Barry R. O’Keefe

7.9k citations

157 papers · 6.1k indexed · h-index 43

Impact in

Virology top 0.5%
- HIV Research and Treatment
Biotechnology top 0.2%
- Transgenic Plants and Applications

Papers in

Virology 28
- HIV Research and Treatment 28
Biotechnology 36
- Marine Sponges and Natural Products 22

Co-authors: James B. McMahon Michael R. Boyd Shilpa R. Shenoy Daniel M. Ratner Peter H. Seeberger Toshiyuki Mori Robert W. Buckheit Alexander Wlodawer
Journals: Journal of Natural Products (33 papers)SLAS DISCOVERY (6 papers)Antimicrobial Agents and Chemotherapy (6 papers)Journal of Virology (5 papers)Molecular Pharmacology (4 papers)
Partner nations: United States Japan Taiwan

In The Last Decade

Barry R. O’Keefe

149 papers receiving 6.0k citations

Peers

Countries citing papers authored by Barry R. O’Keefe

Since Specialization

Citations

This map shows the geographic impact of Barry R. O’Keefe's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Barry R. O’Keefe with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Barry R. O’Keefe more than expected).

Fields of papers citing papers by Barry R. O’Keefe

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Barry R. O’Keefe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Barry R. O’Keefe. The network helps show where Barry R. O’Keefe may publish in the future.

Co-authors

The 25 scholars most cited alongside Barry R. O’Keefe, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Barry R. O’Keefe Line = papers co-authored together Barry R. O’Keefe links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	DeepTarget predicts anti-cancer mechanisms of action of small molecules by integrating drug and genetic screens npj Precision Oncology ·Sanju Sinha, Neelam Sinha, Marlenne Perales, Adi V Tarrab, Trinh Nguyen, Lihe Liu, Thomas Cantore, Kyle Alvarez, Sumeet Patiyal, Sekhar Mukherjee, Sanna Madan, Kevin Tharp, Jianhua Zhao, Ranjit Kumar, Greg Flanigan, John A. Beutler, Barry R. O’Keefe, Daoud Meerzaman, Uri Ben‐David, Aniruddha J. Deshpande, (unknown)	2025	0
2	Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy Antimicrobial Agents and Chemotherapy ·Emily Puumala, Sunna Nabeela, Christopher C. Thornburg, Tanja Grkovic, Priya Uppuluri, Luke Whitesell, Barry R. O’Keefe, Nicole Robbins, Leah E. Cowen	2024	1
3	Structure elucidation, absolute configuration, and biological evaluation of cyclic peroxides from the sponge Plakinastrella sp. Bioorganic & Medicinal Chemistry Letters ·Rohitesh Kumar, Rhone K. Akee, Lucero Martínez-Fructuoso, Vítor F. Freire, Christopher C. Thornburg, Jason R. Evans, Brian D. Peyser, Susan M. Ensel, Barry R. O’Keefe, Tanja Grkovic	2024	1
4	MoMo30 Binds to SARS-CoV-2 Spike Variants and Blocks Infection by SARS-CoV-2 Pseudovirus Viruses ·Kenya DeBarros, Mahfuz Khan, Morgan I. Coleman, Vincent C. Bond, Virginia Floyd, Erick Gbodossou, Amad Diop, Lauren R. H. Krumpe, Barry R. O’Keefe, Michael D. Powell	2024	0
5	Antimicrobial bianthrones from the crinoid Heterometra sp. RSC Advances ·Vítor F. Freire, Lucero Martínez-Fructuoso, Rohitesh Kumar, Rhone K. Akee, Christopher C. Thornburg, Susan M. Ensel, Ekene Okoroafor, Jason R. Evans, Dongdong Wang, Brian D. Peyser, Tanja Grkovic, Barry R. O’Keefe	2024	1
6	Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues Chemical Science ·Taylor B. Smallwood, Lauren R. H. Krumpe, Colton D. Payne, Victoria G. Klein, Barry R. O’Keefe, Richard J. Clark, Christina I. Schroeder, K. Johan Rosengren	2024	3
7	Screen for New Antimicrobial Natural Products from the NCI Program for Natural Product Discovery Prefractionated Extract Library ACS Infectious Diseases ·Lucero Martínez-Fructuoso, S J Ryan Arends, Vítor F. Freire, Jason R. Evans, Sean DeVries, Brian D. Peyser, Rhone K. Akee, Christopher C. Thornburg, Rohitesh Kumar, Susan M. Ensel, Gina Morgan, Grant D. McConachie, Nathan Veeder, Leonard R Duncan, Tanja Grkovic, Barry R. O’Keefe	2023	20
8	National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks ACS Omega ·Jason R. Evans, Rhone K. Akee, Shaurya Chanana, Grant D. McConachie, Christopher C. Thornburg, Tanja Grkovic, Barry R. O’Keefe	2023	4
9	Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein Biochemistry ·Aakansha Nangarlia, Farah Fazloon Hassen, Gabriela Canziani, Praneeta Bandi, Choya Talukder, Fengwen Zhang, Douglas Krauth, E. Gary, David B. Weiner, Paul D. Bieniasz, Sonia Navas, Barry R. O’Keefe, Charles G. Ang, Irwin Chaiken	2023	4
10	Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses Journal of Natural Products ·George S. Hanna, Yeun‐Mun Choo, Ryan Harbit, Heather Paeth, Sarah Wilde, James Mackle, Jacopo Umberto Verga, Bethany J. Wolf, Olivier P. Thomas, Peter Croot, James Cray, Courtney Thomas, Lingzhi Li, Gary Hardiman, Jin‐Feng Hu, Xiaojuan Wang, Dharmeshkumar Patel, Raymond F. Schinazi, Barry R. O’Keefe, Mark T. Hamann	2021	5
11	Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge The Journal of Infectious Diseases ·Michael K. Lo, Jessica R. Spengler, Lauren R. H. Krumpe, Stephen R. Welch, Anasuya Chattopadhyay, Jessica R. Harmon, JoAnn D. Coleman-McCray, Florine E. M. Scholte, Anne L. Hotard, Joshua L. Fuqua, John K. Rose, Stuart T. Nichol, Kenneth E. Palmer, Barry R. O’Keefe, Christina F. Spiropoulou	2020	44
12	Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods Phytochemistry ·Trong D. Tran, Brice A. P. Wilson, Curtis J. Henrich, Karen Wendt, Jarrod B. King, Robert H. Cichewicz, Alberto M. Stchigel, Andrew N. Miller, Barry R. O’Keefe, Kirk R. Gustafson	2020	7
13	Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas Molecular Cancer Therapeutics ·Long‐Sheng Chang, Janet L. Oblinger, Sarah S. Burns, Jie Huang, Larry W. Anderson, Melinda G. Hollingshead, Rulong Shen, Pan Li, Garima Agarwal, Yulin Ren, Ryan D. Roberts, Barry R. O’Keefe, A. Douglas Kinghorn, Jerry M. Collins	2019	16
14	Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm Proceedings of the National Academy of Sciences ·Evangelia Vamvaka, Gemma Farré, Luis M. Molinos‐Albert, Abbey Evans, Anna Canela-Xandri, Richard M. Twyman, Jorge Carrillo, Raziel A. Ordóñez, Robin J. Shattock, Barry R. O’Keefe, Bonaventura Clotet, Julià Blanco, G. S. Khush, Paul Christou, Teresa Capell	2018	28
15	Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina Organic Letters ·Katherine Zlotkowski, William M. Hewitt, Pengcheng Yan, Heidi R. Bokesch, Megan L. Peach, Marc C. Nicklaus, Barry R. O’Keefe, James B. McMahon, Kirk R. Gustafson, John S. Schneekloth	2017	18
16	Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity Structure ·Tinoush Moulaei, Shilpa R. Shenoy, Barbara Giomarelli, Cheryl Thomas, James B. McMahon, Zbigniew Dauter, Barry R. O’Keefe, Alexander Wlodawer	2010	78
17	Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component Proceedings of the National Academy of Sciences ·Barry R. O’Keefe, Fakhrieh Vojdani, Viviana Buffa, Robin J. Shattock, David C. Montefiori, James Bakke, Jon C. Mirsalis, Annalisa D’Andrea, Steven D. Hume, Barry Bratcher, Carrie J. Saucedo, James B. McMahon, Gregory P. Pogue, Kenneth E. Palmer	2009	208
18	The Domain-Swapped Dimer of Cyanovirin-N Is in a Metastable Folded State Structure ·Laura G. Barrientos, John M. Louis, Istvan Botos, Toshiyuki Mori, Zhaozhong Han, Barry R. O’Keefe, Michael R. Boyd, Alexander Wlodawer, Angela M. Gronenborn	2002	105
19	Multisite and Multivalent Binding between Cyanovirin-N and Branched Oligomannosides Chemistry & Biology ·Shilpa R. Shenoy, Laura G. Barrientos, Daniel M. Ratner, Barry R. O’Keefe, Peter H. Seeberger, Angela M. Gronenborn, Michael R. Boyd	2002	83
20	Isolation and characterization of adociavirin, a novel HIV‐inhibitory protein from the sponge Adocia sp.¹ FEBS Letters ·Barry R. O’Keefe, Tolga Erim, John A. Beutler, John H. Cardellina, Robert J. Gulakowski, Benjamin L. Krepps, James B. McMahon, Raymond C. Sowder, Donald G. Johnson, Robert W. Buckheit, Susan M. Halliday, Michael R. Boyd	1998	9

