Patrick Casara

3.2k citations

56 papers · 2.5k indexed · 2 hit papers · h-index 23

Impact in

Biochemistry top 0.2%
- Amino Acid Enzymes and Metabolism
Molecular Biology top 5%
- Polyamine Metabolism and Applications
- Chemical Synthesis and Analysis

Papers in ⓘ

Biochemistry 15
- Amino Acid Enzymes and Metabolism 15
Virology 6
- HIV Research and Treatment 6

Co-authors: Brian W. Metcalf (10 shared papers)Charles Danzin (10 shared papers)Philippe Bey (5 shared papers)Michael J. Jung (4 shared papers)Jean‐Paul Vevert (1 shared paper)Michel J. Jung (5 shared papers)Bruce Lippert (2 shared papers)Nikolaus Seiler (2 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (9 papers)Tetrahedron Letters (6 papers)Biochemical Pharmacology (4 papers)Journal of Medicinal Chemistry (3 papers)Antimicrobial Agents and Chemotherapy (3 papers)
Partner nations: France United Kingdom United States

In The Last Decade

Patrick Casara

55 papers receiving 2.3k citations

Hit Papers

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Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs 1978 · 880 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

1978 Journal of the American Chemical Society
1977 European Journal of Biochemistry

Peers

Countries citing papers authored by Patrick Casara

Since Specialization

Citations

This map shows the geographic impact of Patrick Casara's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick Casara with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick Casara more than expected).

Fields of papers citing papers by Patrick Casara

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick Casara. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick Casara. The network helps show where Patrick Casara may publish in the future.

