers specificity to vascular ECM proteins as targets of tyrosine nitration Journal of Clinical Investigation ·Stephan Baldus, Jason P. Eiserich, Ali R. Mani, Laura Castro, Mario Figueroa, Phillip Chumley, Wenxin Ma, Albert Tousson, 任亚江, Daniel C. Bullard, Marie‐Luise Brennan, Aldons J. Lusis, Kevin P. Moore, Bruce Α. Freeman	2001	246
18	[36] Nitric oxide regulation of lipid oxidation reactions: Formation and analysis of nitrogen-containing oxidized lipid derivatives Methods in enzymology on CD-ROM/Methods in enzymology ·Homero Rubbo, Bruce Α. Freeman	1996	25
19	The double-edged action of nitric oxide on free radical-mediated oxidations Ciencia e cultura ·Rafael Radí, Homero Rubbo, Bruce Α. Freeman	1995	12
20	Tissue slices in the study of lung metabolism and toxicology. Environmental Health Perspectives ·Bruce Α. Freeman, Jakub Irber	1984	23

About Bruce Α. Freeman

Bruce Α. Freeman is a scholar working on Biochemistry, Physiology, Biophysics, Nephrology and Nutrition and Dietetics, having authored 297 papers that have together received 46.5k indexed citations. Recurring topics across this work include Nitric Oxide and Endothelin Effects (103 papers), Eicosanoids and Hypertension Pharmacology (82 papers), Fatty Acid Research and Health (28 papers), Peroxisome Proliferator-Activated Receptors (28 papers), Neutrophil, Myeloperoxidase and Oxidative Mechanisms (25 papers), Heme Oxygenase-1 and Carbon Monoxide (23 papers), Gout, Hyperuricemia, Uric Acid (22 papers) and Electron Spin Resonance Studies (22 papers). The work is most often cited by research in Biochemistry (9.2k citations), Physiology (19.4k citations), Biophysics (2.7k citations), Biochemistry (2.4k citations) and Endocrine and Autonomic Systems (2.1k citations). Bruce Α. Freeman has collaborated with scholars based in United States, Uruguay and Germany. Frequent co-authors include Joseph S. Beckman, Rafael Radí, Crapo Jd, Jake Y. Chen, Pamela A. Marshall, James D. Crapo, Margaret M. Tarpey, Francisco J. Schöpfer, David G. Harrison and Joseph S. Beckman. Their work appears in journals such as Free Radical Biology and Medicine, Journal of Biological Chemistry, Archives of Biochemistry and Biophysics, American Journal of Physiology-Lung Cellular and Molecular Physiology and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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