About Barry R. O’Keefe

Barry R. O’Keefe is a scholar working on Virology, Biotechnology, Pharmacology, Organic Chemistry and Biochemistry, having authored 157 papers that have together received 6.1k indexed citations. Recurring topics across this work include HIV Research and Treatment (28 papers), Microbial Natural Products and Biosynthesis (25 papers), Marine Sponges and Natural Products (22 papers), Carbohydrate Chemistry and Synthesis (21 papers), Glycosylation and Glycoproteins Research (21 papers), Monoclonal and Polyclonal Antibodies Research (13 papers), HIV/AIDS drug development and treatment (10 papers) and Traditional and Medicinal Uses of Annonaceae (10 papers). The work is most often cited by research in Virology (1.1k citations), Biotechnology (998 citations), Microbiology (354 citations), Molecular Biology (3.5k citations) and Organic Chemistry (1.4k citations). Barry R. O’Keefe has collaborated with scholars based in United States, Japan and Taiwan. Frequent co-authors include James B. McMahon, Michael R. Boyd, Shilpa R. Shenoy, Daniel M. Ratner, Peter H. Seeberger, Toshiyuki Mori, Robert W. Buckheit, Alexander Wlodawer, Raymond C. Sowder and Kenneth E. Palmer. Their work appears in journals such as Journal of Natural Products, SLAS DISCOVERY, Antimicrobial Agents and Chemotherapy, Journal of Virology and Molecular Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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