Co-authors

The 25 scholars most cited alongside Patrick Casara, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Patrick Casara Line = papers co-authored together Patrick Casara links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 56 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs Journal of the American Chemical Society ·Brian W. Metcalf, Philippe Bey, Charles Danzin, Michael J. Jung, Patrick Casara, Jean‐Paul Vevert Hit paper breakdown →	1978	880
2	4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian Brain European Journal of Biochemistry ·Bruce Lippert, Brian W. Metcalf, Michel J. Jung, Patrick Casara Hit paper breakdown →	1977	325
3	N-(2,3-Butadienyl)-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase Journal of Medicinal Chemistry ·Philippe Bey, Frank N. Bolkenius, Nikolaus Seiler, Patrick Casara	1985	120
4	Blockade of αvβ3 and αvβ5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells Blood ·Sylvie Maubant, Dominique Saint-Dizier, Morgane Boutillon, Françoise Perron‐Sierra, Patrick Casara, John A. Hickman, Gordon C. Tucker, Ellen Van Obberghen‐Schilling	2006	89
5	Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase Antimicrobial Agents and Chemotherapy ·Alan J. Bitonti, T L Byers, Tammy L. Bush, Patrick Casara, Cyrus J. Bacchi, A B Clarkson, Peter P. McCann, Albert Sjoerdsma	1990	85
6	Regiospecific 1,4 addition of a propargylic anion. A general synthon for 2-substituted propargylamines as potential catalytic irreversible enzyme inhibitors. Tetrahedron Letters ·Brian W. Metcalf, Patrick Casara	1975	66
7	New quinolinic derivatives as centrally active antioxidants Bioorganic & Medicinal Chemistry Letters ·Gilbert Dorey, Brian Lockhart, Pierre Lestage, Patrick Casara	2000	62
8	Irreversible inhibition of rat S-adenosylmethionine decarboxylase by 5′-{[(Z)-4-amino-2-butenyl]methylamino}-5′-deoxyadenosine Biochemical Pharmacology ·Charles Danzin, P. Marchal, Patrick Casara	1990	51
9	5'-{[(Z)-4-Amino-2-butenyl]methylamino}-5'-deoxyadenosine: a potent enzyme-activated irreversible inhibitor of S-adenosyl-L-methionine decarboxylase from Escherichia coli Journal of the American Chemical Society ·Patrick Casara, P. Marchal, Joseph E. Wagner, Charles Danzin	1989	49
10	Effects of (2R, 5R)‐6‐heptyne‐2,5‐diamine, a potent inhibitor of l‐ornithine decarboxylase, on rat hepatoma cells cultured in vitro European Journal of Biochemistry ·Pierre S. Mamont, M Siat, Anne‐Marie JODER‐OHLENBUSCH, Annie Bernhardt, Patrick Casara	1984	48
11	General synthetic access to α-allenyl amines and α-allenyl-α-aminoacids as potential enzyme activated irreversible inhibitors of PLP dependent enzymes Tetrahedron Letters ·Patrick Casara, K. JUND, Philippe Bey	1984	47
12	A One-Step Synthesis of 2-(2-Pyridyl)-3H-indol-3-one N-Oxide: Is It an Efficient Spin Trap for Hydroxyl Radical? The Journal of Organic Chemistry ·Gerald M. Rosen, Pei Tsai, Eugene D. Barth, Gilbert Dorey, Patrick Casara, Michael Spedding, Howard J. Halpern	2000	45
13	.alpha.-Ethynyl and .alpha.-vinyl analogs of ornithine as enzyme-activated inhibitors of mammalian ornithine decarboxylase Journal of Medicinal Chemistry ·Charles Danzin, Patrick Casara, Nicole Claverie, Brian W. Metcalf	1981	45
14	Mechanism of the stereospecific irreversible inhibition of bacterial glutamic acid decarboxylase by (R)-(-)-4-aminohex-5-ynoic acid, an analog of 4-aminobutyric acid Biochemistry ·Michel J. Jung, Brian W. Metcalf, Bruce Lippert, Patrick Casara	1978	40
15	(2R,5R)-6-heptyne-2,5-diamine, an extremely potent inhibitor of mammalian ornithine decarboxylase Biochemical and Biophysical Research Communications ·Charles Danzin, Patrick Casara, Nicole Claverie, Brian W. Metcalf, Michael J. Jung	1983	37
16	Substituted benzocyloheptenes as potent and selective αv integrin antagonists Bioorganic & Medicinal Chemistry Letters ·Françoise Perron‐Sierra, Dominique Saint Dizier, Marc Bertrand, Annie Genton, Gordon C. Tucker, Patrick Casara	2002	36
17	Catalytic irreversible inhibition of bacterial and plant arginine decarboxylase activities by novel substrate and product analogues Biochemical Journal ·Alan J. Bitonti, Patrick Casara, P. P. McCann, Philippe Bey	1987	34
18	Bax Activation by Engagement with, Then Release from, the BH3 Binding Site of Bcl-x _L Molecular and Cellular Biology ·Fabien Gautier, Yannis Guillemin, Pierre‐François Cartron, Tristan Gallenne, Nicolas Cauquil, Thierry Le Diguarher, Patrick Casara, François M. Vallette, Stéphen Manon, John A. Hickman, Olivier Geneste, Philippe Juin	2010	30
19	Trimethylsilylacetylene-N-carboethoxy glycinate dianion - a general synthon for α-acetylenic α-amino acids. Tetrahedron Letters ·Patrick Casara, Brian W. Metcalf	1978	27
20	Synthesis of N,N′-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors Bioorganic & Medicinal Chemistry Letters ·Thierry Le Diguarher, Jean‐Claude Ortuno, David R. Shanks, Nicolas Guilbaud, Alain St. Pierre, Eric Raimbaud, Jean‐Luc Fauchère, John A. Hickman, Gordon C. Tucker, Patrick Casara	2003	25

About Patrick Casara

Patrick Casara is a scholar working on Biochemistry, Virology, Clinical Biochemistry, Pharmaceutical Science and Organic Chemistry, having authored 56 papers that have together received 2.5k indexed citations. Recurring topics across this work include Amino Acid Enzymes and Metabolism (15 papers), Polyamine Metabolism and Applications (15 papers), Chemical Synthesis and Analysis (6 papers), Metabolism and Genetic Disorders (6 papers), HIV Research and Treatment (6 papers), HIV/AIDS drug development and treatment (6 papers), Synthetic Organic Chemistry Methods (4 papers) and Biochemical and Molecular Research (4 papers). The work is most often cited by research in Biochemistry (833 citations), Molecular Biology (1.7k citations), Pharmacology (360 citations), Clinical Biochemistry (144 citations) and Organic Chemistry (514 citations). Patrick Casara has collaborated with scholars based in France, United Kingdom and United States. Frequent co-authors include Brian W. Metcalf, Charles Danzin, Philippe Bey, Michael J. Jung, Jean‐Paul Vevert, Michel J. Jung, Bruce Lippert, Nikolaus Seiler, Frank N. Bolkenius and Gordon C. Tucker. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, Biochemical Pharmacology, Journal of Medicinal Chemistry and Antimicrobial Agents and Chemotherapy.

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