Brian Bigger

5.2k citations

115 papers · 3.5k indexed · h-index 35

Physiology top 1%
- Lysosomal Storage Disorders Research 68
Hepatology top 2%
Cell Biology top 2%
- Cellular transport and secretion 16
Genetics top 2%
- Virus-based gene therapy research 15
Epidemiology top 5%
- Trypanosoma species research and implications 17
Molecular Biology
- CRISPR and Genetic Engineering 13
- RNA Interference and Gene Delivery 7
Hematology
- Autoimmune and Inflammatory Disorders Research 11
Public Health, Environmental and Occupational Health
- Research on Leishmaniasis Studies 7

Co-authors: Robert Wynn Kia Langford‐Smith Simon Jones Fiona L. Wilkinson J. E. Wraith Helen Parker Stuart J. Forbes Rebecca Holley
Cited by: Physiology Hepatology Cell Biology
Journals: Molecular Genetics and Metabolism (21 papers)Journal of Inherited Metabolic Disease (10 papers)PLoS ONE (8 papers)
Partner nations: United Kingdom United States Netherlands

In The Last Decade

Brian Bigger

111 papers receiving 3.5k citations

Peers

Countries citing papers authored by Brian Bigger

Since Specialization

Citations

This map shows the geographic impact of Brian Bigger's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brian Bigger with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brian Bigger more than expected).

Fields of papers citing papers by Brian Bigger

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brian Bigger. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brian Bigger. The network helps show where Brian Bigger may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Brian Bigger, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Brian Bigger Line = papers co-authored together Brian Bigger links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Improving newborn screening test performance for metachromatic leukodystrophy: Recommendation from a pre-pilot study that identified a late-infantile case for treatment Molecular Genetics and Metabolism ·زهرا موسوی,Heather A. Brown,Heather J. Church,Christopher J. Kershaw,Carlos Felipe Bernardes Silva,Christine Egerton,James A. Cooper,Karen Tylee,敏之小林,David Gokhale,Dipak Ram,政治関口,Michael W. Henderson,Brian Bigger,Simon Jones	2024	6
2	Sustained long-term disease correction in a murine model of MPSII following stem cell gene therapy Molecular Therapy — Methods & Clinical Development ·Stuart Ellison,Aiyin Liao,Hélène F.E. Gleitz,Helen Parker,Laura Booth,John E. Robinson,Jindřich Šonský,Yankun Xu,Rebecca Holley,Brian Bigger	2023	5
3	Advances in therapies for neurological lysosomal storage disorders Journal of Inherited Metabolic Disease ·Stuart Ellison,Helen Parker,Brian Bigger	2023	28
4	Sustained biochemical engraftment and early clinical outcomes following autologous stem cell gene therapy for mucopolysaccharidosis type IIIA Molecular Genetics and Metabolism ·Simon Jones,A. Ahmed,Rebecca Holley,Theresa Baxter,Claire Booth,Karen Buckland,Stewart Rust,Heather J. Church,F Marra,Helena Lee,Laura Ford,Stuart Ellison,Brian Bigger,Robert Wynn	2023	2
5	Establishment of the Effectiveness of Early Versus Late Stem Cell Gene Therapy in Mucopolysaccharidosis II for Treating Central Versus Peripheral Disease Human Gene Therapy ·Eli Dansky,Aiyin Liao,Esha Singh,Claire O’Leary,Rebecca Holley,Brian Bigger	2023	5
6	Fusion of Rabies Virus Glycoprotein or gh625 to Iduronate-2-Sulfatase for the Treatment of Mucopolysaccharidosis Type II Human Gene Therapy ·Jindřich Šonský,Nila Kirupaharan,Stuart Ellison,Priscilla Carlson,Ucn Revista Ucn,Nicholas Kormos,Gabriella Forte,Claire O’Leary,Hélène F.E. Gleitz,Aiyin Liao,James Cook,Rebecca Holley,Brian Bigger	2023	2
7	Gene-modified neural progenitor cells for the treatment of neuropathic lysosomal storage diseases Neural Regeneration Research ·Brian Bigger,Eli Dansky	2023	1
8	Bile acid biosynthesis in Smith-Lemli-Opitz syndrome bypassing cholesterol: Potential importance of pathway intermediates The Journal of Steroid Biochemistry and Molecular Biology ·Jonas Abdel‐Khalik,Tom Hearn,Rolan Henrique Pires Brozeghini Rolan Henrique Pires Brozeghini,Peter J. Crick,Eylan Yutuc,Yasuhiro Nishimura,Brian Bigger,Andrew A. M. Morris,Cedric Shackleton,Peter T. Clayton,Takashi Iida,Ria Sircar,Rajat Rohatgi,Hanns–Ulrich Marschall,Jan Sjövall,Ingemar Björkhem,Jonathan G.L. Mullins,William J. Griffiths,Yuqin Wang	2020	12
9	An improved AAV vector for neurological correction of the mouse model of Mucopolysaccharidosis IIIA UCL Discovery (University College London) ·Dadan Muhamad Hidayat,Claire O’Leary,Michele Gallinaro,José A. G. Agúndez,IsabelleSuc,W. F. Cheal,Helen Parker,L Grib,Olivier Danos,Michaël Hocquemiller,O I. Oloyede,S Yan,Els Henckaerts,Shoukofeh Dostvandi,Brian Bigger	2019	1
10	Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours Journal of Neuroinflammation ·余祝文,Aisling Eyers,Claire O’Leary,Gabriella Forte,Helen Parker,Aiyin Liao,Brian A. Telfer,Kaye J. Williams,Ian Kamaly-Asl,Brian Bigger	2019	16
11	Substrate accumulation and extracellular matrix remodelling promote persistent upper airway disease in mucopolysaccharidosis patients on enzyme replacement therapy PLoS ONE ·Abhijit Pal,Jean Mercer,Simon Jones,Iain Bruce,Brian Bigger	2018	12
12	Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients The Journal of Steroid Biochemistry and Molecular Biology ·William J. Griffiths,Jonas Abdel‐Khalik,Peter J. Crick,Michael Ogundare,Cedric Shackleton,Karin Tuschl,Kiyoe Sakai,Brian Bigger,Andrew A. M. Morris,Akira Honda,Libin Xu,Ned A. Porter,Ingemar Björkhem,Peter T. Clayton,Yuqin Wang	2016	34
13	Obstructive Sleep Apnea in MPS Xiaokai Hu,Z. Dragon,Aviwe Simandla,Brian Bigger,Li-Sha Guo	2015	2
14	Myeloid/Microglial Driven Autologous Hematopoietic Stem Cell Gene Therapy Corrects a Neuronopathic Lysosomal Disease Molecular Therapy ·Annette Oxindine,Alex Langford-Smith,崇小島,Claire E. Pickford,John McDermott,Sohta MIYAHARA,Kia Langford‐Smith,Catherine L.R. Merry,Simon Jones,J. E. Wraith,Robert Wynn,Fiona L. Wilkinson,Brian Bigger	2013	99
15	Neuropathology in Mouse Models of Mucopolysaccharidosis Type I, IIIA and IIIB PLoS ONE ·Fiona L. Wilkinson,Rebecca Holley,Kia Langford‐Smith,S Badrinath,Aiyin Liao,Alex Langford-Smith,Jonathan D. Cooper,Simon Jones,J. E. Wraith,Robert Wynn,Catherine L.R. Merry,Brian Bigger	2012	145
16	Hematopoietic stem cell transplantation improves the high incidence of neutralizing allo-antibodies observed in Hurler's syndrome after pharmacological enzyme replacement therapy Haematologica ·Rahmawaty Antu,Brian Bigger,健治金行,Jean Mercer,Karen Tylee,Heather J. Church,Denise Bonney,Simon Jones,J. E. Wraith,Robert Wynn	2012	40
17	Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice Molecular Genetics and Metabolism ·Marcelina Malinowska,Fiona L. Wilkinson,William Bennett,Kia Langford‐Smith,Frédéric Libaud,Joanna Jakóbkiewicz‐Banecka,Robert Wynn,J. E. Wraith,Grzegorz Węgrzyn,Brian Bigger	2009	82
18	Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice (vol 12, pg 763, 2005) UCL Discovery (University College London) ·Michael Themis,Simon N. Waddington,Manfred Schmidt,Christof von Kalle,(unknown),Faisal A. Al-Allaf,(unknown),Megha Nivsarkar,(unknown),A. HAYASHI,Suzanne M. K. Buckley,Niraja Dighe,Yen Woo You,Ajay Mistry,Brian Bigger,Ahad A. Rahim,姚福吉,Didier Trono,Adrian J. Thrasher,Charles Coutelle	2006	0
19	Perspectives on Gene Therapy for Cystic Fibrosis Airway Disease BioDrugs ·Brian Bigger,Charles Coutelle	2001	14
20	Introduction of Chloramphenicol Resistance into the Modified Mouse Mitochondrial Genome: Cloning of Unstable Sequences by Passage through Yeast Analytical Biochemistry ·Brian Bigger,Oleg Tolmachov,Jean-Marc Collombet,Charles Coutelle	2000	14

About Brian Bigger

Brian Bigger is a scholar working on Physiology, Hematology, Genetics, Cell Biology and Physiology, having authored 115 papers that have together received 3.5k indexed citations. Recurring topics across this work include Lysosomal Storage Disorders Research (68 papers), Trypanosoma species research and implications (17 papers), Cellular transport and secretion (16 papers), Virus-based gene therapy research (15 papers), CRISPR and Genetic Engineering (13 papers), Autoimmune and Inflammatory Disorders Research (11 papers), RNA Interference and Gene Delivery (7 papers) and Research on Leishmaniasis Studies (7 papers). The work is most often cited by research in Physiology (1.7k citations), Hepatology (346 citations), Cell Biology (617 citations), Genetics (383 citations) and Epidemiology (801 citations). Brian Bigger has collaborated with scholars based in United Kingdom, United States and Netherlands. Frequent co-authors include Robert Wynn, Kia Langford‐Smith, Simon Jones, Fiona L. Wilkinson, J. E. Wraith, Helen Parker, Stuart J. Forbes, Rebecca Holley, Malcolm Alison and Eunice Amofah. Their work appears in journals such as Molecular Genetics and Metabolism, Journal of Inherited Metabolic Disease, PLoS ONE, Human Gene Therapy and Molecular Therapy — Methods & Clinical Development.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact